ATE382623T1 - Octahydropyrrolo(3,4-c)pyrrolderivate und deren verwendung als antivirale mitteln - Google Patents
Octahydropyrrolo(3,4-c)pyrrolderivate und deren verwendung als antivirale mittelnInfo
- Publication number
- ATE382623T1 ATE382623T1 AT05754708T AT05754708T ATE382623T1 AT E382623 T1 ATE382623 T1 AT E382623T1 AT 05754708 T AT05754708 T AT 05754708T AT 05754708 T AT05754708 T AT 05754708T AT E382623 T1 ATE382623 T1 AT E382623T1
- Authority
- AT
- Austria
- Prior art keywords
- octahydropyrrolo
- antiviral agents
- pyrrole derivatives
- pyrrole
- derivatives
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Pulmonology (AREA)
- Dermatology (AREA)
- Rheumatology (AREA)
- Virology (AREA)
- Physical Education & Sports Medicine (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Molecular Biology (AREA)
- Pain & Pain Management (AREA)
- AIDS & HIV (AREA)
- Communicable Diseases (AREA)
- Neurology (AREA)
- Transplantation (AREA)
- Tropical Medicine & Parasitology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US57875904P | 2004-06-09 | 2004-06-09 |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE382623T1 true ATE382623T1 (de) | 2008-01-15 |
Family
ID=35431500
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT05754708T ATE382623T1 (de) | 2004-06-09 | 2005-06-01 | Octahydropyrrolo(3,4-c)pyrrolderivate und deren verwendung als antivirale mitteln |
Country Status (21)
Country | Link |
---|---|
US (2) | US7164019B2 (de) |
EP (1) | EP1761542B1 (de) |
JP (1) | JP2008501743A (de) |
CN (1) | CN101001860A (de) |
AR (1) | AR049209A1 (de) |
AT (1) | ATE382623T1 (de) |
AU (1) | AU2005251891A1 (de) |
BR (1) | BRPI0511982A (de) |
CA (1) | CA2569910A1 (de) |
DE (1) | DE602005004144T2 (de) |
DK (1) | DK1761542T3 (de) |
ES (1) | ES2297727T3 (de) |
IL (1) | IL179534A0 (de) |
MX (1) | MXPA06014404A (de) |
NO (1) | NO20070137L (de) |
PL (1) | PL1761542T3 (de) |
PT (1) | PT1761542E (de) |
RU (1) | RU2006146608A (de) |
TW (1) | TW200701981A (de) |
WO (1) | WO2005121145A2 (de) |
ZA (1) | ZA200609837B (de) |
Families Citing this family (36)
Publication number | Priority date | Publication date | Assignee | Title |
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AU2006303368B2 (en) | 2005-10-19 | 2011-05-26 | F. Hoffmann-La Roche Ag | Non-Nucleoside Reverse Transcriptase Inhibitors |
EP1987036A1 (de) * | 2006-02-15 | 2008-11-05 | F.Hoffmann-La Roche Ag | Heterobicyclische antivirale verbindungen |
WO2007093515A1 (en) * | 2006-02-15 | 2007-08-23 | F. Hoffmann La-Roche Ag | Heterocyclic antiviral compounds |
WO2008019968A1 (en) | 2006-08-16 | 2008-02-21 | F. Hoffmann-La Roche Ag | Non-nucleoside reverse transcriptase inhibitors |
US20080108586A1 (en) * | 2006-09-06 | 2008-05-08 | Incyte Corporation | Combination therapy for human immunodeficiency virus infection |
JP2010503714A (ja) * | 2006-09-18 | 2010-02-04 | エフ.ホフマン−ラ ロシュ アーゲー | オクタヒドロピロロ[3,4−c]ピロール誘導体、抗ウイルス剤としてのそれらの使用 |
TWI454262B (zh) * | 2006-11-02 | 2014-10-01 | Targacept Inc | 菸鹼乙醯膽鹼受體亞型選擇性之二氮雜雙環烷類醯胺 |
