HUP0500332A2 - Helyettesített 2-pirimidinil-6,7,8,9-tetrahidropirimido[1,2-a]-pirimidin-4-on és 7-piridinil-2,3-dihidroimidazo[1,2-a]-pirimidin-5 (1H)-on-származékok, alkalmazásuk és az ezeket tartalmazó gyógyszerkészítmények - Google Patents

Helyettesített 2-pirimidinil-6,7,8,9-tetrahidropirimido[1,2-a]-pirimidin-4-on és 7-piridinil-2,3-dihidroimidazo[1,2-a]-pirimidin-5 (1H)-on-származékok, alkalmazásuk és az ezeket tartalmazó gyógyszerkészítmények

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Publication number
HUP0500332A2
HUP0500332A2 HU0500332A HUP0500332A HUP0500332A2 HU P0500332 A2 HUP0500332 A2 HU P0500332A2 HU 0500332 A HU0500332 A HU 0500332A HU P0500332 A HUP0500332 A HU P0500332A HU P0500332 A2 HUP0500332 A2 HU P0500332A2
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group
atom
ring
alkyl group
optionally substituted
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HU0500332A
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English (en)
Inventor
Thierry Gallet
Patrick Lardenois
Alistair Lochead
Séverine Marguerie
Alain Nedelec
Mourad Saady
Franck Slowinski
Philippe Yaiche
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Sanofi-Aventis
Mitsubishi Pharma Corporation
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Priority claimed from EP01402431A external-priority patent/EP1295884A1/en
Priority claimed from EP02290488A external-priority patent/EP1340760A1/en
Application filed by Sanofi-Aventis, Mitsubishi Pharma Corporation filed Critical Sanofi-Aventis
Publication of HUP0500332A2 publication Critical patent/HUP0500332A2/hu
Publication of HUP0500332A3 publication Critical patent/HUP0500332A3/hu

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    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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Abstract

A találmány az (I) általános képletű pirimidonszármazékokra vagy sóiravonatkozik, a képletben X jelentése két hidrogénatom, kénatom,oxigénatom vagy egy 1-2 szénatomos alkilcsoport és egy hidrogénatom; Yjelentése vegyértékkötés, eteniléncsoport, etiniléncsoport,oxigénatom, kénatom, szulfonilcsoport, szulfoxidcsoport,karbonilcsoport, nitrogénatom, amely adott esetben helyettesített;vagy metiléncsoport, amely adott esetben helyettesített; R1 jelentésepirimidincsoport, amely adott esetben helyettesített; R2 jelentése 1-6szénatomos alkilcsoport, amely adott esetben 6-10 szénatomosariloxicsoporttal vagy 6-10 szénatomos arilaminocsoporttalhelyettesített; 3-6 szénatomos cikloalkilcsoport, 1-4 szénatomosalkiltiocsoport, 1-4 szénatomos alkoxicsoport, 1-2 szénatomosperhalogénezett alkilcsoport, 1-3 szénatomos halogénezettalkilcsoport, feniltiocsoport, benzilcsoport, benzolgyűrű, indángyűrű,5,6,7,8-tetrahidronaftalingyűrű, naftalingyűrű, piridingyűrű,pirrolgyűrű, tioféngyűrű, furángyűrű vagy imidazolgyűrű; R3 és R4jelentése egymástól függetlenül hidrogénatom, 1-6 szénatomosalkilcsoport, hidroxilcsoport, 1-4 szénatomos alkoxicsoport vagyhalogénatom; R5 jelentése hidrogénatom, 1-6 szénatomos alkilcsoportvagy halogénatom, amikor m értéke 0, p értéke 1, 2 vagy 3, amikor mértéke 1, p értéke 0, 1 vagy 2, amikor m értéke 2, p értéke 0 vagy 1,és n értéke 0, 1, 2 vagy 3. A találmány gyógyszerre is vonatkozik,amely hatóanyagként a fenti származékot vagy sóját tartalmazza, ésamely a GSK3b vagy a GSK3b és cdk5/p25 abnormális aktivitása általokozott neurodegeneratív betegség, például Alzheimer-betegség megelőzőés/vagy terápiás kezelésére alkalmazható. Az (I) általános képletűvegyületek alkalamzhatók rákok megelőző és/vagy terápiás kezelésérealkalmas gyógyszer előállítására is. Ó
HU0500332A 2001-09-21 2002-09-19 Substituted 2-pyrimidinyl-6,7,8,9-tetrahydropyrimido[1,2-a]pyrimidin-4-one and 7-pyrimidinyl-2,3-dihydroimidazo[1,2-a]pyrimidin-5(1h)-one derivatives, their use and pharmaceutical compositions containing them HUP0500332A3 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP01402431A EP1295884A1 (en) 2001-09-21 2001-09-21 2-pyrimidinyl-6,7,8,9-tetrahydropyrimido[1,2-a]Pyrimidin-4-one and 7-Pyrimidinyl-2,3-Dihydroimidazo[1,2-a]Pyrimidin-5(1H)one derivatives
EP02290488A EP1340760A1 (en) 2002-02-28 2002-02-28 Substituted 2-pyrimidinyl-6,7,8,9-tetrahydropyrimido[1,2-a]pyrimidin-4-one and 7-pyrimidinyl-2,3-dihydroimidazo[1,2-a]pyrimidin-5(1H)one derivatives
PCT/EP2002/011127 WO2003027115A1 (en) 2001-09-21 2002-09-19 Substituted 2-pyrimidinyl-6,7,8,9-tetrahydropyrimido[1,2-a]pyrimidin-4-one and 7-pyrimidinyl-2,3-dihydroimidazo[1,2-a]pyrimidin-5(1h)one derivatives for neurodegenerative disorders

