DK3204359T3 - Tetrahydroisoquinolinderivater - Google Patents
Tetrahydroisoquinolinderivater Download PDFInfo
- Publication number
- DK3204359T3 DK3204359T3 DK15775688.3T DK15775688T DK3204359T3 DK 3204359 T3 DK3204359 T3 DK 3204359T3 DK 15775688 T DK15775688 T DK 15775688T DK 3204359 T3 DK3204359 T3 DK 3204359T3
- Authority
- DK
- Denmark
- Prior art keywords
- tetrahydroisoquinoline derivatives
- tetrahydroisoquinoline
- derivatives
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/472—Non-condensed isoquinolines, e.g. papaverine
- A61K31/4725—Non-condensed isoquinolines, e.g. papaverine containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
- C07D217/06—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with the ring nitrogen atom acylated by carboxylic or carbonic acids, or with sulfur or nitrogen analogues thereof, e.g. carbamates
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP14188174 | 2014-10-08 | ||
| PCT/EP2015/073053 WO2016055479A1 (en) | 2014-10-08 | 2015-10-06 | Tetrahydroisoquinoline derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK3204359T3 true DK3204359T3 (da) | 2020-09-14 |
Family
ID=51790569
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK15775688.3T DK3204359T3 (da) | 2014-10-08 | 2015-10-06 | Tetrahydroisoquinolinderivater |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US10105359B2 (da) |
| EP (1) | EP3204359B1 (da) |
| JP (1) | JP6622299B2 (da) |
| CN (1) | CN107001278B (da) |
| BR (1) | BR112017007123B1 (da) |
| CA (1) | CA2963951C (da) |
| CY (1) | CY1123417T1 (da) |
| DK (1) | DK3204359T3 (da) |
| EA (1) | EA035544B1 (da) |
| ES (1) | ES2821821T3 (da) |
| HR (1) | HRP20201469T1 (da) |
| HU (1) | HUE050664T2 (da) |
| LT (1) | LT3204359T (da) |
| PT (1) | PT3204359T (da) |
| RS (1) | RS60933B1 (da) |
| SI (1) | SI3204359T1 (da) |
| WO (1) | WO2016055479A1 (da) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2019510006A (ja) * | 2016-02-25 | 2019-04-11 | エースニューロン・ソシエテ・アノニム | グリコシダーゼ阻害剤 |
| JP6908623B2 (ja) * | 2016-04-13 | 2021-07-28 | ユーシービー バイオファルマ エスアールエル | テトラヒドロイソキノリン誘導体 |
| CN107698433A (zh) * | 2017-09-12 | 2018-02-16 | 潍坊滨海石油化工有限公司 | 苯乙酸的制备方法 |
| CA3083329A1 (en) * | 2017-12-01 | 2019-06-06 | UCB Biopharma SRL | Imaging agents |
| TWI725408B (zh) * | 2018-04-20 | 2021-04-21 | 美商美國禮來大藥廠 | 多巴胺d1受體正向異位調節劑 |
| WO2021001286A1 (en) * | 2019-07-01 | 2021-01-07 | UCB Biopharma SRL | A substituted tetrahydroisoquinoline derivative as a d1 positive allosteric modulator |
| JP2022539152A (ja) * | 2019-07-01 | 2022-09-07 | ユーシービー バイオファルマ エスアールエル | Ｄ１ポジティブアロステリックモジュレーターとしての置換テトラヒドロイソキノリン誘導体 |
| CN111943930B (zh) * | 2020-08-25 | 2022-11-01 | 南京三元阳普医药科技有限公司 | Lasmiditan的合成工艺 |
| DK4200280T3 (da) * | 2020-10-07 | 2024-03-04 | Lilly Co Eli | Phenyl-3,4-dihydroisoquinolin-2(1H)-yl-ethan-on-derivater som positive allosteriske modulatorer af dopamin-D1-receptorer |
| US20240043400A1 (en) | 2020-12-03 | 2024-02-08 | UCB Biopharma SRL | Octahydroisoquinolinyl Derivatives |
| CA3202106A1 (en) | 2020-12-18 | 2022-06-23 | Adrian Hall | Dihydroisoquinolinyl derivatives |
| JP2024500391A (ja) * | 2020-12-18 | 2024-01-09 | ユーシービー バイオファルマ エスアールエル | ２－（３，５－ジクロロ－１－メチル－インダゾール－４－イル）－１－［（１ｓ，３ｒ）－３－（ヒドロキシメチル）－５－（１－ヒドロキシ－１－メチル－エチル）－１－メチル－３，４－ジヒドロ－１ｈ－イソキノリン－２－イル］エタノンのプロドラッグ |
