BR112015000106A2 - moduladores heterocíclicos de síntes de lipídio - Google Patents

moduladores heterocíclicos de síntes de lipídio

Info

Publication number
BR112015000106A2
BR112015000106A2 BR112015000106A BR112015000106A BR112015000106A2 BR 112015000106 A2 BR112015000106 A2 BR 112015000106A2 BR 112015000106 A BR112015000106 A BR 112015000106A BR 112015000106 A BR112015000106 A BR 112015000106A BR 112015000106 A2 BR112015000106 A2 BR 112015000106A2
Authority
BR
Brazil
Prior art keywords
lipid synthesis
heterocyclic
modulators
synthesis modulators
compounds
Prior art date
Application number
BR112015000106A
Other languages
English (en)
Other versions
BR112015000106B1 (pt
Inventor
A Zaharia Cristiana
Cai Haiying
Yang Hanbiao
D Oslob Johan
W Hu Lily
Evanchik Marc
S Mcdowell Robert
Johnson Russell
Original Assignee
3 V Biosciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=48790663&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BR112015000106(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by 3 V Biosciences Inc filed Critical 3 V Biosciences Inc
Publication of BR112015000106A2 publication Critical patent/BR112015000106A2/pt
Publication of BR112015000106B1 publication Critical patent/BR112015000106B1/pt

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/04—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/10—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms
    • C07D211/16—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms with acylated ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Abstract

resumo “moduladores heterocíclicos de síntes de lipídio” moduladores heterocíclicos da síntese de lipídios são fornecidos, bem como sais farmaceuticamente aceitáveis dos mesmos; composições farmacêuticas compreendendo esses compostos; e métodos para tratar condições caracterizadas por desregulação de uma via da sintase de ácidos graxos pela administração desses compostos.
BR112015000106-8A 2012-07-03 2013-07-01 Moduladores heterocíclicos de síntese de lipídio, composição farmacêutica e uso dos referidos moduladores BR112015000106B1 (pt)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US201261667894P 2012-07-03 2012-07-03
US61/667,894 2012-07-03
US201261698511P 2012-09-07 2012-09-07
US61/698,511 2012-09-07
US201261699819P 2012-09-11 2012-09-11
US61/699,819 2012-09-11
US201361785933P 2013-03-14 2013-03-14
US61/785,933 2013-03-14
PCT/US2013/048950 WO2014008197A1 (en) 2012-07-03 2013-07-01 Heterocyclic modulators of lipid synthesis

Publications (2)

Publication Number Publication Date
BR112015000106A2 true BR112015000106A2 (pt) 2017-06-27
BR112015000106B1 BR112015000106B1 (pt) 2022-02-22

Family

ID=48790663

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112015000106-8A BR112015000106B1 (pt) 2012-07-03 2013-07-01 Moduladores heterocíclicos de síntese de lipídio, composição farmacêutica e uso dos referidos moduladores

Country Status (18)

Country Link
US (3) US9428502B2 (pt)
EP (1) EP2870150B1 (pt)
JP (1) JP6109934B2 (pt)
KR (1) KR102071095B1 (pt)
CN (1) CN104507928B (pt)
AU (2) AU2013286894B2 (pt)
BR (1) BR112015000106B1 (pt)
CA (1) CA2877999C (pt)
ES (1) ES2738823T3 (pt)
HK (1) HK1208445A1 (pt)
IL (1) IL236407A (pt)
IN (1) IN2015DN00137A (pt)
MX (1) MX364815B (pt)
NZ (2) NZ703162A (pt)
PL (1) PL2870150T3 (pt)
SG (1) SG11201500024YA (pt)
WO (1) WO2014008197A1 (pt)
ZA (1) ZA201409477B (pt)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11622968B2 (en) 2011-03-08 2023-04-11 Sagimet Biosciences Inc. Heterocyclic modulators of lipid synthesis

