ATE246174T1 - Tosylprolin-derivate als thymidylat-synthase inhibitoren - Google Patents
Tosylprolin-derivate als thymidylat-synthase inhibitorenInfo
- Publication number
- ATE246174T1 ATE246174T1 AT01905352T AT01905352T ATE246174T1 AT E246174 T1 ATE246174 T1 AT E246174T1 AT 01905352 T AT01905352 T AT 01905352T AT 01905352 T AT01905352 T AT 01905352T AT E246174 T1 ATE246174 T1 AT E246174T1
- Authority
- AT
- Austria
- Prior art keywords
- tosylproline
- synthase inhibitors
- derivatives
- thymidylate synthase
- methods
- Prior art date
Links
- CGPHGPCHVUSFFA-UHFFFAOYSA-N 1-(4-methylphenyl)sulfonylpyrrolidine-2-carboxylic acid Chemical class C1=CC(C)=CC=C1S(=O)(=O)N1C(C(O)=O)CCC1 CGPHGPCHVUSFFA-UHFFFAOYSA-N 0.000 title abstract 2
- 239000003734 thymidylate synthase inhibitor Substances 0.000 title abstract 2
- 230000000844 anti-bacterial effect Effects 0.000 abstract 1
- 230000000843 anti-fungal effect Effects 0.000 abstract 1
- 230000002141 anti-parasite Effects 0.000 abstract 1
- 230000000840 anti-viral effect Effects 0.000 abstract 1
- 229940088710 antibiotic agent Drugs 0.000 abstract 1
- 229940121375 antifungal agent Drugs 0.000 abstract 1
- 239000002246 antineoplastic agent Substances 0.000 abstract 1
- 239000003096 antiparasitic agent Substances 0.000 abstract 1
- 229940125687 antiparasitic agent Drugs 0.000 abstract 1
- 239000003443 antiviral agent Substances 0.000 abstract 1
- 229940121357 antivirals Drugs 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/46—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with hetero atoms directly attached to the ring nitrogen atom
- C07D207/48—Sulfur atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/92—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with a hetero atom directly attached to the ring nitrogen atom
- C07D211/96—Sulfur atom
Landscapes
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Virology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyrrole Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Enzymes And Modification Thereof (AREA)
- Cosmetics (AREA)
- Pyrane Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/496,378 US6143776A (en) | 2000-02-02 | 2000-02-02 | Tosylproline analogs as thymidylate synthase inhibitors |
| PCT/US2001/003391 WO2001056987A1 (en) | 2000-02-02 | 2001-02-02 | Tosylproline analogs as thymidylate synthase inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE246174T1 true ATE246174T1 (de) | 2003-08-15 |
Family
ID=23972366
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT01905352T ATE246174T1 (de) | 2000-02-02 | 2001-02-02 | Tosylprolin-derivate als thymidylat-synthase inhibitoren |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US6143776A (de) |
| EP (1) | EP1252141B1 (de) |
| JP (1) | JP2003521535A (de) |
| AT (1) | ATE246174T1 (de) |
| AU (2) | AU2001233242B2 (de) |
| CA (1) | CA2398752A1 (de) |
| DE (1) | DE60100539T2 (de) |
| WO (1) | WO2001056987A1 (de) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6589978B2 (en) * | 2000-06-30 | 2003-07-08 | Hoffman-La Roche Inc. | 1-sulfonyl pyrrolidine derivatives |
| CA2445591A1 (en) * | 2001-04-27 | 2002-11-07 | The Procter & Gamble Company | Nitrogen heterocyclic compounds and compositions for controlling biofilms |
| US8019550B2 (en) * | 2002-07-24 | 2011-09-13 | Keddem Bioscience Ltd. | Drug discovery method |
