SI3220916T1 - Postopek zdravljenja raka z n-((4,6-dimetil-2-okso-1,2-dihidropiridin-3 -il)metil)-5-(etil(tetrahidro-2h-piran-4-il) amino)-4-metil-4'- (morfolinometil)-(1,1'-bifenil)-3-karboksamidom - Google Patents

Postopek zdravljenja raka z n-((4,6-dimetil-2-okso-1,2-dihidropiridin-3 -il)metil)-5-(etil(tetrahidro-2h-piran-4-il) amino)-4-metil-4'- (morfolinometil)-(1,1'-bifenil)-3-karboksamidom

Info

Publication number
SI3220916T1
SI3220916T1 SI201531949T SI201531949T SI3220916T1 SI 3220916 T1 SI3220916 T1 SI 3220916T1 SI 201531949 T SI201531949 T SI 201531949T SI 201531949 T SI201531949 T SI 201531949T SI 3220916 T1 SI3220916 T1 SI 3220916T1
Authority
SI
Slovenia
Prior art keywords
methyl
dihydropyridin
morpholinomethyl
pyran
carboxamide
Prior art date
Application number
SI201531949T
Other languages
English (en)
Inventor
Heike Keilhack
Brett Truitt
Yuta Suzuki
Tsukasa Murase
Futoshi Shikata
Original Assignee
Epizyme, Inc.
Eisai R&D Management Co., Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Epizyme, Inc., Eisai R&D Management Co., Ltd. filed Critical Epizyme, Inc.
Publication of SI3220916T1 publication Critical patent/SI3220916T1/sl

Links

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2095—Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
    • A61K9/284—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone
    • A61K9/2846—Poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2893—Tablet coating processes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Steroid Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
SI201531949T 2014-11-17 2015-11-17 Postopek zdravljenja raka z n-((4,6-dimetil-2-okso-1,2-dihidropiridin-3 -il)metil)-5-(etil(tetrahidro-2h-piran-4-il) amino)-4-metil-4'- (morfolinometil)-(1,1'-bifenil)-3-karboksamidom SI3220916T1 (sl)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201462080985P 2014-11-17 2014-11-17
US201562166572P 2015-05-26 2015-05-26
US201562251903P 2015-11-06 2015-11-06
EP15860676.4A EP3220916B1 (en) 2014-11-17 2015-11-17 Method for treating cancer with n-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-5-(ethyl(tetrahydro-2h-pyran-4-yl) amino)-4-methyl-4'-(morpholinomethyl)-[1,1'-biphenyl]-3-carboxamide
PCT/US2015/061194 WO2016081523A1 (en) 2014-11-17 2015-11-17 Method for treating cancer

Publications (1)

Publication Number Publication Date
SI3220916T1 true SI3220916T1 (sl) 2023-09-29

Family

ID=56014476

Family Applications (1)

Application Number Title Priority Date Filing Date
SI201531949T SI3220916T1 (sl) 2014-11-17 2015-11-17 Postopek zdravljenja raka z n-((4,6-dimetil-2-okso-1,2-dihidropiridin-3 -il)metil)-5-(etil(tetrahidro-2h-piran-4-il) amino)-4-metil-4'- (morfolinometil)-(1,1'-bifenil)-3-karboksamidom

Country Status (22)

Country Link
US (2) US10786511B2 (sl)
EP (2) EP3220916B1 (sl)
JP (3) JP6829684B2 (sl)
KR (3) KR102338802B1 (sl)
CN (2) CN116650500A (sl)
AU (3) AU2015350108B2 (sl)
BR (1) BR112017010166A2 (sl)
CA (1) CA2967664A1 (sl)
DK (1) DK3220916T3 (sl)
EA (1) EA201791095A1 (sl)
ES (1) ES2947819T3 (sl)
FI (1) FI3220916T3 (sl)
HU (1) HUE062159T2 (sl)
IL (3) IL296080B2 (sl)
LT (1) LT3220916T (sl)
MX (2) MX2017006089A (sl)
NZ (1) NZ731696A (sl)
PL (1) PL3220916T3 (sl)
PT (1) PT3220916T (sl)
SG (1) SG11201703806XA (sl)
SI (1) SI3220916T1 (sl)
WO (1) WO2016081523A1 (sl)

