EA200970455A1 - ЗАМЕЩЕННЫЙ 8-ПИПЕРИДИНИЛ-2-ПИРИДИНИЛПИРИМИДО[1,2-a]ПИРИМИДИН-6-ОН И ПРОИЗВОДНЫЕ 8-ПИПЕРИДИНИЛ-2-ПИРИМИДИНИЛПИРИМИДО[1,2-a]ПИРИМИДИН-6-ОНА - Google Patents

ЗАМЕЩЕННЫЙ 8-ПИПЕРИДИНИЛ-2-ПИРИДИНИЛПИРИМИДО[1,2-a]ПИРИМИДИН-6-ОН И ПРОИЗВОДНЫЕ 8-ПИПЕРИДИНИЛ-2-ПИРИМИДИНИЛПИРИМИДО[1,2-a]ПИРИМИДИН-6-ОНА

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Publication number
EA200970455A1
EA200970455A1 EA200970455A EA200970455A EA200970455A1 EA 200970455 A1 EA200970455 A1 EA 200970455A1 EA 200970455 A EA200970455 A EA 200970455A EA 200970455 A EA200970455 A EA 200970455A EA 200970455 A1 EA200970455 A1 EA 200970455A1
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EA
Eurasian Patent Office
Prior art keywords
optionally substituted
pyrimidine
piperidinyl
ring
takes
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EA200970455A
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English (en)
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EA016251B1 (ru
Inventor
Алистер Локхед
Мурад Саади
Франк Словински
Филипп Иэш
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Санофи-Авентис
Мицубиси Танабе Фарма Корпорейшн
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Publication of EA200970455A1 publication Critical patent/EA200970455A1/ru
Publication of EA016251B1 publication Critical patent/EA016251B1/ru

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    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings

Abstract

Изобретение относится к производному пиримидона, представленному формулой I или его солигде Х представляет собой два атома водорода, атом серы, атом кислорода или Cалкильную группу и атом водорода; Y представляет собой связь, карбонильную группу или необязательно замещенную метиленовую группу; R1 представляет собой 2, 3 или 4-пиридиновое кольцо или 2, 4 или 5-пиримидиновое кольцо, где кольцо необязательно является замещенным; R2 представляет собой бензольное кольцо или нафталиновую систему колец, где кольца необязательно являются замещенными; R3 представляет собой атом водорода, Cалкильную группу или атом галогена; R4 представляет собой атом водорода, Cалкоксикарбонильную группу или необязательно замещенную Cалкильную группу; n принимает значения от 0 до 3, р обозначает 2; q является 0; о принимает значения 0, 1 или 2; m, соответственно, принимает значения 4, 3 или 2, при том что о+m равно 4. Изобретение относится также к лекарственному средству, содержащему указанное производное или его соль в качестве активного ингредиента, которое используют для профилактического и/или терапевтического лечения такого нейродегенеративного заболевания, как болезнь Альцгеймера, вызываемого аномальной активностью GSK3β.
EA200970455A 2006-11-07 2007-11-06 ПРОИЗВОДНЫЕ 8-ПИПЕРИДИНИЛ-2-ПИРИДИНИЛПИРИМИДО[1,2-a]ПИРИМИДИН-4-ОНА EA016251B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP06291725A EP1921080B1 (en) 2006-11-07 2006-11-07 Subsitituted 8-piperidinyl-2-pyridinyl-pyrimido(1,2-a)pyrimidin-6-one and 8-piperidinyl-2-pyrimidinyl-pyrimido(1,2-a)pyrimidin-6-one derivatives
PCT/IB2007/004272 WO2008056266A2 (en) 2006-11-07 2007-11-06 Substituted 8-piperidinyl-2-pyridinyl-pyrimido [1,2-a]pyrimidin-6-one and 8-piperidinyl-2-pyrimidinyl-pyrimido[1,2-a]pyrimidin-6-one derivatives

Publications (2)

Publication Number Publication Date
EA200970455A1 true EA200970455A1 (ru) 2009-12-30
EA016251B1 EA016251B1 (ru) 2012-03-30

