DK1761542T3 - Octahydropyrrolo[3,4-C] pyrrolderivater og anvendelsen deraf som antivirusmidler - Google Patents

Octahydropyrrolo[3,4-C] pyrrolderivater og anvendelsen deraf som antivirusmidler

Info

Publication number
DK1761542T3
DK1761542T3 DK05754708T DK05754708T DK1761542T3 DK 1761542 T3 DK1761542 T3 DK 1761542T3 DK 05754708 T DK05754708 T DK 05754708T DK 05754708 T DK05754708 T DK 05754708T DK 1761542 T3 DK1761542 T3 DK 1761542T3
Authority
DK
Denmark
Prior art keywords
octahydropyrrolo
antiviral agents
pyrrole derivatives
pyrrole
derivatives
Prior art date
Application number
DK05754708T
Other languages
English (en)
Inventor
Eun Kyung Lee
Chris Richard Melville
David Mark Rotstein
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Application granted granted Critical
Publication of DK1761542T3 publication Critical patent/DK1761542T3/da

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/06Antiasthmatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/06Antipsoriatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/08Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • A61P31/18Antivirals for RNA viruses for HIV
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/06Immunosuppressants, e.g. drugs for graft rejection
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/08Antiallergic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Dermatology (AREA)
  • Rheumatology (AREA)
  • Virology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Neurosurgery (AREA)
  • AIDS & HIV (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Communicable Diseases (AREA)
  • Pain & Pain Management (AREA)
  • Transplantation (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
DK05754708T 2004-06-09 2005-06-01 Octahydropyrrolo[3,4-C] pyrrolderivater og anvendelsen deraf som antivirusmidler DK1761542T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US57875904P 2004-06-09 2004-06-09
PCT/EP2005/005895 WO2005121145A2 (en) 2004-06-09 2005-06-01 Octahydro-pyrrolo[3,4-c] derivatives and their use as antiviral compounds

Publications (1)

Publication Number Publication Date
DK1761542T3 true DK1761542T3 (da) 2008-04-28

Family

ID=35431500

Family Applications (1)

Application Number Title Priority Date Filing Date
DK05754708T DK1761542T3 (da) 2004-06-09 2005-06-01 Octahydropyrrolo[3,4-C] pyrrolderivater og anvendelsen deraf som antivirusmidler

Country Status (21)

Country Link
US (2) US7164019B2 (da)
EP (1) EP1761542B1 (da)
JP (1) JP2008501743A (da)
CN (1) CN101001860A (da)
AR (1) AR049209A1 (da)
AT (1) ATE382623T1 (da)
AU (1) AU2005251891A1 (da)
BR (1) BRPI0511982A (da)
CA (1) CA2569910A1 (da)
DE (1) DE602005004144T2 (da)
DK (1) DK1761542T3 (da)
ES (1) ES2297727T3 (da)
IL (1) IL179534A0 (da)
MX (1) MXPA06014404A (da)
NO (1) NO20070137L (da)
PL (1) PL1761542T3 (da)
PT (1) PT1761542E (da)
RU (1) RU2006146608A (da)
TW (1) TW200701981A (da)
WO (1) WO2005121145A2 (da)
ZA (1) ZA200609837B (da)

