ATE491704T1 - 4-ä2-(cycloalkylamino)pyrimidin-4-ylü- (phenyl)imidazolin-2-onderivate als inhibitoren der p38-map-kinase zur behandlung von entzündlichen krankheiten - Google Patents
4-ä2-(cycloalkylamino)pyrimidin-4-ylü- (phenyl)imidazolin-2-onderivate als inhibitoren der p38-map-kinase zur behandlung von entzündlichen krankheitenInfo
- Publication number
- ATE491704T1 ATE491704T1 AT05738662T AT05738662T ATE491704T1 AT E491704 T1 ATE491704 T1 AT E491704T1 AT 05738662 T AT05738662 T AT 05738662T AT 05738662 T AT05738662 T AT 05738662T AT E491704 T1 ATE491704 T1 AT E491704T1
- Authority
- AT
- Austria
- Prior art keywords
- map kinase
- ylü
- cycloalkylamino
- imidazoline
- pyrimidine
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2004133204 | 2004-04-28 | ||
| US56608904P | 2004-04-29 | 2004-04-29 | |
| JP2005007832 | 2005-01-14 | ||
| PCT/JP2005/008564 WO2005105790A1 (en) | 2004-04-28 | 2005-04-28 | 4- 2- (cycloalkylamino) pyrimidin-4-yl ! - (phenyl) - imidazolin-2- one derivatives as p38 map- kinase inhibitors for the treatment of inflammatory diseases |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE491704T1 true ATE491704T1 (de) | 2011-01-15 |
Family
ID=43384198
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT05738662T ATE491704T1 (de) | 2004-04-28 | 2005-04-28 | 4-ä2-(cycloalkylamino)pyrimidin-4-ylü- (phenyl)imidazolin-2-onderivate als inhibitoren der p38-map-kinase zur behandlung von entzündlichen krankheiten |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US7700771B2 (de) |
| EP (1) | EP1740578B1 (de) |
| JP (1) | JP2007535476A (de) |
| AT (1) | ATE491704T1 (de) |
| AU (1) | AU2005238390C1 (de) |
| BR (1) | BRPI0510335A (de) |
| CA (1) | CA2563042C (de) |
| DE (1) | DE602005025332D1 (de) |
| MY (1) | MY143245A (de) |
| NO (1) | NO20064175L (de) |
| TW (1) | TWI326282B (de) |
| WO (1) | WO2005105790A1 (de) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20100113481A1 (en) | 2003-12-17 | 2010-05-06 | Alcon Research, Ltd. | Use of serum amyloid a gene in diagnosis and treatment of glaucoma and identification of anti-glaucoma agents |
| ES2600460T3 (es) | 2005-05-10 | 2017-02-09 | Intermune, Inc. | Derivados de piridona-2-ona como moduladores del sistema de proteína cinasa activada por estrés |
| EP1992344A1 (de) | 2007-05-18 | 2008-11-19 | Institut Curie | P38 Alpha als therapeutisches Target für Erkrankungen, die mit einer FGFR3- Mutation assoziiert sind |
| CA3034994A1 (en) | 2008-06-03 | 2009-12-10 | Intermune, Inc. | Substituted aryl-2 pyridone compounds and use thereof for treating inflammatory and fibrotic disorders |
| DE102009043260A1 (de) | 2009-09-28 | 2011-04-28 | Merck Patent Gmbh | Pyridinyl-imidazolonderivate |
| DE102009049679A1 (de) | 2009-10-19 | 2011-04-21 | Merck Patent Gmbh | Pyrazolopyrimidinderivate |
| DE102010049595A1 (de) | 2010-10-26 | 2012-04-26 | Merck Patent Gmbh | Chinazolinderivate |
| UA114410C2 (uk) * | 2011-10-06 | 2017-06-12 | Байєр Інтеллектуал Проперті Гмбх | Гетероциклілпіри(mi)динілпіразол |
| AR092742A1 (es) | 2012-10-02 | 2015-04-29 | Intermune Inc | Piridinonas antifibroticas |
