EA201790785A1 - Производные тетрагидроизохинолина - Google Patents
Производные тетрагидроизохинолинаInfo
- Publication number
- EA201790785A1 EA201790785A1 EA201790785A EA201790785A EA201790785A1 EA 201790785 A1 EA201790785 A1 EA 201790785A1 EA 201790785 A EA201790785 A EA 201790785A EA 201790785 A EA201790785 A EA 201790785A EA 201790785 A1 EA201790785 A1 EA 201790785A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- derivatives
- tetrahydroisoquinoline
- pharmaceuticals
- diseases
- role
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/472—Non-condensed isoquinolines, e.g. papaverine
- A61K31/4725—Non-condensed isoquinolines, e.g. papaverine containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
- C07D217/06—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with the ring nitrogen atom acylated by carboxylic or carbonic acids, or with sulfur or nitrogen analogues thereof, e.g. carbamates
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
Abstract
В заявке описаны производные тетрагидроизохинолина формулы Iкоторые являются позитивными аллостерическими модуляторами D1 и поэтому полезны для применения в качестве фармацевтических средств, предназначенных для лечения заболеваний, в которых играют роль рецепторы D1.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP14188174 | 2014-10-08 | ||
PCT/EP2015/073053 WO2016055479A1 (en) | 2014-10-08 | 2015-10-06 | Tetrahydroisoquinoline derivatives |
Publications (2)
Publication Number | Publication Date |
---|---|
EA201790785A1 true EA201790785A1 (ru) | 2017-10-31 |
EA035544B1 EA035544B1 (ru) | 2020-07-03 |
Family
ID=51790569
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA201790785A EA035544B1 (ru) | 2014-10-08 | 2015-10-06 | Производные тетрагидроизохинолина |
Country Status (17)
Country | Link |
---|---|
US (1) | US10105359B2 (ru) |
EP (1) | EP3204359B1 (ru) |
JP (1) | JP6622299B2 (ru) |
CN (1) | CN107001278B (ru) |
BR (1) | BR112017007123B1 (ru) |
CA (1) | CA2963951C (ru) |
CY (1) | CY1123417T1 (ru) |
DK (1) | DK3204359T3 (ru) |
EA (1) | EA035544B1 (ru) |
ES (1) | ES2821821T3 (ru) |
HR (1) | HRP20201469T1 (ru) |
HU (1) | HUE050664T2 (ru) |
LT (1) | LT3204359T (ru) |
PT (1) | PT3204359T (ru) |
RS (1) | RS60933B1 (ru) |
SI (1) | SI3204359T1 (ru) |
WO (1) | WO2016055479A1 (ru) |
Families Citing this family (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR20180132629A (ko) * | 2016-02-25 | 2018-12-12 | 아셰뉴론 에스아 | 글리코시다제 저해제 |
EP3442945B1 (en) * | 2016-04-13 | 2020-07-08 | UCB Biopharma SRL | Tetrahydroisoquinoline derivatives |
CN107698433A (zh) * | 2017-09-12 | 2018-02-16 | 潍坊滨海石油化工有限公司 | 苯乙酸的制备方法 |
US20200369675A1 (en) | 2017-12-01 | 2020-11-26 | UCB Biopharma SRL | Imaging Agents |
TWI725408B (zh) * | 2018-04-20 | 2021-04-21 | 美商美國禮來大藥廠 | 多巴胺d1受體正向異位調節劑 |
CA3139571A1 (en) | 2019-07-01 | 2021-01-07 | UCB Biopharma SRL | A substituted tetrahydroisoquinoline derivative as a d1 positive allosteric modulator |
CA3139622A1 (en) | 2019-07-01 | 2021-01-07 | UCB Biopharma SRL | A substituted tetrahydroisoquinoline derivative as a d1 positive allosteric modulator |
CN111943930B (zh) * | 2020-08-25 | 2022-11-01 | 南京三元阳普医药科技有限公司 | Lasmiditan的合成工艺 |
WO2022076418A1 (en) * | 2020-10-07 | 2022-04-14 | Eli Lilly And Company | Phenyl-3,4-dihydroisoquinolin-2(1h)-yl-ethan-1-one derivatives as dopamine d1 receptor positive allosteric modulators |
JP2023551173A (ja) | 2020-12-03 | 2023-12-07 | ユーシービー バイオファルマ エスアールエル | オクタヒドロイソキノリニル誘導体 |
EP4263522A1 (en) | 2020-12-18 | 2023-10-25 | UCB Biopharma SRL | Dihydroisoquinolinyl derivatives |
CA3203281A1 (en) * | 2020-12-18 | 2022-06-23 | UCB Biopharma SRL | Prodrugs of 2-(3,5-dichloro-1-methyl-indazol-4-yl)-1-[(1s,3r)-3-(hydroxymethyl)-5-(1-hydroxy-1-methyl-ethyl)-1-methyl-3,4-dihydro-1h-isoquinolin-2-yl]ethanone |
KR20230121849A (ko) | 2020-12-18 | 2023-08-21 | 유씨비 바이오파마 에스알엘 | D1 포지티브 알로스테릭 모듈레이터로서 치환된 테트라하이드로이소퀴놀린유도체 |
PE20240021A1 (es) * | 2020-12-18 | 2024-01-04 | UCB Biopharma SRL | Dispersiones solidas amorfas |
WO2022192231A1 (en) | 2021-03-08 | 2022-09-15 | Eli Lilly And Company | Use of mevidalen and other d1 positive allosteric modulators in the treatment of hallucinations and dementia-related psychosis |
EP4304577A1 (en) | 2021-03-09 | 2024-01-17 | Eli Lilly And Co. | Use of mevidalen and other d1 positive allosteric modulators for slowing of parkinson's disease progression |
CN114671810B (zh) * | 2022-03-21 | 2024-03-22 | 济南鸿湾生物技术有限公司 | 一种咪唑苯脲的制备方法 |
CN115611768B (zh) * | 2022-11-14 | 2024-03-05 | 郑州大学 | 一种3,4-二氯苯腈的合成方法 |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4766131A (en) * | 1980-10-17 | 1988-08-23 | Pennwalt Corporation | 2-amino (or hydroxy) phenethyl-1,2,3,4-tetrahydroisoquinolines as analgesics |
EP1458714A1 (en) * | 2001-12-19 | 2004-09-22 | H. Lundbeck A/S | 3,4-dihydro-1h-isoquinoloin-2-yl-derivatives |
ES2342083T3 (es) * | 2004-04-29 | 2010-07-01 | Aventis Pharmaceuticals Inc. | 3-piperidinilisocroman-5-oles como agonistas de dopamina. |
CN101668746A (zh) * | 2007-03-01 | 2010-03-10 | 詹森药业有限公司 | 作为组胺h3受体调节剂的四氢异喹啉化合物 |
-
2015
- 2015-10-06 CN CN201580064005.3A patent/CN107001278B/zh active Active
- 2015-10-06 EP EP15775688.3A patent/EP3204359B1/en active Active
- 2015-10-06 DK DK15775688.3T patent/DK3204359T3/da active
- 2015-10-06 US US15/517,795 patent/US10105359B2/en active Active
- 2015-10-06 LT LTEP15775688.3T patent/LT3204359T/lt unknown
- 2015-10-06 ES ES15775688T patent/ES2821821T3/es active Active
- 2015-10-06 RS RS20201139A patent/RS60933B1/sr unknown
- 2015-10-06 CA CA2963951A patent/CA2963951C/en active Active
- 2015-10-06 EA EA201790785A patent/EA035544B1/ru not_active IP Right Cessation
- 2015-10-06 PT PT157756883T patent/PT3204359T/pt unknown
- 2015-10-06 JP JP2017518989A patent/JP6622299B2/ja active Active
- 2015-10-06 HU HUE15775688A patent/HUE050664T2/hu unknown
- 2015-10-06 BR BR112017007123-1A patent/BR112017007123B1/pt active IP Right Grant
- 2015-10-06 SI SI201531348T patent/SI3204359T1/sl unknown
- 2015-10-06 WO PCT/EP2015/073053 patent/WO2016055479A1/en active Application Filing
-
2020
- 2020-09-15 HR HRP20201469TT patent/HRP20201469T1/hr unknown
- 2020-09-30 CY CY20201100923T patent/CY1123417T1/el unknown
Also Published As
Publication number | Publication date |
---|---|
CY1123417T1 (el) | 2021-12-31 |
HRP20201469T1 (hr) | 2020-12-11 |
US20170304292A1 (en) | 2017-10-26 |
PT3204359T (pt) | 2020-09-24 |
CA2963951A1 (en) | 2016-04-14 |
ES2821821T3 (es) | 2021-04-27 |
EP3204359B1 (en) | 2020-07-01 |
JP2017530185A (ja) | 2017-10-12 |
CA2963951C (en) | 2023-02-28 |
SI3204359T1 (sl) | 2020-10-30 |
HUE050664T2 (hu) | 2020-12-28 |
RS60933B1 (sr) | 2020-11-30 |
BR112017007123B1 (pt) | 2023-01-31 |
WO2016055479A1 (en) | 2016-04-14 |
LT3204359T (lt) | 2020-10-12 |
EP3204359A1 (en) | 2017-08-16 |
CN107001278B (zh) | 2020-11-24 |
DK3204359T3 (da) | 2020-09-14 |
EA035544B1 (ru) | 2020-07-03 |
US10105359B2 (en) | 2018-10-23 |
BR112017007123A2 (pt) | 2017-12-19 |
CN107001278A (zh) | 2017-08-01 |
JP6622299B2 (ja) | 2019-12-18 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
MM4A | Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s) |
Designated state(s): AM AZ BY KZ KG TJ TM |