BRPI0511982A - compostos antiviróticos heterocìclicos - Google Patents

compostos antiviróticos heterocìclicos

Info

Publication number
BRPI0511982A
BRPI0511982A BRPI0511982-0A BRPI0511982A BRPI0511982A BR PI0511982 A BRPI0511982 A BR PI0511982A BR PI0511982 A BRPI0511982 A BR PI0511982A BR PI0511982 A BRPI0511982 A BR PI0511982A
Authority
BR
Brazil
Prior art keywords
compounds
treating
formula
antiviral compounds
diseases
Prior art date
Application number
BRPI0511982-0A
Other languages
English (en)
Inventor
Eun Kyung Lee
Chris Richard Melville
David Mark Rotstein
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of BRPI0511982A publication Critical patent/BRPI0511982A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Virology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Dermatology (AREA)
  • Rheumatology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • Oncology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Communicable Diseases (AREA)
  • Transplantation (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • AIDS & HIV (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

COMPOSTOS ANTIVIRóTICOS HETEROCìCLICOS. Os antagonistas de receptor de quimiocina, em particular, compostos de 3,7-diazabiciclo¢3.3.0! octano de acordo com a fórmula (I) são antagonistas de receptores de CCR5 de quimiocina que são úteis para tratar ou prevenir uma infecção por vírus da imunodeficiência humana (HIV), ou tratar AIDS ou ARC. A invenção também fornece métodos para tratar doenças que são aliviadas com antagonistas de CCR5. A invenção inclui composições farmacêuticas e métodos de empregar os compostos para o tratamento destas doenças. A invenção também inclui processos para a preparação de compostos de acordo com a fórmula (I).
BRPI0511982-0A 2004-06-09 2005-06-01 compostos antiviróticos heterocìclicos BRPI0511982A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US57875904P 2004-06-09 2004-06-09
PCT/EP2005/005895 WO2005121145A2 (en) 2004-06-09 2005-06-01 Octahydro-pyrrolo[3,4-c] derivatives and their use as antiviral compounds

Publications (1)

Publication Number Publication Date
BRPI0511982A true BRPI0511982A (pt) 2008-01-22

Family

ID=35431500

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0511982-0A BRPI0511982A (pt) 2004-06-09 2005-06-01 compostos antiviróticos heterocìclicos

Country Status (21)

