ES2297727T3 - Derivados de octahidropirrolo(3,4-c)pirrol y su empleo como agentes antiviricos. - Google Patents

Derivados de octahidropirrolo(3,4-c)pirrol y su empleo como agentes antiviricos. Download PDF

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Publication number
ES2297727T3
ES2297727T3 ES05754708T ES05754708T ES2297727T3 ES 2297727 T3 ES2297727 T3 ES 2297727T3 ES 05754708 T ES05754708 T ES 05754708T ES 05754708 T ES05754708 T ES 05754708T ES 2297727 T3 ES2297727 T3 ES 2297727T3
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Spain
Prior art keywords
group
octahidropirrolo
antivirical
pirrol
employment
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Active
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ES05754708T
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English (en)
Inventor
Eun Kyung Lee
Chris Richard Melville
David Mark Rotstein
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F Hoffmann La Roche AG
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F Hoffmann La Roche AG
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Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
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Publication of ES2297727T3 publication Critical patent/ES2297727T3/es
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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Abstract

Un compuesto de la fórmula I, en la que: X1 se elige entre el grupo formado por -C(=O)R3, -S(=O)2R3 y -C(=O)OR3; X2 se elige entre el grupo formado por -C(=O)R4, -S(=O)2R4, bencilo y -CH2(piridin-3-ilo), dicho bencilo está opcionalmente sustituido por halógeno o alquilo C1-3; uno de R1 y R2 es: (i) fenilo opcionalmente sustituido de una a cuatro veces por sustituyentes elegidos con independencia de su aparición entre el grupo formado por halógeno, alquilo C1-6 y alcoxi C1-6; (ii) heteroarilo elegido entre el grupo formado por piridinilo, N-óxido de piridinilo, pirimidinilo y tiazolilo, dicho heteroarilo está opcionalmente sustituido de una a tres veces por sustituyentes elegidos con independencia entre sí entre el grupo formado por halógeno, alquilo C1-6, haloalquilo C1-6 y alcoxi C1-6; y el otro de R1 y R2 es hidrógeno.
ES05754708T 2004-06-09 2005-06-01 Derivados de octahidropirrolo(3,4-c)pirrol y su empleo como agentes antiviricos. Active ES2297727T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US57875904P 2004-06-09 2004-06-09
US578759P 2004-06-09

Publications (1)

Publication Number Publication Date
ES2297727T3 true ES2297727T3 (es) 2008-05-01

Family

ID=35431500

Family Applications (1)

Application Number Title Priority Date Filing Date
ES05754708T Active ES2297727T3 (es) 2004-06-09 2005-06-01 Derivados de octahidropirrolo(3,4-c)pirrol y su empleo como agentes antiviricos.

Country Status (21)

Country Link
US (2) US7164019B2 (es)
EP (1) EP1761542B1 (es)
JP (1) JP2008501743A (es)
CN (1) CN101001860A (es)
AR (1) AR049209A1 (es)
AT (1) ATE382623T1 (es)
AU (1) AU2005251891A1 (es)
BR (1) BRPI0511982A (es)
CA (1) CA2569910A1 (es)
DE (1) DE602005004144T2 (es)
DK (1) DK1761542T3 (es)
ES (1) ES2297727T3 (es)
IL (1) IL179534A0 (es)
MX (1) MXPA06014404A (es)
NO (1) NO20070137L (es)
PL (1) PL1761542T3 (es)
PT (1) PT1761542E (es)
RU (1) RU2006146608A (es)
TW (1) TW200701981A (es)
WO (1) WO2005121145A2 (es)
ZA (1) ZA200609837B (es)

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MA37756B1 (fr) 2012-06-13 2018-09-28 Hoffmann La Roche Nouveaux composés diazaspirocycloalcane et azaspirocycloalcane
EP3590940B1 (en) * 2012-09-25 2021-06-09 F. Hoffmann-La Roche AG Hexahydropyrrolo[3,4-c]pyrrole derivatives and related compounds as autotaxin (atx) inhibitors and as inhibitors of the lysophosphatidic acid (lpa) production for treating e.g. renal diseases
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MX2016010675A (es) 2014-03-26 2016-11-10 Hoffmann La Roche Compuestos condensados de [1,4]diazepina como inhibidores de produccion de la autotaxina (atx) y acido lisofosfatidico (lpa).
CN106103446B (zh) 2014-03-26 2019-07-30 豪夫迈·罗氏有限公司 作为自分泌运动因子(atx)和溶血磷脂酸(lpa)生产抑制剂的二环化合物
JO3579B1 (ar) 2014-09-26 2020-07-05 Luc Therapeutics Inc مُعدِلات تفاغرية سالبة لمستقبل nr2b من المركب n-ألكيل أريل-5-أوكسي أريل-ثامن هيدرو-خماسي الحلقة [c] بيرول
MA41898A (fr) 2015-04-10 2018-02-13 Hoffmann La Roche Dérivés de quinazolinone bicyclique
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JP6845230B2 (ja) 2015-09-24 2021-03-17 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ デュアルａｔｘ／ｃａ阻害剤としての新規な二環式化合物
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Also Published As

Publication number Publication date
CA2569910A1 (en) 2005-12-22
CN101001860A (zh) 2007-07-18
US7714018B2 (en) 2010-05-11
EP1761542A2 (en) 2007-03-14
US20070117859A1 (en) 2007-05-24
PL1761542T3 (pl) 2008-06-30
BRPI0511982A (pt) 2008-01-22
ZA200609837B (en) 2008-09-25
WO2005121145A2 (en) 2005-12-22
TW200701981A (en) 2007-01-16
US7164019B2 (en) 2007-01-16
AR049209A1 (es) 2006-07-05
AU2005251891A1 (en) 2005-12-22
IL179534A0 (en) 2007-05-15
US20060014767A1 (en) 2006-01-19
MXPA06014404A (es) 2007-02-19
ATE382623T1 (de) 2008-01-15
NO20070137L (no) 2007-03-06
RU2006146608A (ru) 2008-07-20
DK1761542T3 (da) 2008-04-28
DE602005004144D1 (de) 2008-02-14
DE602005004144T2 (de) 2009-01-29
EP1761542B1 (en) 2008-01-02
JP2008501743A (ja) 2008-01-24
PT1761542E (pt) 2008-03-26
WO2005121145A3 (en) 2006-03-02

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