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HUP0500332A2 true HUP0500332A2 (hu) 2005-07-28
HUP0500332A3 HUP0500332A3 (en) 2009-12-28

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HU0500332A HUP0500332A3 (en) 2001-09-21 2002-09-19 Substituted 2-pyrimidinyl-6,7,8,9-tetrahydropyrimido[1,2-a]pyrimidin-4-one and 7-pyrimidinyl-2,3-dihydroimidazo[1,2-a]pyrimidin-5(1h)-one derivatives, their use and pharmaceutical compositions containing them

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US (2) US7388005B2 (hu)
EP (1) EP1430056B1 (hu)
JP (2) JP4570361B2 (hu)
KR (1) KR100868840B1 (hu)
CN (1) CN1247586C (hu)
AR (1) AR036599A1 (hu)
AT (1) ATE307815T1 (hu)
AU (1) AU2002342798C1 (hu)
BR (1) BR0212904A (hu)
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CY (1) CY1105553T1 (hu)
DE (1) DE60206946T2 (hu)
DK (1) DK1430056T3 (hu)
EA (2) EA009456B1 (hu)
ES (1) ES2250721T3 (hu)
HK (1) HK1091495A1 (hu)
HU (1) HUP0500332A3 (hu)
IL (2) IL160397A0 (hu)
MX (1) MXPA04002632A (hu)
NO (1) NO329566B1 (hu)
NZ (1) NZ531244A (hu)
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Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1454909B1 (en) * 2003-03-07 2008-08-20 Sanofi Aventis 8'-pyridinyl-dihydrospiro (cycloalkyl) -pyrimido (1,2-a) pyrimidin-6-one and 8'-pyrimidinyl-dihydrospiro (cycloalkyl) pyrimido (1,2-a) pyrimidin-6 derivatives -one and their use against neurodegenerative diseases
EP1557417B1 (en) * 2003-12-19 2007-03-07 Sanofi-Aventis Substituted 8'-pyri(mi)dinyl-dihydrospiro-[cycloalkylamine]-pyrimido[1,2-a] pyrimidin-6-one derivatives
ATE393157T1 (de) 2004-01-22 2008-05-15 Amgen Inc Substituierte heterocyclische verbindungen und anwendungsverfahren
CN101198609A (zh) * 2005-06-14 2008-06-11 先灵公司 天冬氨酰基蛋白酶抑制剂
CA2620333A1 (en) 2005-08-26 2007-03-01 Braincells, Inc. Neurogenesis by muscarinic receptor modulation
EP2258359A3 (en) 2005-08-26 2011-04-06 Braincells, Inc. Neurogenesis by muscarinic receptor modulation with sabcomelin
EP2377530A3 (en) 2005-10-21 2012-06-20 Braincells, Inc. Modulation of neurogenesis by PDE inhibition
WO2007053596A1 (en) 2005-10-31 2007-05-10 Braincells, Inc. Gaba receptor mediated modulation of neurogenesis
US20100216734A1 (en) 2006-03-08 2010-08-26 Braincells, Inc. Modulation of neurogenesis by nootropic agents
JP2009536669A (ja) 2006-05-09 2009-10-15 ブレインセルス,インコーポレイティド アンジオテンシン調節による神経新生
US20100184806A1 (en) 2006-09-19 2010-07-22 Braincells, Inc. Modulation of neurogenesis by ppar agents
EP1939187A1 (en) * 2006-12-20 2008-07-02 Sanofi-Aventis Substituted heteroaryl pyridopyrimidone derivatives
EP1992624A1 (en) * 2007-05-16 2008-11-19 Sanofi-Aventis Heteroarylamide pyrimidone compounds
EP1992621A1 (en) 2007-05-16 2008-11-19 Sanofi-Aventis Heteroarylamide-substituted pyrimidone derivatives for the treatment of neurodegenerative diseases
EP1992620A1 (en) * 2007-05-16 2008-11-19 Sanofi-Aventis Arylamide pyrimidone derivatives for the treatment of neurodegenerative diseases
EP1992625A1 (en) 2007-05-16 2008-11-19 Sanofi-Aventis Arylamide pyrimidone compounds
EP2085400A1 (en) * 2008-01-29 2009-08-05 Sanofi-Aventis Substituted heteroarylamide oxazepinopyrimidone derivatives
EP2085399A1 (en) * 2008-01-29 2009-08-05 Sanofi-Aventis substituted arylamide oxazepinopyrimidone derivatives
EP2090578A1 (en) * 2008-01-29 2009-08-19 Sanofi-Aventis Substituted arylamide diazepinopyrimidone derivatives for the treatment of neurodegenerative diseases caused by abnormal activity of GSK3-beta
EP2090579A1 (en) * 2008-01-29 2009-08-19 Sanofi-Aventis Substituted heteroarylamide diazepinopyrimidone derivatives
EP2138494A1 (en) 2008-06-26 2009-12-30 Sanofi-Aventis Substituted alkyl pyrimidin-4-one derivatives
EP2138498A1 (en) 2008-06-26 2009-12-30 sanofi-aventis Substituted tricyclic derivatives against neurodegenerative diseases
EP2138495A1 (en) 2008-06-26 2009-12-30 sanofi-aventis Substituted pyrimido[2,1-a]isoquinolin-4-one derivatives
EP2138492A1 (en) 2008-06-26 2009-12-30 Sanofi-Aventis Substituted pyrimidin-4-one derivatives
EP2138488A1 (en) 2008-06-26 2009-12-30 sanofi-aventis 4-(pyridin-4-yl)-1H-[1,3,5]triazin-2-one derivatives as GSK3-beta inhibitors for the treatment of neurodegenerative diseases
EP2138485A1 (en) 2008-06-26 2009-12-30 sanofi-aventis Substituted N-Oxide pyrazine derivatives
EP2138493A1 (en) 2008-06-26 2009-12-30 Sanofi-Aventis Substituted pyrimidone derivatives
US20100216805A1 (en) 2009-02-25 2010-08-26 Braincells, Inc. Modulation of neurogenesis using d-cycloserine combinations
US8421890B2 (en) 2010-01-15 2013-04-16 Picofield Technologies, Inc. Electronic imager using an impedance sensor grid array and method of making
CA2945263A1 (en) 2014-04-09 2015-10-15 Christopher Rudd Use of gsk-3 inhibitors or activators which modulate pd-1 or t-bet expression to modulate t cell immunity

