EA200970598A1 - Замещенные производные гетероарилпиридопиримидона - Google Patents

Замещенные производные гетероарилпиридопиримидона

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Publication number
EA200970598A1
EA200970598A1 EA200970598A EA200970598A EA200970598A1 EA 200970598 A1 EA200970598 A1 EA 200970598A1 EA 200970598 A EA200970598 A EA 200970598A EA 200970598 A EA200970598 A EA 200970598A EA 200970598 A1 EA200970598 A1 EA 200970598A1
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group
atom
alkyl group
hydrogen atom
optionally substituted
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EA200970598A
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English (en)
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Од Фэйоль
Тьерри Галле
Алистер Локхед
Мурад Саади
Коринн Вероник
Филипп Иэш
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Санофи-Авентис
Мицубиси Танабе Фарма Корпорейшн
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Publication of EA200970598A1 publication Critical patent/EA200970598A1/ru

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    • A—HUMAN NECESSITIES
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    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems

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Abstract

Производное пиримидона, представленное формулой (I), или его соль, или его сольват, или его гидрат, где Y представляет собой два атома водорода, атом серы, атом кислорода или Cалкильную группу и атом водорода; Z представляет собой связь, атом кислорода, атом азота, атом серы, метиленовую группу, необязательно замещенную одной или двумя группами, выбранными из Cалкильной группы, гидроксильной группы, Cалкоксигруппы, Cпергалогенированной алкильной группы или аминогруппы; R1 представляет собой 2-, 3- или 4-пиридиновое кольцо или 2-, 4- или 5-пиримидиновое кольцо; R2 представляет собой необязательно замещенную 4-15-членную гетероциклическую группу; R3 представляет собой атом водорода, Cалкильную группу или атом галогена; R4 и R5 представляют собой, каждый независимо, атом водорода, Cалкильную группу, необязательно замещенную 1-4 заместителями, выбранными из атома галогена, фенильной группы, гидроксильной группы или Cалкоксигруппы; R6 представляет собой атом водорода, Cалкильную группу, циклоалкильную группу или атом галогена; R7 представляет собой атом водорода или Cалкильную группу; n представляет собой 0-3; m представляет собой 0-1; о представляет собой 0-2; в форме свободного основания или кислотно-аддитивной соли. Настоящее изобретение относится также к лекарственному средству, включающему указанное производное или его соль в качестве активного ингредиента, которое используют для профилактики и/или терапевтического лечения нейродегенеративного заболевания, вызванного аномальной активностью GSK3β, такого как болезнь Альцгеймера.
EA200970598A 2006-12-20 2007-12-20 Замещенные производные гетероарилпиридопиримидона EA200970598A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP06291995A EP1939187A1 (en) 2006-12-20 2006-12-20 Substituted heteroaryl pyridopyrimidone derivatives
PCT/IB2007/004409 WO2008078196A2 (en) 2006-12-20 2007-12-20 Substituted heteroaryl pyridopyrimidone derivatives

Publications (1)

Publication Number Publication Date
EA200970598A1 true EA200970598A1 (ru) 2009-12-30

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ID=38002236

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200970598A EA200970598A1 (ru) 2006-12-20 2007-12-20 Замещенные производные гетероарилпиридопиримидона

Country Status (16)

Country Link
US (1) US8198287B2 (ru)
EP (2) EP1939187A1 (ru)
JP (1) JP2010513463A (ru)
KR (1) KR20090102756A (ru)
CN (1) CN101563328B (ru)
AU (1) AU2007337826A1 (ru)
BR (1) BRPI0721058A2 (ru)
CA (1) CA2672564A1 (ru)
EA (1) EA200970598A1 (ru)
IL (1) IL198524A (ru)
MX (1) MX2009006024A (ru)
NO (1) NO20092373L (ru)
NZ (1) NZ576894A (ru)
TW (1) TW200831099A (ru)
WO (1) WO2008078196A2 (ru)
ZA (1) ZA200903237B (ru)

