MX2007001952A - Compuestos y composiciones utiles como inhibidores de catepsina-s. - Google Patents
Compuestos y composiciones utiles como inhibidores de catepsina-s.Info
- Publication number
- MX2007001952A MX2007001952A MX2007001952A MX2007001952A MX2007001952A MX 2007001952 A MX2007001952 A MX 2007001952A MX 2007001952 A MX2007001952 A MX 2007001952A MX 2007001952 A MX2007001952 A MX 2007001952A MX 2007001952 A MX2007001952 A MX 2007001952A
- Authority
- MX
- Mexico
- Prior art keywords
- cathepsin
- inhibitors
- compounds
- compositions useful
- inhibitor
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/34—One oxygen atom
- C07D239/36—One oxygen atom as doubly bound oxygen atom or as unsubstituted hydroxy radical
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/42—One nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/47—One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/48—Two nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
Abstract
La presente invencion se refiere al uso de un compuesto de 2-ciano-pirimidina de la formula: en donde: R1, R2, R3, y X son como se definen en la memoria descriptiva y en las reivindicaciones, en forma libre o en forma de sal, y donde sea posible, en forma tautomerica, como un inhibidor de la actividad de la catepsina S. (Ver formula).
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB0418353.9A GB0418353D0 (en) | 2004-08-17 | 2004-08-17 | Organic compounds |
PCT/EP2005/008896 WO2006018284A1 (en) | 2004-08-17 | 2005-08-16 | Compounds and compositions useful as cathepsin s inhibitors |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2007001952A true MX2007001952A (es) | 2007-05-09 |
Family
ID=33042203
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2007001952A MX2007001952A (es) | 2004-08-17 | 2005-08-16 | Compuestos y composiciones utiles como inhibidores de catepsina-s. |
Country Status (16)
Country | Link |
---|---|
US (1) | US7704996B2 (es) |
EP (1) | EP1781623A1 (es) |
JP (1) | JP2008509959A (es) |
KR (1) | KR20070036183A (es) |
CN (2) | CN101671310A (es) |
AR (1) | AR050786A1 (es) |
AU (1) | AU2005274319A1 (es) |
BR (1) | BRPI0514383A (es) |
CA (1) | CA2575826A1 (es) |
GB (1) | GB0418353D0 (es) |
GT (1) | GT200500220A (es) |
MX (1) | MX2007001952A (es) |
PE (1) | PE20060647A1 (es) |
RU (1) | RU2007109650A (es) |
TW (1) | TW200621727A (es) |
WO (1) | WO2006018284A1 (es) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1991692A4 (en) * | 2006-02-21 | 2009-07-22 | Agency Science Tech & Res | METHOD AND REAGENTS FOR TREATING HEPATIC FIBROSIS AND INFLAMMATION |
EP2202228B1 (en) | 2007-10-15 | 2014-12-10 | Takeda Pharmaceutical Company Limited | Amide compounds and use of the same |
WO2010065704A1 (en) * | 2008-12-04 | 2010-06-10 | Glaxo Group Limited | Method for preparing a spiroindoline and a precursor thereof |
TWI402072B (zh) * | 2010-10-19 | 2013-07-21 | Lilly Co Eli | 組織蛋白酶s抑制劑化合物 |
EP3946332A1 (en) | 2019-04-05 | 2022-02-09 | Université de Bretagne Occidentale | Protease-activated receptor-2 inhibitors for the treatment of sensory neuropathy induced by a marine neurotoxic poisoning |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SE0201976D0 (sv) * | 2002-06-24 | 2002-06-24 | Astrazeneca Ab | Novel compounds |
GB0220187D0 (en) | 2002-08-30 | 2002-10-09 | Novartis Ag | Organic compounds |
-
2004
- 2004-08-17 GB GBGB0418353.9A patent/GB0418353D0/en not_active Ceased
-
2005
- 2005-08-15 PE PE2005000946A patent/PE20060647A1/es not_active Application Discontinuation
- 2005-08-16 MX MX2007001952A patent/MX2007001952A/es not_active Application Discontinuation
- 2005-08-16 CN CN200910179114A patent/CN101671310A/zh active Pending
- 2005-08-16 CA CA002575826A patent/CA2575826A1/en not_active Abandoned
- 2005-08-16 BR BRPI0514383-7A patent/BRPI0514383A/pt not_active IP Right Cessation
- 2005-08-16 JP JP2007526382A patent/JP2008509959A/ja active Pending
- 2005-08-16 WO PCT/EP2005/008896 patent/WO2006018284A1/en active Application Filing
- 2005-08-16 TW TW094127954A patent/TW200621727A/zh unknown
- 2005-08-16 EP EP05782460A patent/EP1781623A1/en not_active Withdrawn
- 2005-08-16 US US11/573,451 patent/US7704996B2/en not_active Expired - Fee Related
- 2005-08-16 RU RU2007109650/04A patent/RU2007109650A/ru not_active Application Discontinuation
- 2005-08-16 GT GT200500220A patent/GT200500220A/es unknown
- 2005-08-16 CN CNA2005800344018A patent/CN101035768A/zh active Pending
- 2005-08-16 AU AU2005274319A patent/AU2005274319A1/en not_active Abandoned
- 2005-08-16 KR KR1020077003902A patent/KR20070036183A/ko not_active Application Discontinuation
- 2005-08-19 AR ARP050103494A patent/AR050786A1/es unknown
Also Published As
Publication number | Publication date |
---|---|
CN101671310A (zh) | 2010-03-17 |
AR050786A1 (es) | 2006-11-22 |
PE20060647A1 (es) | 2006-08-11 |
JP2008509959A (ja) | 2008-04-03 |
CN101035768A (zh) | 2007-09-12 |
RU2007109650A (ru) | 2008-09-27 |
EP1781623A1 (en) | 2007-05-09 |
AU2005274319A1 (en) | 2006-02-23 |
CA2575826A1 (en) | 2006-02-23 |
KR20070036183A (ko) | 2007-04-02 |
WO2006018284A1 (en) | 2006-02-23 |
GB0418353D0 (en) | 2004-09-22 |
BRPI0514383A (pt) | 2008-06-10 |
US20090048230A1 (en) | 2009-02-19 |
US7704996B2 (en) | 2010-04-27 |
GT200500220A (es) | 2006-03-29 |
TW200621727A (en) | 2006-07-01 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
TNSN06405A1 (en) | Quinazolinone derivatives useful as vanilloid antagonistes | |
TW200626610A (en) | Analogs of 17-hydroxywortmannin as PI3K inhibitors | |
SG154433A1 (en) | Phthalazine derivatives as parp inhibitors | |
WO2007056159A3 (en) | Hydrazone derivatives and uses thereof | |
MY140841A (en) | Indozolone derivatives as 11b-hsd1 inhibitors | |
EA200701257A1 (ru) | Пирролопиразолы в качестве сильнодействующих ингибиторов киназы | |
MX2009009540A (es) | Inhibidores de metaloproteasa que contienen una porcion heterociclica. | |
MX2009003834A (es) | Derivados de pirrolidina como inhibidores de iap. | |
SG154434A1 (en) | Quinazolinone derivatives as parp inhibitors | |
SG154432A1 (en) | Quinazolinedione derivatives as parp inhibitors | |
WO2007105058A3 (en) | Pyrazole compounds | |
GEP20125537B (en) | Derivatives of 1-phenyl-2-pyridinyl alkyl alcohols as phosphodiesterase inhibitors | |
TW200720271A (en) | DNA-PK inhibitors | |
MX338557B (es) | Compuesto heterociclico y uso del mismo. | |
WO2007019191A3 (en) | Thiazolopyrimidine kinase inhibitors | |
UA98608C2 (en) | Benzofused five-membered heterocycles and use thereof | |
WO2006047415A3 (en) | FACTOR Xa COMPOUNDS | |
TW200613289A (en) | Prodrugs of hiv protease inhibitors | |
MX2008016358A (es) | Derivados de tiazolil-urea como inhibidores de cinasa de fosfatidil-inositol-3. | |
MX2007001952A (es) | Compuestos y composiciones utiles como inhibidores de catepsina-s. | |
WO2006031929A3 (en) | Thiazolopyridine kinase inhibitors | |
TW200612944A (en) | 4-(2,4-dichloro-5-methoxyphenyl)amino-6-methoxy-7-{[5-(substituted-amino)methyl]-3-furyl}-3-quinolinecarbonitriles as kinase inhibitors | |
TW200801011A (en) | New compounds II | |
MXPA06000988A (es) | Derivados de nicotinamida utiles como inhibidores de pde4. | |
UA90716C2 (en) | Dna-pk inhibitors |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FA | Abandonment or withdrawal |