PL2501683T3 - Podstawione pochodne kwasu karbamoilometyloaminooctowego jako nowe inhibitory NEP - Google Patents
Podstawione pochodne kwasu karbamoilometyloaminooctowego jako nowe inhibitory NEPInfo
- Publication number
- PL2501683T3 PL2501683T3 PL10781884T PL10781884T PL2501683T3 PL 2501683 T3 PL2501683 T3 PL 2501683T3 PL 10781884 T PL10781884 T PL 10781884T PL 10781884 T PL10781884 T PL 10781884T PL 2501683 T3 PL2501683 T3 PL 2501683T3
- Authority
- PL
- Poland
- Prior art keywords
- carbamoylmethylamino
- substituted
- acetic acid
- acid derivatives
- nep inhibitors
- Prior art date
Links
- AWEZYTUWDZADKR-UHFFFAOYSA-N 2-[(2-amino-2-oxoethyl)azaniumyl]acetate Chemical class NC(=O)CNCC(O)=O AWEZYTUWDZADKR-UHFFFAOYSA-N 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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- A—HUMAN NECESSITIES
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D231/38—Nitrogen atoms
- C07D231/40—Acylated on said nitrogen atom
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
- C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D257/04—Five-membered rings
- C07D257/06—Five-membered rings with nitrogen atoms directly attached to the ring carbon atom
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
- C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
- C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
- C07D261/10—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D261/14—Nitrogen atoms
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- Endocrinology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Cardiology (AREA)
- Obesity (AREA)
- Epidemiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pain & Pain Management (AREA)
- Oncology (AREA)
- Psychiatry (AREA)
- Reproductive Health (AREA)
- Ophthalmology & Optometry (AREA)
- Pulmonology (AREA)
- Dermatology (AREA)
- Gynecology & Obstetrics (AREA)
- Rheumatology (AREA)
- Urology & Nephrology (AREA)
- Communicable Diseases (AREA)
- Nutrition Science (AREA)
- Hospice & Palliative Care (AREA)
- Pregnancy & Childbirth (AREA)
- Emergency Medicine (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US26313709P | 2009-11-20 | 2009-11-20 | |
| US35991410P | 2010-06-30 | 2010-06-30 | |
| EP10781884.1A EP2501683B1 (en) | 2009-11-20 | 2010-11-18 | Substituted carbamoylmethylamino acetic acid derivatives as novel nep inhibitors |
| PCT/EP2010/067781 WO2011061271A1 (en) | 2009-11-20 | 2010-11-18 | Substituted carbamoylmethylamino acetic acid derivatives as novel nep inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL2501683T3 true PL2501683T3 (pl) | 2014-09-30 |
Family
ID=43431937
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL10781884T PL2501683T3 (pl) | 2009-11-20 | 2010-11-18 | Podstawione pochodne kwasu karbamoilometyloaminooctowego jako nowe inhibitory NEP |
Country Status (37)
| Country | Link |
|---|---|
| US (4) | US8222286B2 (pl) |
| EP (2) | EP2501683B1 (pl) |
| JP (2) | JP5543609B2 (pl) |
| KR (1) | KR101460421B1 (pl) |
| CN (1) | CN102666493B (pl) |
| AR (1) | AR079061A1 (pl) |
| AU (1) | AU2010320930B2 (pl) |
| BR (1) | BR112012011977A2 (pl) |
| CA (1) | CA2780150C (pl) |
| CL (1) | CL2012001298A1 (pl) |
| CO (1) | CO6540001A2 (pl) |
| CR (1) | CR20120237A (pl) |
| DK (1) | DK2501683T3 (pl) |
| EA (1) | EA021479B1 (pl) |
| EC (1) | ECSP12011978A (pl) |
| ES (2) | ES2598961T3 (pl) |
| GT (1) | GT201200153A (pl) |
| HN (1) | HN2012001037A (pl) |
| HR (1) | HRP20140691T1 (pl) |
