TW200701981A - Heterocyclic antiviral compounds - Google Patents

Heterocyclic antiviral compounds

Info

Publication number
TW200701981A
TW200701981A TW094118518A TW94118518A TW200701981A TW 200701981 A TW200701981 A TW 200701981A TW 094118518 A TW094118518 A TW 094118518A TW 94118518 A TW94118518 A TW 94118518A TW 200701981 A TW200701981 A TW 200701981A
Authority
TW
Taiwan
Prior art keywords
treating
antagonists
formula
antiviral compounds
invention further
Prior art date
Application number
TW094118518A
Other languages
English (en)
Inventor
Eun-Kyung Lee
Chris Richard Melville
David Mark Rotstein
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of TW200701981A publication Critical patent/TW200701981A/zh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
TW094118518A 2004-06-09 2005-07-08 Heterocyclic antiviral compounds TW200701981A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US57875904P 2004-06-09 2004-06-09

Publications (1)

Publication Number Publication Date
TW200701981A true TW200701981A (en) 2007-01-16

Family

ID=35431500

Family Applications (1)

Application Number Title Priority Date Filing Date
TW094118518A TW200701981A (en) 2004-06-09 2005-07-08 Heterocyclic antiviral compounds

Country Status (21)

Country Link
US (2) US7164019B2 (zh)
EP (1) EP1761542B1 (zh)
JP (1) JP2008501743A (zh)
CN (1) CN101001860A (zh)
AR (1) AR049209A1 (zh)
AT (1) ATE382623T1 (zh)
AU (1) AU2005251891A1 (zh)
BR (1) BRPI0511982A (zh)
CA (1) CA2569910A1 (zh)
DE (1) DE602005004144T2 (zh)
DK (1) DK1761542T3 (zh)
ES (1) ES2297727T3 (zh)
IL (1) IL179534A0 (zh)
MX (1) MXPA06014404A (zh)
NO (1) NO20070137L (zh)
PL (1) PL1761542T3 (zh)
PT (1) PT1761542E (zh)
RU (1) RU2006146608A (zh)
TW (1) TW200701981A (zh)
WO (1) WO2005121145A2 (zh)
ZA (1) ZA200609837B (zh)