Family

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EA200970455A EA016251B1 (ru) 2006-11-07 2007-11-06 ПРОИЗВОДНЫЕ 8-ПИПЕРИДИНИЛ-2-ПИРИДИНИЛПИРИМИДО[1,2-a]ПИРИМИДИН-4-ОНА

Country Status (16)

Country Link
US (1) US20090281121A1 (ru)
EP (2) EP1921080B1 (ru)
JP (1) JP2010509203A (ru)
KR (1) KR20090091123A (ru)
CN (1) CN101535314A (ru)
AR (1) AR063577A1 (ru)
AU (1) AU2007318927A1 (ru)
BR (1) BRPI0718519A2 (ru)
CA (1) CA2668682A1 (ru)
EA (1) EA016251B1 (ru)
IL (1) IL198239A0 (ru)
MX (1) MX2009004884A (ru)
NZ (1) NZ576773A (ru)
TW (1) TW200835495A (ru)
WO (1) WO2008056266A2 (ru)
ZA (1) ZA200902630B (ru)

Families Citing this family (10)

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Publication number Priority date Publication date Assignee Title
EP2025674A1 (de) 2007-08-15 2009-02-18 sanofi-aventis Substituierte Tetrahydronaphthaline, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
WO2011107494A1 (de) 2010-03-03 2011-09-09 Sanofi Neue aromatische glykosidderivate, diese verbindungen enthaltende arzneimittel und deren verwendung
WO2011157827A1 (de) 2010-06-18 2011-12-22 Sanofi Azolopyridin-3-on-derivate als inhibitoren von lipasen und phospholipasen
US8530413B2 (en) 2010-06-21 2013-09-10 Sanofi Heterocyclically substituted methoxyphenyl derivatives with an oxo group, processes for preparation thereof and use thereof as medicaments
TW201215388A (en) 2010-07-05 2012-04-16 Sanofi Sa (2-aryloxyacetylamino)phenylpropionic acid derivatives, processes for preparation thereof and use thereof as medicaments
TW201221505A (en) 2010-07-05 2012-06-01 Sanofi Sa Aryloxyalkylene-substituted hydroxyphenylhexynoic acids, process for preparation thereof and use thereof as a medicament
TW201215387A (en) 2010-07-05 2012-04-16 Sanofi Aventis Spirocyclically substituted 1,3-propane dioxide derivatives, processes for preparation thereof and use thereof as a medicament
WO2013037390A1 (en) 2011-09-12 2013-03-21 Sanofi 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
WO2013045413A1 (en) 2011-09-27 2013-04-04 Sanofi 6-(4-hydroxy-phenyl)-3-alkyl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
FR2992316A1 (fr) * 2012-06-22 2013-12-27 Sanofi Sa Derives de pyrimidinones, leur preparation et leur application en therapeutique

Family Cites Families (2)

* Cited by examiner, † Cited by third party
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CN100393700C (zh) * 2003-06-30 2008-06-11 麦克弗罗斯特(加拿大)公司 组织蛋白酶半胱氨酸蛋白酶抑制剂
EP1557417B1 (en) * 2003-12-19 2007-03-07 Sanofi-Aventis Substituted 8'-pyri(mi)dinyl-dihydrospiro-[cycloalkylamine]-pyrimido[1,2-a] pyrimidin-6-one derivatives

Also Published As

Publication number Publication date
IL198239A0 (en) 2009-12-24
EP1921080B1 (en) 2009-08-05
WO2008056266A3 (en) 2008-07-10
AR063577A1 (es) 2009-02-04
WO2008056266A2 (en) 2008-05-15
EP1921080A1 (en) 2008-05-14
EP2081938A2 (en) 2009-07-29
AU2007318927A1 (en) 2008-05-15
CA2668682A1 (en) 2008-05-15
CN101535314A (zh) 2009-09-16
KR20090091123A (ko) 2009-08-26
JP2010509203A (ja) 2010-03-25
ZA200902630B (en) 2010-06-30
MX2009004884A (es) 2009-05-21
TW200835495A (en) 2008-09-01
US20090281121A1 (en) 2009-11-12
NZ576773A (en) 2011-09-30
WO2008056266A8 (en) 2009-06-18
EA016251B1 (ru) 2012-03-30
BRPI0718519A2 (pt) 2014-04-15

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MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM RU