ES2550152T3 (es) | 2006-12-13 | 2015-11-04 | F. Hoffmann-La Roche Ag | Derivados de 2-(piperidin-4-il)-4-fenoxi-o fenilamino-pirimidina como inhibidores no nucleósidos de transcriptasa inversa |
US8464207B2 (en) * | 2007-10-12 | 2013-06-11 | Novell Intellectual Property Holdings, Inc. | System and method for tracking software changes |
GB0724251D0 (en) | 2007-12-12 | 2008-02-06 | Univ Edinburgh | Therapeutic compounds and their use |
GB0804685D0 (en) | 2008-03-13 | 2008-04-16 | Univ Edinburgh | Therapeutic compounds and their use |
ES2540547T3 (es) | 2009-09-16 | 2015-07-10 | The University Of Edinburgh | Compuestos de (4-fenil-piperidin-1-il)-[5-(1H-pirazol-4-il)-tiofen-3-il]-metanona y su uso |
MX2012007935A (es) | 2010-01-07 | 2012-08-15 | Du Pont | Compuestos heterociclicos fungicidas. |
KR101714820B1 (ko) | 2010-04-29 | 2017-03-09 | 더 유니버시티 오브 에든버러 | 11(베타)-hsd1의 억제제로서 3,3-이치환된-(8-아자-비시클로[3.2.1]옥트-8-일)-[5-(1h-피라졸-4-일)-티오펜-3-일]-메탄온 |
DE102010025663A1 (de) * | 2010-06-30 | 2012-01-05 | Karl-Heinz Glüsenkamp | Neue beta-Aminoaldehyd-Derivate, Verfahren zu ihrer Herstellung und ihre chemische Verwendung als reaktive Intermediate |
IN2014DN09346A (de) | 2012-06-13 | 2015-07-17 | Hoffmann La Roche | |
AU2013322838B2 (en) * | 2012-09-25 | 2018-02-01 | F. Hoffmann-La Roche Ag | New bicyclic derivatives |
AR095079A1 (es) | 2013-03-12 | 2015-09-16 | Hoffmann La Roche | Derivados de octahidro-pirrolo[3,4-c]-pirrol y piridina-fenilo |
EP3461827B1 (de) * | 2013-09-26 | 2022-02-23 | Cadent Therapeutics, Inc. | Selektive negative octahydro-cyclopenta[c]pyrrol-modulatoren von nr2b |
UA118201C2 (uk) | 2013-11-26 | 2018-12-10 | Ф. Хоффманн-Ля Рош Аг | НОВИЙ ОКТАГІДРОЦИКЛОБУТА[1,2-c;3,4-c']ДИПІРОЛ-2-ІЛ |
CN104744451A (zh) * | 2013-12-30 | 2015-07-01 | 中国科学院上海药物研究所 | 一种1-(3-氨基丙基)取代环状胺类化合物、其制备方法、药物组合物及用途 |
CA2937616A1 (en) | 2014-03-26 | 2015-10-01 | F. Hoffmann-La Roche Ag | Bicyclic compounds as autotaxin (atx) and lysophosphatidic acid (lpa) production inhibitors |
EA032357B1 (ru) | 2014-03-26 | 2019-05-31 | Ф. Хоффманн-Ля Рош Аг | Конденсированные [1,4]диазепиновые соединения в качестве ингибиторов продукции аутотаксина (atx) и лизофосфатидиловой кислоты (lpa) |
JO3579B1 (ar) * | 2014-09-26 | 2020-07-05 | Luc Therapeutics Inc | مُعدِلات تفاغرية سالبة لمستقبل nr2b من المركب n-ألكيل أريل-5-أوكسي أريل-ثامن هيدرو-خماسي الحلقة [c] بيرول |
MA41898A (fr) | 2015-04-10 | 2018-02-13 | Hoffmann La Roche | Dérivés de quinazolinone bicyclique |
UA123362C2 (uk) | 2015-09-04 | 2021-03-24 | Ф. Хоффманн-Ля Рош Аг | Феноксиметильні похідні |
JP6845230B2 (ja) | 2015-09-24 | 2021-03-17 | エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft | デュアルatx/ca阻害剤としての新規な二環式化合物 |
KR20180054635A (ko) | 2015-09-24 | 2018-05-24 | 에프. 호프만-라 로슈 아게 | 오토탁신(atx) 억제제로서 이환형 화합물 |
CR20180057A (es) | 2015-09-24 | 2018-04-02 | Hoffmann La Roche | Nuevos compuestos biciclicos como inhibidores duales de atx/ca. |
AU2016328535A1 (en) | 2015-09-24 | 2017-11-09 | F. Hoffmann-La Roche Ag | Bicyclic compounds as ATX inhibitors |
