EA200601192A1 - ЗАМЕЩЁННЫЕ ПРОИЗВОДНЫЕ 8'-ПИРИ(МИ)ДИНИЛДИГИДРОСПИРО[ЦИКЛОАЛКИЛАМИН]ПИРИМИДО[1,2-a]ПИРИМИДИН-6-ОНА - Google Patents

ЗАМЕЩЁННЫЕ ПРОИЗВОДНЫЕ 8'-ПИРИ(МИ)ДИНИЛДИГИДРОСПИРО[ЦИКЛОАЛКИЛАМИН]ПИРИМИДО[1,2-a]ПИРИМИДИН-6-ОНА

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EA200601192A1
EA200601192A1 EA200601192A EA200601192A EA200601192A1 EA 200601192 A1 EA200601192 A1 EA 200601192A1 EA 200601192 A EA200601192 A EA 200601192A EA 200601192 A EA200601192 A EA 200601192A EA 200601192 A1 EA200601192 A1 EA 200601192A1
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Eurasian Patent Office
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group
optionally substituted
ring
atom
alkyl group
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EA200601192A
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EA010419B1 (ru
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Натали Шерез
Алистер Локхед
Мурад Саади
Франк Словински
Филипп Иэш
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Санофи-Авентис
Мицубиси Фарма Корпорейшн
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Publication of EA010419B1 publication Critical patent/EA010419B1/ru

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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
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Abstract

В заявке описаны производные дигидроспиро[циклоалкиламин]пиримидона, представленные формулой (I), или их солигде Х представляет собой два атома водорода, атом серы, атом кислорода или Cалкильную группу и атом водорода; Y представляет собой связь, карбонильную группу, метиленовую группу, необязательно замещенную; R1 представляет собой 2, 3 или 4-пиридиновое кольцо или 2, 4 или 5-пиримидиновое кольцо, кольцо необязательно замещено; R2 представляет собой бензольное кольцо или нафталиновое кольцо; кольца необязательно замещены; R3 представляет собой атом водорода, Cалкильную группу или атом галогена; R4 представляет собой атом водорода, Cалкоксикарбонильную группу, Сциклоалкилкарбонильную группу, бензоильную группу, Cалкильную группу, где группы необязательно замещены; о и m принимают значения от 1 до 2; n принимает значения от 0 до 3, р принимает значения от 0 до 2; q принимает значения от 0 до 2. Изобретение относится также к лекарственному препарату, содержащему указанное производное или его соль в качестве активного ингредиента, который используют для профилактики и/или терапевтического лечения нейродегенеративного заболевания, вызываемого аномальной активностью GSK3β, такого как болезнь Альцгеймера.
EA200601192A 2003-12-19 2004-12-17 ЗАМЕЩЁННЫЕ ПРОИЗВОДНЫЕ 8`-ПИРИ(МИ)ДИНИЛДИГИДРОСПИРО[ЦИКЛОАЛКИЛАМИН]ПИРИМИДО[1,2-a]ПИРИМИДИН-6-ОНА EA010419B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP03293236A EP1557417B1 (en) 2003-12-19 2003-12-19 Substituted 8'-pyri(mi)dinyl-dihydrospiro-[cycloalkylamine]-pyrimido[1,2-a] pyrimidin-6-one derivatives
PCT/EP2004/014846 WO2005058908A1 (en) 2003-12-19 2004-12-17 SUBSTITUTED 8’-PYRI(MI)DINYL-DIHYDROSPIRO-[CYCLOALKYLAMINE]-PYRIMIDO[1,2-a]PYRIMIDIN-6-ONE DERIVATIVES

Publications (2)

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EA200601192A1 true EA200601192A1 (ru) 2006-10-27
EA010419B1 EA010419B1 (ru) 2008-08-29

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EA200601192A EA010419B1 (ru) 2003-12-19 2004-12-17 ЗАМЕЩЁННЫЕ ПРОИЗВОДНЫЕ 8`-ПИРИ(МИ)ДИНИЛДИГИДРОСПИРО[ЦИКЛОАЛКИЛАМИН]ПИРИМИДО[1,2-a]ПИРИМИДИН-6-ОНА

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US (2) US7294631B2 (ru)
EP (2) EP1557417B1 (ru)
JP (1) JP4896734B2 (ru)
KR (1) KR20060127055A (ru)
CN (1) CN1914208B (ru)
AR (1) AR047056A1 (ru)
AT (1) ATE360632T1 (ru)
AU (1) AU2004299285B2 (ru)
BR (1) BRPI0417208A (ru)
CA (1) CA2550168A1 (ru)
CY (1) CY1107982T1 (ru)
DE (1) DE602004006169T2 (ru)
DK (1) DK1699795T3 (ru)
EA (1) EA010419B1 (ru)
ES (1) ES2286707T3 (ru)
HK (1) HK1096401A1 (ru)
HR (1) HRP20070328T3 (ru)
IL (1) IL176287A0 (ru)
ME (1) MEP21408A (ru)
MX (1) MXPA06006931A (ru)
NO (1) NO20063187L (ru)
NZ (1) NZ547956A (ru)
PL (1) PL1699795T3 (ru)
PT (1) PT1699795E (ru)
RS (1) RS50519B (ru)
SI (1) SI1699795T1 (ru)
TW (1) TWI346664B (ru)
WO (1) WO2005058908A1 (ru)
ZA (1) ZA200604960B (ru)

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EP1295884A1 (en) * 2001-09-21 2003-03-26 Sanofi-Synthelabo 2-pyrimidinyl-6,7,8,9-tetrahydropyrimido[1,2-a]Pyrimidin-4-one and 7-Pyrimidinyl-2,3-Dihydroimidazo[1,2-a]Pyrimidin-5(1H)one derivatives
EP1340760A1 (en) * 2002-02-28 2003-09-03 Sanofi-Synthelabo Substituted 2-pyrimidinyl-6,7,8,9-tetrahydropyrimido[1,2-a]pyrimidin-4-one and 7-pyrimidinyl-2,3-dihydroimidazo[1,2-a]pyrimidin-5(1H)one derivatives
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KR101030629B1 (ko) * 2002-02-28 2011-04-20 미쯔비시 웰 파마 가부시키가이샤 헤테로아릴 치환된 2-피리디닐 및2-피리미디닐-6,7,8,9-테트라히드로피리미도[1,2-ａ]피리미딘-4-온 유도체
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DE602004006169D1 (de) 2007-06-06
US20070010539A1 (en) 2007-01-11
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