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EP2521450B1 (en) 2010-01-07 2015-02-25 E.I. Du Pont De Nemours And Company Fungicidal heterocyclic compounds
ES2543692T3 (es) 2010-04-29 2015-08-21 The University Of Edinburgh (8-aza-biciclo[3.2.1biciclo[oct-8-il)-[5-(1H-pirazol-4-il)-tiofeno-3-il]-metanonas 3,3-disustituidas como inhibidores de 11beta-HSD1
DE102010025663A1 (de) * 2010-06-30 2012-01-05 Karl-Heinz Glüsenkamp Neue beta-Aminoaldehyd-Derivate, Verfahren zu ihrer Herstellung und ihre chemische Verwendung als reaktive Intermediate
CN104364239B (zh) 2012-06-13 2017-08-25 霍夫曼-拉罗奇有限公司 二氮杂螺环烷烃和氮杂螺环烷烃
AR092645A1 (es) * 2012-09-25 2015-04-29 Hoffmann La Roche Derivados biciclicos inhibidores de autotaxina (atx)
AR095079A1 (es) 2013-03-12 2015-09-16 Hoffmann La Roche Derivados de octahidro-pirrolo[3,4-c]-pirrol y piridina-fenilo
ES2707739T3 (es) 2013-09-26 2019-04-04 Cadent Therapeutics Inc Moduladores negativos de octahidro-ciclopenta[c]pirrol selectivo de NR2B
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PL3122750T3 (pl) 2014-03-26 2020-03-31 F.Hoffmann-La Roche Ag Związki bicykliczne jako inhibitory wytwarzania autotaksyny (ATX) i kwasu lizofosfatydowego (LPA)
EA032357B1 (ru) 2014-03-26 2019-05-31 Ф. Хоффманн-Ля Рош Аг Конденсированные [1,4]диазепиновые соединения в качестве ингибиторов продукции аутотаксина (atx) и лизофосфатидиловой кислоты (lpa)
JO3579B1 (ar) * 2014-09-26 2020-07-05 Luc Therapeutics Inc مُعدِلات تفاغرية سالبة لمستقبل nr2b من المركب n-ألكيل أريل-5-أوكسي أريل-ثامن هيدرو-خماسي الحلقة [c] بيرول
MA41898A (fr) 2015-04-10 2018-02-13 Hoffmann La Roche Dérivés de quinazolinone bicyclique
MX2018000511A (es) 2015-09-04 2018-04-24 Hoffmann La Roche Derivados de fenoximetilo.
MA42923A (fr) 2015-09-24 2021-04-28 Hoffmann La Roche Composés bicycliques comme inhibiteurs mixtes de atx/ca
CR20180143A (es) 2015-09-24 2018-05-03 Hoffmann La Roche Nuevos compuestos biciclicos como inhibidores duales de atx/ca
EP3353180B1 (en) 2015-09-24 2022-03-16 F. Hoffmann-La Roche AG Bicyclic compounds as atx inhibitors
AU2016328437A1 (en) 2015-09-24 2018-01-25 F. Hoffmann-La Roche Ag Bicyclic compounds as ATX inhibitors
WO2018011681A1 (en) 2016-07-14 2018-01-18 Pfizer Inc. Novel pyrimidine carboxamides as inhibitors of vanin-1 enzyme
CA3053329A1 (en) 2017-03-16 2018-09-20 F. Hoffmann-La Roche Ag Heterocyclic compounds useful as dual atx/ca inhibitors
JP7090099B2 (ja) 2017-03-16 2022-06-23 エフ.ホフマン-ラ ロシュ アーゲー Atxインヒビターとしての新規二環式化合物
US11629196B2 (en) 2020-04-27 2023-04-18 Incelldx, Inc. Method of treating SARS-CoV-2-associated hypercytokinemia by administering a human monoclonal antibody (PRO-140) that inhibits CCR5/CCL5 binding interactions
EP4165043A1 (en) * 2020-06-10 2023-04-19 Cyxone AB Method for preparing a crystalline form of rabeximod
CN113845439B (zh) * 2021-10-11 2024-02-09 杭州师范大学 双苄酰胺类cxcr4拮抗剂及其制备和应用

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Also Published As

Publication number Publication date
AR049209A1 (es) 2006-07-05
US20070117859A1 (en) 2007-05-24
WO2005121145A3 (en) 2006-03-02
WO2005121145A2 (en) 2005-12-22
CN101001860A (zh) 2007-07-18
PL1761542T3 (pl) 2008-06-30
US20060014767A1 (en) 2006-01-19
AU2005251891A1 (en) 2005-12-22
PT1761542E (pt) 2008-03-26
EP1761542A2 (en) 2007-03-14
CA2569910A1 (en) 2005-12-22
DE602005004144D1 (de) 2008-02-14
US7164019B2 (en) 2007-01-16
NO20070137L (no) 2007-03-06
EP1761542B1 (en) 2008-01-02
ES2297727T3 (es) 2008-05-01
TW200701981A (en) 2007-01-16
RU2006146608A (ru) 2008-07-20
US7714018B2 (en) 2010-05-11
IL179534A0 (en) 2007-05-15
ATE382623T1 (de) 2008-01-15
BRPI0511982A (pt) 2008-01-22
ZA200609837B (en) 2008-09-25
MXPA06014404A (es) 2007-02-19
JP2008501743A (ja) 2008-01-24
DE602005004144T2 (de) 2009-01-29

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