MA45656A (fr) | 2016-07-14 | 2021-03-24 | Pfizer | Nouveaux pyrimidine carboxamides utilisées comme inhibiteurs de l'enzyme vanin-1 |
BR112019019017A2 (pt) | 2017-03-16 | 2020-04-14 | Hoffmann La Roche | compostos heterocíclicos de utilidade como inibidores duplos de atx/ca |
JP7090099B2 (ja) | 2017-03-16 | 2022-06-23 | エフ.ホフマン-ラ ロシュ アーゲー | Atxインヒビターとしての新規二環式化合物 |
US11629196B2 (en) | 2020-04-27 | 2023-04-18 | Incelldx, Inc. | Method of treating SARS-CoV-2-associated hypercytokinemia by administering a human monoclonal antibody (PRO-140) that inhibits CCR5/CCL5 binding interactions |
AU2021289006A1 (en) * | 2020-06-10 | 2023-02-09 | Cyxone Ab | Method for preparing a crystalline form of rabeximod |
CN113845439B (zh) * | 2021-10-11 | 2024-02-09 | 杭州师范大学 | 双苄酰胺类cxcr4拮抗剂及其制备和应用 |
Family Cites Families (21)
Publication number | Priority date | Publication date | Assignee | Title |
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DE3930266A1 (de) | 1989-09-11 | 1991-03-14 | Thomae Gmbh Dr K | Kondensierte diazepinone, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel |
DE4338396A1 (de) | 1993-11-10 | 1995-05-11 | Basf Ag | N-Substituierte Azabicycloalkan-Derivate, ihre Herstellung und Verwendung |
DE4341403A1 (de) | 1993-12-04 | 1995-06-08 | Basf Ag | N-substituierte 3-Azabicycloalkan-Derivate, ihre Herstellung und Verwendung |
US5457121A (en) | 1994-09-02 | 1995-10-10 | Eli Lilly And Company | Cis-hexahydro-5-(1,2,3,4-tetrahydro-2-naphthalenyl)pyrrolo<3,4-c>pyrroles as inhibitors of serotonin reuptake |
ES2207657T3 (es) * | 1995-02-27 | 2004-06-01 | F. Hoffmann-La Roche Ag | Pirrolderivados de dioxopirrolo. |
GB9519563D0 (en) | 1995-09-26 | 1995-11-29 | Merck Sharp & Dohme | Therapeutic agents |
CN1084751C (zh) | 1996-08-13 | 2002-05-15 | 麦克公司 | 钯催化的吲哚化反应 |
US7217714B1 (en) | 1998-12-23 | 2007-05-15 | Agouron Pharmaceuticals, Inc. | CCR5 modulators |
PE20001420A1 (es) | 1998-12-23 | 2000-12-18 | Pfizer | Moduladores de ccr5 |
AU3555200A (en) * | 1999-03-17 | 2000-10-04 | F. Hoffmann-La Roche Ag | Oxazolone derivatives and their use as alpha-1 adrenoreceptor modulators |
ES2244437T3 (es) | 1999-05-04 | 2005-12-16 | Schering Corporation | Derivados de piperazina utiles como antagonistas de ccr5. |
AU780983B2 (en) | 1999-05-04 | 2005-04-28 | Schering Corporation | Piperidine derivatives useful as CCR5 antagonists |
AU780419C (en) * | 1999-12-03 | 2005-09-29 | Ono Pharmaceutical Co. Ltd. | Triazaspiro(5.5)undecane derivatives and drugs containing the same as the active ingredient |
DE60018312T2 (de) | 1999-12-14 | 2005-08-18 | Neurosearch A/S | Neue heteroaryl-diazabizykloalkane |
DE60023100T2 (de) | 2000-01-05 | 2006-07-06 | Pfizer Inc. | Benzimidazol-Verbindungen zur Verwendung als ORL1-Rezeptor-Antagonisten |
ES2215129T3 (es) | 2000-05-26 | 2004-10-01 | Pfizer Inc. | Derivados de triazolil tropano como modulares de ccr5. |
ES2253409T3 (es) | 2000-07-21 | 2006-06-01 | Ak Food Technology, Inc | Procedimiento, aparato y producto de infusion liquida y ablandamiento. |
