ATE384725T1 - Pyrimido 4,5-d pyrimidinderivate mitantikrebswirkung - Google Patents
Pyrimido 4,5-d pyrimidinderivate mitantikrebswirkungInfo
- Publication number
- ATE384725T1 ATE384725T1 AT03810410T AT03810410T ATE384725T1 AT E384725 T1 ATE384725 T1 AT E384725T1 AT 03810410 T AT03810410 T AT 03810410T AT 03810410 T AT03810410 T AT 03810410T AT E384725 T1 ATE384725 T1 AT E384725T1
- Authority
- AT
- Austria
- Prior art keywords
- pyrimido
- pyrimidine derivatives
- cancer effect
- cancer
- effect
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Oncology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US42367002P | 2002-11-04 | 2002-11-04 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE384725T1 true ATE384725T1 (de) | 2008-02-15 |
Family
ID=32312700
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT03758072T ATE386744T1 (de) | 2002-11-04 | 2003-10-27 | Pyrimidoderivate mit antiproliferativer aktivität (ii) |
| AT03810410T ATE384725T1 (de) | 2002-11-04 | 2003-10-27 | Pyrimido 4,5-d pyrimidinderivate mitantikrebswirkung |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT03758072T ATE386744T1 (de) | 2002-11-04 | 2003-10-27 | Pyrimidoderivate mit antiproliferativer aktivität (ii) |
Country Status (16)
| Country | Link |
|---|---|
| US (2) | US7112676B2 (de) |
| EP (2) | EP1560832B1 (de) |
| JP (2) | JP2006507292A (de) |
| KR (4) | KR100774230B1 (de) |
| CN (2) | CN1711266A (de) |
| AR (2) | AR041739A1 (de) |
| AT (2) | ATE386744T1 (de) |
| AU (1) | AU2003276190A1 (de) |
| BR (2) | BR0315912A (de) |
| CA (2) | CA2502182A1 (de) |
| DE (2) | DE60318888T2 (de) |
| ES (2) | ES2298622T3 (de) |
| MX (2) | MXPA05004757A (de) |
| PL (2) | PL376916A1 (de) |
| RU (2) | RU2326882C2 (de) |
| WO (2) | WO2004041821A1 (de) |
Families Citing this family (55)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2003903501A0 (en) * | 2003-07-07 | 2003-07-24 | Commonwealth Scientific And Industrial Research Organisation | A method of forming a reflective authentication device |
| WO2005011597A2 (en) * | 2003-07-29 | 2005-02-10 | Irm Llc | Compounds and compositions as protein kinase inhibitors |
| FR2873127B1 (fr) | 2004-07-13 | 2008-08-29 | Omya Development Ag | Procede de fabrication de particules pigmentaires autoliantes, seches ou en suspension ou dispersion aqueuses, contenant des matieres inorganiques et des liants |
| US7655651B2 (en) | 2004-08-31 | 2010-02-02 | Hoffmann-La Roche Inc. | Amide derivatives of 3-phenyl-dihydropyrimido[4,5-d]pyrimidinones, their manufacture and use as pharmaceutical agents |
| MX2007002089A (es) * | 2004-08-31 | 2007-03-29 | Hoffmann La Roche | Derivados de amida de 7-amino-3-fenil-dihidropirimido[4,5-d]pirimidonas, su fabricacion y su uso como inhibidores de proteina cinasa. |
| PT1951684T (pt) * | 2005-11-01 | 2016-10-13 | Targegen Inc | Inibidores de cinases de tipo biaril-meta-pirimidina |
| CA2636981A1 (en) | 2006-01-31 | 2007-08-09 | F. Hoffmann-La Roche Ag | 7h-pyrido[3,4-d]pyrimidin-8-ones, their manufacture and use as protein kinase inhibitors |
| CA2646369A1 (en) * | 2006-03-29 | 2007-11-08 | North Carolina State University | Synthesis and regioselective substitution of 6-halo- and 6-alkoxy nicotine derivatives |
| WO2007136465A2 (en) * | 2006-05-15 | 2007-11-29 | Irm Llc | Compositions and methods for fgf receptor kinases inhibitors |
| US7897762B2 (en) * | 2006-09-14 | 2011-03-01 | Deciphera Pharmaceuticals, Llc | Kinase inhibitors useful for the treatment of proliferative diseases |
