JO3121B1 - مشتقات 1 - ((5-هيتيرورلثيازول-2-يل) أمينوكاربونيل) بيروليدين-2-كربوكساميد كمثبات الفوسفاتديلينوسيتول 3-كيناس (pi3k) مفيدة في علاج الأمراض التصاعدية - Google Patents

مشتقات 1 - ((5-هيتيرورلثيازول-2-يل) أمينوكاربونيل) بيروليدين-2-كربوكساميد كمثبات الفوسفاتديلينوسيتول 3-كيناس (pi3k) مفيدة في علاج الأمراض التصاعدية

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Publication number
JO3121B1
JO3121B1 JOP/2009/0334A JOP20090334A JO3121B1 JO 3121 B1 JO3121 B1 JO 3121B1 JO P20090334 A JOP20090334 A JO P20090334A JO 3121 B1 JO3121 B1 JO 3121B1
Authority
JO
Jordan
Prior art keywords
kinase
treatment
heteroarylthiazol
pi3k
phosphatidylinositol
Prior art date
Application number
JOP/2009/0334A
Other languages
English (en)
Inventor
Imbach Patricia
Furet Pascal
Caravatti Giorgio
Alec Fairhurst Robin
Guagnano Vito
Original Assignee
Novartis Ag
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=40350060&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=JO3121(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis Ag filed Critical Novartis Ag
Application granted granted Critical
Publication of JO3121B1 publication Critical patent/JO3121B1/ar

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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
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Abstract

يتعلق الإختراع الحالي بمركب الصيغة (I) (I) أو ملح من ذلك، الذى به المستبدلات كما عرف في الوصف، إلى التراكيب وإستعمال المركبات في معالجة أمراض المحسنة ameloriated بمنع فوسفاتيديل لينوسيتول 3-كينيز.
JOP/2009/0334A 2008-09-10 2009-09-09 مشتقات 1 - ((5-هيتيرورلثيازول-2-يل) أمينوكاربونيل) بيروليدين-2-كربوكساميد كمثبات الفوسفاتديلينوسيتول 3-كيناس (pi3k) مفيدة في علاج الأمراض التصاعدية JO3121B1 (ar)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP08164104 2008-09-10
US9667408P 2008-09-12 2008-09-12

Publications (1)

Publication Number Publication Date
JO3121B1 true JO3121B1 (ar) 2017-09-20

Family

ID=40350060

Family Applications (1)

Application Number Title Priority Date Filing Date
JOP/2009/0334A JO3121B1 (ar) 2008-09-10 2009-09-09 مشتقات 1 - ((5-هيتيرورلثيازول-2-يل) أمينوكاربونيل) بيروليدين-2-كربوكساميد كمثبات الفوسفاتديلينوسيتول 3-كيناس (pi3k) مفيدة في علاج الأمراض التصاعدية