| KR102373700B1 (ko) | 2014-04-02 | 2022-03-11 | 인터뮨, 인크. | 항섬유성 피리디논 |
| JP7268049B2 (ja) | 2018-03-08 | 2023-05-02 | インサイト・コーポレイション | ＰＩ３Ｋ－γ阻害剤としてのアミノピラジンジオール化合物 |
| WO2020010003A1 (en) | 2018-07-02 | 2020-01-09 | Incyte Corporation | AMINOPYRAZINE DERIVATIVES AS PI3K-γ INHIBITORS |
| US11993580B1 (en) | 2022-12-02 | 2024-05-28 | Neumora Therapeutics, Inc. | Methods of treating neurological disorders |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5658903A (en) | 1995-06-07 | 1997-08-19 | Smithkline Beecham Corporation | Imidazole compounds, compositions and use |
| AR016294A1 (es) * | 1997-07-02 | 2001-07-04 | Smithkline Beecham Corp | Compuesto de imidazol sustituido, composicion farmaceutica que la contiene, su uso en la fabricacion de un medicamento y procedimiento para supreparacion |
| JP2001519381A (ja) | 1997-10-10 | 2001-10-23 | インペリアル・カレッジ・イノベイションズ・リミテッド | 子宮収縮管理のためのｃｓａｉｄｔｍ化合物の使用 |
| CO5170501A1 (es) * | 1999-04-14 | 2002-06-27 | Novartis Ag | AZOLES SUSTITUIDOS UTILES PARA EL TRATAMIENTO DE ENFERMEDADES MEDIADAS POR TNFa eIL-1 Y ENFERMEDADES DEL METABOLISMO OSEO |
| US6492516B1 (en) * | 1999-05-14 | 2002-12-10 | Merck & Co., Inc. | Compounds having cytokine inhibitory activity |
| AU6909600A (en) * | 1999-08-13 | 2001-03-13 | Vertex Pharmaceuticals Incorporated | Inhibitors of c-jun n-terminal kinases (jnk) and other protein kinases |
| WO2001091749A1 (en) | 2000-06-01 | 2001-12-06 | Merck & Co., Inc. | Use of (di-substituted-phenyl)-pyrimidinyl-imidazole derivatives as jnk-inhibitors |
| PE20020506A1 (es) * | 2000-08-22 | 2002-07-09 | Glaxo Group Ltd | Derivados de pirazol fusionados como inhibidores de la proteina cinasa |
| PL210470B1 (pl) | 2001-10-22 | 2012-01-31 | Mitsubishi Tanabe Pharma Corp | Związki 4-imidazolin-2-onu i jego zastosowanie |
| MXPA04011638A (es) * | 2002-06-05 | 2005-03-07 | Pharmacia Corp | Derivados de pirazol como inhibidores de la quinasa p38. |
| JP2005529493A (ja) | 2002-06-06 | 2005-09-29 | コーニンクレッカ フィリップス エレクトロニクス エヌ ヴィ | 半導体デバイスを有するノンリードクワッドフラットパッケージ |
| MXPA05012377A (es) * | 2003-05-15 | 2006-05-25 | Arqule Inc | Derivados de imidazotiazoles e imidazoxazol como inhibidores de p38. |
-
2005
- 2005-04-27 MY MYPI20051847A patent/MY143245A/en unknown
- 2005-04-27 TW TW094113384A patent/TWI326282B/zh not_active IP Right Cessation
- 2005-04-28 EP EP05738662A patent/EP1740578B1/de not_active Not-in-force
- 2005-04-28 WO PCT/JP2005/008564 patent/WO2005105790A1/en active Application Filing
- 2005-04-28 CA CA2563042A patent/CA2563042C/en not_active Expired - Fee Related
- 2005-04-28 AT AT05738662T patent/ATE491704T1/de not_active IP Right Cessation
- 2005-04-28 AU AU2005238390A patent/AU2005238390C1/en not_active Ceased
- 2005-04-28 JP JP2006519531A patent/JP2007535476A/ja not_active Ceased
- 2005-04-28 BR BRPI0510335-5A patent/BRPI0510335A/pt not_active IP Right Cessation
- 2005-04-28 DE DE602005025332T patent/DE602005025332D1/de active Active
- 2005-04-28 US US11/587,498 patent/US7700771B2/en not_active Expired - Fee Related
-
2006
- 2006-09-15 NO NO20064175A patent/NO20064175L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| NO20064175L (no) | 2006-12-13 |
