EA200801134A1 - Замещенные бициклические пиримидоновые производные - Google Patents
Замещенные бициклические пиримидоновые производныеInfo
- Publication number
- EA200801134A1 EA200801134A1 EA200801134A EA200801134A EA200801134A1 EA 200801134 A1 EA200801134 A1 EA 200801134A1 EA 200801134 A EA200801134 A EA 200801134A EA 200801134 A EA200801134 A EA 200801134A EA 200801134 A1 EA200801134 A1 EA 200801134A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- alkyl group
- atom
- hydrogen atom
- optionally substituted
- ring
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/14—Drugs for dermatological disorders for baldness or alopecia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
- A61P33/06—Antimalarials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Abstract
Пиримидоновое производное, представленное формулой (I), или его соль, его сольват, или его гидрат, где Y представляет собой два атома водорода, атом серы, атом кислорода или Cалкильную группу и атом водорода; Z представляет собой связь, атом кислорода, атом азота, замещенный атомом водорода или Салкильной группой, атом серы, метиленовую группу, которая, необязательно, является замещенной; Rпредставляет собой 2, 3 или 4-пиридиновое кольцо или 2, 4 или 5-пиримидиновое кольцо, при этом указанное кольцо, необязательно, является замещенным; Rпредставляет собой бензольное кольцо или нафталиновое кольцо; указанные кольца, необязательно, являются замещенными; Rпредставляет собой атом водорода, Салкильную группу или атом галогена; Rпредставляет собой атом водорода или Салкильную группу; Rпредставляет собой атом водорода, Салкильную группу, которая, необязательно, является замещенной; R6 представляет собой атом водорода, Салкильную группу или атом галогена; Rпредставляет собой атом водорода или Салкильную группу; n имеет значение от 0 до 3; m имеет значение от 0 до 1; o имеет значение от 0 до 2. Изобретение также относится к лекарственному средству, включающему указанное производное или его соль в качестве активного ингредиента, которое применяют для профилактического и/или терапевтического лечения заболевания, вызванного аномальной активностью GSK3β, такого как болезнь Альцгеймера.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP05292457A EP1790649A1 (en) | 2005-11-21 | 2005-11-21 | Substituted bicyclic pyrimidone derivatives |
| PCT/IB2006/004046 WO2007057790A2 (en) | 2005-11-21 | 2006-11-21 | Substituted bicyclic pyrimidone derivatives |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| EA200801134A1 true EA200801134A1 (ru) | 2009-02-27 |
| EA014918B1 EA014918B1 (ru) | 2011-04-29 |
Family
ID=35659035
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EA200801134A EA014918B1 (ru) | 2005-11-21 | 2006-11-21 | Замещенные бициклические пиримидоновые производные |
Country Status (25)
| Country | Link |
|---|---|
| US (2) | US8148364B2 (ru) |
| EP (2) | EP1790649A1 (ru) |
| JP (1) | JP5124471B2 (ru) |
| KR (1) | KR20080070671A (ru) |
| CN (1) | CN101312971B (ru) |
| AR (1) | AR057906A1 (ru) |
| AT (1) | ATE487718T1 (ru) |
| BR (1) | BRPI0618752A2 (ru) |
| CA (1) | CA2630360A1 (ru) |
| CY (1) | CY1111125T1 (ru) |
| DE (1) | DE602006018190D1 (ru) |
| DK (1) | DK1957492T3 (ru) |
| EA (1) | EA014918B1 (ru) |