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US8871790B2 (en) * 2011-03-08 2014-10-28 3-V Biosciences, Inc. Heterocyclic modulators of lipid synthesis
US9624173B2 (en) * 2011-03-08 2017-04-18 3-V Biosciences, Inc. Heterocyclic modulators of lipid synthesis
SG11201500024YA (en) * 2012-07-03 2015-03-30 3 V Biosciences Inc Heterocyclic modulators of lipid synthesis
ES2841137T3 (es) * 2013-12-20 2021-07-07 Sagimet Biosciences Inc Moduladores heterocíclicos de la síntesis de lípidos y combinaciones de los mismos
AU2015204907B2 (en) 2014-01-07 2018-08-02 Sagimet Biosciences Inc. Heterocyclic modulators of lipid synthesis for use against cancer and viral infections
WO2016025816A1 (en) * 2014-08-15 2016-02-18 3-V Biosciences, Inc. Fatty acid synthase inhibitor for use in the treatment of drug resistant cancer
ES2838573T3 (es) * 2014-08-21 2021-07-02 Bristol Myers Squibb Co Derivados de benzamida ligados como inhibidores potentes de ROCK
US10967078B2 (en) 2014-12-03 2021-04-06 Janssen Pharmaceutica Nv Radiolabelled mGluR2 PET ligands
JP6758314B2 (ja) * 2015-03-19 2020-09-23 サギメット バイオサイエンシーズ インコーポレイテッド 脂質合成の複素環式調節因子
JP2018083758A (ja) * 2015-03-25 2018-05-31 旭硝子株式会社 ピラゾール誘導体の製造方法
ES2849951T3 (es) 2015-06-18 2021-08-24 89Bio Ltd Derivados de piperidina 4-bencil y 4-benzoil sustituidos
PE20180572A1 (es) 2015-06-18 2018-04-04 Cephalon Inc Derivados de piperidina 1,4-sustituidos
US11045562B2 (en) 2015-12-18 2021-06-29 Janssen Pharmaceutica Nv Radiolabelled mGluR2/3 PET ligands
US11033641B2 (en) 2015-12-18 2021-06-15 Janssen Pharmaceutica Nv Radiolabelled mGluR2/3 pet ligands
EP3399968B8 (en) 2016-01-07 2021-12-01 Xuanzhu Biopharmaceutical Co., Ltd. Selective inhibitors of clinically important mutants of the egfr tyrosine kinase
WO2017119732A1 (en) 2016-01-08 2017-07-13 Samsung Electronics Co., Ltd. Electronic device and operating method thereof
CN108884445A (zh) 2016-03-09 2018-11-23 北京智康博药肿瘤医学研究有限公司 肿瘤细胞悬浮培养物和相关方法
EP3538088A1 (en) * 2016-11-11 2019-09-18 3-V Biosciences, Inc. Heterocyclic modulators of lipid synthesis
CN107954852A (zh) * 2017-11-30 2018-04-24 贝利化学（张家港）有限公司 2，5-二卤代苯甲酸的制备方法
CN111592495A (zh) * 2020-07-06 2020-08-28 上海启讯医药科技有限公司 一种2-正丁基-4-氯-5甲酰基咪唑的制备方法
CN114988975A (zh) * 2022-06-28 2022-09-02 江苏科技大学 一种基于有机染料催化的β-三氟甲基烯胺化合物的制备方法
CN116482278B (zh) * 2023-05-06 2024-02-09 广州清瑞生物科技有限责任公司 一种用于检测阿昔洛韦的对照品的制备方法

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SG11201500024YA (en) * 2012-07-03 2015-03-30 3 V Biosciences Inc Heterocyclic modulators of lipid synthesis
ES2841137T3 (es) * 2013-12-20 2021-07-07 Sagimet Biosciences Inc Moduladores heterocíclicos de la síntesis de lípidos y combinaciones de los mismos
AU2015204907B2 (en) * 2014-01-07 2018-08-02 Sagimet Biosciences Inc. Heterocyclic modulators of lipid synthesis for use against cancer and viral infections
WO2016025816A1 (en) * 2014-08-15 2016-02-18 3-V Biosciences, Inc. Fatty acid synthase inhibitor for use in the treatment of drug resistant cancer
JP6758314B2 (ja) * 2015-03-19 2020-09-23 サギメット バイオサイエンシーズ インコーポレイテッド 脂質合成の複素環式調節因子

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11622968B2 (en) 2011-03-08 2023-04-11 Sagimet Biosciences Inc. Heterocyclic modulators of lipid synthesis

Also Published As

Publication number Publication date
MX2015000151A (es) 2015-04-10
US20160311803A1 (en) 2016-10-27
SG11201500024YA (en) 2015-03-30
WO2014008197A1 (en) 2014-01-09
EP2870150B1 (en) 2019-06-19
US20180222892A1 (en) 2018-08-09
IL236407A0 (en) 2015-02-26
US10053450B2 (en) 2018-08-21
CN104507928B (zh) 2016-09-28
ZA201409477B (en) 2021-05-26
KR20150032571A (ko) 2015-03-26
KR102071095B1 (ko) 2020-01-29
CA2877999C (en) 2021-02-23
RU2015103345A (ru) 2016-08-20
US20150210688A1 (en) 2015-07-30
CN104507928A (zh) 2015-04-08
MX364815B (es) 2019-05-08
HK1208445A1 (en) 2016-03-04
CA2877999A1 (en) 2014-01-09
JP6109934B2 (ja) 2017-04-05
IN2015DN00137A (pt) 2015-06-12
AU2017265027A1 (en) 2017-12-14
AU2013286894B2 (en) 2017-12-07
ES2738823T3 (es) 2020-01-27
US9428502B2 (en) 2016-08-30
AU2013286894A1 (en) 2015-01-22
JP2015522036A (ja) 2015-08-03
IL236407A (en) 2017-10-31
PL2870150T3 (pl) 2019-12-31
EP2870150A1 (en) 2015-05-13
BR112015000106B1 (pt) 2022-02-22
NZ703162A (en) 2017-05-26
US10118913B2 (en) 2018-11-06
NZ729443A (en) 2017-11-24

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B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
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