ES2100291T3 - Cristales de n-(trans-4-isopropilciclohexilcarbonil)-d-fenilalanina y metodos para prepararlos. - Google Patents

Cristales de n-(trans-4-isopropilciclohexilcarbonil)-d-fenilalanina y metodos para prepararlos.

Info

Publication number
ES2100291T3
ES2100291T3 ES92306895T ES92306895T ES2100291T3 ES 2100291 T3 ES2100291 T3 ES 2100291T3 ES 92306895 T ES92306895 T ES 92306895T ES 92306895 T ES92306895 T ES 92306895T ES 2100291 T3 ES2100291 T3 ES 2100291T3
Authority
ES
Spain
Prior art keywords
crystals
phenylalanine
trans
solvent
compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES92306895T
Other languages
English (en)
Inventor
Michito Sumikawa
Yoshihito Koguchi
Takao Ohgane
Yasuo Irie
Satoji Takahashi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ajinomoto Co Inc
Original Assignee
Ajinomoto Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27169694&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES2100291(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Ajinomoto Co Inc filed Critical Ajinomoto Co Inc
Application granted granted Critical
Publication of ES2100291T3 publication Critical patent/ES2100291T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/22—Separation; Purification; Stabilisation; Use of additives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/57—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C07C233/63—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of rings other than six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups

Abstract

SE PUEDEN PRODUCIR CRISTALES ESTABLES DE N-(TRANS-4-ISOPROPILCICLOEXILCARBONIL)-D-FENILALANINA TRATANDO ESTE COMPUESTO CON UN DISOLVENTE A TEMPERATURA DE AL MENOS 10 GRADOS C Y FORMANDO CRISTALES EN EL DISOLVENTE A UNA TEMPERATURA DE AL MENOS 10 GRADOS C. POR EJEMPLO, SE PUEDEN FORMAR CRISTALES MEDIANTE CRISTALIZACION FUERA DE LA SOLUCION O A PARTIR DE PARTICULAS SOLIDAS DEL COMPUESTO SUSPENDIDAS EN UN DISOLVENTE. LOS CRISTALES FORMADOS DE ESTE MODO TIENEN DIFERENTES PUNTOS DE FUSION, ESPECTROS INFRARROJOS Y PATRONES DE DIFRACCION DE RAYOS X DE LAS FORMAS ANTERIORMENTE CONOCIDAS DEL COMPUESTO Y TIENEN PROCESABILIDAD MEJORADA, ES DECIR, ESTABILIDAD AL MOLIDO.
ES92306895T 1991-07-30 1992-07-29 Cristales de n-(trans-4-isopropilciclohexilcarbonil)-d-fenilalanina y metodos para prepararlos. Expired - Lifetime ES2100291T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP18969691 1991-07-30
JP19945391 1991-08-08
CA002114678A CA2114678C (en) 1991-07-30 1994-02-01 Crystals of n-(trans-4-isopropylcyclohexylcarbonyl)- d-phenylalanine and methods for preparing them

Publications (1)

Publication Number Publication Date
ES2100291T3 true ES2100291T3 (es) 1997-06-16

Family

ID=27169694

Family Applications (1)

Application Number Title Priority Date Filing Date
ES92306895T Expired - Lifetime ES2100291T3 (es) 1991-07-30 1992-07-29 Cristales de n-(trans-4-isopropilciclohexilcarbonil)-d-fenilalanina y metodos para prepararlos.

Country Status (11)

Country Link
US (1) US5488150A (es)
EP (1) EP0526171B1 (es)
JP (1) JP2508949B2 (es)
AT (1) ATE149483T1 (es)
BR (1) BR1100807A (es)
CA (1) CA2114678C (es)
DE (2) DE10199058I2 (es)
DK (1) DK0526171T3 (es)
ES (1) ES2100291T3 (es)
LU (2) LU90843I2 (es)
NL (1) NL300063I2 (es)