| ES (1) | ES2355756T3 (ru) |
| HK (1) | HK1126204A1 (ru) |
| HR (1) | HRP20100724T1 (ru) |
| IL (1) | IL191213A (ru) |
| MX (1) | MX2008006321A (ru) |
| NZ (1) | NZ568014A (ru) |
| PL (1) | PL1957492T3 (ru) |
| PT (1) | PT1957492E (ru) |
| RS (1) | RS51654B (ru) |
| SI (1) | SI1957492T1 (ru) |
| WO (1) | WO2007057790A2 (ru) |
| ZA (1) | ZA200804335B (ru) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1992621A1 (en) | 2007-05-16 | 2008-11-19 | Sanofi-Aventis | Heteroarylamide-substituted pyrimidone derivatives for the treatment of neurodegenerative diseases |
| EP1992625A1 (en) | 2007-05-16 | 2008-11-19 | Sanofi-Aventis | Arylamide pyrimidone compounds |
| EP1992624A1 (en) | 2007-05-16 | 2008-11-19 | Sanofi-Aventis | Heteroarylamide pyrimidone compounds |
| EP1992620A1 (en) | 2007-05-16 | 2008-11-19 | Sanofi-Aventis | Arylamide pyrimidone derivatives for the treatment of neurodegenerative diseases |
| EP2090579A1 (en) * | 2008-01-29 | 2009-08-19 | Sanofi-Aventis | Substituted heteroarylamide diazepinopyrimidone derivatives |
| EP2085400A1 (en) | 2008-01-29 | 2009-08-05 | Sanofi-Aventis | Substituted heteroarylamide oxazepinopyrimidone derivatives |
| EP2090578A1 (en) | 2008-01-29 | 2009-08-19 | Sanofi-Aventis | Substituted arylamide diazepinopyrimidone derivatives for the treatment of neurodegenerative diseases caused by abnormal activity of GSK3-beta |
| EP2085399A1 (en) | 2008-01-29 | 2009-08-05 | Sanofi-Aventis | substituted arylamide oxazepinopyrimidone derivatives |
| EP2138493A1 (en) * | 2008-06-26 | 2009-12-30 | Sanofi-Aventis | Substituted pyrimidone derivatives |
| EP2138498A1 (en) | 2008-06-26 | 2009-12-30 | sanofi-aventis | Substituted tricyclic derivatives against neurodegenerative diseases |
| EP2138492A1 (en) | 2008-06-26 | 2009-12-30 | Sanofi-Aventis | Substituted pyrimidin-4-one derivatives |
| EP2138495A1 (en) * | 2008-06-26 | 2009-12-30 | sanofi-aventis | Substituted pyrimido[2,1-a]isoquinolin-4-one derivatives |
| EP2138485A1 (en) | 2008-06-26 | 2009-12-30 | sanofi-aventis | Substituted N-Oxide pyrazine derivatives |
| EP2138488A1 (en) | 2008-06-26 | 2009-12-30 | sanofi-aventis | 4-(pyridin-4-yl)-1H-[1,3,5]triazin-2-one derivatives as GSK3-beta inhibitors for the treatment of neurodegenerative diseases |
| EP2138494A1 (en) * | 2008-06-26 | 2009-12-30 | Sanofi-Aventis | Substituted alkyl pyrimidin-4-one derivatives |
| EP3693368B1 (en) * | 2017-10-06 | 2023-12-06 | Takeda Pharmaceutical Company Limited | Heterocyclic compound |
| US11447488B2 (en) | 2017-10-06 | 2022-09-20 | Takeda Pharmaceutical Company Limited | Heterocyclic compounds |
| CN109748914B (zh) * | 2018-12-29 | 2021-05-25 | 上海珂臻医药科技有限公司 | 吡啶并嘧啶类化合物及其应用 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HU178496B (en) * | 1977-12-29 | 1982-05-28 | Chinoin Gyogyszer Es Vegyeszet | Process for preparing 6,7,8,9-tetrahydro-4h-pyrido/1,2-a/pyrimidine derivatives with antiallergic activity |
| ES2246927T3 (es) * | 1999-12-17 | 2006-03-01 | Chiron Corporation | Inhibidores biciclicos de glucogeno sintasa quinasa 3. |
| EP1460076A1 (en) * | 2003-03-21 | 2004-09-22 | Sanofi-Synthelabo | Substituted 8-perfluoroalkyl-6,7,8,9-tetrahydropyrimido[1,2-a] pyrimidin-4-one derivatives |
