ATE149483T1 - Kristalle von n-(trans-4- isopropylcyclohexylcarbonyl)-d-phenylalanin und verfahren zu ihrer herstellung - Google Patents

Kristalle von n-(trans-4- isopropylcyclohexylcarbonyl)-d-phenylalanin und verfahren zu ihrer herstellung

Info

Publication number
ATE149483T1
ATE149483T1 AT92306895T AT92306895T ATE149483T1 AT E149483 T1 ATE149483 T1 AT E149483T1 AT 92306895 T AT92306895 T AT 92306895T AT 92306895 T AT92306895 T AT 92306895T AT E149483 T1 ATE149483 T1 AT E149483T1
Authority
AT
Austria
Prior art keywords
crystals
solvent
isopropylcyclohexylcarbonyl
phenylalanine
trans
Prior art date
Application number
AT92306895T
Other languages
English (en)
Inventor
Michito Sumikawa
Yoshihito Koguchi
Takao Ohgane
Yasuo Irie
Satoji Takahashi
Original Assignee
Ajinomoto Kk
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27169694&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE149483(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Ajinomoto Kk filed Critical Ajinomoto Kk
Application granted granted Critical
Publication of ATE149483T1 publication Critical patent/ATE149483T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/22—Separation; Purification; Stabilisation; Use of additives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/57—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C07C233/63—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of rings other than six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
AT92306895T 1991-07-30 1992-07-29 Kristalle von n-(trans-4- isopropylcyclohexylcarbonyl)-d-phenylalanin und verfahren zu ihrer herstellung ATE149483T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP18969691 1991-07-30
JP19945391 1991-08-08
CA002114678A CA2114678C (en) 1991-07-30 1994-02-01 Crystals of n-(trans-4-isopropylcyclohexylcarbonyl)- d-phenylalanine and methods for preparing them

Publications (1)

Publication Number Publication Date
ATE149483T1 true ATE149483T1 (de) 1997-03-15

Family

ID=27169694

Family Applications (1)

Application Number Title Priority Date Filing Date
AT92306895T ATE149483T1 (de) 1991-07-30 1992-07-29 Kristalle von n-(trans-4- isopropylcyclohexylcarbonyl)-d-phenylalanin und verfahren zu ihrer herstellung

Country Status (11)

Country Link
US (1) US5488150A (de)
EP (1) EP0526171B1 (de)
JP (1) JP2508949B2 (de)
AT (1) ATE149483T1 (de)
BR (1) BR1100807A (de)
CA (1) CA2114678C (de)
DE (2) DE69217762T2 (de)
DK (1) DK0526171T3 (de)
ES (1) ES2100291T3 (de)
LU (2) LU90843I2 (de)
NL (1) NL300063I2 (de)