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US (4) US8227462B2 (ar)
EP (1) EP2331537B1 (ar)
JP (1) JP5486601B2 (ar)
KR (1) KR101290844B1 (ar)
CN (1) CN102149711B (ar)
AR (2) AR073369A1 (ar)
AU (1) AU2009290904B2 (ar)
BR (1) BRPI0918750B8 (ar)
CA (1) CA2734819C (ar)
CL (1) CL2011000504A1 (ar)
CO (1) CO6351738A2 (ar)
CR (1) CR20110059A (ar)
CU (1) CU24000B1 (ar)
CY (2) CY1117078T1 (ar)
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DO (1) DOP2011000070A (ar)
EA (1) EA018863B1 (ar)
EC (1) ECSP11010880A (ar)
ES (1) ES2560673T3 (ar)
FI (1) FIC20200046I1 (ar)
GE (1) GEP20135991B (ar)
HN (1) HN2011000699A (ar)
HR (1) HRP20160014T1 (ar)
HU (2) HUE025884T2 (ar)
IL (1) IL210976A (ar)
JO (1) JO3121B1 (ar)
LT (1) LTC2331537I2 (ar)
LU (1) LUC00186I2 (ar)
MA (1) MA32604B1 (ar)
ME (1) ME01284B (ar)
MX (1) MX2011002597A (ar)
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PA (1) PA8841901A1 (ar)
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SM (1) SMP201100019B (ar)
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MX336723B (es) 2008-07-11 2016-01-28 Novartis Ag Combinacion de (a) un inhibidor de fosfoinositido 3-cinasa y (b) un modulador de la ruta de ras/raf/mek.
UA104147C2 (uk) 2008-09-10 2014-01-10 Новартис Аг Похідна піролідиндикарбонової кислоти та її застосування у лікуванні проліферативних захворювань
US8293753B2 (en) * 2009-07-02 2012-10-23 Novartis Ag Substituted 2-carboxamide cycloamino ureas
AR082418A1 (es) 2010-08-02 2012-12-05 Novartis Ag Formas cristalinas de 1-(4-metil-5-[2-(2,2,2-trifluoro-1,1-dimetil-etil)-piridin-4-il]-tiazol-2-il)-amida de 2-amida del acido (s)-pirrolidin-1,2-dicarboxilico
AU2011328227B2 (en) * 2010-11-08 2015-04-09 Novartis Ag Use of 2-carboxamide cycloamino urea derivatives in the treatment of EGFR dependent diseases or diseases that have acquired resistance to agents that target EGFR family members
AU2015203865B2 (en) * 2010-11-08 2016-11-03 Novartis Ag Use of 2-carboxamide cycloamino urea derivatives in the treatment of EGFR dependent diseases or diseases that have acquired resistance to agents that target EGFR family members
UA112539C2 (uk) * 2011-03-03 2016-09-26 Новартіс Аг Спосіб одержання похідних 2-карбоксамідциклоаміносечовини
BR112013027486A2 (pt) 2011-04-25 2017-02-14 Novartis Ag combinação de um inibidor de fosfatidilinositol-3-cinase (pi3k) e um inibidor de mtor
JP2014517049A (ja) * 2011-06-21 2014-07-17 ノバルティス アーゲー （ｓ）−ピロリジン−１，２−ジカルボン酸２−アミド１−（｛４−メチル−５−［２−（２，２，２−トリフルオロ−１，１−ジメチル−エチル）−ピリジン−４−イル］−チアゾール−２−イル｝−アミドの多形
AU2012279117A1 (en) * 2011-07-01 2014-01-09 Novartis Ag Combination therapy comprising a CDK4/6 inhibitor and a PI3K inhibitor for use in the treatment of cancer
CA2846454A1 (en) * 2011-08-31 2013-05-10 Novartis Ag Synergistic combinations of pi3k- and mek-inhibitors
US20140235630A1 (en) * 2011-09-30 2014-08-21 Beth Israel Deaconess Medical Center, Inc. Compositions and methods for the treatment of proliferative diseases
KR20140078656A (ko) * 2011-10-14 2014-06-25 노파르티스 아게 증식성 질환의 치료를 위한 hsp90 억제제와 조합된 2-카르복스아미드 시클로아미노 우레아 유도체
BR112014009993A2 (pt) * 2011-10-28 2017-04-25 Novartis Ag método para o tratamento de tumores do estroma gastrointestinal
AU2012331125A1 (en) * 2011-11-02 2014-05-22 Novartis Ag 2-carboxamide cycloamino urea derivatives for use in treating VEGF - dependent diseases
US9458147B2 (en) * 2012-02-22 2016-10-04 Sanford-Burnham Medical Research Institute Sulfonamide compounds and uses as TNAP inhibitors
BR112014023530A2 (pt) * 2012-03-29 2017-07-18 Novartis Ag diagnóstico farmacêutico
US20150051252A1 (en) * 2012-03-30 2015-02-19 Xizhong Huang Compounds for use in the treatment of neuroblastoma, ewing's sarcoma or rhabdomyosarcoma
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