| WO2010014939A1 (en) * | 2008-07-31 | 2010-02-04 | Genentech, Inc. | Pyrimidine compounds, compositions and methods of use |
| BRPI0919248A2 (pt) | 2008-09-25 | 2019-09-24 | Hoffmann La Roche | derivados de 3-amino-indazol ou 3-amino-4,5,6,7-tetraidroindazol |
| EP2376494A4 (de) | 2008-12-12 | 2012-07-11 | Msd Kk | Dihydropyrimidopyrimidinderivate |
| CA2745970A1 (en) | 2008-12-12 | 2010-06-17 | Msd K.K. | Dihydropyrimidopyrimidine derivative |
| HUP0800768A2 (en) | 2008-12-18 | 2012-08-28 | Bioblocks Magyarorszag Gyogyszerkemiai Es Fejlesztoe Kft | 1,3-heterocycles condensed with monoterpene skeleton, their use and pharmaceutical compositions comprising such compounds |
| US20120189641A1 (en) | 2009-02-25 | 2012-07-26 | OSI Pharmaceuticals, LLC | Combination anti-cancer therapy |
| US8642834B2 (en) | 2009-02-27 | 2014-02-04 | OSI Pharmaceuticals, LLC | Methods for the identification of agents that inhibit mesenchymal-like tumor cells or their formation |
| WO2010099138A2 (en) | 2009-02-27 | 2010-09-02 | Osi Pharmaceuticals, Inc. | Methods for the identification of agents that inhibit mesenchymal-like tumor cells or their formation |
| US8465912B2 (en) | 2009-02-27 | 2013-06-18 | OSI Pharmaceuticals, LLC | Methods for the identification of agents that inhibit mesenchymal-like tumor cells or their formation |
| US20100318651A1 (en) * | 2009-06-10 | 2010-12-16 | Everis, Inc. | Network Communication System With Monitoring |
| US8754114B2 (en) | 2010-12-22 | 2014-06-17 | Incyte Corporation | Substituted imidazopyridazines and benzimidazoles as inhibitors of FGFR3 |
| US9896730B2 (en) | 2011-04-25 | 2018-02-20 | OSI Pharmaceuticals, LLC | Use of EMT gene signatures in cancer drug discovery, diagnostics, and treatment |
| GB201204384D0 (en) | 2012-03-13 | 2012-04-25 | Univ Dundee | Anti-flammatory agents |
| WO2013152252A1 (en) | 2012-04-06 | 2013-10-10 | OSI Pharmaceuticals, LLC | Combination anti-cancer therapy |
| DK3176170T3 (en) | 2012-06-13 | 2019-01-28 | Incyte Holdings Corp | SUBSTITUTED TRICYCLIC RELATIONS AS FGFR INHIBITORS |
| SG10201610869TA (en) | 2012-06-26 | 2017-02-27 | Del Mar Pharmaceuticals | Methods for treating tyrosine-kinase-inhibitor-resistant malignancies in patients with genetic polymorphisms or ahi1 dysregulations or mutations employing dianhydrogalactitol, diacetyldianhydrogalacti |
| US9388185B2 (en) | 2012-08-10 | 2016-07-12 | Incyte Holdings Corporation | Substituted pyrrolo[2,3-b]pyrazines as FGFR inhibitors |
| US9266892B2 (en) | 2012-12-19 | 2016-02-23 | Incyte Holdings Corporation | Fused pyrazoles as FGFR inhibitors |
| MY181020A (en) | 2013-03-15 | 2020-12-16 | Sanofi Sa | Heteroaryl compounds and uses thereof |
| AR095464A1 (es) | 2013-03-15 | 2015-10-21 | Celgene Avilomics Res Inc | Compuestos de heteroarilo y usos de los mismos |
| JP6576325B2 (ja) | 2013-03-15 | 2019-09-18 | セルジーン シーエーアール エルエルシー | ヘテロアリール化合物およびそれらの使用 |
| SI2986610T1 (en) | 2013-04-19 | 2018-04-30 | Incyte Holdings Corporation | Bicyclic heterocycles as inhibitors of FGFR |
| US9783504B2 (en) * | 2013-07-09 | 2017-10-10 | Dana-Farber Cancer Institute, Inc. | Kinase inhibitors for the treatment of disease |
| CA2954187C (en) | 2014-07-21 | 2022-08-16 | Dana-Farber Cancer Institute, Inc. | Macrocyclic kinase inhibitors and uses thereof |
| CA2954186A1 (en) | 2014-07-21 | 2016-01-28 | Dana-Farber Cancer Institute, Inc. | Imidazolyl kinase inhibitors and uses thereof |
| CA2955082A1 (en) | 2014-08-08 | 2016-02-11 | Dana-Farber Cancer Institute, Inc. | Uses of salt-inducible kinase (sik) inhibitors |
| US10851105B2 (en) | 2014-10-22 | 2020-12-01 | Incyte Corporation | Bicyclic heterocycles as FGFR4 inhibitors |
| EP3617205B1 (de) | 2015-02-20 | 2021-08-04 | Incyte Corporation | Bicyclische heterocyclen als fgfr-inhibitoren |
| MA41551A (fr) | 2015-02-20 | 2017-12-26 | Incyte Corp | Hétérocycles bicycliques utilisés en tant qu'inhibiteurs de fgfr4 |
| WO2016134294A1 (en) | 2015-02-20 | 2016-08-25 | Incyte Corporation | Bicyclic heterocycles as fgfr4 inhibitors |
| CA3069016A1 (en) * | 2016-07-05 | 2018-01-11 | The Broad Institute, Inc. | Bicyclic urea kinase inhibitors and uses thereof |
| WO2018053373A1 (en) | 2016-09-16 | 2018-03-22 | The General Hospital Corporation | Uses of satl-inducible kinase (sik) inhibitors for treating osteoporosis |
| US11285158B2 (en) | 2017-02-28 | 2022-03-29 | The General Hospital Corporation | Uses of pyrimidopyrimidinones as SIK inhibitors |
| AR111960A1 (es) | 2017-05-26 | 2019-09-04 | Incyte Corp | Formas cristalinas de un inhibidor de fgfr y procesos para su preparación |
| BR112020022392A2 (pt) | 2018-05-04 | 2021-02-02 | Incyte Corporation | formas sólidas de um inibidor de fgfr e processos para preparação das mesmas |
| AU2019262579A1 (en) | 2018-05-04 | 2020-12-24 | Incyte Corporation | Salts of an FGFR inhibitor |
| CA3124678A1 (en) * | 2018-12-27 | 2020-07-02 | Zenon D. Konteatis | Aza-heterobicyclic inhibitors of mat2a and methods of use for treating cancer |
| WO2020185532A1 (en) | 2019-03-08 | 2020-09-17 | Incyte Corporation | Methods of treating cancer with an fgfr inhibitor |
| US11591329B2 (en) | 2019-07-09 | 2023-02-28 | Incyte Corporation | Bicyclic heterocycles as FGFR inhibitors |
| WO2021076602A1 (en) | 2019-10-14 | 2021-04-22 | Incyte Corporation | Bicyclic heterocycles as fgfr inhibitors |
| US11566028B2 (en) | 2019-10-16 | 2023-01-31 | Incyte Corporation | Bicyclic heterocycles as FGFR inhibitors |
| JP2023505258A (ja) | 2019-12-04 | 2023-02-08 | インサイト・コーポレイション | Ｆｇｆｒ阻害剤としての三環式複素環 |
| JP2023505257A (ja) | 2019-12-04 | 2023-02-08 | インサイト・コーポレイション | Ｆｇｆｒ阻害剤の誘導体 |
| US12012409B2 (en) | 2020-01-15 | 2024-06-18 | Incyte Corporation | Bicyclic heterocycles as FGFR inhibitors |
| EP4352059A1 (de) | 2021-06-09 | 2024-04-17 | Incyte Corporation | Tricyclische heterocyclen als fgfr-inhibitoren |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2949466A (en) | 1958-03-04 | 1960-08-16 | Parke Davis & Co | Pyrimidine compounds and means of producing the same |
| NL6704601A (de) | 1966-04-06 | 1967-10-09 | ||
| US4425346A (en) | 1980-08-01 | 1984-01-10 | Smith And Nephew Associated Companies Limited | Pharmaceutical compositions |
| JPS60226882A (ja) | 1984-04-24 | 1985-11-12 | Nippon Zoki Pharmaceut Co Ltd | 新規ピリミドピリミジン誘導体 |
| AU7622698A (en) | 1996-12-05 | 1998-06-29 | Sugen, Inc. | Use of indolinone compounds as modulators of protein kinases |
| KR200143829Y1 (ko) * | 1996-12-30 | 1999-06-15 | 양재신 | 연료펌프 교환시 연료의 비산 방지구 |
| BR9911590A (pt) | 1998-05-26 | 2001-02-13 | Warner Lambert Co | Pirimidinas bicìclicas e 3,4-diidropirimidinas bicìclicas como inibidores da proliferação celular |
| AU769989B2 (en) | 1998-10-23 | 2004-02-12 | F. Hoffmann-La Roche Ag | Bicyclic nitrogen heterocycles |
| ATE353329T1 (de) | 1999-10-21 | 2007-02-15 | Hoffmann La Roche | Heteroalkylamino-substituierte bicyclische stickstoffheterocyclen |
| AU776695B2 (en) | 1999-10-21 | 2004-09-16 | F. Hoffmann-La Roche Ag | Alkylamino substituted bicyclic nitrogen heterocycles as inhibitors of p38 protein kinase |
