MX2008016358A - Derivados de tiazolil-urea como inhibidores de cinasa de fosfatidil-inositol-3. - Google Patents

Derivados de tiazolil-urea como inhibidores de cinasa de fosfatidil-inositol-3.

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Publication number
MX2008016358A
MX2008016358A MX2008016358A MX2008016358A MX2008016358A MX 2008016358 A MX2008016358 A MX 2008016358A MX 2008016358 A MX2008016358 A MX 2008016358A MX 2008016358 A MX2008016358 A MX 2008016358A MX 2008016358 A MX2008016358 A MX 2008016358A
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MX
Mexico
Prior art keywords
phosphatidylinositol
kinase inhibitors
urea derivatives
thiazolyl urea
thiazolyl
Prior art date
Application number
MX2008016358A
Other languages
English (en)
Inventor
Ian Bruce
Gabriele Weitz Schmidt
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of MX2008016358A publication Critical patent/MX2008016358A/es

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    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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Abstract

La presente invención se refiere a un compuesto de la fórmula (I): (ver fórmula (I)) o una sal farmacéuticamente aceptable, o un solvato del mismo, en donde los grupos R1- R5 se definen en la descripción, a composiciones, y al uso de los compuestos en el tratamiento de enfermedades mejoradas por la inhibición de la cinasa de fosfatidil-inositol-3.
MX2008016358A 2006-06-26 2007-06-25 Derivados de tiazolil-urea como inhibidores de cinasa de fosfatidil-inositol-3. MX2008016358A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0612630.4A GB0612630D0 (en) 2006-06-26 2006-06-26 Organic compounds
PCT/EP2007/005599 WO2008000421A2 (en) 2006-06-26 2007-06-25 Thiazolyl urea derivatives as phosphatidylinositol 3-kinase inhibitors

Publications (1)

Publication Number Publication Date
MX2008016358A true MX2008016358A (es) 2009-01-16

Family

ID=36803903

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2008016358A MX2008016358A (es) 2006-06-26 2007-06-25 Derivados de tiazolil-urea como inhibidores de cinasa de fosfatidil-inositol-3.

Country Status (12)

Country Link
US (1) US7799810B2 (es)
EP (1) EP2035413A2 (es)
JP (1) JP4944954B2 (es)
KR (1) KR20090024294A (es)
CN (1) CN101479258A (es)
AU (1) AU2007264033A1 (es)
BR (1) BRPI0713784A2 (es)
CA (1) CA2655568A1 (es)
GB (1) GB0612630D0 (es)
MX (1) MX2008016358A (es)
RU (1) RU2009102270A (es)
WO (1) WO2008000421A2 (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2342181A1 (en) 2008-08-29 2011-07-13 Topo Target A/S Novel urea and thiourea derivatives
UA104147C2 (uk) 2008-09-10 2014-01-10 Новартис Аг Похідна піролідиндикарбонової кислоти та її застосування у лікуванні проліферативних захворювань
AU2009322187B2 (en) * 2008-12-04 2015-02-19 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Phosphatidylinositol-3-kinase p110 delta-targeted drugs in the treatment of CNS disorders
JPWO2010092962A1 (ja) 2009-02-12 2012-08-16 アステラス製薬株式会社 へテロ環誘導体
WO2011048936A1 (ja) 2009-10-19 2011-04-28 大正製薬株式会社 アミノチアゾール誘導体
CN103025725B (zh) 2010-08-10 2015-09-16 安斯泰来制药有限公司 杂环化合物
CN103476410B (zh) 2011-01-11 2020-02-21 戴麦里克斯生物科学有限公司 联合疗法
DK2790705T3 (en) 2011-12-15 2018-03-12 Novartis Ag Use of inhibitors of the activity or function of PI3K
WO2015055691A1 (en) * 2013-10-17 2015-04-23 Glaxosmithkline Intellectual Property Development Limited Pi3k inhibitor for treatment of respiratory disease

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PE20030968A1 (es) * 2002-02-28 2004-01-12 Novartis Ag Derivados de 5-feniltiazol como inhibidores de cinasas
TW200519106A (en) * 2003-05-02 2005-06-16 Novartis Ag Organic compounds
TWI334868B (en) * 2003-06-03 2010-12-21 Nippon Kayaku Kk [1,2,4] triazoro [1,5-a] pyrimidine-2-ylurea derivative and use thereof
GB0320197D0 (en) * 2003-08-28 2003-10-01 Novartis Ag Organic compounds
GB0423653D0 (en) 2004-10-25 2004-11-24 Piramed Ltd Pharmaceutical compounds

Also Published As

Publication number Publication date
CA2655568A1 (en) 2008-01-03
JP2009541387A (ja) 2009-11-26
WO2008000421A3 (en) 2008-05-22
JP4944954B2 (ja) 2012-06-06
CN101479258A (zh) 2009-07-08
AU2007264033A1 (en) 2008-01-03
BRPI0713784A2 (pt) 2012-10-30
US7799810B2 (en) 2010-09-21
KR20090024294A (ko) 2009-03-06
GB0612630D0 (en) 2006-08-02
WO2008000421A2 (en) 2008-01-03
RU2009102270A (ru) 2010-08-10
EP2035413A2 (en) 2009-03-18
US20100120865A1 (en) 2010-05-13

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