BR112013028197A2 - compostos de benzofurano-piperidina - Google Patents
compostos de benzofurano-piperidinaInfo
- Publication number
- BR112013028197A2 BR112013028197A2 BR112013028197A BR112013028197A BR112013028197A2 BR 112013028197 A2 BR112013028197 A2 BR 112013028197A2 BR 112013028197 A BR112013028197 A BR 112013028197A BR 112013028197 A BR112013028197 A BR 112013028197A BR 112013028197 A2 BR112013028197 A2 BR 112013028197A2
- Authority
- BR
- Brazil
- Prior art keywords
- benzofuran
- piperidine compounds
- formula
- compounds
- relates
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
- A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/4525—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with oxygen as a ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/10—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Psychiatry (AREA)
- Addiction (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
resumo patente de invenção: "compostos de benzofurano-piperidina". a presente invenção refere-se a novos moduladores duplos seletivos dos receptores 5-ht2a e d3 de fórmula (i) (i) em que r1, r2, r3, n, e y são como descrito neste relatório, assim como a sais e ésteres farmaceuticamente aceitáveis dos mesmos. além disso, a presente invenção refere-se à produção dos compostos de fórmula (i), a composições farmacêuticas compreendendo os mesmos e ao uso dos mesmos como medicamentos.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP11164716 | 2011-05-04 | ||
PCT/EP2012/057965 WO2012150231A1 (en) | 2011-05-04 | 2012-05-02 | Novel benzofurane-piperidine compounds |
Publications (1)
Publication Number | Publication Date |
---|---|
BR112013028197A2 true BR112013028197A2 (pt) | 2017-01-17 |
Family
ID=46044685
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112013028197A BR112013028197A2 (pt) | 2011-05-04 | 2012-05-02 | compostos de benzofurano-piperidina |
Country Status (10)
Country | Link |
---|---|
US (1) | US8921397B2 (pt) |
EP (1) | EP2704707A1 (pt) |
JP (1) | JP2014513109A (pt) |
KR (1) | KR20140037106A (pt) |
CN (1) | CN103501780B (pt) |
BR (1) | BR112013028197A2 (pt) |
CA (1) | CA2832302A1 (pt) |
MX (1) | MX2013011728A (pt) |
RU (1) | RU2013152142A (pt) |
WO (1) | WO2012150231A1 (pt) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP3495363B1 (en) | 2016-07-28 | 2023-08-23 | Shionogi & Co., Ltd | Nitrogen-containing condensed ring compounds having dopamine d3 receptor antagonistic effect |
CN111801330B (zh) | 2018-01-26 | 2024-04-05 | 盐野义制药株式会社 | 具有多巴胺d3受体拮抗作用的稠环化合物 |
WO2019146740A1 (ja) * | 2018-01-26 | 2019-08-01 | 塩野義製薬株式会社 | ドーパミンd3受容体拮抗作用を有する環式化合物 |
Family Cites Families (25)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5776963A (en) | 1989-05-19 | 1998-07-07 | Hoechst Marion Roussel, Inc. | 3-(heteroaryl)-1- (2,3-dihydro-1h-isoindol-2-yl)alkyl!pyrrolidines and 3-(heteroaryl)-1- (2,3-dihydro-1h-indol-1-yl)alkyl!pyrrolidines and related compounds and their therapeutic untility |
DK60693D0 (da) | 1993-05-26 | 1993-05-26 | Novo Nordisk As | Kemiske forbindelser, deres fremstilling og anvendelse |
DE69812980T2 (de) | 1997-02-07 | 2003-11-13 | Aventis Pharma Inc | (4-piperidinyl)-1h-2-benzopyran derivate verwendbar als antipsychotische mittel |
TW530054B (en) | 1997-09-24 | 2003-05-01 | Duphar Int Res | New piperazine and piperidine compounds |
ES2131020B1 (es) | 1997-10-13 | 2000-03-01 | Lacer Sa | Derivados de benzofurano, dihidrobenzofunaro, dihidrobenzopirano y benzopirano como agentes antidepresivos. |
WO1999040067A2 (en) | 1998-02-09 | 1999-08-12 | Duphar International Research B.V. | Benzisoxazole derivatives having d4-antagonistic activity |
GB0117577D0 (en) * | 2001-02-16 | 2001-09-12 | Aventis Pharm Prod Inc | Novel heterocyclic substituted carbonyl derivatives and their use as dopamine D receptor ligands |
