CU20130082A7 - 1,2 oxazol-8-azabiciclo[3,2,1]octano 8 il como moduladores de fxr - Google Patents

1,2 oxazol-8-azabiciclo[3,2,1]octano 8 il como moduladores de fxr

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Publication number
CU20130082A7
CU20130082A7 CUP2013000082A CU20130082A CU20130082A7 CU 20130082 A7 CU20130082 A7 CU 20130082A7 CU P2013000082 A CUP2013000082 A CU P2013000082A CU 20130082 A CU20130082 A CU 20130082A CU 20130082 A7 CU20130082 A7 CU 20130082A7
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CU
Cuba
Prior art keywords
azabiciclo
octano
oxazol
fxr modulators
fxr
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CUP2013000082A
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English (en)
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CU24152B1 (es
Inventor
David C Tully
Paul Vincent Rucker
Phillip B Alper
Daniel Mutnick
Donatella Chianelli
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Irm Llc
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Publication date
Application filed by Irm Llc filed Critical Irm Llc
Publication of CU20130082A7 publication Critical patent/CU20130082A7/es
Publication of CU24152B1 publication Critical patent/CU24152B1/es

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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
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    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
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Abstract

La presente invención se refiere a compuestos de la fórmula (I), un estereisómero, enantiómero, una sal farmacéuticamente aceptable o un conjugado de aminoácidos del mismo; en donde las variables son como se definen en la presente, y sus composiciones farmacéuticas, que son útiles como moduladores de la actividad de los receptores X Fernesoides ( FXR).
CU20130082A 2010-12-20 2011-10-30 1,2 oxazol-8-azabiciclo[3,2,1]octano 8 il como moduladores de fxr CU24152B1 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201061425189P 2010-12-20 2010-12-20
US201161554297P 2011-11-01 2011-11-01
PCT/US2011/062724 WO2012087519A1 (en) 2010-12-20 2011-11-30 Compositions and methods for modulating fxr

Publications (2)

Publication Number Publication Date
CU20130082A7 true CU20130082A7 (es) 2013-10-29
CU24152B1 CU24152B1 (es) 2016-02-29

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US (2) US9150568B2 (es)
EP (1) EP2655370B1 (es)
JP (1) JP5740483B2 (es)
KR (1) KR101626046B1 (es)
CN (1) CN103443099B (es)
AP (1) AP3414A (es)
AR (1) AR084425A1 (es)
AU (1) AU2011345233B2 (es)
BR (1) BR112013015452B1 (es)
CA (1) CA2819825C (es)
CL (1) CL2013001677A1 (es)
CO (1) CO6801729A2 (es)
CR (1) CR20130307A (es)
CU (1) CU24152B1 (es)
CY (1) CY1119530T1 (es)
DK (1) DK2655370T3 (es)
EA (1) EA025569B1 (es)
ES (1) ES2645728T3 (es)
GT (1) GT201300159A (es)
HR (1) HRP20171615T1 (es)
HU (1) HUE034150T2 (es)
IL (1) IL226853A (es)
JO (1) JO3297B1 (es)
LT (1) LT2655370T (es)
MA (1) MA34767B1 (es)
MX (1) MX338845B (es)
MY (1) MY163216A (es)
NZ (1) NZ613234A (es)
PE (1) PE20140207A1 (es)
PL (1) PL2655370T3 (es)
PT (1) PT2655370T (es)
RS (1) RS56335B1 (es)
SG (1) SG191046A1 (es)
SI (1) SI2655370T1 (es)
TW (1) TWI427078B (es)
UY (1) UY33815A (es)
WO (1) WO2012087519A1 (es)
ZA (1) ZA201304044B (es)

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