BRPI0510335A - composto heterocìclico - Google Patents
composto heterocìclicoInfo
- Publication number
- BRPI0510335A BRPI0510335A BRPI0510335-5A BRPI0510335A BRPI0510335A BR PI0510335 A BRPI0510335 A BR PI0510335A BR PI0510335 A BRPI0510335 A BR PI0510335A BR PI0510335 A BRPI0510335 A BR PI0510335A
- Authority
- BR
- Brazil
- Prior art keywords
- ring
- heterocyclic compound
- alkyl
- heterocyclic group
- imidazolin
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Abstract
COMPOSTO HETEROCìCLICO. A presente invenção refere-se proporcionar um novo composto heterocíclico da fórmula ¢I!: em que R¬ 1¬ é um halogênio, nitro, uma alquila, etc.; R¬ 2¬ é hidrogênio, uma alquila, etc.; Anel A é 2-oxo-4-imidazolin-3,4-diila, etc.; Anel B é um cicloalquila, grupo heterocíclico saturado monocíclico; X é CH, N; Y é uma ligação única, CO, SO~ 2~; Z é O, NH, etc.; e Anel C é uma arila, um grupo heterocíclico, ou um sal farmaceuticamente aceitável do mesmo, o qual é útil como um inibidor da p38 MAR quinase.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2004133204 | 2004-04-28 | ||
US56608904P | 2004-04-29 | 2004-04-29 | |
JP2005007832 | 2005-01-14 | ||
PCT/JP2005/008564 WO2005105790A1 (en) | 2004-04-28 | 2005-04-28 | 4- 2- (cycloalkylamino) pyrimidin-4-yl ! - (phenyl) - imidazolin-2- one derivatives as p38 map- kinase inhibitors for the treatment of inflammatory diseases |
Publications (1)
Publication Number | Publication Date |
---|---|
BRPI0510335A true BRPI0510335A (pt) | 2007-10-23 |
Family
ID=43384198
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0510335-5A BRPI0510335A (pt) | 2004-04-28 | 2005-04-28 | composto heterocìclico |
Country Status (12)
Country | Link |
---|---|
US (1) | US7700771B2 (pt) |
EP (1) | EP1740578B1 (pt) |
JP (1) | JP2007535476A (pt) |
AT (1) | ATE491704T1 (pt) |
AU (1) | AU2005238390C1 (pt) |
BR (1) | BRPI0510335A (pt) |
CA (1) | CA2563042C (pt) |
DE (1) | DE602005025332D1 (pt) |
MY (1) | MY143245A (pt) |
NO (1) | NO20064175L (pt) |
TW (1) | TWI326282B (pt) |
WO (1) | WO2005105790A1 (pt) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20100113481A1 (en) * | 2003-12-17 | 2010-05-06 | Alcon Research, Ltd. | Use of serum amyloid a gene in diagnosis and treatment of glaucoma and identification of anti-glaucoma agents |
ES2600460T3 (es) | 2005-05-10 | 2017-02-09 | Intermune, Inc. | Derivados de piridona-2-ona como moduladores del sistema de proteína cinasa activada por estrés |
EP1992344A1 (en) | 2007-05-18 | 2008-11-19 | Institut Curie | P38 alpha as a therapeutic target in pathologies linked to FGFR3 mutation |
CA2726588C (en) | 2008-06-03 | 2019-04-16 | Karl Kossen | Compounds and methods for treating inflammatory and fibrotic disorders |
DE102009043260A1 (de) | 2009-09-28 | 2011-04-28 | Merck Patent Gmbh | Pyridinyl-imidazolonderivate |
DE102009049679A1 (de) | 2009-10-19 | 2011-04-21 | Merck Patent Gmbh | Pyrazolopyrimidinderivate |
DE102010049595A1 (de) | 2010-10-26 | 2012-04-26 | Merck Patent Gmbh | Chinazolinderivate |
KR20140072177A (ko) * | 2011-10-06 | 2014-06-12 | 바이엘 인텔렉쳐 프로퍼티 게엠베하 | 헤테로사이클릴피리(미)디닐피라졸 |
AR092742A1 (es) | 2012-10-02 | 2015-04-29 | Intermune Inc | Piridinonas antifibroticas |
WO2015153683A1 (en) | 2014-04-02 | 2015-10-08 | Intermune, Inc. | Anti-fibrotic pyridinones |
IL277071B1 (en) | 2018-03-08 | 2024-03-01 | Incyte Corp | Aminopyrizine diol compounds as PI3K–y inhibitors |
US11046658B2 (en) | 2018-07-02 | 2021-06-29 | Incyte Corporation | Aminopyrazine derivatives as PI3K-γ inhibitors |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5658903A (en) * | 1995-06-07 | 1997-08-19 | Smithkline Beecham Corporation | Imidazole compounds, compositions and use |