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WO1998022105A1 (fr) 1996-11-15 1998-05-28 Ajinomoto Co., Inc. Preparation en comprimes
GB9713730D0 (en) 1997-06-30 1997-09-03 Ciba Geigy Ag Organic compounds
US6878749B2 (en) * 1999-09-17 2005-04-12 Novartis Ag Method of treating metabolic disorders, especially diabetes, or a disease or condition associated with diabetes
CO5200844A1 (es) 1999-09-17 2002-09-27 Novartis Ag Una combinacion que comprende nateglinida y cuando por menos otro compuesto antidiabetico usada para el tratamiento de desordenes metabolicos, especialmente diabetes, o de una enfermedad o condicion asociada con dibetes
US6559188B1 (en) 1999-09-17 2003-05-06 Novartis Ag Method of treating metabolic disorders especially diabetes, or a disease or condition associated with diabetes
DK1741445T3 (da) 2000-01-21 2013-11-04 Novartis Ag Kombinationer omfattende dipeptidylpeptidase-IV-inhibitorer og antidiabetiske midler
AR033390A1 (es) 2000-08-22 2003-12-17 Novartis Ag Una composicion farmaceutica que comprende un antagonista del receptor at1 y un potenciador de la secrecion de insulina, el uso de dicha composicion para la fabricacion de un medicamento y un kit de partes
PT1334963E (pt) 2000-10-18 2007-09-20 Ajinomoto Kk Processo para a produção de cristais de nateglinida
DK1334962T3 (da) * 2000-10-18 2007-12-10 Ajinomoto Kk Fremgangsmåder til fremstilling af acylphenylalanin
CA2426764C (en) * 2000-10-24 2010-04-20 Ajinomoto Co., Inc. Nateglinide-containing hydrophilic pharmaceutical preparation
ES2288997T3 (es) * 2000-10-24 2008-02-01 Ajinomoto Co., Inc. Procedimiento para producir cristales de nateglinida de tipo b.
CA2426263C (en) * 2000-10-24 2010-05-25 Ajinomoto Co., Inc. Nateglinide-containing preparation
AR035425A1 (es) * 2001-01-30 2004-05-26 Teijin Ltd Cristal de diclorhidrato del acido 3-(3-amidinofenil)-5-[({[1-(iminoetil)-4-piperidil]metil}amino)metil]benzoico y proceso para prepararlo
WO2003022251A1 (en) * 2001-09-12 2003-03-20 Alembic Limited Novel stable crystal form of n-trans-4-isopropylcyclohexyl carbonyl)-d-phenylalanine and process of preparation
TW200304813A (en) * 2002-03-11 2003-10-16 Novartis Ag Salts of organic acid
EP1496048A4 (de) * 2002-04-15 2006-08-02 Ajinomoto Kk Neuer nateglinidkristall
US7411089B2 (en) 2002-04-15 2008-08-12 Ajinomoto Co., Inc. Nateglinide crystals
JP4615866B2 (ja) * 2002-04-15 2011-01-19 ノバルティス アーゲー Ｎ−（トランス−４−イソプロピルシクロヘキシルカルボニル）−ｄ−フェニルアラニンの結晶形
MXNL04000084A (es) * 2002-04-29 2006-02-28 Biocon Ltd Forma novedosa de n-(trans-4-isopropilciclohexilcarbonil)-d-fenilalanina.
US6861553B2 (en) * 2002-07-03 2005-03-01 Teva Pharmaceuticals Industries Ltd. Process for preparing nateglinide and intermediates thereof
CN100384813C (zh) * 2002-07-03 2008-04-30 特瓦制药工业有限公司 制备那格列奈及其中间体的方法
US7420084B2 (en) * 2002-07-18 2008-09-02 Teva Pharmaceutical Industries Ltd. Polymorphic forms of nateglinide
US7358390B2 (en) * 2002-07-18 2008-04-15 Teva Pharmaceutical Industries Ltd. Polymorphic forms of nateglinide
US7534913B2 (en) * 2002-07-18 2009-05-19 Teva Pharmaceutica Industries Ltd. Crystalline form of nateglinide
US7148376B2 (en) * 2002-07-18 2006-12-12 Teva Pharmaceutical Industries Ltd. Polymorphic forms of nateglinide
US20050075400A1 (en) * 2002-07-18 2005-04-07 Ronit Yahalomi Polymorphic forms of nateglinide
AU2003262928A1 (en) * 2002-08-28 2004-03-19 Dr. Reddy's Laboratories Limited Crystalline form of nateglinide and process for preparation thereof