| WO2010138955A2 (en) * | 2009-05-29 | 2010-12-02 | University Of Florida Research Foundation, Inc. | Methods and compositions for treating neoplasia |
| ITMI20130085A1 (it) * | 2013-01-22 | 2014-07-23 | Gabriele Cruciani | Nuove molecole per uso come agenti antitumorali |
| AU2019269544B2 (en) | 2018-05-16 | 2024-03-21 | Infex Therapeutics Limited | Antibacterial compounds |
| AR119732A1 (es) | 2019-05-06 | 2022-01-05 | Janssen Sciences Ireland Unlimited Co | Derivados de amida útiles en el tratamiento de la infección por vhb o de enfermedades inducidas por vhb |
| US20230212122A1 (en) * | 2020-05-26 | 2023-07-06 | The Regents Of The University Of Michigan | Mitochondrial targeting compounds for the treatment of associated diseases |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0031237B1 (de) * | 1979-12-19 | 1984-10-17 | National Research Development Corporation | Chinazolinderivate, Verfahren zu ihrer Herstellung, sie enthaltende Zusammensetzungen und ihre Verwendung als Anti-Krebs-Mittel |
| GB8607683D0 (en) * | 1986-03-27 | 1986-04-30 | Ici Plc | Anti-tumor agents |
| US4925939A (en) * | 1989-01-05 | 1990-05-15 | Sloan-Kettering Institute For Cancer Research | 6,7-dihydropyrrol[3,4-c]pyrido[2,3-d]pyrimidine derivatives |
| US5958930A (en) * | 1991-04-08 | 1999-09-28 | Duquesne University Of The Holy Ghost | Pyrrolo pyrimidine and furo pyrimidine derivatives |
| GB9205320D0 (en) * | 1992-03-11 | 1992-04-22 | Ici Plc | Anti-tumour compounds |
| GB9205907D0 (en) * | 1992-03-18 | 1992-04-29 | Cancer Res Inst Royal | Anti-cancer compounds |
| DE69716449T2 (de) * | 1996-08-28 | 2003-08-07 | The Procter & Gamble Company, Cincinnati | Substituierte zyklische amine als metalloproteaseinhibitoren |
| WO1998017625A1 (en) * | 1996-10-22 | 1998-04-30 | Daiichi Pharmaceutical Co., Ltd. | Novel remedies for infectious diseases |
| AR016133A1 (es) * | 1997-07-31 | 2001-06-20 | Wyeth Corp | Compuesto de carbamiloxi que inhiben la adhesion de leucocitos mediada por vla-4, compuestos que son prodrogas de dichos compuestos, composicionfarmaceutica, metodo para fijar vla-4 a una muestra biologica, metodo para el tratamiento de una condicion inflamatoria |
-
2000
- 2000-02-02 US US09/496,378 patent/US6143776A/en not_active Expired - Fee Related
-
2001
- 2001-02-02 CA CA002398752A patent/CA2398752A1/en not_active Abandoned
- 2001-02-02 AT AT01905352T patent/ATE246174T1/de not_active IP Right Cessation
- 2001-02-02 WO PCT/US2001/003391 patent/WO2001056987A1/en not_active Ceased
- 2001-02-02 DE DE60100539T patent/DE60100539T2/de not_active Expired - Fee Related
- 2001-02-02 AU AU2001233242A patent/AU2001233242B2/en not_active Ceased
- 2001-02-02 AU AU3324201A patent/AU3324201A/xx active Pending
- 2001-02-02 JP JP2001556837A patent/JP2003521535A/ja not_active Withdrawn
- 2001-02-02 EP EP01905352A patent/EP1252141B1/de not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| CA2398752A1 (en) | 2001-08-09 |
| AU2001233242B2 (en) | 2004-11-18 |
| DE60100539D1 (en) | 2003-09-04 |
| WO2001056987A1 (en) | 2001-08-09 |
| EP1252141A1 (de) | 2002-10-30 |
| JP2003521535A (ja) | 2003-07-15 |
| EP1252141B1 (de) | 2003-07-30 |
| US6143776A (en) | 2000-11-07 |
| AU3324201A (en) | 2001-08-14 |
| DE60100539T2 (de) | 2004-06-09 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |