EA200600196A1 - Производные замещенного 2-пиримидинил-6,7,8,9-тетрагидропиримидо[1,2-a]пиримидин-4-она и 7-пиримидинил-2,3-дигидроимидазо[1,2-a]пиримидин-5(1н) она для нейродегенеративных нарушений - Google Patents

Производные замещенного 2-пиримидинил-6,7,8,9-тетрагидропиримидо[1,2-a]пиримидин-4-она и 7-пиримидинил-2,3-дигидроимидазо[1,2-a]пиримидин-5(1н) она для нейродегенеративных нарушений

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Publication number
EA200600196A1
EA200600196A1 EA200600196A EA200600196A EA200600196A1 EA 200600196 A1 EA200600196 A1 EA 200600196A1 EA 200600196 A EA200600196 A EA 200600196A EA 200600196 A EA200600196 A EA 200600196A EA 200600196 A1 EA200600196 A1 EA 200600196A1
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Eurasian Patent Office
Prior art keywords
group
ring
atom
alkyl group
pyrimidine
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EA200600196A
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English (en)
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EA009456B1 (ru
Inventor
Тьерри Галле
Патрик Ларденуа
Алистер Локхид
Северен Маргери
Ален Неделек
Мурад Саади
Франк Словински
Филипп Йеш
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Санофи-Авентис
Мицубиси Фарма Корпорейшн
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Priority claimed from EP01402431A external-priority patent/EP1295884A1/en
Priority claimed from EP02290488A external-priority patent/EP1340760A1/en
Application filed by Санофи-Авентис, Мицубиси Фарма Корпорейшн filed Critical Санофи-Авентис
Publication of EA200600196A1 publication Critical patent/EA200600196A1/ru
Publication of EA009456B1 publication Critical patent/EA009456B1/ru

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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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Abstract

Данное изобретение относится к производному пиримидона, представленному формулой (I), или его соли, где Х представляет собой два атома водорода, атом серы, атом кислорода или Салкильную группу и атом водорода; Y представляет собой связь, этениленовую группу, этиниленовую группу, атом кислорода, атом серы, сульфонильную группу, сульфоксидную группу, карбонильную группу, возможно замещенный атом азота; или возможно замещенную метиленовую группу; R1 представляет собой возможно замещенную пиримидиновую группу; R2 может представлять собой Cалкильную группу, возможно замещенную Сарилокси или Сариламиногруппой; Сциклоалкильную группу, Салкилтиогруппу, Салкоксигруппу, Спергалогенированную алкильную группу, Cгалогенированную алкильную группу, фенилтиогруппу, бензильную группу, бензольное кольцо, индановое кольцо, 5,6,7,8-тетрагидронафталиновое кольцо, нафталиновое кольцо, пиридиновое кольцо, пиррольное кольцо, тиофеновое кольцо, фурановое кольцо или имидазольное кольцо; R3 и R4 каждый независимо представляет собой атом водорода, Салкильную группу, гидроксигруппу, Салкоксигруппу или атом галогена; R5 представляет собой атом водорода, Cалкильную группу или атом галогена. Данное изобретение относится также к лекарству, содержащему указанное производное или его соль в качестве активного ингредиента, которое применяют для профилактического и/или терапевтического лечения нейродегенеративного заболевания, вызванного ненормальной активностью GSK3β3 или GSK3β3 и cdk5/p25, такого как болезнь Альцгеймера.
EA200600196A 2001-09-21 2002-09-19 ПРОИЗВОДНЫЕ ПИРИМИДОНА В КАЧЕСТВЕ ПРОМЕЖУТОЧНЫХ СОЕДИНЕНИЙ ДЛЯ ПОЛУЧЕНИЯ ИНГИБИТОРОВ GSK3β ИЛИ GSK3β И CDK5/P25 EA009456B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP01402431A EP1295884A1 (en) 2001-09-21 2001-09-21 2-pyrimidinyl-6,7,8,9-tetrahydropyrimido[1,2-a]Pyrimidin-4-one and 7-Pyrimidinyl-2,3-Dihydroimidazo[1,2-a]Pyrimidin-5(1H)one derivatives
EP02290488A EP1340760A1 (en) 2002-02-28 2002-02-28 Substituted 2-pyrimidinyl-6,7,8,9-tetrahydropyrimido[1,2-a]pyrimidin-4-one and 7-pyrimidinyl-2,3-dihydroimidazo[1,2-a]pyrimidin-5(1H)one derivatives

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EA200600196A1 true EA200600196A1 (ru) 2006-08-25
EA009456B1 EA009456B1 (ru) 2007-12-28

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EA200600196A EA009456B1 (ru) 2001-09-21 2002-09-19 ПРОИЗВОДНЫЕ ПИРИМИДОНА В КАЧЕСТВЕ ПРОМЕЖУТОЧНЫХ СОЕДИНЕНИЙ ДЛЯ ПОЛУЧЕНИЯ ИНГИБИТОРОВ GSK3β ИЛИ GSK3β И CDK5/P25
EA200400236A EA007165B1 (ru) 2001-09-21 2002-09-19 Производные замещенного 2-пиримидинил-6, 7, 8, 9-тетрагидропиримидо [1,2-а]пиримидин-4-она и 7-пиримидинил-2,3-дигидроимидазо[1, 2-а]пиримидин-5( 1н )она для нейродегенеративных нарушений

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EA200400236A EA007165B1 (ru) 2001-09-21 2002-09-19 Производные замещенного 2-пиримидинил-6, 7, 8, 9-тетрагидропиримидо [1,2-а]пиримидин-4-она и 7-пиримидинил-2,3-дигидроимидазо[1, 2-а]пиримидин-5( 1н )она для нейродегенеративных нарушений

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US (2) US7388005B2 (ru)
EP (1) EP1430056B1 (ru)
JP (2) JP4570361B2 (ru)
KR (1) KR100868840B1 (ru)
CN (1) CN1247586C (ru)
AR (1) AR036599A1 (ru)
AT (1) ATE307815T1 (ru)
AU (1) AU2002342798C1 (ru)
BR (1) BR0212904A (ru)
CA (1) CA2457952C (ru)
CY (1) CY1105553T1 (ru)
DE (1) DE60206946T2 (ru)
DK (1) DK1430056T3 (ru)
EA (2) EA009456B1 (ru)
ES (1) ES2250721T3 (ru)
HK (1) HK1091495A1 (ru)
HU (1) HUP0500332A3 (ru)
IL (2) IL160397A0 (ru)
MX (1) MXPA04002632A (ru)
NO (1) NO329566B1 (ru)
NZ (1) NZ531244A (ru)
PL (1) PL370535A1 (ru)
SI (1) SI1430056T1 (ru)
WO (1) WO2003027115A1 (ru)

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