Families Citing this family (52)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW492878B (en) 1996-11-15 2002-07-01 Ajinomoto Kk Tablet composition
GB9713730D0 (en) 1997-06-30 1997-09-03 Ciba Geigy Ag Organic compounds
US6559188B1 (en) 1999-09-17 2003-05-06 Novartis Ag Method of treating metabolic disorders especially diabetes, or a disease or condition associated with diabetes
AR028299A1 (es) 1999-09-17 2003-05-07 Novartis Ag Una composicion farmaceutica que comprende nateglinida, un proceso para su preparacion y el uso de dicha composicion para la preparacion de un medicamento para el tratamiento de desordenes metabolicos, especialmente diabetes, o de una enfermedad o condicion asociada con diabetes.
US6878749B2 (en) * 1999-09-17 2005-04-12 Novartis Ag Method of treating metabolic disorders, especially diabetes, or a disease or condition associated with diabetes
CN1977842A (zh) 2000-01-21 2007-06-13 诺瓦提斯公司 含有二肽基肽酶－iv抑制剂和抗糖尿病药物的联合形式
AR033390A1 (es) 2000-08-22 2003-12-17 Novartis Ag Una composicion farmaceutica que comprende un antagonista del receptor at1 y un potenciador de la secrecion de insulina, el uso de dicha composicion para la fabricacion de un medicamento y un kit de partes
JP4114200B2 (ja) * 2000-10-18 2008-07-09 味の素株式会社 ナテグリニド結晶の製造方法
JP4158192B2 (ja) * 2000-10-18 2008-10-01 味の素株式会社 アシルフェニルアラニンの製造方法
CA2426263C (en) * 2000-10-24 2010-05-25 Ajinomoto Co., Inc. Nateglinide-containing preparation
DE60138476D1 (de) * 2000-10-24 2009-06-04 Ajinomoto Kk Nateglinid enthaltende hydrophile arzneimittelpräparate
KR100810930B1 (ko) * 2000-10-24 2008-03-10 아지노모토 가부시키가이샤 나테글리니드 ｂ형 결정의 제조방법
AR035425A1 (es) * 2001-01-30 2004-05-26 Teijin Ltd Cristal de diclorhidrato del acido 3-(3-amidinofenil)-5-[({[1-(iminoetil)-4-piperidil]metil}amino)metil]benzoico y proceso para prepararlo
EP1435912A4 (en) * 2001-09-12 2005-03-30 Alembic Ltd NOVEL STABLE CRYSTAL FORM OF N- (TRANS-4-ISOPROPYLCYCLOHEXYL CARBONYL) -D-PHENYLALANINE AND PREPARATION METHOD THEREOF
TW200304813A (en) * 2002-03-11 2003-10-16 Novartis Ag Salts of organic acid
US7411089B2 (en) 2002-04-15 2008-08-12 Ajinomoto Co., Inc. Nateglinide crystals
JP4615866B2 (ja) * 2002-04-15 2011-01-19 ノバルティス アーゲー Ｎ−（トランス−４−イソプロピルシクロヘキシルカルボニル）−ｄ−フェニルアラニンの結晶形
EP1496048A4 (en) * 2002-04-15 2006-08-02 Ajinomoto Kk NEW NATEGLINID CRYSTAL
MXNL04000084A (es) * 2002-04-29 2006-02-28 Biocon Ltd Forma novedosa de n-(trans-4-isopropilciclohexilcarbonil)-d-fenilalanina.
EP1487782A1 (en) * 2002-07-03 2004-12-22 Teva Pharmaceutical Industries Ltd. Process for preparing nateglinide and intermediates thereof
US6861553B2 (en) * 2002-07-03 2005-03-01 Teva Pharmaceuticals Industries Ltd. Process for preparing nateglinide and intermediates thereof
US20050075400A1 (en) * 2002-07-18 2005-04-07 Ronit Yahalomi Polymorphic forms of nateglinide
US7358390B2 (en) * 2002-07-18 2008-04-15 Teva Pharmaceutical Industries Ltd. Polymorphic forms of nateglinide
US7534913B2 (en) * 2002-07-18 2009-05-19 Teva Pharmaceutica Industries Ltd. Crystalline form of nateglinide
US7420084B2 (en) * 2002-07-18 2008-09-02 Teva Pharmaceutical Industries Ltd. Polymorphic forms of nateglinide
US7148376B2 (en) * 2002-07-18 2006-12-12 Teva Pharmaceutical Industries Ltd. Polymorphic forms of nateglinide
WO2004020396A1 (en) * 2002-08-28 2004-03-11 Dr. Reddy's Laboratories Limited Crystalline form of nateglinide and process for preparation thereof