| MY143245A (en) | 2011-04-15 |
| US7700771B2 (en) | 2010-04-20 |
| TW200536843A (en) | 2005-11-16 |
| CA2563042C (en) | 2010-04-27 |
| CA2563042A1 (en) | 2005-11-10 |
| AU2005238390B2 (en) | 2009-01-08 |
| EP1740578B1 (de) | 2010-12-15 |
| US20070185326A1 (en) | 2007-08-09 |
| DE602005025332D1 (de) | 2011-01-27 |
| WO2005105790A1 (en) | 2005-11-10 |
| JP2007535476A (ja) | 2007-12-06 |
| AU2005238390A1 (en) | 2005-11-10 |
| EP1740578A1 (de) | 2007-01-10 |
| AU2005238390C1 (en) | 2009-06-25 |
| BRPI0510335A (pt) | 2007-10-23 |
| TWI326282B (en) | 2010-06-21 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ATE491704T1 (de) | 4-ä2-(cycloalkylamino)pyrimidin-4-ylü- (phenyl)imidazolin-2-onderivate als inhibitoren der p38-map-kinase zur behandlung von entzündlichen krankheiten | |
| JO2791B1 (en) | Acid secretion inhibitor | |
| EA200701257A1 (ru) | Пирролопиразолы в качестве сильнодействующих ингибиторов киназы | |
| EA200870358A1 (ru) | 2-(циклический амино) пиримидоновые производные в качестве ингибиторов tpk1 | |
| TW200740820A (en) | Fused heterocyclic derivatives and use thereof | |
| TW200633991A (en) | Chemical compounds | |
| BRPI0506817A (pt) | inibidores seletivos de quinase | |
| ATE479667T1 (de) | Als kinaseinhibitoren geeignete verbindungen auf thiazolylbasis | |
| AR053662A1 (es) | Compuestos de pirazol inhibidores de la actividad quinasa cdk y gsk | |
| DE602005009209D1 (de) | Zur behandlung von entzündungen geeignete indole | |
| NO20072605L (no) | Nytt antranilinsyrederivat eller et salt derav | |
| EA200700141A1 (ru) | Новые аминоциклические производные мочевины, их получение и фармацевтическое применение в качестве ингибиторов киназы | |
| UA83243C2 (ru) | Соединения, которые ингибируют натриезависимый переносчик глюкозы | |
| EA200601358A1 (ru) | Новые ингибиторы химазы | |
| WO2007016392A3 (en) | Benzothiazole and azabenzothiazole compounds useful as kinase inhibitors | |
| NO20065537L (no) | Heterosykliske amidforbindelser og anvendelse derav som en MMP-13-inhibitor | |
| MX2016006685A (es) | Compuestos heterociclicos de n-acilimino. | |
| ATE553077T1 (de) | Peptidaseinhibitoren | |
| ATE543803T1 (de) | 3-ä2-(3-azylamino-2-oxo-2h-pyridin-1- yl)acetylaminoü-4-oxopentansäurederivate und deren verwendung als caspase-inhibitoren | |
| EA200700758A1 (ru) | Новые производные бис-азаиндолов, их получение и фармацевтическое применение в качестве ингибиторов киназ | |
| PE20020524A1 (es) | 7-oxo-piridopirimidinas como inhibidores de quinasas | |
| CO5680420A2 (es) | Compuestos de 6-amino-1h-indazol y 4-aminobenzenofurano como inhibidores de la fosfodiesterasa 4 | |
| DE502006008710D1 (de) | Substituierte tetrahydroisochinoline als mmp-inhibitoren, verfahren zu ihrer herstellung und ihre verwendung als medikament | |
| TW200616997A (en) | The preparation method for 6-substituted-1-methyl-1h-benzoimidazol derivatives and their preparation imtermediates | |
| ATE550332T1 (de) | 4-imidazolin-2-onverbindungen als p38-map- kinaseinhibitors |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |