BR112015010512A2 - derivados de carboxamida de 3-aminociclopentano - Google Patents

derivados de carboxamida de 3-aminociclopentano

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Publication number
BR112015010512A2
BR112015010512A2 BR112015010512A BR112015010512A BR112015010512A2 BR 112015010512 A2 BR112015010512 A2 BR 112015010512A2 BR 112015010512 A BR112015010512 A BR 112015010512A BR 112015010512 A BR112015010512 A BR 112015010512A BR 112015010512 A2 BR112015010512 A2 BR 112015010512A2
Authority
BR
Brazil
Prior art keywords
aminocyclopentane
carboxamide derivatives
inflammation
cancer
diseases
Prior art date
Application number
BR112015010512A
Other languages
English (en)
Inventor
Leuthner Brigitta
Tsaklakidis Christos
Czodrowski Paul
Staehle Wolfgang
Original Assignee
Merck Patent Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh
Publication of BR112015010512A2 publication Critical patent/BR112015010512A2/pt

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    • C07C233/81—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/166—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the carbon of a carboxamide group directly attached to the aromatic ring, e.g. procainamide, procarbazine, metoclopramide, labetalol
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Abstract

resumo patente de invenção: "derivados de carboxamida de 3-aminociclopentano". a presente invenção refere-se a compostos da fórmula (i) em que r1, r4, r, x1, x2, x3, x4, q e w têm os significados indicados na reivindicação 1, que são inibidores de sintase de ácido graxo, e podem ser empregados, inter alia, para o tratamento de doenças tais como câncer, doenças cardiovasculares, lesão do sistema nervoso central e diferentes formas de inflamação.
BR112015010512A 2012-11-16 2013-10-17 derivados de carboxamida de 3-aminociclopentano BR112015010512A2 (pt)

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PCT/EP2013/003128 WO2014075754A1 (en) 2012-11-16 2013-10-17 3-aminocyclopentane carboxamide derivatives

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AU2015306643B2 (en) * 2014-08-28 2020-05-07 X-Chem, Inc. Soluble epoxide hydrolase inhibitors and uses thereof
ES2849951T3 (es) 2015-06-18 2021-08-24 89Bio Ltd Derivados de piperidina 4-bencil y 4-benzoil sustituidos
PE20180572A1 (es) 2015-06-18 2018-04-04 Cephalon Inc Derivados de piperidina 1,4-sustituidos

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RU2641913C2 (ru) 2018-01-23
WO2014075754A1 (en) 2014-05-22
JP2016504280A (ja) 2016-02-12
AR093461A1 (es) 2015-06-10
SG11201503628YA (en) 2015-06-29
US20160264517A1 (en) 2016-09-15
CN104797553B (zh) 2017-07-21
MX2015006037A (es) 2015-08-07
IL238827A0 (en) 2015-06-30
AU2013347232A8 (en) 2015-08-06
ZA201504323B (en) 2017-09-27
EP2920146B1 (en) 2016-09-28
ES2608355T3 (es) 2017-04-10
HK1212671A1 (zh) 2016-06-17
JP6316835B2 (ja) 2018-04-25
KR20150085045A (ko) 2015-07-22
CA2891484A1 (en) 2014-05-22
US9732032B2 (en) 2017-08-15
RU2015122801A (ru) 2017-01-10
AU2013347232A1 (en) 2015-07-02
CN104797553A (zh) 2015-07-22

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