EP1616886A4 (en) * 2003-02-18 2006-06-14 Konishi Co Ltd CURABLE RESIN, PROCESS FOR PRODUCING THE SAME, AND CURABLE RESIN COMPOSITION
HU227073B1 (hu) 2003-07-10 2010-06-28 Richter Gedeon Nyrt Eljárás királisan tiszta N-(transz-4-izopropil-ciklohexilkarbonil)-D-fenil-alanin (nateglinid) és kristálymódosulatainak elõállítására, valamint a G-kristálymódosulata
CN1950331A (zh) * 2004-05-07 2007-04-18 特瓦制药工业有限公司 那格列奈的多晶型物
US7425648B2 (en) 2005-01-03 2008-09-16 A.M.S.A. Anonima Materie Sintetiche E. Affini S.P.A. Process for the preparation of nateglinide, preferably in B-form
GT200600381A (es) 2005-08-25 2007-03-28 Compuestos organicos
CA2622608C (en) 2005-09-14 2014-08-19 Takeda Pharmaceutical Company Limited Dipeptidyl peptidase inhibitors for treating diabetes
JP5152699B2 (ja) * 2006-03-31 2013-02-27 味の素株式会社 カルボン酸クロリド化合物の製造方法
DK2091910T3 (en) * 2006-12-06 2014-12-01 Conatus Pharmaceuticals Inc Crystalline forms of (3S) -3- [N- (N '- (2-tert-butylphenyl) oxamyl) alaninyl] amino-5- (2', 3 ', 5', 6'-tetrafluorophenoxy) -4-oxopentanoic acid
SI2429995T1 (sl) 2009-05-15 2014-05-30 Novartis Ag Arilpiridini kot inhibitorji aldosteron sintaze
EA201101672A1 (ru) 2009-05-28 2012-06-29 Новартис Аг Замещенные производные аминомасляной кислоты в качестве ингибиторов неприлизина
DK2435409T3 (da) 2009-05-28 2014-10-27 Novartis Ag Substituerede aminopropionsyrederivater som neprilysininhibitorer
WO2011041293A1 (en) 2009-09-30 2011-04-07 Takeda Pharmaceutical Company Limited Pyrazolo [1, 5-a] pyrimidine derivatives as apoptosis signal-regulating kinase 1 inhibitors
ES2663351T3 (es) 2009-11-17 2018-04-12 Novartis Ag Derivados de aril-piridina como inhibidores de la aldosterona sintasa
JO2967B1 (en) 2009-11-20 2016-03-15 نوفارتس ايه جي Acetic acid derivatives of carbamoyl methyl amino are substituted as new NEP inhibitors
ES2472446T3 (es) 2009-11-30 2014-07-01 Novartis Ag Derivados de imidazol como inhibidores de aldosterona sintasa
US8802695B2 (en) 2010-02-03 2014-08-12 Takeda Pharmaceutical Company Limited Apoptosis signal-regulating kinase 1 inhibitors
US8673974B2 (en) 2010-11-16 2014-03-18 Novartis Ag Substituted amino bisphenyl pentanoic acid derivatives as NEP inhibitors
US8877815B2 (en) 2010-11-16 2014-11-04 Novartis Ag Substituted carbamoylcycloalkyl acetic acid derivatives as NEP
UY35144A (es) 2012-11-20 2014-06-30 Novartis Ag Miméticos lineales sintéticos de apelina para el tratamiento de insuficiencia cardiaca
HUE038248T2 (hu) 2013-02-14 2018-10-29 Novartis Ag Helyettesített biszfenil-bután-foszfonsav származékok, mint NEP (semleges endopeptidáz) inhibitorok
CN105705167A (zh) 2013-07-25 2016-06-22 诺华股份有限公司 合成的apelin多肽的生物缀合物
TN2016000031A1 (en) 2013-07-25 2017-07-05 Novartis Ag Cyclic polypeptides for the treatment of heart failure
CN107406490A (zh) 2015-01-23 2017-11-28 诺华股份有限公司 具有改善的半衰期的合成apelin脂肪酸缀合物
UY38072A (es) 2018-02-07 2019-10-01 Novartis Ag Compuestos derivados de éster butanoico sustituido con bisfenilo como inhibidores de nep, composiciones y combinaciones de los mismos
CN109369443A (zh) * 2018-11-05 2019-02-22 扬子江药业集团江苏海慈生物药业有限公司 一种新的那格列奈h晶型的制备方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US196222A (en) * 1877-10-16 Improvement in belt-tighteners
JPS6354321A (ja) * 1985-03-27 1988-03-08 Ajinomoto Co Inc 血糖降下剤