| IL (1) | IL219314A0 (pl) |
| IN (1) | IN2012DN02465A (pl) |
| JO (1) | JO2967B1 (pl) |
| MA (1) | MA33886B1 (pl) |
| MX (1) | MX2012005813A (pl) |
| MY (1) | MY158299A (pl) |
| NZ (1) | NZ599136A (pl) |
| PE (1) | PE20121311A1 (pl) |
| PH (1) | PH12012500519A1 (pl) |
| PL (1) | PL2501683T3 (pl) |
| PT (1) | PT2501683E (pl) |
| RS (1) | RS53422B (pl) |
| SI (1) | SI2501683T1 (pl) |
| TN (1) | TN2012000125A1 (pl) |
| TW (1) | TWI481598B (pl) |
| UY (1) | UY33044A (pl) |
| WO (1) | WO2011061271A1 (pl) |
| ZA (1) | ZA201202018B (pl) |
Families Citing this family (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2602902T3 (es) | 2009-05-28 | 2017-02-22 | Novartis Ag | Derivados aminopropiónicos sustituidos como inhibidores de neprilisina |
| CN102448928B (zh) * | 2009-05-28 | 2014-10-01 | 诺华股份有限公司 | 作为中性溶酶(neprilysin)抑制剂的取代的氨基丁酸衍生物 |
| JO2967B1 (en) * | 2009-11-20 | 2016-03-15 | نوفارتس ايه جي | Acetic acid derivatives of carbamoyl methyl amino are substituted as new NEP inhibitors |
| US8993631B2 (en) | 2010-11-16 | 2015-03-31 | Novartis Ag | Method of treating contrast-induced nephropathy |
| HRP20151115T1 (en) | 2010-12-15 | 2015-11-20 | Theravance Biopharma R&D Ip, Llc | Neprilysin inhibitors |
| CA2819153A1 (en) | 2010-12-15 | 2012-06-21 | Theravance, Inc. | Neprilysin inhibitors |
| KR101854874B1 (ko) | 2011-02-17 | 2018-05-04 | 세라밴스 바이오파마 알앤디 아이피, 엘엘씨 | 네프릴리신 억제제로서 치환된 아미노부티릭 유도체 |
| US8449890B2 (en) | 2011-02-17 | 2013-05-28 | Theravance, Inc. | Neprilysin inhibitors |
| EP2714660B1 (en) | 2011-05-31 | 2018-09-26 | Theravance Biopharma R&D IP, LLC | Neprilysin inhibitors |
| CN103596928B (zh) | 2011-05-31 | 2017-02-15 | 施万生物制药研发Ip有限责任公司 | 脑啡肽酶抑制剂 |
| WO2012166389A1 (en) | 2011-05-31 | 2012-12-06 | Theravance, Inc. | Neprilysin inhibitors |
| TWI560172B (en) | 2011-11-02 | 2016-12-01 | Theravance Biopharma R&D Ip Llc | Neprilysin inhibitors |
| ES2609810T3 (es) | 2012-05-31 | 2017-04-24 | Theravance Biopharma R&D Ip, Llc | Inhibidores de neprilisina donadores de óxido nítrico |
| CN104470521B (zh) | 2012-06-08 | 2017-04-12 | 施万生物制药研发Ip有限责任公司 | 脑啡肽酶抑制剂 |
| PT2864292T (pt) | 2012-06-08 | 2017-07-10 | Theravance Biopharma R&D Ip Llc | Inibidores de neprisilina |
| KR102104954B1 (ko) | 2012-08-08 | 2020-04-27 | 세라밴스 바이오파마 알앤디 아이피, 엘엘씨 | 네프릴리신 억제제 |
| UY35144A (es) | 2012-11-20 | 2014-06-30 | Novartis Ag | Miméticos lineales sintéticos de apelina para el tratamiento de insuficiencia cardiaca |
| TR201808541T4 (tr) | 2013-02-14 | 2018-07-23 | Novartis Ag | Nep (nötr endopeptidaz) inhibitörleri olarak ikame edilmiş bisfenil butanoik fosfonik asit türevleri. |
| EP2956445A1 (en) | 2013-02-14 | 2015-12-23 | Novartis AG | Substituted bisphenyl butanoic acid derivatives as nep inhibitors with improved in vivo efficacy |
| WO2014138053A1 (en) | 2013-03-05 | 2014-09-12 | Theravance Biopharma R&D Ip, Llc | Neprilysin inhibitors |
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| CN102448928B (zh) | 2009-05-28 | 2014-10-01 | 诺华股份有限公司 | 作为中性溶酶(neprilysin)抑制剂的取代的氨基丁酸衍生物 |
| ES2602902T3 (es) | 2009-05-28 | 2017-02-22 | Novartis Ag | Derivados aminopropiónicos sustituidos como inhibidores de neprilisina |
| BR112012006406A2 (pt) | 2009-09-23 | 2016-04-12 | Novartis Ag | "processo para a fabrição de n-acilbifenil alanina" |
| JO2967B1 (en) | 2009-11-20 | 2016-03-15 | نوفارتس ايه جي | Acetic acid derivatives of carbamoyl methyl amino are substituted as new NEP inhibitors |
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