SE0100326D0 (sv) * | 2001-02-02 | 2001-02-02 | Astrazeneca Ab | New compounds |
MXPA03008109A (es) * | 2001-03-07 | 2003-12-12 | Pfizer Prod Inc | Moduladores de la actividad de receptores de quimiocinas. |
GB0211418D0 (en) * | 2002-05-17 | 2002-06-26 | Glaxo Group Ltd | Compounds |
AR042628A1 (es) | 2002-12-20 | 2005-06-29 | Astrazeneca Ab | Derivados de piperidina como moduladores del receptor ccr5 |
-
2005
- 2005-06-01 ES ES05754708T patent/ES2297727T3/es active Active
- 2005-06-01 JP JP2007526249A patent/JP2008501743A/ja active Pending
- 2005-06-01 DE DE602005004144T patent/DE602005004144T2/de active Active
- 2005-06-01 CN CNA2005800270118A patent/CN101001860A/zh active Pending
- 2005-06-01 AU AU2005251891A patent/AU2005251891A1/en not_active Abandoned
- 2005-06-01 PL PL05754708T patent/PL1761542T3/pl unknown
- 2005-06-01 RU RU2006146608/04A patent/RU2006146608A/ru not_active Application Discontinuation
- 2005-06-01 EP EP05754708A patent/EP1761542B1/de active Active
- 2005-06-01 DK DK05754708T patent/DK1761542T3/da active
- 2005-06-01 BR BRPI0511982-0A patent/BRPI0511982A/pt not_active IP Right Cessation
- 2005-06-01 CA CA002569910A patent/CA2569910A1/en not_active Abandoned
- 2005-06-01 WO PCT/EP2005/005895 patent/WO2005121145A2/en active IP Right Grant
- 2005-06-01 AT AT05754708T patent/ATE382623T1/de not_active IP Right Cessation
- 2005-06-01 PT PT05754708T patent/PT1761542E/pt unknown
- 2005-06-01 MX MXPA06014404A patent/MXPA06014404A/es active IP Right Grant
- 2005-06-08 AR ARP050102332A patent/AR049209A1/es unknown
- 2005-06-08 US US11/147,851 patent/US7164019B2/en not_active Expired - Fee Related
- 2005-07-08 TW TW094118518A patent/TW200701981A/zh unknown
-
2006
- 2006-11-23 IL IL179534A patent/IL179534A0/en unknown
- 2006-11-24 ZA ZA200609837A patent/ZA200609837B/xx unknown
- 2006-12-11 US US11/637,423 patent/US7714018B2/en not_active Expired - Fee Related
-
2007
- 2007-01-08 NO NO20070137A patent/NO20070137L/no not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
TW200701981A (en) | 2007-01-16 |
AU2005251891A1 (en) | 2005-12-22 |
US20070117859A1 (en) | 2007-05-24 |
WO2005121145A2 (en) | 2005-12-22 |
EP1761542A2 (de) | 2007-03-14 |
MXPA06014404A (es) | 2007-02-19 |
CA2569910A1 (en) | 2005-12-22 |
US20060014767A1 (en) | 2006-01-19 |
DE602005004144T2 (de) | 2009-01-29 |
ZA200609837B (en) | 2008-09-25 |
RU2006146608A (ru) | 2008-07-20 |
PT1761542E (pt) | 2008-03-26 |
CN101001860A (zh) | 2007-07-18 |
PL1761542T3 (pl) | 2008-06-30 |
IL179534A0 (en) | 2007-05-15 |
AR049209A1 (es) | 2006-07-05 |
US7164019B2 (en) | 2007-01-16 |
US7714018B2 (en) | 2010-05-11 |
WO2005121145A3 (en) | 2006-03-02 |
BRPI0511982A (pt) | 2008-01-22 |
JP2008501743A (ja) | 2008-01-24 |
EP1761542B1 (de) | 2008-01-02 |
DE602005004144D1 (de) | 2008-02-14 |
ES2297727T3 (es) | 2008-05-01 |
NO20070137L (no) | 2007-03-06 |
DK1761542T3 (da) | 2008-04-28 |
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