CA2236851A1 - Substituted vinylpyridine derivatives and drugs containing the same - Google Patents

Substituted vinylpyridine derivatives and drugs containing the same

Info

Publication number
CA2236851A1
CA2236851A1 CA002236851A CA2236851A CA2236851A1 CA 2236851 A1 CA2236851 A1 CA 2236851A1 CA 002236851 A CA002236851 A CA 002236851A CA 2236851 A CA2236851 A CA 2236851A CA 2236851 A1 CA2236851 A1 CA 2236851A1
Authority
CA
Canada
Prior art keywords
derivative
salt
group
same
inhibitory action
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002236851A
Other languages
French (fr)
Other versions
CA2236851C (en
Inventor
Kazuo Yamazaki
Yoichiro Ogawa
Hidehiko Kohya
Tadashi Mikami
Noriyuki Kawamoto
Noriaki Shioiri
Hiroshi Hasegawa
Susumu Sato
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hisamitsu Pharmaceutical Co Inc
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Priority claimed from PCT/JP1997/003354 external-priority patent/WO1998013348A1/en
Publication of CA2236851A1 publication Critical patent/CA2236851A1/en
Application granted granted Critical
Publication of CA2236851C publication Critical patent/CA2236851C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/69—Two or more oxygen atoms

Abstract

The present invention relates to a substituted vinylpyridine derivative represented by the following formula (1):

See Formula I

(wherein R1 represents a hydrogen atom, an alkyl group, etc., R2 represents an alkyl group; one of R3 and R4, which are different from each other, represents a hydrogen atom and the other represents a nitrile group, R5 represents an aryl group or a heteroaryl group, X represents an oxygen atom, etc., and one of Q1, Q2, and Q3 represents a nitrogen atom and the other two represent CH); a salt of the derivative;
and a drug containing the derivative or salt as the active ingredient. Due to strong PDE inhibitory action and TNF-.alpha.
production inhibitory action, the derivative, salt, and drug are useful for the prevention and treatment of a wide variety of inflammatory diseases and autoimmune diseases.
CA002236851A 1996-09-25 1997-09-22 Substituted vinylpyridine derivatives and drugs containing the same Expired - Fee Related CA2236851C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP8/252944 1996-09-25
JP25294496 1996-09-25
PCT/JP1997/003354 WO1998013348A1 (en) 1996-09-25 1997-09-22 Substituted vinylpyridine derivatives and drugs containing the same

Publications (2)

Publication Number Publication Date
CA2236851A1 true CA2236851A1 (en) 1998-04-02
CA2236851C CA2236851C (en) 2006-08-01

Family

ID=36764309

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002236851A Expired - Fee Related CA2236851C (en) 1996-09-25 1997-09-22 Substituted vinylpyridine derivatives and drugs containing the same

Country Status (1)

Country Link
CA (1) CA2236851C (en)

Also Published As

Publication number Publication date
CA2236851C (en) 2006-08-01

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Legal Events

Date Code Title Description
EEER Examination request
MKLA Lapsed