CY1105553T1 - Υποκαταστατα 2-πυριμιδινυλιο-6,7,8,9-τετραϋδροπυριμιδο[1,2-α]πυριμιδιν-4-ονιο και 7-πυριμιδινυλιο-2,3-διυδροιμιδαζο[1,2-α]πυριμιδιν-5(1η)ονιο για νευροεκφυλιστικες διαταραχες - Google Patents

Υποκαταστατα 2-πυριμιδινυλιο-6,7,8,9-τετραϋδροπυριμιδο[1,2-α]πυριμιδιν-4-ονιο και 7-πυριμιδινυλιο-2,3-διυδροιμιδαζο[1,2-α]πυριμιδιν-5(1η)ονιο για νευροεκφυλιστικες διαταραχες

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Publication number
CY1105553T1
CY1105553T1 CY20061100020T CY061100020T CY1105553T1 CY 1105553 T1 CY1105553 T1 CY 1105553T1 CY 20061100020 T CY20061100020 T CY 20061100020T CY 061100020 T CY061100020 T CY 061100020T CY 1105553 T1 CY1105553 T1 CY 1105553T1
Authority
CY
Cyprus
Prior art keywords
pyrimidin
pyrimidinyl
neurodegeneral
tetrahydropyrimido
dihydroimidazo
Prior art date
Application number
CY20061100020T
Other languages
English (en)
Inventor
Thierry Gallet
Patrick Lardenois
Alistair Lochead
Severine Marguerie
Alain Nedelec
Mourad Saady
Franck Slowinski
Philippe Yaiche
Original Assignee
Sanofi-Aventis
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from EP01402431A external-priority patent/EP1295884A1/en
Priority claimed from EP02290488A external-priority patent/EP1340760A1/en
Application filed by Sanofi-Aventis filed Critical Sanofi-Aventis
Publication of CY1105553T1 publication Critical patent/CY1105553T1/el

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
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Abstract

Η εφεύρεση αφορά ένα παράγωγο πυριμιδονίου που αναπαρίσταται από τη φόρμουλα (I) ή ένα άλας αυτού
CY20061100020T 2001-09-21 2006-01-09 Υποκαταστατα 2-πυριμιδινυλιο-6,7,8,9-τετραϋδροπυριμιδο[1,2-α]πυριμιδιν-4-ονιο και 7-πυριμιδινυλιο-2,3-διυδροιμιδαζο[1,2-α]πυριμιδιν-5(1η)ονιο για νευροεκφυλιστικες διαταραχες CY1105553T1 (el)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
EP01402431A EP1295884A1 (en) 2001-09-21 2001-09-21 2-pyrimidinyl-6,7,8,9-tetrahydropyrimido[1,2-a]Pyrimidin-4-one and 7-Pyrimidinyl-2,3-Dihydroimidazo[1,2-a]Pyrimidin-5(1H)one derivatives
EP02290488A EP1340760A1 (en) 2002-02-28 2002-02-28 Substituted 2-pyrimidinyl-6,7,8,9-tetrahydropyrimido[1,2-a]pyrimidin-4-one and 7-pyrimidinyl-2,3-dihydroimidazo[1,2-a]pyrimidin-5(1H)one derivatives
EP02779461A EP1430056B1 (en) 2001-09-21 2002-09-19 Substituted 2-pyrimidinyl-6,7,8,9-tetrahydropyrimido[1,2-a]pyrimidin-4-one and 7-pyrimidinyl-2,3-dihydroimidazo[1,2-a]pyrimidin-5(1h)one derivatives for neurodegenerative disorders
PCT/EP2002/011127 WO2003027115A1 (en) 2001-09-21 2002-09-19 Substituted 2-pyrimidinyl-6,7,8,9-tetrahydropyrimido[1,2-a]pyrimidin-4-one and 7-pyrimidinyl-2,3-dihydroimidazo[1,2-a]pyrimidin-5(1h)one derivatives for neurodegenerative disorders

Publications (1)

Publication Number Publication Date
CY1105553T1 true CY1105553T1 (el) 2010-07-28

Family

ID=26077255

Family Applications (1)

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CY20061100020T CY1105553T1 (el) 2001-09-21 2006-01-09 Υποκαταστατα 2-πυριμιδινυλιο-6,7,8,9-τετραϋδροπυριμιδο[1,2-α]πυριμιδιν-4-ονιο και 7-πυριμιδινυλιο-2,3-διυδροιμιδαζο[1,2-α]πυριμιδιν-5(1η)ονιο για νευροεκφυλιστικες διαταραχες

Country Status (24)

Country Link
US (2) US7388005B2 (el)
EP (1) EP1430056B1 (el)
JP (2) JP4570361B2 (el)
KR (1) KR100868840B1 (el)
CN (1) CN1247586C (el)
AR (1) AR036599A1 (el)
AT (1) ATE307815T1 (el)
AU (1) AU2002342798C1 (el)
BR (1) BR0212904A (el)
CA (1) CA2457952C (el)
CY (1) CY1105553T1 (el)
DE (1) DE60206946T2 (el)
DK (1) DK1430056T3 (el)
EA (2) EA009456B1 (el)
ES (1) ES2250721T3 (el)
HK (1) HK1091495A1 (el)
HU (1) HUP0500332A3 (el)
IL (2) IL160397A0 (el)
MX (1) MXPA04002632A (el)
NO (1) NO329566B1 (el)
NZ (1) NZ531244A (el)
PL (1) PL370535A1 (el)
SI (1) SI1430056T1 (el)
WO (1) WO2003027115A1 (el)