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US8464207B2 (en) * 2007-10-12 2013-06-11 Novell Intellectual Property Holdings, Inc. System and method for tracking software changes
GB0724251D0 (en) 2007-12-12 2008-02-06 Univ Edinburgh Therapeutic compounds and their use
GB0804685D0 (en) 2008-03-13 2008-04-16 Univ Edinburgh Therapeutic compounds and their use
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CN102791133B (zh) 2010-01-07 2015-09-23 纳幕尔杜邦公司 杀真菌杂环化合物
DK2563780T3 (en) 2010-04-29 2015-07-27 Univ Edinburgh 3,3-DISUBSTITUEREDE- (8-aza-bicyclo [3.2.1] oct-8-yl) - [5- (1H-pyrazol-4-yl) -thiophene-3-yl] -METHANONER as inhibitors of 11 ( BETA) -HSD1
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CN104684915B (zh) * 2012-09-25 2017-10-31 霍夫曼-拉罗奇有限公司 新型双环衍生物
AR095079A1 (es) 2013-03-12 2015-09-16 Hoffmann La Roche Derivados de octahidro-pirrolo[3,4-c]-pirrol y piridina-fenilo
AR097794A1 (es) * 2013-09-26 2016-04-13 Mnemosyne Pharmaceuticals Inc Moduladores octahidro-ciclopenta[c]pirrol negativos de nr2b
PE20160845A1 (es) 2013-11-26 2016-09-10 Hoffmann La Roche Nuevo octahidro-ciclobuta[1,2-c;3,4-c']dipirrol-2-ilo
CN104744451A (zh) * 2013-12-30 2015-07-01 中国科学院上海药物研究所 一种1-(3-氨基丙基)取代环状胺类化合物、其制备方法、药物组合物及用途
DK3122750T3 (da) 2014-03-26 2019-11-04 Hoffmann La Roche Bicykliske forbindelser som autotaxin (ATX)- og lysofosfatidsyre (LPA)-produktionshæmmere
JP6554481B2 (ja) 2014-03-26 2019-07-31 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ オートタキシン（ａｔｘ）及びリゾホスファチジン酸（ｌｐａ）産生の阻害剤としての縮合［１，４］ジアゼピン化合物
JO3579B1 (ar) * 2014-09-26 2020-07-05 Luc Therapeutics Inc مُعدِلات تفاغرية سالبة لمستقبل nr2b من المركب n-ألكيل أريل-5-أوكسي أريل-ثامن هيدرو-خماسي الحلقة [c] بيرول
MA41898A (fr) 2015-04-10 2018-02-13 Hoffmann La Roche Dérivés de quinazolinone bicyclique
KR20180043837A (ko) 2015-09-04 2018-04-30 에프. 호프만-라 로슈 아게 페녹시메틸 유도체
RU2018114289A (ru) 2015-09-24 2019-10-24 Ф. Хоффманн-Ля Рош Аг Бициклические соединения в качестве ингибиторов аутотаксина (atx)
KR20180053408A (ko) 2015-09-24 2018-05-21 에프. 호프만-라 로슈 아게 이중 오토탁신(atx)/탄산 무수화효소(ca) 억제제로서의 신규한 이환형 화합물
CN107922412B (zh) 2015-09-24 2021-02-23 豪夫迈·罗氏有限公司 作为atx抑制剂的二环化合物
CR20180057A (es) 2015-09-24 2018-04-02 Hoffmann La Roche Nuevos compuestos biciclicos como inhibidores duales de atx/ca.
EP3484876A1 (en) 2016-07-14 2019-05-22 Pfizer Inc Novel pyrimidine carboxamides as inhibitors of vanin-1 enzyme
WO2018167113A1 (en) 2017-03-16 2018-09-20 F. Hoffmann-La Roche Ag New bicyclic compounds as atx inhibitors
WO2018167001A1 (en) 2017-03-16 2018-09-20 F. Hoffmann-La Roche Ag Heterocyclic compounds useful as dual atx/ca inhibitors
US20230227455A1 (en) * 2020-06-10 2023-07-20 Cyxone Ab Method for preparing a crystalline form of rabeximod
CN113845439B (zh) * 2021-10-11 2024-02-09 杭州师范大学 双苄酰胺类cxcr4拮抗剂及其制备和应用

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Also Published As

Publication number Publication date
CN101001860A (zh) 2007-07-18
DE602005004144T2 (de) 2009-01-29
ES2297727T3 (es) 2008-05-01
WO2005121145A2 (en) 2005-12-22
RU2006146608A (ru) 2008-07-20
US7164019B2 (en) 2007-01-16
US20070117859A1 (en) 2007-05-24
NO20070137L (no) 2007-03-06
AU2005251891A1 (en) 2005-12-22
PL1761542T3 (pl) 2008-06-30
US20060014767A1 (en) 2006-01-19
PT1761542E (pt) 2008-03-26
WO2005121145A3 (en) 2006-03-02
JP2008501743A (ja) 2008-01-24
AR049209A1 (es) 2006-07-05
CA2569910A1 (en) 2005-12-22
BRPI0511982A (pt) 2008-01-22
EP1761542A2 (en) 2007-03-14
DK1761542T3 (da) 2008-04-28
IL179534A0 (en) 2007-05-15
ZA200609837B (en) 2008-09-25
EP1761542B1 (en) 2008-01-02
ATE382623T1 (de) 2008-01-15
DE602005004144D1 (de) 2008-02-14
US7714018B2 (en) 2010-05-11
MXPA06014404A (es) 2007-02-19

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