Country Link
US (2) US7164019B2 (pt)
EP (1) EP1761542B1 (pt)
JP (1) JP2008501743A (pt)
CN (1) CN101001860A (pt)
AR (1) AR049209A1 (pt)
AT (1) ATE382623T1 (pt)
AU (1) AU2005251891A1 (pt)
BR (1) BRPI0511982A (pt)
CA (1) CA2569910A1 (pt)
DE (1) DE602005004144T2 (pt)
DK (1) DK1761542T3 (pt)
ES (1) ES2297727T3 (pt)
IL (1) IL179534A0 (pt)
MX (1) MXPA06014404A (pt)
NO (1) NO20070137L (pt)
PL (1) PL1761542T3 (pt)
PT (1) PT1761542E (pt)
RU (1) RU2006146608A (pt)
TW (1) TW200701981A (pt)
WO (1) WO2005121145A2 (pt)
ZA (1) ZA200609837B (pt)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BRPI0617720A2 (pt) 2005-10-19 2011-08-02 Hoffmann La Roche compostos inibidores de nnrt de fenil-acetamida, usos dos referidos compostos e composição farmacêutica que os contém
KR20080102386A (ko) * 2006-02-15 2008-11-25 에프. 호프만-라 로슈 아게 헤테로사이클릭 항바이러스 화합물
WO2007093520A1 (en) * 2006-02-15 2007-08-23 F. Hoffmann-La Roche Ag Hetero-bycyclic antiviral compounds
WO2008019968A1 (en) 2006-08-16 2008-02-21 F. Hoffmann-La Roche Ag Non-nucleoside reverse transcriptase inhibitors
WO2008030853A2 (en) * 2006-09-06 2008-03-13 Incyte Corporation Combination therapy for human immunodeficiency virus infection
CN101516884A (zh) 2006-09-18 2009-08-26 弗·哈夫曼-拉罗切有限公司 八氢吡咯并[3,4-c]吡咯衍生物和它们作为抗病毒药的用途
TWI404532B (zh) * 2006-11-02 2013-08-11 Targacept Inc 菸鹼乙醯膽鹼受體亞型選擇性之二氮雜雙環烷類醯胺
CN101553483B (zh) 2006-12-13 2013-04-17 弗·哈夫曼-拉罗切有限公司 作为非核苷逆转录酶抑制剂的2-(哌啶-4-基)-4-苯氧基-或苯基氨基-嘧啶衍生物
US8464207B2 (en) * 2007-10-12 2013-06-11 Novell Intellectual Property Holdings, Inc. System and method for tracking software changes
GB0724251D0 (en) 2007-12-12 2008-02-06 Univ Edinburgh Therapeutic compounds and their use
GB0804685D0 (en) 2008-03-13 2008-04-16 Univ Edinburgh Therapeutic compounds and their use
AU2010297068B2 (en) 2009-09-16 2015-10-01 The University Of Edinburgh (4-phenyl-piperidin-1-yl)-[5-1H-pyrazol-4yl)-thiophen-3-yl]-methanone compounds and their use
CN102791133B (zh) 2010-01-07 2015-09-23 纳幕尔杜邦公司 杀真菌杂环化合物
DK2563780T3 (en) 2010-04-29 2015-07-27 Univ Edinburgh 3,3-DISUBSTITUEREDE- (8-aza-bicyclo [3.2.1] oct-8-yl) - [5- (1H-pyrazol-4-yl) -thiophene-3-yl] -METHANONER as inhibitors of 11 ( BETA) -HSD1
DE102010025663A1 (de) * 2010-06-30 2012-01-05 Karl-Heinz Glüsenkamp Neue beta-Aminoaldehyd-Derivate, Verfahren zu ihrer Herstellung und ihre chemische Verwendung als reaktive Intermediate
EA201492223A1 (ru) 2012-06-13 2015-03-31 Ф. Хоффманн-Ля Рош Аг Новые диазаспироциклоалканы и азаспироциклоалканы
CN104684915B (zh) * 2012-09-25 2017-10-31 霍夫曼-拉罗奇有限公司 新型双环衍生物
AR095079A1 (es) 2013-03-12 2015-09-16 Hoffmann La Roche Derivados de octahidro-pirrolo[3,4-c]-pirrol y piridina-fenilo
AR097794A1 (es) * 2013-09-26 2016-04-13 Mnemosyne Pharmaceuticals Inc Moduladores octahidro-ciclopenta[c]pirrol negativos de nr2b
PE20160845A1 (es) 2013-11-26 2016-09-10 Hoffmann La Roche Nuevo octahidro-ciclobuta[1,2-c;3,4-c']dipirrol-2-ilo
CN104744451A (zh) * 2013-12-30 2015-07-01 中国科学院上海药物研究所 一种1-(3-氨基丙基)取代环状胺类化合物、其制备方法、药物组合物及用途
DK3122750T3 (da) 2014-03-26 2019-11-04 Hoffmann La Roche Bicykliske forbindelser som autotaxin (ATX)- og lysofosfatidsyre (LPA)-produktionshæmmere
JP6554481B2 (ja) 2014-03-26 2019-07-31 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ オートタキシン（ａｔｘ）及びリゾホスファチジン酸（ｌｐａ）産生の阻害剤としての縮合［１，４］ジアゼピン化合物
JO3579B1 (ar) * 2014-09-26 2020-07-05 Luc Therapeutics Inc مُعدِلات تفاغرية سالبة لمستقبل nr2b من المركب n-ألكيل أريل-5-أوكسي أريل-ثامن هيدرو-خماسي الحلقة [c] بيرول
MA41898A (fr) 2015-04-10 2018-02-13 Hoffmann La Roche Dérivés de quinazolinone bicyclique
KR20180043837A (ko) 2015-09-04 2018-04-30 에프. 호프만-라 로슈 아게 페녹시메틸 유도체
RU2018114289A (ru) 2015-09-24 2019-10-24 Ф. Хоффманн-Ля Рош Аг Бициклические соединения в качестве ингибиторов аутотаксина (atx)
KR20180053408A (ko) 2015-09-24 2018-05-21 에프. 호프만-라 로슈 아게 이중 오토탁신(atx)/탄산 무수화효소(ca) 억제제로서의 신규한 이환형 화합물
CN107922412B (zh) 2015-09-24 2021-02-23 豪夫迈·罗氏有限公司 作为atx抑制剂的二环化合物
CR20180057A (es) 2015-09-24 2018-04-02 Hoffmann La Roche Nuevos compuestos biciclicos como inhibidores duales de atx/ca.
EP3484876A1 (en) 2016-07-14 2019-05-22 Pfizer Inc Novel pyrimidine carboxamides as inhibitors of vanin-1 enzyme
WO2018167113A1 (en) 2017-03-16 2018-09-20 F. Hoffmann-La Roche Ag New bicyclic compounds as atx inhibitors
WO2018167001A1 (en) 2017-03-16 2018-09-20 F. Hoffmann-La Roche Ag Heterocyclic compounds useful as dual atx/ca inhibitors
US20230227455A1 (en) * 2020-06-10 2023-07-20 Cyxone Ab Method for preparing a crystalline form of rabeximod
CN113845439B (zh) * 2021-10-11 2024-02-09 杭州师范大学 双苄酰胺类cxcr4拮抗剂及其制备和应用