| AR030053A1 (es) | 2000-03-02 | 2003-08-13 | Smithkline Beecham Corp | 1h-pirimido [4,5-d] pirimidin-2-onas y sales, composiciones farmaceuticas, uso para la fabricacion de un medicamento y procedimiento para producirlas |
| EP1315726A1 (de) | 2000-08-31 | 2003-06-04 | F. Hoffmann-La Roche Ag | 7-oxopyridopyrimidine als inhibitoren von zellvermehrung |
| KR20060111716A (ko) | 2002-01-22 | 2006-10-27 | 워너-램버트 캄파니 엘엘씨 | 2-(피리딘-2-일아미노)-피리도[2,3-ｄ]피리미딘-7-온 |
| US7196090B2 (en) | 2002-07-25 | 2007-03-27 | Warner-Lambert Company | Kinase inhibitors |
| AU2003270701B2 (en) | 2002-10-31 | 2009-11-12 | Amgen Inc. | Antiinflammation agents |
-
2003
- 2003-10-20 US US10/689,235 patent/US7112676B2/en not_active Expired - Fee Related
- 2003-10-20 US US10/689,438 patent/US7129351B2/en not_active Expired - Fee Related
- 2003-10-27 PL PL376916A patent/PL376916A1/pl not_active Application Discontinuation
- 2003-10-27 CN CNA2003801028610A patent/CN1711266A/zh active Pending
- 2003-10-27 AT AT03758072T patent/ATE386744T1/de not_active IP Right Cessation
- 2003-10-27 WO PCT/EP2003/011892 patent/WO2004041821A1/de active IP Right Grant
- 2003-10-27 KR KR1020077016286A patent/KR100774230B1/ko not_active IP Right Cessation
- 2003-10-27 KR KR1020057007981A patent/KR100763299B1/ko not_active IP Right Cessation
- 2003-10-27 EP EP03810410A patent/EP1560832B1/de not_active Expired - Lifetime
- 2003-10-27 DE DE60318888T patent/DE60318888T2/de not_active Expired - Fee Related
- 2003-10-27 RU RU2005117341/04A patent/RU2326882C2/ru not_active IP Right Cessation
- 2003-10-27 CA CA002502182A patent/CA2502182A1/en not_active Abandoned
- 2003-10-27 AT AT03810410T patent/ATE384725T1/de not_active IP Right Cessation
- 2003-10-27 JP JP2004548791A patent/JP2006507292A/ja active Pending
- 2003-10-27 AU AU2003276190A patent/AU2003276190A1/en not_active Abandoned
- 2003-10-27 PL PL376924A patent/PL376924A1/pl not_active Application Discontinuation
- 2003-10-27 BR BR0315912-4A patent/BR0315912A/pt not_active IP Right Cessation
- 2003-10-27 BR BR0316001-7A patent/BR0316001A/pt not_active IP Right Cessation
- 2003-10-27 RU RU2005117340/04A patent/RU2331641C2/ru not_active IP Right Cessation
- 2003-10-27 DE DE60319260T patent/DE60319260T2/de not_active Expired - Fee Related
- 2003-10-27 WO PCT/EP2003/011896 patent/WO2004041822A1/en active IP Right Grant
- 2003-10-27 CA CA002502180A patent/CA2502180A1/en not_active Abandoned
- 2003-10-27 MX MXPA05004757A patent/MXPA05004757A/es active IP Right Grant
- 2003-10-27 MX MXPA05004756A patent/MXPA05004756A/es active IP Right Grant
- 2003-10-27 ES ES03810410T patent/ES2298622T3/es not_active Expired - Lifetime
- 2003-10-27 JP JP2004548792A patent/JP2006513999A/ja active Pending
- 2003-10-27 CN CNB2003801028485A patent/CN100420688C/zh not_active Expired - Fee Related
- 2003-10-27 ES ES03758072T patent/ES2300609T3/es not_active Expired - Lifetime
- 2003-10-27 KR KR1020077017255A patent/KR100774231B1/ko not_active IP Right Cessation
- 2003-10-27 KR KR1020057007906A patent/KR100763300B1/ko not_active IP Right Cessation
- 2003-10-27 EP EP03758072A patent/EP1560829B1/de not_active Expired - Lifetime
- 2003-10-31 AR ARP030104000A patent/AR041739A1/es unknown
- 2003-10-31 AR ARP030103999A patent/AR041738A1/es unknown
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| DE50106542D1 (de) | Substituierte 3,4-dihydro-pyrido[1,2-a]pyrimidine |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
Ref document number: 1560832 Country of ref document: EP |
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| REN | Ceased due to non-payment of the annual fee |