PE20110117A1 - Derivados de 3,5-piridina como inhibidores de renina - Google Patents
Derivados de 3,5-piridina como inhibidores de reninaInfo
- Publication number
- PE20110117A1 PE20110117A1 PE2010000928A PE2010000928A PE20110117A1 PE 20110117 A1 PE20110117 A1 PE 20110117A1 PE 2010000928 A PE2010000928 A PE 2010000928A PE 2010000928 A PE2010000928 A PE 2010000928A PE 20110117 A1 PE20110117 A1 PE 20110117A1
- Authority
- PE
- Peru
- Prior art keywords
- alkyl
- carbonyl
- pyridine derivatives
- renin inhibitors
- cycloalkyl
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Abstract
SE REFIERE A UN COMPUESTO DE FORMULA I, DONDE r1 ES H, ALQUILO C1-C7, CICLOALQUILO C3-C8; R2 ES PIRIMIDILO, PIRIDILO, NAFTIL-(ALQUILO C1-C7), INDOLIL-(ALQUILO C1-C7), ENTRE OTROS; R3 ES H, ALQUILO C1-C7; R4 ES ALQUILO C4-C10, ALQUILO C1-C7 LINEAL SUSTITUIDO O NO, CICLOALQUILO C3-C8 SUSTITUIDO O NO, ENTRE OTROS; R6 ES OH; R7 Y R8 SON CADA UNO H, HALO; T ES METILENO, CARBONILO. UN COMPUESTO PREFERIDO ES: 3-[N-CICLOPROPIL-N-(1-PROPOXIMETIL-4-IL-QUINOLIN)METIL]CARBONIL-5-(N-TERCBUTIL)AMINO-CARBONIL-PIPERIDINA. REFERIDA TAMBIEN A UN PROCESO DE PREPARACION. DICHOS COMPUESTOS SON DEPENDIENTES DE LA ACTIVIDAD DE RENINA, UTIL EN EL TRATAMIENTO DE HIPERTENSION
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP05028771 | 2005-12-30 | ||
GB0604223A GB0604223D0 (en) | 2006-03-02 | 2006-03-02 | Organic compounds |
GB0611390A GB0611390D0 (en) | 2006-06-08 | 2006-06-08 | Organic compounds |
Publications (1)
Publication Number | Publication Date |
---|---|
PE20110117A1 true PE20110117A1 (es) | 2011-03-07 |
Family
ID=37875514
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2006001709A PE20071177A1 (es) | 2005-12-30 | 2006-12-28 | Derivados de 3,5-piridina como inhibidores de renina |
PE2010000928A PE20110117A1 (es) | 2005-12-30 | 2006-12-28 | Derivados de 3,5-piridina como inhibidores de renina |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2006001709A PE20071177A1 (es) | 2005-12-30 | 2006-12-28 | Derivados de 3,5-piridina como inhibidores de renina |
Country Status (20)
Country | Link |
---|---|
US (1) | US8129411B2 (es) |
EP (2) | EP2420491B1 (es) |
JP (1) | JP5306821B2 (es) |
KR (1) | KR20080086921A (es) |
AR (1) | AR058885A1 (es) |
AU (1) | AU2006332124B2 (es) |
BR (1) | BRPI0620736A2 (es) |
CA (1) | CA2633624C (es) |
CR (1) | CR10091A (es) |
EC (1) | ECSP088587A (es) |
ES (2) | ES2430139T3 (es) |
IL (1) | IL192024A0 (es) |
MA (1) | MA30073B1 (es) |
NO (1) | NO20083315L (es) |
NZ (1) | NZ569135A (es) |
PE (2) | PE20071177A1 (es) |
PL (1) | PL2420491T3 (es) |
PT (1) | PT2420491E (es) |
TW (1) | TW200738698A (es) |
WO (1) | WO2007077005A1 (es) |
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GB0514203D0 (en) * | 2005-07-11 | 2005-08-17 | Novartis Ag | Organic compounds |
CA2633624C (en) | 2005-12-30 | 2013-11-19 | Novartis Ag | 3,5-substituted piperidine compounds as renin inhibitors |
CA2664335C (en) | 2006-09-20 | 2014-12-02 | Boehringer Ingelheim International Gmbh | Rho kinase inhibitors |
US8455513B2 (en) | 2007-01-10 | 2013-06-04 | Aerie Pharmaceuticals, Inc. | 6-aminoisoquinoline compounds |
US8129538B1 (en) | 2007-03-28 | 2012-03-06 | Takeda Pharmaceutical Company Limited | Renin inhibitors |
ES2543641T3 (es) * | 2007-06-25 | 2015-08-20 | Novartis Ag | Derivados de N5-(2-etoxietil)-N3-(2-piridinil)-3,5-piperidinadicarboxamida para uso como inhibidores de renina |
WO2009051112A1 (ja) | 2007-10-15 | 2009-04-23 | Takeda Pharmaceutical Company Limited | アミド化合物およびその用途 |
TWI434690B (zh) | 2007-12-19 | 2014-04-21 | Dainippon Sumitomo Pharma Co | 雜雙環衍生物 |
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CN102123990B (zh) * | 2008-06-19 | 2014-07-09 | 武田药品工业株式会社 | 杂环化合物及其用途 |
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WO2010122580A2 (en) * | 2009-04-24 | 2010-10-28 | Cadila Healthcare Limited | Novel compounds as inhibitors of renin |
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EP3130581A4 (en) * | 2014-04-10 | 2017-11-22 | Takeda Pharmaceutical Company Limited | Method for producing heterocyclic compound |
