WO2006032466A3 - New bicyclic antibiotics - Google Patents

New bicyclic antibiotics Download PDF

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Publication number
WO2006032466A3
WO2006032466A3 PCT/EP2005/010154 EP2005010154W WO2006032466A3 WO 2006032466 A3 WO2006032466 A3 WO 2006032466A3 EP 2005010154 W EP2005010154 W EP 2005010154W WO 2006032466 A3 WO2006032466 A3 WO 2006032466A3
Authority
WO
WIPO (PCT)
Prior art keywords
represent
halogen
new bicyclic
antibiotics
alkoxy
Prior art date
Application number
PCT/EP2005/010154
Other languages
French (fr)
Other versions
WO2006032466A2 (en
Inventor
Christian Hubschwerlen
Jean-Philippe Surivet
Acklin Cornelia Zumbrunn
Original Assignee
Actelion Pharmaceuticals Ltd
Christian Hubschwerlen
Jean-Philippe Surivet
Acklin Cornelia Zumbrunn
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Actelion Pharmaceuticals Ltd, Christian Hubschwerlen, Jean-Philippe Surivet, Acklin Cornelia Zumbrunn filed Critical Actelion Pharmaceuticals Ltd
Priority to EP05784860A priority Critical patent/EP1799676A2/en
Priority to CA002580621A priority patent/CA2580621A1/en
Priority to JP2007532823A priority patent/JP4887297B2/en
Publication of WO2006032466A2 publication Critical patent/WO2006032466A2/en
Publication of WO2006032466A3 publication Critical patent/WO2006032466A3/en

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

Abstract

The invention relates to novel antibiotics of formula (I) wherein R1 represents alkyl, alkoxy, haloalkoxy, halogen or cyano; one or two of U, V, W and X represent(s) N, the remaining represent CH, or, in case of U, V and/or W, may also represent CRa and, in the case of X, may also represent CRb; Ra represents halogen; Rb represents halogen or alkoxy; M is a linking chain containing a non-aromatic cyclic or heterocyclic group, and D represents alkyl, aryl or heteroaryl.
PCT/EP2005/010154 2004-09-24 2005-09-20 New bicyclic antibiotics WO2006032466A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
EP05784860A EP1799676A2 (en) 2004-09-24 2005-09-20 New bicyclic antibiotics
CA002580621A CA2580621A1 (en) 2004-09-24 2005-09-20 New bicyclic antibiotics
JP2007532823A JP4887297B2 (en) 2004-09-24 2005-09-20 New bicyclic antibiotics

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
EP2004010762 2004-09-24
EPPCT/EP2004/010762 2004-09-24
EPPCT/EP2005/007731 2005-07-15
EP2005007731 2005-07-15

Publications (2)

Publication Number Publication Date
WO2006032466A2 WO2006032466A2 (en) 2006-03-30
WO2006032466A3 true WO2006032466A3 (en) 2006-12-14

Family

ID=36090370

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2005/010154 WO2006032466A2 (en) 2004-09-24 2005-09-20 New bicyclic antibiotics

Country Status (5)

Country Link
JP (1) JP4887297B2 (en)
AR (1) AR050958A1 (en)
CA (1) CA2580621A1 (en)
TW (1) TW200615267A (en)
WO (1) WO2006032466A2 (en)

