RS60933B1 - Derivati tetrahidroizohinolina - Google Patents
Derivati tetrahidroizohinolinaInfo
- Publication number
- RS60933B1 RS60933B1 RS20201139A RSP20201139A RS60933B1 RS 60933 B1 RS60933 B1 RS 60933B1 RS 20201139 A RS20201139 A RS 20201139A RS P20201139 A RSP20201139 A RS P20201139A RS 60933 B1 RS60933 B1 RS 60933B1
- Authority
- RS
- Serbia
- Prior art keywords
- tetrahydroisoquinoline derivatives
- tetrahydroisoquinoline
- derivatives
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/472—Non-condensed isoquinolines, e.g. papaverine
- A61K31/4725—Non-condensed isoquinolines, e.g. papaverine containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
- C07D217/06—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with the ring nitrogen atom acylated by carboxylic or carbonic acids, or with sulfur or nitrogen analogues thereof, e.g. carbamates
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Psychiatry (AREA)
- Psychology (AREA)
- Epidemiology (AREA)
- Addiction (AREA)
- Hospice & Palliative Care (AREA)
- Anesthesiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP14188174 | 2014-10-08 | ||
| EP15775688.3A EP3204359B1 (en) | 2014-10-08 | 2015-10-06 | Tetrahydroisoquinoline derivatives |
| PCT/EP2015/073053 WO2016055479A1 (en) | 2014-10-08 | 2015-10-06 | Tetrahydroisoquinoline derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RS60933B1 true RS60933B1 (sr) | 2020-11-30 |
Family
ID=51790569
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RS20201139A RS60933B1 (sr) | 2014-10-08 | 2015-10-06 | Derivati tetrahidroizohinolina |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US10105359B2 (sr) |
| EP (1) | EP3204359B1 (sr) |
| JP (1) | JP6622299B2 (sr) |
| CN (1) | CN107001278B (sr) |
| BR (1) | BR112017007123B1 (sr) |
| CA (1) | CA2963951C (sr) |
| CY (1) | CY1123417T1 (sr) |
| DK (1) | DK3204359T3 (sr) |
| EA (1) | EA035544B1 (sr) |
| ES (1) | ES2821821T3 (sr) |
| HR (1) | HRP20201469T1 (sr) |
| HU (1) | HUE050664T2 (sr) |
| LT (1) | LT3204359T (sr) |
| PT (1) | PT3204359T (sr) |
| RS (1) | RS60933B1 (sr) |
| SI (1) | SI3204359T1 (sr) |
| WO (1) | WO2016055479A1 (sr) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2017222958B2 (en) * | 2016-02-25 | 2019-07-18 | Asceneuron S. A. | Glycosidase inhibitors |
| JP6908623B2 (ja) * | 2016-04-13 | 2021-07-28 | ユーシービー バイオファルマ エスアールエル | テトラヒドロイソキノリン誘導体 |
| CN107698433A (zh) * | 2017-09-12 | 2018-02-16 | 潍坊滨海石油化工有限公司 | 苯乙酸的制备方法 |
| CN111432847A (zh) * | 2017-12-01 | 2020-07-17 | Ucb生物制药有限责任公司 | 显像剂 |
| TWI725408B (zh) * | 2018-04-20 | 2021-04-21 | 美商美國禮來大藥廠 | 多巴胺d1受體正向異位調節劑 |
| CA3139571A1 (en) | 2019-07-01 | 2021-01-07 | UCB Biopharma SRL | A substituted tetrahydroisoquinoline derivative as a d1 positive allosteric modulator |
| KR20220029687A (ko) * | 2019-07-01 | 2022-03-08 | 유씨비 바이오파마 에스알엘 | D1 양성 알로스테릭 조절제로서의 치환된 테트라히드로이소퀴놀린 유도체 |
| CN111943930B (zh) * | 2020-08-25 | 2022-11-01 | 南京三元阳普医药科技有限公司 | Lasmiditan的合成工艺 |
| FI4200280T3 (fi) * | 2020-10-07 | 2024-05-03 | Lilly Co Eli | Fenyyli-3,4-dihydroisokinolin-2(1H)-yylietan-1-onijohdannaisia dopamiini D1 reseptoripositiivisina allosteerisina |
| CA3198635A1 (en) | 2020-12-03 | 2022-06-09 | UCB Biopharma SRL | Octahydroisoquinolinyl derivatives |
| AU2021401128A1 (en) * | 2020-12-18 | 2023-07-13 | UCB Biopharma SRL | Amorphous solid dispersions |
| MX2023007155A (es) | 2020-12-18 | 2023-06-28 | UCB Biopharma SRL | Un derivado de tetrahidroisoquinolina sustituido como un modulador alosterico positivo de d1. |
| WO2022129356A1 (en) * | 2020-12-18 | 2022-06-23 | UCB Biopharma SRL | Prodrugs of 2-(3,5-dichloro-1-methyl-indazol-4-yl)-1-[(1s,3r)-3-(hydroxymethyl)-5-(1-hydroxy-1-methyl-ethyl)-1-methyl-3,4-dihydro-1h-isoquinolin-2-yl]ethanone |
| CN116615198A (zh) | 2020-12-18 | 2023-08-18 | Ucb生物制药有限责任公司 | 二氢异喹啉基衍生物 |