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3865836A (en) * 1972-12-08 1975-02-11 Janssen Pharmaceutica Nv Bicyclic imidazoles
SU600143A1 (ru) * 1976-12-06 1978-03-30 Ордена Трудового Красного Знамени Институт Органического Синтеза Ан Латвийской Сср Способ получени гетероциклических систем, содержащих бормзамещенный имидазол
JPS63216886A (ja) * 1987-03-05 1988-09-09 Sumitomo Chem Co Ltd ピリミドピリミジン誘導体およびその製造法
JP2862958B2 (ja) * 1990-06-09 1999-03-03 三協化学株式会社 感熱転写記録用色素
US6153618A (en) * 1996-10-11 2000-11-28 Chiron Corporation Inhibitors of glycogen synthase 3 kinase
IL130181A0 (en) * 1996-12-05 2000-06-01 Amgen Inc Substituted pyrimidone and pyridone compounds and methods of use
NZ506417A (en) * 1998-02-17 2003-05-30 Tularik Inc Anti-viral pyrimidine derivatives
ATE303383T1 (de) * 1999-12-17 2005-09-15 Chiron Corp Bizyklische inhibitoren von glycogen synthase kinase 3
FR2804959B1 (fr) 2000-02-15 2006-04-28 Centre Nat Rech Scient Utilisation de derives de paullones pour la fabrication de medicaments

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AU2002342798B2 (en) 2008-01-10
SI1430056T1 (sl) 2006-02-28
HK1091495A1 (en) 2007-01-19
CA2457952A1 (en) 2003-04-03
KR20040039390A (ko) 2004-05-10
IL160397A (en) 2009-07-20
MXPA04002632A (es) 2004-07-08
EA200600196A1 (ru) 2006-08-25
NO329566B1 (no) 2010-11-15
AR036599A1 (es) 2004-09-22
DE60206946D1 (de) 2005-12-01
EA007165B1 (ru) 2006-08-25
KR100868840B1 (ko) 2008-11-14
EP1430056A1 (en) 2004-06-23
EP1430056B1 (en) 2005-10-26
US7388005B2 (en) 2008-06-17
US7781440B2 (en) 2010-08-24
CA2457952C (en) 2009-11-10
IL160397A0 (en) 2004-07-25
JP2005504809A (ja) 2005-02-17
AU2002342798C1 (en) 2008-09-25
BR0212904A (pt) 2004-10-13
HUP0500332A3 (en) 2009-12-28
DK1430056T3 (da) 2006-02-27
US20040266793A1 (en) 2004-12-30
US20080269257A1 (en) 2008-10-30
NZ531244A (en) 2006-06-30
CY1105553T1 (el) 2010-07-28
DE60206946T2 (de) 2006-07-27
EA200400236A1 (ru) 2004-10-28
EA009456B1 (ru) 2007-12-28
CN1247586C (zh) 2006-03-29
PL370535A1 (en) 2005-05-30
ES2250721T3 (es) 2006-04-16
JP4570361B2 (ja) 2010-10-27
WO2003027115A1 (en) 2003-04-03
CN1556810A (zh) 2004-12-22
JP2010189422A (ja) 2010-09-02
ATE307815T1 (de) 2005-11-15
NO20041142L (no) 2004-06-21

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