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MX2007014507A (en) * 2005-05-24 2008-02-07 Astrazeneca Ab Aminopiperidine quinolines and their azaisosteric analogues with antibacterial activity.
MY150958A (en) 2005-06-16 2014-03-31 Astrazeneca Ab Compounds for the treatment of multi-drug resistant bacterial infections
CA2635126A1 (en) 2006-01-26 2007-08-02 Actelion Pharmaceuticals Ltd Tetrahydropyrane antibiotics
US7820655B2 (en) 2006-02-15 2010-10-26 Actelion Pharmaceuticals Ltd. Ethanol or 1,2-ethanediol cyclohexyl antibiotic derivatives
EP1996579A2 (en) * 2006-03-10 2008-12-03 Actelion Pharmaceuticals Ltd. Antibiotic compounds
DE602007009205D1 (en) 2006-04-06 2010-10-28 Glaxo Group Ltd PYRROLOCHINOXALINONE DERIVATIVES AS ANTIBACTERIAL AGENTS
WO2007141318A1 (en) * 2006-06-08 2007-12-13 Speedel Experimenta Ag 2,5-disubstituted piperidines
EP1992628A1 (en) 2007-05-18 2008-11-19 Glaxo Group Limited Derivatives and analogs of N-ethylquinolones and N-ethylazaquinolones
TW200819457A (en) * 2006-08-30 2008-05-01 Actelion Pharmaceuticals Ltd Spiro antibiotic derivatives
CL2007003693A1 (en) * 2006-12-22 2008-06-27 Actelion Pharmaceuticals Ltd COMPOUNDS DERIVED FROM PIRIDO [3,2-B] [1,4] THIAZINE; PHARMACEUTICAL COMPOSITION CONTAINING SUCH COMPOUNDS; AND ITS USE IN THE TREATMENT OF BACTERIAL INFECTIONS.
CL2008001003A1 (en) 2007-04-11 2008-10-17 Actelion Pharmaceuticals Ltd COMPOUNDS DERIVED FROM OXAZOLIDINONA; PHARMACEUTICAL COMPOSITION THAT INCLUDES SUCH COMPOUNDS; AND ITS USE TO PREPARE A MEDICINAL PRODUCT TO TREAT A BACTERIAL INFECTION.
CL2008001002A1 (en) 2007-04-11 2008-10-17 Actelion Pharmaceuticals Ltd COMPOUNDS DERIVED FROM OXAZOLIDINONA; PHARMACEUTICAL COMPOSITION THAT INCLUDES SUCH COMPOUNDS; AND ITS USE TO PREPARE A MEDICINAL PRODUCT TO TREAT A BACTERIAL INFECTION.
WO2008128942A1 (en) 2007-04-20 2008-10-30 Glaxo Group Limited Tricyclic nitrogen containing compounds as antibacterial agents
PL2167494T3 (en) * 2007-06-15 2012-01-31 Idorsia Pharmaceuticals Ltd 3-amino-6-(1-amino-ethyl)-tetrahydropyran derivatives
EP2005995A1 (en) * 2007-06-22 2008-12-24 Glaxo Group Limited Heterocyclic compounds for the treatment of tuberculosis
ES2380398T3 (en) 2007-12-18 2012-05-11 Actelion Pharmaceuticals Ltd. 5-Aminocyclylmethyl-oxazolidin-2-one derivatives
EP2080761A1 (en) 2008-01-18 2009-07-22 Glaxo Group Limited Compounds
CA2713182C (en) 2008-02-20 2016-09-13 Actelion Pharmaceuticals Ltd Azatricyclic antibiotic compounds
JP2011518149A (en) 2008-04-15 2011-06-23 アクテリオン ファーマシューティカルズ リミテッド Tricyclic antibacterial agent
WO2009147616A1 (en) 2008-06-03 2009-12-10 Actelion Pharmaceuticals Ltd [4-(1-amino-ethyl) -cyclohexyl] -methyl-amine and [6-(1-amino-ethyl) -tetrahydro- pyran-3-yl] -methyl-amine derivatives as antibacterials
JP2011529960A (en) 2008-08-04 2011-12-15 アクテリオン ファーマシューティカルズ リミテッド Tricyclic alkylaminomethyloxazolidinone derivatives
BRPI0920895A8 (en) 2008-10-07 2017-12-26 Actelion Pharmaceuticals Ltd TRICYCLIC OXAZOLIDINONE ANTIBIOTIC COMPOUNDS
JP2012505866A (en) 2008-10-17 2012-03-08 グラクソ グループ リミテッド Tricyclic nitrogen compounds used as antibacterial agents
NZ591914A (en) 2008-11-17 2013-04-26 Hoffmann La Roche Naphthylacetic acids