JP4497815B2 (ja) | 2001-02-16 | 2010-07-07 | アベンティス・ファーマスーティカルズ・インコーポレイテツド | 新規な複素環式アミド誘導体およびドーパミンd3受容体リガンドとしてのその使用 |
ATE412638T1 (de) | 2001-02-16 | 2008-11-15 | Aventis Pharma Inc | Heterocyclische substituierte carbonyl derivate und ihre verwendung als dopamin d3 rezeptor liganden |
GB0117950D0 (en) | 2001-02-16 | 2001-09-19 | Aventis Pharma Inc | Novel heterocyclic urea derivatives andd their use as dopamine D3 receptor ligands |
JP2006503106A (ja) | 2002-09-17 | 2006-01-26 | ワーナー−ランバート・カンパニー、リミテッド、ライアビリティ、カンパニー | 統合失調症を処置するためのヘテロ環式置換ピペラジン |
CA2525866A1 (en) | 2003-05-16 | 2004-11-25 | Pfizer Products Inc. | Treatment of psychotic and depressive disorders |
BRPI0410419A (pt) | 2003-05-16 | 2006-05-30 | Pfizer Prod Inc | tratamento para a ansiedade com ziprasidona |
HUP0500170A3 (en) | 2005-02-03 | 2007-11-28 | Richter Gedeon Nyrt | Piperazine derivatives, process for producing them and pharmaceutical compositions containing them |
BRPI0707960A2 (pt) | 2006-02-17 | 2011-05-10 | Hoffmann La Roche | derivados de benzoil-piperidina como moduladores de 5ht2/d3, medicamento e uso dos mesmos |
EP1870405A1 (en) | 2006-06-22 | 2007-12-26 | Bioprojet | Carbonylated (Aza)cyclohexanes as dopamine D3 receptor ligands |
AU2007316249B2 (en) | 2006-10-31 | 2013-01-24 | F. Hoffmann-La Roche Ag | Ether derivatives dual modulators of the 5-HT2A and D3 receptors |
AU2008280187B2 (en) | 2007-07-26 | 2013-05-16 | F. Hoffmann-La Roche Ag | Dual modulators of 5-HT2A and D3 receptors |
CA2694057A1 (en) | 2007-08-09 | 2009-02-12 | F. Hoffmann-La Roche Ag | Benzoyl-piperidine derivatives as dual modulators of the 5-ht2a and d3 receptors |
AU2009294695B2 (en) | 2008-09-22 | 2012-09-13 | F. Hoffmann-La Roche Ag | Piperazine D3 and 5-HT2a receptor modulators |
JP2012502948A (ja) | 2008-09-23 | 2012-02-02 | エフ.ホフマン−ラ ロシュ アーゲー | ドーパミンd3受容体の調節剤として有用なイソオキサゾロ[4,5]ピリジン−3−イル−ピペラジン誘導体 |
JP2012502947A (ja) | 2008-09-23 | 2012-02-02 | エフ.ホフマン−ラ ロシュ アーゲー | ドーパミンD3受容体の調節剤として有用なベンゾ[d]イソオキサゾール−3−イル−ピペラジン誘導体 |
WO2010034648A1 (en) | 2008-09-23 | 2010-04-01 | F. Hoffmann-La Roche Ag | Pyridinylpiperazin derivatives useful as modulators of dopamine d3 receptors |
US8586579B2 (en) | 2010-06-21 | 2013-11-19 | Hoffmann-La Roche Inc. | Anellated pyridine compounds |
US8470828B2 (en) | 2010-07-06 | 2013-06-25 | Hoffmann-La Roche Inc. | Anellated pyridine compounds |
-
2012
- 2012-04-27 US US13/457,532 patent/US8921397B2/en not_active Expired - Fee Related
- 2012-05-02 EP EP12719356.3A patent/EP2704707A1/en not_active Withdrawn
- 2012-05-02 CA CA2832302A patent/CA2832302A1/en not_active Abandoned
- 2012-05-02 RU RU2013152142/04A patent/RU2013152142A/ru not_active Application Discontinuation
- 2012-05-02 BR BR112013028197A patent/BR112013028197A2/pt not_active IP Right Cessation
- 2012-05-02 CN CN201280021055.XA patent/CN103501780B/zh not_active Expired - Fee Related
- 2012-05-02 JP JP2014508769A patent/JP2014513109A/ja active Pending
- 2012-05-02 WO PCT/EP2012/057965 patent/WO2012150231A1/en active Application Filing
- 2012-05-02 MX MX2013011728A patent/MX2013011728A/es unknown
- 2012-05-02 KR KR1020137032202A patent/KR20140037106A/ko not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
CN103501780A (zh) | 2014-01-08 |
MX2013011728A (es) | 2013-11-01 |
CN103501780B (zh) | 2015-11-25 |
WO2012150231A1 (en) | 2012-11-08 |
US8921397B2 (en) | 2014-12-30 |
EP2704707A1 (en) | 2014-03-12 |
US20120283254A1 (en) | 2012-11-08 |
RU2013152142A (ru) | 2015-06-10 |
CA2832302A1 (en) | 2012-11-08 |
KR20140037106A (ko) | 2014-03-26 |
JP2014513109A (ja) | 2014-05-29 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B08F | Application fees: application dismissed [chapter 8.6 patent gazette] | ||
B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |