CL2012001298A1 - Compuestos derivados del acido carbomoil-metilamino acetico sustituido, inhibidores de nep; composicion farmaceutica; combinacion farmaceutica; y uso para el tratamiento de hipertension arterial, hipertension pulmonar, insuficiencia cardiaca, entre otras. - Google Patents

Compuestos derivados del acido carbomoil-metilamino acetico sustituido, inhibidores de nep; composicion farmaceutica; combinacion farmaceutica; y uso para el tratamiento de hipertension arterial, hipertension pulmonar, insuficiencia cardiaca, entre otras.

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Publication number
CL2012001298A1
CL2012001298A1 CL2012001298A CL2012001298A CL2012001298A1 CL 2012001298 A1 CL2012001298 A1 CL 2012001298A1 CL 2012001298 A CL2012001298 A CL 2012001298A CL 2012001298 A CL2012001298 A CL 2012001298A CL 2012001298 A1 CL2012001298 A1 CL 2012001298A1
Authority
CL
Chile
Prior art keywords
treatment
acetic acid
heart failure
hypertension
pharmaceutical composition
Prior art date
Application number
CL2012001298A
Other languages
English (en)
Inventor
Gary Michael Ksander
Yuki Iwaki
Toshio Kawanami
Muneto Mogi
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of CL2012001298A1 publication Critical patent/CL2012001298A1/es

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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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    • C07D231/38—Nitrogen atoms
    • C07D231/40—Acylated on said nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
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    • C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
    • C07D261/10—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D261/14—Nitrogen atoms

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  • Health & Medical Sciences (AREA)
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  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
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  • Pharmacology & Pharmacy (AREA)
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  • Diabetes (AREA)
  • Hematology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Endocrinology (AREA)
  • Neurology (AREA)
  • Cardiology (AREA)
  • Obesity (AREA)
  • Epidemiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Oncology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Psychiatry (AREA)
  • Reproductive Health (AREA)
  • Pulmonology (AREA)
  • Hospice & Palliative Care (AREA)
  • Urology & Nephrology (AREA)
  • Nutrition Science (AREA)
  • Rheumatology (AREA)
  • Communicable Diseases (AREA)
  • Gynecology & Obstetrics (AREA)
  • Dermatology (AREA)
  • Pregnancy & Childbirth (AREA)
  • Vascular Medicine (AREA)

Abstract

Compuestos derivados del ácido carbomoil metilamino acético sustituido, inhibidores de NEP; composición farmacéutica que comprende dichos compuestos; combinación farmacéutica; y su uso para el tratamiento de hipertensión arterial, hipertensión pulmonar, insuficiencia cardíaca, entre otros.
CL2012001298A 2009-11-20 2012-05-18 Compuestos derivados del acido carbomoil-metilamino acetico sustituido, inhibidores de nep; composicion farmaceutica; combinacion farmaceutica; y uso para el tratamiento de hipertension arterial, hipertension pulmonar, insuficiencia cardiaca, entre otras. CL2012001298A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US26313709P 2009-11-20 2009-11-20
US35991410P 2010-06-30 2010-06-30

Publications (1)

Publication Number Publication Date
CL2012001298A1 true CL2012001298A1 (es) 2012-10-05

Family

ID=43431937

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2012001298A CL2012001298A1 (es) 2009-11-20 2012-05-18 Compuestos derivados del acido carbomoil-metilamino acetico sustituido, inhibidores de nep; composicion farmaceutica; combinacion farmaceutica; y uso para el tratamiento de hipertension arterial, hipertension pulmonar, insuficiencia cardiaca, entre otras.

Country Status (37)

Country Link
US (4) US8222286B2 (es)
EP (2) EP2501683B1 (es)
JP (2) JP5543609B2 (es)
KR (1) KR101460421B1 (es)
CN (1) CN102666493B (es)
AR (1) AR079061A1 (es)
AU (1) AU2010320930B2 (es)
BR (1) BR112012011977A2 (es)
CA (1) CA2780150C (es)
CL (1) CL2012001298A1 (es)
CO (1) CO6540001A2 (es)
CR (1) CR20120237A (es)
DK (1) DK2501683T3 (es)
EA (1) EA021479B1 (es)
EC (1) ECSP12011978A (es)
ES (2) ES2481890T3 (es)
GT (1) GT201200153A (es)
HK (1) HK1170475A1 (es)
HN (1) HN2012001037A (es)
HR (1) HRP20140691T1 (es)
IL (1) IL219314A0 (es)
IN (1) IN2012DN02465A (es)
JO (1) JO2967B1 (es)
MA (1) MA33886B1 (es)
MX (1) MX2012005813A (es)
MY (1) MY158299A (es)
NZ (1) NZ599136A (es)
PE (1) PE20121311A1 (es)
PL (1) PL2501683T3 (es)
PT (1) PT2501683E (es)
RS (1) RS53422B (es)
SI (1) SI2501683T1 (es)
TN (1) TN2012000125A1 (es)
TW (1) TWI481598B (es)
UY (1) UY33044A (es)
WO (1) WO2011061271A1 (es)
ZA (1) ZA201202018B (es)

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AU2010251967B9 (en) 2009-05-28 2014-04-03 Novartis Ag Substituted aminopropionic derivatives as neprilysin inhibitors
JO2967B1 (en) * 2009-11-20 2016-03-15 نوفارتس ايه جي Acetic acid derivatives of carbamoyl methyl amino are substituted as new NEP inhibitors
US8993631B2 (en) 2010-11-16 2015-03-31 Novartis Ag Method of treating contrast-induced nephropathy
MX354476B (es) 2010-12-15 2018-03-07 Theravance Inc Inhibidores de neprilisina.
SI2651896T1 (sl) 2010-12-15 2015-11-30 Theravance Biopharma R&D Ip, Llc Inhibitorji neprilizina
MX342212B (es) 2011-02-17 2016-09-20 Theravance Inc Inhibidores de neprilisina.
US8449890B2 (en) 2011-02-17 2013-05-28 Theravance, Inc. Neprilysin inhibitors
EP2714648B1 (en) 2011-05-31 2017-08-16 Theravance Biopharma R&D IP, LLC Neprilysin inhibitors
CA2835216A1 (en) 2011-05-31 2012-12-06 Theravance, Inc. Neprilysin inhibitors
WO2012166390A1 (en) 2011-05-31 2012-12-06 Theravance, Inc. Neprilysin inhibitors
TWI560172B (en) 2011-11-02 2016-12-01 Theravance Biopharma R&D Ip Llc Neprilysin inhibitors
CN104350052B (zh) 2012-05-31 2017-05-31 施万生物制药研发Ip有限责任公司 一氧化氮供体脑啡肽酶抑制剂
US8871792B2 (en) 2012-06-08 2014-10-28 Theravance Biopharma R&D Ip, Llc Neprilysin inhibitors
ME02698B (me) 2012-06-08 2017-10-20 Theravance Biopharma R&D Ip Llc Inhibitori neprilizina
CN104520277B (zh) 2012-08-08 2018-01-19 施万生物制药研发Ip有限责任公司 脑啡肽酶抑制剂
UY35144A (es) 2012-11-20 2014-06-30 Novartis Ag Miméticos lineales sintéticos de apelina para el tratamiento de insuficiencia cardiaca
CA2900226A1 (en) 2013-02-14 2014-08-21 Novartis Ag Substituted bisphenyl butanoic acid derivatives as nep inhibitors with improved in vivo efficacy
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