Also Published As

Publication number Publication date
NL300063I2 (nl) 2002-02-01
BR1100807A (pt) 1999-12-28
EP0526171A3 (en) 1993-05-05
DE69217762D1 (de) 1997-04-10
LU90846I2 (fr) 2002-02-04
CA2114678C (en) 1999-04-27
JP2508949B2 (ja) 1996-06-19
US5488150A (en) 1996-01-30
DE69217762T2 (de) 1997-10-09
EP0526171A2 (en) 1993-02-03
DK0526171T3 (da) 1997-08-25
CA2114678A1 (en) 1995-08-02
ATE149483T1 (de) 1997-03-15
DE10199058I2 (de) 2006-04-27
EP0526171B1 (en) 1997-03-05
DE10199058I1 (de) 2002-01-24
JPH05208943A (ja) 1993-08-20
LU90843I2 (fr) 2002-02-04
NL300063I1 (nl) 2001-12-01

Similar Documents

Publication Publication Date Title
ES2100291T3 (es) Cristales de n-(trans-4-isopropilciclohexilcarbonil)-d-fenilalanina y metodos para prepararlos.
DE69112463D1 (de) Vorrichtung zur Herstellung von Monokristallen nach dem Czochralski-Verfahren.
ES2096152T3 (es) Procedimiento para producir peliculas de revestimiento de oxido de titanio.
DZ1792A1 (fr) Une nouvelle forme de composé.
PT97890A (pt) Processo para a preparacao de ftalidas substituidas e de ftalidas heterociclicas
FR2552423B1 (fr) Compositions d'oligomeres de polyarylalcanes et leur procede de fabrication
DE69017642D1 (de) Vorrichtung zur Herstellung von Einkristallen nach dem Czochralski-Verfahren.
ES2023509B3 (es) Producto granular (i).
DK0400522T3 (da) Fremgangsmåde til fremstilling af mikroniserede bionedbrydelige partikler
MX9100174A (es) 4,5-dihidro-1h-pirazol-1-carboxamidas-n-aril-3aril-4-substituidas y metodos para su produccion
NO175776C (no) 1-aminopropandiol-2,3 med höy renhet, samt fremgangsmåte for fremstilling av forbindelsen
BR8205906A (pt) Processo para preparacao de diamidas de acido hidroxi-malonico substituidas composicoes pesticidas processo para combate contra pestes e processo para preparacao de tais composicoes
DE69013994D1 (de) Aromatische und heteroaromatische Amine zur Behandlung von Depressionen, Hirnleistungsstörungen und Dementia.
PT84498B (pt) Processo para a preparacao de novas fenil-ureias
BR8902740A (pt) Processo para a preparacao de 2,2,4-trimetil-1,2-dihidroquinolina oligomera
BR9103415A (pt) Derivados de halogenoalquil-azolila,processo para sua preparacao,composicoes microbicidas,emprego e processos para o combate de microorganismos indesejados e para a preparacao de composicoes
IT1193500B (it) Processo per la preparazione di 2,2'-bis/4-(1,1,3,3-tetrametilbutil) fenol/solfuro
MX9100345A (es) Procedimiento para la preparacion de derivados 6-(aminopropionil sustituidos)de forscolina
DE69012845D1 (de) Exo-3'-4'-O-benzyliden-3"-demethylchartreusin und seine Salze.
BR8805500A (pt) Processo para preparacao de isotiazolonas substituidas com halogenio
FI102537B (fi) Dehalogenointimenetelmä 3-aroyyli-2-oksindoli-1-karboksiamidien valmis tamiseksi
FI102372B1 (fi) Menetelmä karbamyylijohdannaisen kiteisen muodon valmistamiseksi
AT341534B (de) Verfahren zur herstellung von neuen 5,6-diaryl-1,2,4-triazinverbindungen und ihren saureadditionssalzen
NO834759L (no) Fremgangsmaate ved fremstilling av nye 6alfa-methylprednisolonderivater
DK93884A (da) Fremgangsmaade til fremstilling af 1,5-dibeskyttede-1,5,10-triazadecaner, mellemprodukter derfor samt disses fremstilling

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 526171

Country of ref document: ES

SPCF Request for supplementary protection certificate filed

Free format text: NATEGLINIDA (STARLIX)

Spc suppl protection certif: C200100034

Filing date: 20011003

SPCG Supplementary protection certificate granted

Free format text: NATEGLINIDA (STARLIX).

Spc suppl protection certif: C200100034

Filing date: 20011003

Expiry date: 20160403

Effective date: 20040614