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GB0511063D0 (en) | 2005-05-31 | 2005-07-06 | Novartis Ag | Organic compounds |
GB0514203D0 (en) | 2005-07-11 | 2005-08-17 | Novartis Ag | Organic compounds |
PL1937248T3 (pl) | 2005-09-17 | 2010-11-30 | Novartis Ag | Amidy kwasów alkanowych podstawione nasyconymi grupami O-heterocyklicznymi |
EP1948654B1 (en) | 2005-09-17 | 2009-06-24 | Novartis Ag | 5-amino-4-hydroxy-7- (imidazo [1,2-a] pyridin-6- ylmethyl)-8-methyl-nonamide derivatives and related compounds as renin inhibitors for the treatment of hypertension |
PE20071079A1 (es) | 2005-11-15 | 2007-12-16 | Cytokinetics Inc | Compuestos de piperidina como inhibidores de la proliferacion celular |
CA2633624C (en) | 2005-12-30 | 2013-11-19 | Novartis Ag | 3,5-substituted piperidine compounds as renin inhibitors |
EP1816122A3 (en) * | 2006-01-19 | 2007-09-19 | Speedel Experimenta AG | 3,4,5-substituted piperidines as therapeutic compounds |
EP1979323A1 (en) | 2006-01-30 | 2008-10-15 | Speedel Experimenta AG | Process for the stereoselective preparation of alcohols from alpha, beta-insaturated compounds |
JP2009539806A (ja) | 2006-06-08 | 2009-11-19 | シュペーデル・エクスペリメンタ・アーゲー | 2,5−二置換ピペリジン |
GB0611697D0 (en) | 2006-06-13 | 2006-07-26 | Novartis Ag | Organic compounds |
GB0611696D0 (en) | 2006-06-13 | 2006-07-26 | Novartis Ag | Organic compounds |
EP1908471A1 (en) | 2006-10-04 | 2008-04-09 | Speedel Experimenta AG | Tetrahydropyridines as renin inhibitors |
-
2006
- 2006-12-28 CA CA2633624A patent/CA2633624C/en not_active Expired - Fee Related
- 2006-12-28 PE PE2006001709A patent/PE20071177A1/es not_active Application Discontinuation
- 2006-12-28 BR BRPI0620736-7A patent/BRPI0620736A2/pt not_active IP Right Cessation
- 2006-12-28 EP EP11185536.7A patent/EP2420491B1/en active Active
- 2006-12-28 ES ES11185536T patent/ES2430139T3/es active Active
- 2006-12-28 KR KR1020087018705A patent/KR20080086921A/ko active IP Right Grant
- 2006-12-28 JP JP2008547900A patent/JP5306821B2/ja not_active Expired - Fee Related
- 2006-12-28 PE PE2010000928A patent/PE20110117A1/es not_active Application Discontinuation
- 2006-12-28 US US12/159,749 patent/US8129411B2/en not_active Expired - Fee Related
- 2006-12-28 PT PT111855367T patent/PT2420491E/pt unknown
- 2006-12-28 WO PCT/EP2006/012581 patent/WO2007077005A1/en active Application Filing
- 2006-12-28 AU AU2006332124A patent/AU2006332124B2/en not_active Ceased
- 2006-12-28 EP EP06829892.6A patent/EP1968940B1/en not_active Revoked
- 2006-12-28 ES ES06829892.6T patent/ES2476422T3/es active Active
- 2006-12-28 PL PL11185536T patent/PL2420491T3/pl unknown
- 2006-12-28 NZ NZ569135A patent/NZ569135A/en not_active IP Right Cessation
- 2006-12-28 AR ARP060105852A patent/AR058885A1/es not_active Application Discontinuation
- 2006-12-29 TW TW095149881A patent/TW200738698A/zh unknown
-
2008
- 2008-06-10 IL IL192024A patent/IL192024A0/en unknown
- 2008-06-19 CR CR10091A patent/CR10091A/es not_active Application Discontinuation
- 2008-06-19 MA MA31057A patent/MA30073B1/fr unknown
- 2008-06-27 EC EC2008008587A patent/ECSP088587A/es unknown
- 2008-07-25 NO NO20083315A patent/NO20083315L/no not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
US20090192148A1 (en) | 2009-07-30 |
EP1968940A1 (en) | 2008-09-17 |
TW200738698A (en) | 2007-10-16 |
AU2006332124B2 (en) | 2011-03-03 |
CA2633624A1 (en) | 2007-07-12 |
ES2476422T3 (es) | 2014-07-14 |
AR058885A1 (es) | 2008-02-27 |
JP5306821B2 (ja) | 2013-10-02 |
NZ569135A (en) | 2011-08-26 |
AU2006332124A1 (en) | 2007-07-12 |
BRPI0620736A2 (pt) | 2011-12-20 |
KR20080086921A (ko) | 2008-09-26 |
PE20071177A1 (es) | 2008-01-18 |
ECSP088587A (es) | 2008-07-30 |
MA30073B1 (fr) | 2008-12-01 |
JP2009522226A (ja) | 2009-06-11 |
CR10091A (es) | 2008-10-27 |
EP2420491B1 (en) | 2013-07-03 |
PT2420491E (pt) | 2013-10-14 |
IL192024A0 (en) | 2008-12-29 |
NO20083315L (no) | 2008-09-19 |
PL2420491T3 (pl) | 2013-12-31 |
WO2007077005A1 (en) | 2007-07-12 |
CA2633624C (en) | 2013-11-19 |
EP1968940B1 (en) | 2014-04-02 |
US8129411B2 (en) | 2012-03-06 |
ES2430139T3 (es) | 2013-11-19 |
EP2420491A1 (en) | 2012-02-22 |
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