| EP4304581A1 (en) | 2021-03-08 | 2024-01-17 | Eli Lilly And Co. | Use of mevidalen and other d1 positive allosteric modulators in the treatment of hallucinations and dementia-related psychosis |
| KR20230154968A (ko) | 2021-03-09 | 2023-11-09 | 일라이 릴리 앤드 캄파니 | 파킨슨병 진행을 늦추기 위한 메비달렌 및 다른 d1 양성 알로스테릭 조절제의 용도 |
| CN114671810B (zh) * | 2022-03-21 | 2024-03-22 | 济南鸿湾生物技术有限公司 | 一种咪唑苯脲的制备方法 |
| CN115611768B (zh) * | 2022-11-14 | 2024-03-05 | 郑州大学 | 一种3,4-二氯苯腈的合成方法 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4766131A (en) * | 1980-10-17 | 1988-08-23 | Pennwalt Corporation | 2-amino (or hydroxy) phenethyl-1,2,3,4-tetrahydroisoquinolines as analgesics |
| EP1458714A1 (en) * | 2001-12-19 | 2004-09-22 | H. Lundbeck A/S | 3,4-dihydro-1h-isoquinoloin-2-yl-derivatives |
| JP4685861B2 (ja) * | 2004-04-29 | 2011-05-18 | アベンティス・ファーマスーティカルズ・インコーポレイテツド | ドーパミンアゴニストとしての３−ピペリジニルイソクロマン−５−オール |
| CN101668746A (zh) * | 2007-03-01 | 2010-03-10 | 詹森药业有限公司 | 作为组胺h3受体调节剂的四氢异喹啉化合物 |
-
2015
- 2015-10-06 CN CN201580064005.3A patent/CN107001278B/zh active Active
- 2015-10-06 BR BR112017007123-1A patent/BR112017007123B1/pt active IP Right Grant
- 2015-10-06 SI SI201531348T patent/SI3204359T1/sl unknown
- 2015-10-06 EP EP15775688.3A patent/EP3204359B1/en active Active
- 2015-10-06 WO PCT/EP2015/073053 patent/WO2016055479A1/en active Application Filing
- 2015-10-06 EA EA201790785A patent/EA035544B1/ru not_active IP Right Cessation
- 2015-10-06 ES ES15775688T patent/ES2821821T3/es active Active
- 2015-10-06 LT LTEP15775688.3T patent/LT3204359T/lt unknown
- 2015-10-06 JP JP2017518989A patent/JP6622299B2/ja active Active
- 2015-10-06 CA CA2963951A patent/CA2963951C/en active Active
- 2015-10-06 HU HUE15775688A patent/HUE050664T2/hu unknown
- 2015-10-06 DK DK15775688.3T patent/DK3204359T3/da active
- 2015-10-06 PT PT157756883T patent/PT3204359T/pt unknown
- 2015-10-06 RS RS20201139A patent/RS60933B1/sr unknown
- 2015-10-06 US US15/517,795 patent/US10105359B2/en active Active
-
2020
- 2020-09-15 HR HRP20201469TT patent/HRP20201469T1/hr unknown
- 2020-09-30 CY CY20201100923T patent/CY1123417T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| BR112017007123A2 (pt) | 2017-12-19 |
| CY1123417T1 (el) | 2021-12-31 |
| LT3204359T (lt) | 2020-10-12 |
| WO2016055479A1 (en) | 2016-04-14 |
| EP3204359A1 (en) | 2017-08-16 |
| PT3204359T (pt) | 2020-09-24 |
| EA035544B1 (ru) | 2020-07-03 |
| BR112017007123B1 (pt) | 2023-01-31 |
| CA2963951C (en) | 2023-02-28 |
| HUE050664T2 (hu) | 2020-12-28 |
| CN107001278A (zh) | 2017-08-01 |
| SI3204359T1 (sl) | 2020-10-30 |
| HRP20201469T1 (hr) | 2020-12-11 |
| DK3204359T3 (da) | 2020-09-14 |
| EA201790785A1 (ru) | 2017-10-31 |
| EP3204359B1 (en) | 2020-07-01 |
| ES2821821T3 (es) | 2021-04-27 |
| US10105359B2 (en) | 2018-10-23 |
| JP6622299B2 (ja) | 2019-12-18 |
| CN107001278B (zh) | 2020-11-24 |
| CA2963951A1 (en) | 2016-04-14 |
| JP2017530185A (ja) | 2017-10-12 |
| US20170304292A1 (en) | 2017-10-26 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| LT3204359T (lt) | Tetrahidroizochinolino dariniai | |
| IL253381B (en) | History of h9–pyrrolo–dipyridine | |
| HK1245258A1 (zh) | 新的二氟酮酰胺衍生物 | |
| SG11201609205WA (en) | Heterocyclyl-butanamide derivatives | |
| PT3131898T (pt) | Derivados de fluoroalquilfluoreno | |
| IL248773A0 (en) | History of naphthyridinedione | |
| IL248629B (en) | Substances containing diheteroaryl conjugated to cycloalkyl and their uses | |
| PL3418273T3 (pl) | Pochodne flawaglin | |
| PL3097076T3 (pl) | Nowe pochodne CYP-eikozanoidowe | |
| IL251005B (en) | Pyrido-oxazinone derivatives | |
| PL3119744T3 (pl) | Pochodne 2-cyjano-3-cyklopropylo-3-hydroksy-N-arylo-tioakryloamidu | |
| IL261055A (en) | Derivatives of tetrahydroisoquinoline | |
| GB201707862D0 (en) | Tracers | |
| GB2530305B (en) | Tracers | |
| GB201418365D0 (en) | Tracers | |
| GB201409664D0 (en) | Tracers | |
| GB201407585D0 (en) | SMA-Inter Act |