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3930266A1 (de) 1989-09-11 1991-03-14 Thomae Gmbh Dr K Kondensierte diazepinone, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
DE4338396A1 (de) 1993-11-10 1995-05-11 Basf Ag N-Substituierte Azabicycloalkan-Derivate, ihre Herstellung und Verwendung
DE4341403A1 (de) 1993-12-04 1995-06-08 Basf Ag N-substituierte 3-Azabicycloalkan-Derivate, ihre Herstellung und Verwendung
US5457121A (en) 1994-09-02 1995-10-10 Eli Lilly And Company Cis-hexahydro-5-(1,2,3,4-tetrahydro-2-naphthalenyl)pyrrolo<3,4-c>pyrroles as inhibitors of serotonin reuptake
EP0728758B1 (de) * 1995-02-27 2003-10-15 F. Hoffmann-La Roche Ag Dioxopyrrolo-pyrrolderivate
GB9519563D0 (en) 1995-09-26 1995-11-29 Merck Sharp & Dohme Therapeutic agents
CZ48299A3 (cs) 1996-08-13 1999-07-14 Merck & Co., Inc. Způsob výroby indolových derivátů
US7217714B1 (en) 1998-12-23 2007-05-15 Agouron Pharmaceuticals, Inc. CCR5 modulators
PE20001420A1 (es) 1998-12-23 2000-12-18 Pfizer Moduladores de ccr5
AU3555200A (en) * 1999-03-17 2000-10-04 F. Hoffmann-La Roche Ag Oxazolone derivatives and their use as alpha-1 adrenoreceptor modulators
RU2299206C9 (ru) 1999-05-04 2007-11-20 Шеринг Корпорейшн Производные пиперазина, фармацевтические композиции, их содержащие, и применение в качестве антагонистов ccr5
KR100439357B1 (ko) 1999-05-04 2004-07-07 쉐링 코포레이션 Ｃｃｒ５ 길항제로서 유용한 피페리딘 유도체
WO2001040227A1 (fr) * 1999-12-03 2001-06-07 Ono Pharmaceutical Co., Ltd. Derives triazaspiro[5.5]undecane et medicaments contenant ces derives en tant que principe actif
ATE289607T1 (de) 1999-12-14 2005-03-15 Neurosearch As Neue heteroaryl-diazabizykloalkane
DE60023100T2 (de) 2000-01-05 2006-07-06 Pfizer Inc. Benzimidazol-Verbindungen zur Verwendung als ORL1-Rezeptor-Antagonisten
TR200400541T4 (tr) 2000-05-26 2004-04-21 Pfizer Inc. Terapide faydalı tropan türevleri.
AU2001280671A1 (en) 2000-07-21 2002-02-05 Ak Food Technology, Inc. Liquid infusion and tenderization process, apparatus, and product
SE0100326D0 (sv) * 2001-02-02 2001-02-02 Astrazeneca Ab New compounds
BR0207952A (pt) * 2001-03-07 2004-07-27 Pfizer Prod Inc Moduladores da atividade de receptores de quimiocina
GB0211418D0 (en) * 2002-05-17 2002-06-26 Glaxo Group Ltd Compounds
AR042628A1 (es) 2002-12-20 2005-06-29 Astrazeneca Ab Derivados de piperidina como moduladores del receptor ccr5

Also Published As

Publication number Publication date
CN101001860A (zh) 2007-07-18
DE602005004144T2 (de) 2009-01-29
ES2297727T3 (es) 2008-05-01
WO2005121145A2 (en) 2005-12-22
RU2006146608A (ru) 2008-07-20
US7164019B2 (en) 2007-01-16
US20070117859A1 (en) 2007-05-24
NO20070137L (no) 2007-03-06
TW200701981A (en) 2007-01-16
AU2005251891A1 (en) 2005-12-22
PL1761542T3 (pl) 2008-06-30
US20060014767A1 (en) 2006-01-19
PT1761542E (pt) 2008-03-26
WO2005121145A3 (en) 2006-03-02
JP2008501743A (ja) 2008-01-24
AR049209A1 (es) 2006-07-05
CA2569910A1 (en) 2005-12-22
EP1761542A2 (en) 2007-03-14
DK1761542T3 (da) 2008-04-28
IL179534A0 (en) 2007-05-15
ZA200609837B (en) 2008-09-25
EP1761542B1 (en) 2008-01-02
ATE382623T1 (de) 2008-01-15
DE602005004144D1 (de) 2008-02-14
US7714018B2 (en) 2010-05-11
MXPA06014404A (es) 2007-02-19

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Legal Events

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B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 7A ANUIDADE.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2158 DE 15/05/2012.