NZ593891A (en) * 2008-12-12 2013-05-31 Actelion Pharmaceuticals Ltd 5-amino-2-(1-hydroxy-ethyl)-tetrahydropyran derivatives
US8318940B2 (en) 2009-01-15 2012-11-27 Glaxo Group Limited Naphthyridin-2 (1 H)-one compounds useful as antibacterials
WO2010084152A1 (en) 2009-01-21 2010-07-29 Basilea Pharmaceutica Ag Novel bicyclic antibiotics
AR076222A1 (en) 2009-04-09 2011-05-26 Actelion Pharmaceuticals Ltd DERIVATIVES 2-HYDROXIETIL-1H-QUINOLIN-ONA AND ITS AZAISOTHERAL ANALOGS WITH ANTIBACTERIAL ACTIVITY AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
EP2621902B1 (en) 2010-09-28 2017-04-12 Panacea Biotec Ltd 3-azabicyclo[3.1.0]hexane compounds useful for the treatment of cns disorders
HUE038714T2 (en) 2011-03-10 2018-11-28 Daiichi Sankyo Co Ltd Dispiropyrrolidine derivative
EP2685828A4 (en) * 2011-03-17 2014-08-13 Merck Sharp & Dohme Substituted 3-azabicyclo[3.1.0]hexane derivatives useful as ccr2 antagonists
SG195289A1 (en) * 2011-06-17 2013-12-30 Astrazeneca Ab Process for preparing heterocyclic compounds including trans-7-oxo-6-(sulphooxy)-1,6-diazabicyclo[3,2,1]octane-2-carboxamide and salts thereof
JP2014518267A (en) * 2011-06-27 2014-07-28 杏林製薬株式会社 Bridged bicyclic compounds for the treatment of bacterial infections
US8470884B2 (en) 2011-11-09 2013-06-25 Hoffmann-La Roche Inc. Alkenyl naphthylacetic acids
CA2854266A1 (en) 2011-11-30 2013-06-06 Actelion Pharmaceuticals Ltd 3,7-disubstituted octahydro-2h-pyrido[4,3-e][1,3]oxazin-2-one antibiotics
EP3639824A1 (en) 2014-08-22 2020-04-22 GlaxoSmithKline Intellectual Property Development Limited Tricyclic nitrogen containing compounds for treating neisseria gonorrhoea infection
UY36851A (en) 2015-08-16 2017-03-31 Glaxosmithkline Ip Dev Ltd COMPOUNDS FOR USE IN ANTIBACTERIAL APPLICATIONS
EP4248965A3 (en) * 2017-09-01 2023-11-22 Denali Therapeutics Inc. Compounds, compositions and methods
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WO2004002490A2 (en) * 2002-06-26 2004-01-08 Glaxo Group Limited Piperidine compounds as antibacterials
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WO2004089947A2 (en) * 2003-04-08 2004-10-21 Morphochem Ag Novel compounds having an antibacterial activity

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Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003064421A1 (en) * 2002-01-29 2003-08-07 Glaxo Group Limited Aminopiperidine derivatives
WO2004002490A2 (en) * 2002-06-26 2004-01-08 Glaxo Group Limited Piperidine compounds as antibacterials
WO2004035569A2 (en) * 2002-10-10 2004-04-29 Morphochem Aktiengesellschaft für kombinatorische Chemie Novel compounds with antibacterial activity
DE10256405A1 (en) * 2002-12-02 2004-06-17 Morphochem Aktiengesellschaft für kombinatorische Chemie New 4-substituted quinoline derivatives, useful for treating bacterial infections, optionally including additional ring nitrogens
WO2004089947A2 (en) * 2003-04-08 2004-10-21 Morphochem Ag Novel compounds having an antibacterial activity

Also Published As

Publication number Publication date
AR050958A1 (en) 2006-12-06
WO2006032466A2 (en) 2006-03-30
CA2580621A1 (en) 2006-03-30
JP2008514563A (en) 2008-05-08
JP4887297B2 (en) 2012-02-29
TW200615267A (en) 2006-05-16

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