| WO2022129268A1 (en) | 2020-12-18 | 2022-06-23 | UCB Biopharma SRL | A substituted tetrahydroisoquinoline derivative as a d1 positive allosteric modulator |
| CA3201298A1 (en) * | 2020-12-18 | 2022-06-23 | UCB Biopharma SRL | Amorphous solid dispersions |
| CA3211261A1 (en) | 2021-03-08 | 2022-09-15 | Kevin Michael BIGLAN | Use of mevidalen and other d1 positive allosteric modulators in the treatment of hallucinations and dementia-related psychosis |
| KR20230154968A (ko) | 2021-03-09 | 2023-11-09 | 일라이 릴리 앤드 캄파니 | 파킨슨병 진행을 늦추기 위한 메비달렌 및 다른 d1 양성 알로스테릭 조절제의 용도 |
| CN114671810B (zh) * | 2022-03-21 | 2024-03-22 | 济南鸿湾生物技术有限公司 | 一种咪唑苯脲的制备方法 |
| CN115611768B (zh) * | 2022-11-14 | 2024-03-05 | 郑州大学 | 一种3,4-二氯苯腈的合成方法 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4766131A (en) * | 1980-10-17 | 1988-08-23 | Pennwalt Corporation | 2-amino (or hydroxy) phenethyl-1,2,3,4-tetrahydroisoquinolines as analgesics |
| US7384957B2 (en) * | 2001-12-19 | 2008-06-10 | H. Lundbeck A/S | 3,4-dihydro-1H-isoquinolin-2-yl-derivatives |
| PT1749001E (pt) * | 2004-04-29 | 2010-05-31 | Aventis Pharma Inc | 3-piperidinilisocroman-5-oles como agonistas da dopamina |
| RU2009136330A (ru) * | 2007-03-01 | 2011-04-10 | Янссен Фармацевтика Н.В. (Be) | Тетрагидроизохинолиновые соединения в качестве модуляторов гистаминового н3 рецептора |
-
2015
- 2015-10-06 PT PT157756883T patent/PT3204359T/pt unknown
- 2015-10-06 EP EP15775688.3A patent/EP3204359B1/en active Active
- 2015-10-06 RS RS20201139A patent/RS60933B1/sr unknown
- 2015-10-06 US US15/517,795 patent/US10105359B2/en active Active
- 2015-10-06 ES ES15775688T patent/ES2821821T3/es active Active
- 2015-10-06 HU HUE15775688A patent/HUE050664T2/hu unknown
- 2015-10-06 LT LTEP15775688.3T patent/LT3204359T/lt unknown
- 2015-10-06 WO PCT/EP2015/073053 patent/WO2016055479A1/en active Application Filing
- 2015-10-06 SI SI201531348T patent/SI3204359T1/sl unknown
- 2015-10-06 BR BR112017007123-1A patent/BR112017007123B1/pt active IP Right Grant
- 2015-10-06 JP JP2017518989A patent/JP6622299B2/ja active Active
- 2015-10-06 EA EA201790785A patent/EA035544B1/ru not_active IP Right Cessation
- 2015-10-06 CA CA2963951A patent/CA2963951C/en active Active
- 2015-10-06 DK DK15775688.3T patent/DK3204359T3/da active
- 2015-10-06 CN CN201580064005.3A patent/CN107001278B/zh active Active
-
2020
- 2020-09-15 HR HRP20201469TT patent/HRP20201469T1/hr unknown
- 2020-09-30 CY CY20201100923T patent/CY1123417T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| HRP20201469T1 (hr) | 2020-12-11 |
| RS60933B1 (sr) | 2020-11-30 |
| JP6622299B2 (ja) | 2019-12-18 |
| CN107001278A (zh) | 2017-08-01 |
| CA2963951C (en) | 2023-02-28 |
| BR112017007123B1 (pt) | 2023-01-31 |
| EP3204359B1 (en) | 2020-07-01 |
| SI3204359T1 (sl) | 2020-10-30 |
| EA035544B1 (ru) | 2020-07-03 |
| EP3204359A1 (en) | 2017-08-16 |
| HUE050664T2 (hu) | 2020-12-28 |
| US20170304292A1 (en) | 2017-10-26 |
| BR112017007123A2 (pt) | 2017-12-19 |
| CY1123417T1 (el) | 2021-12-31 |
| PT3204359T (pt) | 2020-09-24 |
| JP2017530185A (ja) | 2017-10-12 |
| CA2963951A1 (en) | 2016-04-14 |
| CN107001278B (zh) | 2020-11-24 |
| US10105359B2 (en) | 2018-10-23 |
| LT3204359T (lt) | 2020-10-12 |
| WO2016055479A1 (en) | 2016-04-14 |
| EA201790785A1 (ru) | 2017-10-31 |
| ES2821821T3 (es) | 2021-04-27 |
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