AR016294A1 (es) | 1997-07-02 | 2001-07-04 | Smithkline Beecham Corp | Compuesto de imidazol sustituido, composicion farmaceutica que la contiene, su uso en la fabricacion de un medicamento y procedimiento para supreparacion |
EP1021173A1 (en) * | 1997-10-10 | 2000-07-26 | Imperial College Innovations Limited | Use of csaid?tm compounds for the management of uterine contractions |
CO5170501A1 (es) * | 1999-04-14 | 2002-06-27 | Novartis Ag | AZOLES SUSTITUIDOS UTILES PARA EL TRATAMIENTO DE ENFERMEDADES MEDIADAS POR TNFa eIL-1 Y ENFERMEDADES DEL METABOLISMO OSEO |
US6492516B1 (en) * | 1999-05-14 | 2002-12-10 | Merck & Co., Inc. | Compounds having cytokine inhibitory activity |
PL366110A1 (en) | 1999-08-13 | 2005-01-24 | Vertex Pharmaceuticals Incorporated | Inhibitors of c-jun n-terminal kinases (jnk) and other protein kinases |
WO2001091749A1 (en) * | 2000-06-01 | 2001-12-06 | Merck & Co., Inc. | Use of (di-substituted-phenyl)-pyrimidinyl-imidazole derivatives as jnk-inhibitors |
PE20020506A1 (es) * | 2000-08-22 | 2002-07-09 | Glaxo Group Ltd | Derivados de pirazol fusionados como inhibidores de la proteina cinasa |
HUP0401949A3 (en) * | 2001-10-22 | 2009-07-28 | Mitsubishi Tanabe Pharma Corp | 4-imidazolin-2-one derivatives |
EP1511743A1 (en) * | 2002-06-05 | 2005-03-09 | Pharmacia Corporation | Pyrazole-derivatives as p38 kinase inhibitors |
AU2003242873A1 (en) | 2002-06-06 | 2003-12-22 | Koninklijke Philips Electronics N.V. | Quad flat non-leaded package comprising a semiconductor device |
MXPA05012377A (es) * | 2003-05-15 | 2006-05-25 | Arqule Inc | Derivados de imidazotiazoles e imidazoxazol como inhibidores de p38. |
-
2005
- 2005-04-27 TW TW094113384A patent/TWI326282B/zh not_active IP Right Cessation
- 2005-04-27 MY MYPI20051847A patent/MY143245A/en unknown
- 2005-04-28 BR BRPI0510335-5A patent/BRPI0510335A/pt not_active IP Right Cessation
- 2005-04-28 JP JP2006519531A patent/JP2007535476A/ja not_active Ceased
- 2005-04-28 DE DE602005025332T patent/DE602005025332D1/de active Active
- 2005-04-28 US US11/587,498 patent/US7700771B2/en not_active Expired - Fee Related
- 2005-04-28 AU AU2005238390A patent/AU2005238390C1/en not_active Ceased
- 2005-04-28 EP EP05738662A patent/EP1740578B1/en not_active Not-in-force
- 2005-04-28 AT AT05738662T patent/ATE491704T1/de not_active IP Right Cessation
- 2005-04-28 CA CA2563042A patent/CA2563042C/en not_active Expired - Fee Related
- 2005-04-28 WO PCT/JP2005/008564 patent/WO2005105790A1/en active Application Filing
-
2006
- 2006-09-15 NO NO20064175A patent/NO20064175L/no not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
NO20064175L (no) | 2006-12-13 |
ATE491704T1 (de) | 2011-01-15 |
JP2007535476A (ja) | 2007-12-06 |
EP1740578B1 (en) | 2010-12-15 |
DE602005025332D1 (de) | 2011-01-27 |
AU2005238390B2 (en) | 2009-01-08 |
US7700771B2 (en) | 2010-04-20 |
MY143245A (en) | 2011-04-15 |
CA2563042C (en) | 2010-04-27 |
AU2005238390A1 (en) | 2005-11-10 |
CA2563042A1 (en) | 2005-11-10 |
WO2005105790A1 (en) | 2005-11-10 |
TWI326282B (en) | 2010-06-21 |
EP1740578A1 (en) | 2007-01-10 |
US20070185326A1 (en) | 2007-08-09 |
AU2005238390C1 (en) | 2009-06-25 |
TW200536843A (en) | 2005-11-16 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B25D | Requested change of name of applicant approved |
Owner name: MITSUBISHI TANABE PHARMA CORPORATION (JP) Free format text: ALTERADO DE: TANABE SEIYAKU CO., LTD. |
|
B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 7A ANUIDADE. |
|
B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2158 DE 15/05/2012. |