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EP2138492A1 (en) * 2008-06-26 2009-12-30 Sanofi-Aventis Substituted pyrimidin-4-one derivatives
EP2138494A1 (en) * 2008-06-26 2009-12-30 Sanofi-Aventis Substituted alkyl pyrimidin-4-one derivatives
DE102008038221A1 (de) 2008-08-18 2010-02-25 Merck Patent Gmbh 7-Azaindolderivate
DE102008038220A1 (de) 2008-08-18 2010-02-25 Merck Patent Gmbh Oxadiazolderivate
WO2011107494A1 (de) 2010-03-03 2011-09-09 Sanofi Neue aromatische glykosidderivate, diese verbindungen enthaltende arzneimittel und deren verwendung
AU2011261164A1 (en) * 2010-06-01 2012-12-13 The University Of Queensland Haematopoietic-prostaglandin D2 synthase inhibitors
US8933024B2 (en) 2010-06-18 2015-01-13 Sanofi Azolopyridin-3-one derivatives as inhibitors of lipases and phospholipases
US8530413B2 (en) 2010-06-21 2013-09-10 Sanofi Heterocyclically substituted methoxyphenyl derivatives with an oxo group, processes for preparation thereof and use thereof as medicaments
TW201215387A (en) 2010-07-05 2012-04-16 Sanofi Aventis Spirocyclically substituted 1,3-propane dioxide derivatives, processes for preparation thereof and use thereof as a medicament
TW201215388A (en) 2010-07-05 2012-04-16 Sanofi Sa (2-aryloxyacetylamino)phenylpropionic acid derivatives, processes for preparation thereof and use thereof as medicaments
TW201221505A (en) 2010-07-05 2012-06-01 Sanofi Sa Aryloxyalkylene-substituted hydroxyphenylhexynoic acids, process for preparation thereof and use thereof as a medicament
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FR2992316A1 (fr) * 2012-06-22 2013-12-27 Sanofi Sa Derives de pyrimidinones, leur preparation et leur application en therapeutique
MA44007A (fr) * 2016-02-05 2018-12-19 Denali Therapeutics Inc Inhibiteurs du récepteur interagissant avec protéine kinase 1
EP3497102B1 (de) 2016-08-15 2022-12-07 Bayer CropScience Aktiengesellschaft Kondensierte bicyclische heterocyclen-derivate als schädlingsbekämpfungsmittel
LT3552017T (lt) 2016-12-09 2022-05-10 Denali Therapeutics Inc. Junginiai, naudotini kaip ripk1 inhibitoriai
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CA3056886A1 (en) * 2017-03-21 2018-09-27 Arbutus Biopharma Corporation Substituted dihydroindene-4-carboxamides and analogs thereof, and methods using same
DK3830092T3 (en) 2018-08-03 2023-08-07 Novartis Ag Heteroaromatic nmda receptor modulators and uses thereof
CN109748914B (zh) * 2018-12-29 2021-05-25 上海珂臻医药科技有限公司 吡啶并嘧啶类化合物及其应用
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Publication number Publication date
US20090306088A1 (en) 2009-12-10
US8198287B2 (en) 2012-06-12
EP2121635A2 (en) 2009-11-25
MX2009006024A (es) 2009-06-30
IL198524A0 (en) 2010-02-17
EP1939187A1 (en) 2008-07-02
IL198524A (en) 2013-03-24
CA2672564A1 (en) 2008-07-03
WO2008078196A2 (en) 2008-07-03
JP2010513463A (ja) 2010-04-30
WO2008078196A3 (en) 2008-11-06
CN101563328A (zh) 2009-10-21
AU2007337826A1 (en) 2008-07-03
NO20092373L (no) 2009-08-28
ZA200903237B (en) 2010-08-25
TW200831099A (en) 2008-08-01
KR20090102756A (ko) 2009-09-30
BRPI0721058A2 (pt) 2014-02-25
CN101563328B (zh) 2012-03-14
NZ576894A (en) 2011-09-30

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