CR20120237A - Derivados del ácido carbamoil-metil-amino-acético sustituido como inhibidores de nep novedosos - Google Patents

Derivados del ácido carbamoil-metil-amino-acético sustituido como inhibidores de nep novedosos

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Publication number
CR20120237A
CR20120237A CR20120237A CR20120237A CR20120237A CR 20120237 A CR20120237 A CR 20120237A CR 20120237 A CR20120237 A CR 20120237A CR 20120237 A CR20120237 A CR 20120237A CR 20120237 A CR20120237 A CR 20120237A
Authority
CR
Costa Rica
Prior art keywords
novedous
carbamoil
derivatives
amino
methyl
Prior art date
Application number
CR20120237A
Other languages
English (en)
Inventor
Yuki Iwaki
Toshio Kawanami
Gary Michael Ksander
Muneto Mogi
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of CR20120237A publication Critical patent/CR20120237A/es

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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/38—Nitrogen atoms
    • C07D231/40—Acylated on said nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D257/04—Five-membered rings
    • C07D257/06—Five-membered rings with nitrogen atoms directly attached to the ring carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
    • C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
    • C07D261/10—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D261/14—Nitrogen atoms

Abstract

La presente invención proporciona un compuesto de la fórmula o una sal farmacéuticamente aceptable del mismo, en donde R1, R2, R3, R4, R6, A1, A2, X1, s y m se definen en la presente. La invención también se refiere a un método para la elaboración de los compuestos de la invención, y a sus usos terapéuticos. La presente invención proporciona además una combinación de agentes farmacológicamente activos y una composición farmacéutica.
CR20120237A 2009-11-20 2012-05-08 Derivados del ácido carbamoil-metil-amino-acético sustituido como inhibidores de nep novedosos CR20120237A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US26313709P 2009-11-20 2009-11-20
US35991410P 2010-06-30 2010-06-30

Publications (1)

Publication Number Publication Date
CR20120237A true CR20120237A (es) 2012-06-07

Family

ID=43431937

Family Applications (1)

Application Number Title Priority Date Filing Date
CR20120237A CR20120237A (es) 2009-11-20 2012-05-08 Derivados del ácido carbamoil-metil-amino-acético sustituido como inhibidores de nep novedosos

Country Status (37)

Country Link
US (4) US8222286B2 (es)
EP (2) EP2735561B1 (es)
JP (2) JP5543609B2 (es)
KR (1) KR101460421B1 (es)
CN (1) CN102666493B (es)
AR (1) AR079061A1 (es)
AU (1) AU2010320930B2 (es)
BR (1) BR112012011977A2 (es)
CA (1) CA2780150C (es)
CL (1) CL2012001298A1 (es)
CO (1) CO6540001A2 (es)
CR (1) CR20120237A (es)
DK (1) DK2501683T3 (es)
EA (1) EA021479B1 (es)
EC (1) ECSP12011978A (es)
ES (2) ES2481890T3 (es)
GT (1) GT201200153A (es)
HK (1) HK1170475A1 (es)
HN (1) HN2012001037A (es)
HR (1) HRP20140691T1 (es)
IL (1) IL219314A0 (es)
IN (1) IN2012DN02465A (es)
JO (1) JO2967B1 (es)
MA (1) MA33886B1 (es)
MX (1) MX2012005813A (es)
MY (1) MY158299A (es)
NZ (1) NZ599136A (es)
PE (1) PE20121311A1 (es)
PL (1) PL2501683T3 (es)
PT (1) PT2501683E (es)
RS (1) RS53422B (es)
SI (1) SI2501683T1 (es)
TN (1) TN2012000125A1 (es)
TW (1) TWI481598B (es)
UY (1) UY33044A (es)
WO (1) WO2011061271A1 (es)
ZA (1) ZA201202018B (es)

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JO2967B1 (en) * 2009-11-20 2016-03-15 نوفارتس ايه جي Acetic acid derivatives of carbamoyl methyl amino are substituted as new NEP inhibitors
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UY35670A (es) 2013-07-25 2015-02-27 Novartis Ag Polipéptidos cíclicos para el tratamiento de insuficiencia cardíaca
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ES2718239T3 (es) 2014-01-30 2019-06-28 Theravance Biopharma R&D Ip Llc Inhibidores de neprilisina
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KR101460421B1 (ko) 2014-11-10
SI2501683T1 (sl) 2014-07-31
DK2501683T3 (da) 2014-06-30
EP2735561A1 (en) 2014-05-28
UY33044A (es) 2011-06-30
AU2010320930B2 (en) 2014-05-15
JO2967B1 (en) 2016-03-15

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