| JO2985B1 (ar) * | 2006-12-20 | 2016-09-05 | Takeda Pharmaceuticals Co | مثبطات كينازmapk/erk |
-
2005
- 2005-11-21 EP EP05292457A patent/EP1790649A1/en not_active Withdrawn
-
2006
- 2006-11-12 ZA ZA200804335A patent/ZA200804335B/xx unknown
- 2006-11-17 AR ARP060105057A patent/AR057906A1/es not_active Application Discontinuation
- 2006-11-21 DK DK06847275.2T patent/DK1957492T3/da active
- 2006-11-21 DE DE602006018190T patent/DE602006018190D1/de active Active
- 2006-11-21 CN CN2006800435223A patent/CN101312971B/zh not_active Expired - Fee Related
- 2006-11-21 MX MX2008006321A patent/MX2008006321A/es active IP Right Grant
- 2006-11-21 EP EP06847275A patent/EP1957492B1/en active Active
- 2006-11-21 KR KR1020087012084A patent/KR20080070671A/ko not_active Application Discontinuation
- 2006-11-21 BR BRPI0618752-8A patent/BRPI0618752A2/pt not_active IP Right Cessation
- 2006-11-21 AT AT06847275T patent/ATE487718T1/de active
- 2006-11-21 PL PL06847275T patent/PL1957492T3/pl unknown
- 2006-11-21 JP JP2008540723A patent/JP5124471B2/ja not_active Expired - Fee Related
- 2006-11-21 NZ NZ568014A patent/NZ568014A/en not_active IP Right Cessation
- 2006-11-21 CA CA002630360A patent/CA2630360A1/en not_active Abandoned
- 2006-11-21 EA EA200801134A patent/EA014918B1/ru not_active IP Right Cessation
- 2006-11-21 WO PCT/IB2006/004046 patent/WO2007057790A2/en active Application Filing
- 2006-11-21 RS RS20110055A patent/RS51654B/en unknown
- 2006-11-21 ES ES06847275T patent/ES2355756T3/es active Active
- 2006-11-21 PT PT06847275T patent/PT1957492E/pt unknown
- 2006-11-21 SI SI200630901T patent/SI1957492T1/sl unknown
-
2008
- 2008-05-01 IL IL191213A patent/IL191213A/en not_active IP Right Cessation
- 2008-05-16 US US12/122,111 patent/US8148364B2/en not_active Expired - Fee Related
-
2009
- 2009-05-22 HK HK09104689.9A patent/HK1126204A1/xx not_active IP Right Cessation
-
2010
- 2010-12-27 HR HR20100724T patent/HRP20100724T1/hr unknown
-
2011
- 2011-01-21 CY CY20111100069T patent/CY1111125T1/el unknown
- 2011-08-03 US US13/197,228 patent/US20110294786A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| JP5124471B2 (ja) | 2013-01-23 |
| DK1957492T3 (da) | 2011-02-28 |
| EA014918B1 (ru) | 2011-04-29 |
| ATE487718T1 (de) | 2010-11-15 |
| HK1126204A1 (en) | 2009-08-28 |
| CA2630360A1 (en) | 2007-05-24 |
| MX2008006321A (es) | 2009-03-23 |
| BRPI0618752A2 (pt) | 2011-09-27 |
| JP2009516676A (ja) | 2009-04-23 |
| NZ568014A (en) | 2011-07-29 |
| ES2355756T3 (es) | 2011-03-30 |
| EP1957492B1 (en) | 2010-11-10 |
| HRP20100724T1 (hr) | 2011-02-28 |
| PT1957492E (pt) | 2011-01-24 |
| ZA200804335B (en) | 2010-05-26 |
| WO2007057790A3 (en) | 2007-10-11 |
| WO2007057790A2 (en) | 2007-05-24 |
| KR20080070671A (ko) | 2008-07-30 |
| AR057906A1 (es) | 2007-12-26 |
| CY1111125T1 (el) | 2015-06-11 |
| PL1957492T3 (pl) | 2011-04-29 |
| IL191213A (en) | 2012-02-29 |
| EP1957492A2 (en) | 2008-08-20 |
| SI1957492T1 (sl) | 2011-02-28 |
| US20090036427A1 (en) | 2009-02-05 |
| RS51654B (en) | 2011-10-31 |
| US20110294786A1 (en) | 2011-12-01 |
| CN101312971A (zh) | 2008-11-26 |
| US8148364B2 (en) | 2012-04-03 |
| EP1790649A1 (en) | 2007-05-30 |
| DE602006018190D1 (de) | 2010-12-23 |
| CN101312971B (zh) | 2011-09-07 |
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