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KR20210117347A (ko) 2013-12-06 2021-09-28 에피자임, 인코포레이티드 암 치료를 위한 병용 요법
JP6779793B2 (ja) 2014-06-17 2020-11-04 エピザイム，インコーポレイティド リンパ腫を治療するためのｅｚｈ２阻害剤
CN116650500A (zh) 2014-11-17 2023-08-29 Epizyme股份有限公司 治疗癌症的方法
WO2016172199A1 (en) 2015-04-20 2016-10-27 Epizyme, Inc. Combination therapy for treating cancer
EA201890009A1 (ru) 2015-06-10 2018-07-31 Эпизайм, Инк. Ингибиторы ezh2 для лечения лимфомы
CA2996412A1 (en) 2015-08-24 2017-03-02 Epizyme, Inc. Method for treating cancer
US11951108B2 (en) 2016-01-29 2024-04-09 Epizyme, Inc. Combination therapy for treating cancer
US11786533B2 (en) 2016-06-01 2023-10-17 Epizyme, Inc. Use of EZH2 inhibitors for treating cancer
MA45406A (fr) 2016-06-17 2019-04-24 Epizyme Inc Inhibiteurs d'ezh2 pour traiter le cancer
KR20190105602A (ko) 2017-01-19 2019-09-17 다이이찌 산쿄 가부시키가이샤 Htlv-1 관련 척수증을 치료하는 것에 사용하기 위한 의약 조성물
US11642346B2 (en) 2017-03-31 2023-05-09 Epizyme, Inc. Combination therapy for treating cancer
CN110944628A (zh) 2017-06-02 2020-03-31 Epizyme股份有限公司 使用ezh2抑制剂治疗癌症
JP7399079B2 (ja) 2017-09-05 2023-12-15 エピザイム，インコーポレイティド 癌を処置するための併用療法
JP2022167451A (ja) 2021-04-23 2022-11-04 日立Astemo株式会社 情報処理装置、情報処理方法、プログラムおよび記憶媒体
WO2023159124A2 (en) * 2022-02-17 2023-08-24 Memorial Sloan-Kettering Cancer Center Methods for overcoming tazemetostat-resistance in cancer patients
WO2023209591A1 (en) 2022-04-27 2023-11-02 Daiichi Sankyo Company, Limited Combination of antibody-drug conjugate with ezh1 and/or ezh2 inhibitor

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US7229774B2 (en) 2001-08-02 2007-06-12 Regents Of The University Of Michigan Expression profile of prostate cancer
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JP6779793B2 (ja) * 2014-06-17 2020-11-04 エピザイム，インコーポレイティド リンパ腫を治療するためのｅｚｈ２阻害剤
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JP2017532338A (ja) 2014-10-16 2017-11-02 エピザイム，インコーポレイティド 癌を治療する方法
CN116650500A (zh) 2014-11-17 2023-08-29 Epizyme股份有限公司 治疗癌症的方法
EA201890009A1 (ru) * 2015-06-10 2018-07-31 Эпизайм, Инк. Ингибиторы ezh2 для лечения лимфомы
MA45406A (fr) * 2016-06-17 2019-04-24 Epizyme Inc Inhibiteurs d'ezh2 pour traiter le cancer

Also Published As

Publication number Publication date
AU2015350108B2 (en) 2021-04-08
US10786511B2 (en) 2020-09-29
IL296080A (en) 2022-11-01
IL296080B2 (en) 2023-12-01
JP7485810B2 (ja) 2024-05-16
MX2017006089A (es) 2017-12-11
EP3220916A4 (en) 2018-07-11
AU2021204706A1 (en) 2021-07-29
IL304252A (en) 2023-09-01
LT3220916T (lt) 2023-07-25
NZ731696A (en) 2024-03-22
KR102644844B1 (ko) 2024-03-07
PT3220916T (pt) 2023-06-26
JP2023062189A (ja) 2023-05-02
EP3220916A1 (en) 2017-09-27
US20170360797A1 (en) 2017-12-21
BR112017010166A2 (pt) 2018-02-14
ES2947819T3 (es) 2023-08-21
MX2021006734A (es) 2021-07-02
KR102338802B1 (ko) 2021-12-14
AU2021204706B2 (en) 2023-11-23
KR20170103768A (ko) 2017-09-13
KR20210156840A (ko) 2021-12-27
SG11201703806XA (en) 2017-06-29
US20210060030A1 (en) 2021-03-04
CN107249591A (zh) 2017-10-13
CN107249591B (zh) 2024-01-30
AU2015350108A1 (en) 2017-05-25
WO2016081523A1 (en) 2016-05-26
IL252182B2 (en) 2023-02-01
FI3220916T3 (fi) 2023-06-19
KR20240035908A (ko) 2024-03-18
AU2024201171A1 (en) 2024-03-14
IL252182A0 (en) 2017-07-31
CA2967664A1 (en) 2016-05-26
JP2021073241A (ja) 2021-05-13
CN116650500A (zh) 2023-08-29
HUE062159T2 (hu) 2023-10-28
PL3220916T3 (pl) 2023-08-14
JP2017537899A (ja) 2017-12-21
JP6829684B2 (ja) 2021-02-10
IL296080B1 (en) 2023-08-01
EA201791095A1 (ru) 2017-10-31
IL252182B (en) 2022-10-01
EP4272742A1 (en) 2023-11-08
EP3220916B1 (en) 2023-04-19
DK3220916T3 (da) 2023-06-26

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