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EP1992624A1 (en) * 2007-05-16 2008-11-19 Sanofi-Aventis Heteroarylamide pyrimidone compounds
EP1992621A1 (en) 2007-05-16 2008-11-19 Sanofi-Aventis Heteroarylamide-substituted pyrimidone derivatives for the treatment of neurodegenerative diseases
EP1992620A1 (en) * 2007-05-16 2008-11-19 Sanofi-Aventis Arylamide pyrimidone derivatives for the treatment of neurodegenerative diseases
EP1992625A1 (en) 2007-05-16 2008-11-19 Sanofi-Aventis Arylamide pyrimidone compounds
EP2085400A1 (en) * 2008-01-29 2009-08-05 Sanofi-Aventis Substituted heteroarylamide oxazepinopyrimidone derivatives
EP2085399A1 (en) * 2008-01-29 2009-08-05 Sanofi-Aventis substituted arylamide oxazepinopyrimidone derivatives
EP2090578A1 (en) * 2008-01-29 2009-08-19 Sanofi-Aventis Substituted arylamide diazepinopyrimidone derivatives for the treatment of neurodegenerative diseases caused by abnormal activity of GSK3-beta
EP2090579A1 (en) * 2008-01-29 2009-08-19 Sanofi-Aventis Substituted heteroarylamide diazepinopyrimidone derivatives
EP2138494A1 (en) 2008-06-26 2009-12-30 Sanofi-Aventis Substituted alkyl pyrimidin-4-one derivatives
EP2138498A1 (en) 2008-06-26 2009-12-30 sanofi-aventis Substituted tricyclic derivatives against neurodegenerative diseases
EP2138495A1 (en) 2008-06-26 2009-12-30 sanofi-aventis Substituted pyrimido[2,1-a]isoquinolin-4-one derivatives
EP2138492A1 (en) 2008-06-26 2009-12-30 Sanofi-Aventis Substituted pyrimidin-4-one derivatives
EP2138488A1 (en) 2008-06-26 2009-12-30 sanofi-aventis 4-(pyridin-4-yl)-1H-[1,3,5]triazin-2-one derivatives as GSK3-beta inhibitors for the treatment of neurodegenerative diseases
EP2138485A1 (en) 2008-06-26 2009-12-30 sanofi-aventis Substituted N-Oxide pyrazine derivatives
EP2138493A1 (en) 2008-06-26 2009-12-30 Sanofi-Aventis Substituted pyrimidone derivatives
US20100216805A1 (en) 2009-02-25 2010-08-26 Braincells, Inc. Modulation of neurogenesis using d-cycloserine combinations
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CA2945263A1 (en) 2014-04-09 2015-10-15 Christopher Rudd Use of gsk-3 inhibitors or activators which modulate pd-1 or t-bet expression to modulate t cell immunity

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AU2002342798B2 (en) 2008-01-10
SI1430056T1 (sl) 2006-02-28
HK1091495A1 (en) 2007-01-19
HUP0500332A2 (hu) 2005-07-28
CA2457952A1 (en) 2003-04-03
KR20040039390A (ko) 2004-05-10
IL160397A (en) 2009-07-20
MXPA04002632A (es) 2004-07-08
EA200600196A1 (ru) 2006-08-25
NO329566B1 (no) 2010-11-15
AR036599A1 (es) 2004-09-22
DE60206946D1 (de) 2005-12-01
EA007165B1 (ru) 2006-08-25
KR100868840B1 (ko) 2008-11-14
EP1430056A1 (en) 2004-06-23
EP1430056B1 (en) 2005-10-26
US7388005B2 (en) 2008-06-17
US7781440B2 (en) 2010-08-24
CA2457952C (en) 2009-11-10
IL160397A0 (en) 2004-07-25
JP2005504809A (ja) 2005-02-17
AU2002342798C1 (en) 2008-09-25
BR0212904A (pt) 2004-10-13
HUP0500332A3 (en) 2009-12-28
DK1430056T3 (da) 2006-02-27
US20040266793A1 (en) 2004-12-30
US20080269257A1 (en) 2008-10-30
NZ531244A (en) 2006-06-30
DE60206946T2 (de) 2006-07-27
EA200400236A1 (ru) 2004-10-28
EA009456B1 (ru) 2007-12-28
CN1247586C (zh) 2006-03-29
PL370535A1 (en) 2005-05-30
ES2250721T3 (es) 2006-04-16
JP4570361B2 (ja) 2010-10-27
WO2003027115A1 (en) 2003-04-03
CN1556810A (zh) 2004-12-22
JP2010189422A (ja) 2010-09-02
ATE307815T1 (de) 2005-11-15
NO20041142L (no) 2004-06-21

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