EP1616886A4 (de) * 2003-02-18 2006-06-14 Konishi Co Ltd Kuratives harz, herstellungsverfahren und kurative harzzusammensetzung
HU227073B1 (hu) 2003-07-10 2010-06-28 Richter Gedeon Nyrt Eljárás királisan tiszta N-(transz-4-izopropil-ciklohexilkarbonil)-D-fenil-alanin (nateglinid) és kristálymódosulatainak elõállítására, valamint a G-kristálymódosulata
EP1656339A1 (de) * 2004-05-07 2006-05-17 Teva Pharmaceutical Industries Ltd Polymorphe form von nateglinid
US7425648B2 (en) 2005-01-03 2008-09-16 A.M.S.A. Anonima Materie Sintetiche E. Affini S.P.A. Process for the preparation of nateglinide, preferably in B-form
GT200600381A (es) 2005-08-25 2007-03-28 Compuestos organicos
KR101352588B1 (ko) 2005-09-14 2014-01-17 다케다 야쿠힌 고교 가부시키가이샤 당뇨병 치료용 디펩티딜 펩티다아제 억제제
CN101415668B (zh) * 2006-03-31 2013-06-19 味之素株式会社 羧酸酰氯化合物的制造方法
DK2091910T3 (en) * 2006-12-06 2014-12-01 Conatus Pharmaceuticals Inc Crystalline forms of (3S) -3- [N- (N '- (2-tert-butylphenyl) oxamyl) alaninyl] amino-5- (2', 3 ', 5', 6'-tetrafluorophenoxy) -4-oxopentanoic acid
JP5659224B2 (ja) 2009-05-15 2015-01-28 ノバルティス アーゲー アルドステロンシンターゼ阻害剤としてのアリールピリジン
AU2010251967B9 (en) 2009-05-28 2014-04-03 Novartis Ag Substituted aminopropionic derivatives as neprilysin inhibitors
SG176010A1 (en) 2009-05-28 2011-12-29 Novartis Ag Substituted aminobutyric derivatives as neprilysin inhibitors
WO2011041293A1 (en) 2009-09-30 2011-04-07 Takeda Pharmaceutical Company Limited Pyrazolo [1, 5-a] pyrimidine derivatives as apoptosis signal-regulating kinase 1 inhibitors
ES2663351T3 (es) 2009-11-17 2018-04-12 Novartis Ag Derivados de aril-piridina como inhibidores de la aldosterona sintasa
JO2967B1 (en) 2009-11-20 2016-03-15 نوفارتس ايه جي Acetic acid derivatives of carbamoyl methyl amino are substituted as new NEP inhibitors
JP5575913B2 (ja) 2009-11-30 2014-08-20 ノバルティス アーゲー アルドステロン合成酵素阻害剤としてのイミダゾール誘導体
PL2531501T3 (pl) 2010-02-03 2014-05-30 Takeda Pharmaceuticals Co Inhibitory kinazy 1 regulującej sygnał apoptotyczny
US8877815B2 (en) 2010-11-16 2014-11-04 Novartis Ag Substituted carbamoylcycloalkyl acetic acid derivatives as NEP
US8673974B2 (en) 2010-11-16 2014-03-18 Novartis Ag Substituted amino bisphenyl pentanoic acid derivatives as NEP inhibitors
UY35144A (es) 2012-11-20 2014-06-30 Novartis Ag Miméticos lineales sintéticos de apelina para el tratamiento de insuficiencia cardiaca
JP6295277B2 (ja) 2013-02-14 2018-03-14 ノバルティス アーゲー Ｎｅｐ（中性エンドペプチダーゼ）阻害剤としての置換ビスフェニルブタン酸ホスホン酸誘導体
AU2014293387B2 (en) 2013-07-25 2017-04-20 Novartis Ag Bioconjugates of synthetic apelin polypeptides
KR20160031551A (ko) 2013-07-25 2016-03-22 노파르티스 아게 심부전의 치료를 위한 시클릭 폴리펩티드
EA201791668A1 (ru) 2015-01-23 2017-11-30 Новартис Аг Синтетические конъюгаты апелина с жирной кислотой с улучшенным периодом полураспада
UY38072A (es) 2018-02-07 2019-10-01 Novartis Ag Compuestos derivados de éster butanoico sustituido con bisfenilo como inhibidores de nep, composiciones y combinaciones de los mismos
CN109369443A (zh) * 2018-11-05 2019-02-22 扬子江药业集团江苏海慈生物药业有限公司 一种新的那格列奈h晶型的制备方法

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US196222A (en) * 1877-10-16 Improvement in belt-tighteners
JPS6354321A (ja) * 1985-03-27 1988-03-08 Ajinomoto Co Inc 血糖降下剤

Also Published As

Publication number Publication date
JPH05208943A (ja) 1993-08-20
LU90843I2 (fr) 2002-02-04
NL300063I1 (nl) 2001-12-01
DE69217762T2 (de) 1997-10-09
NL300063I2 (nl) 2002-02-01
JP2508949B2 (ja) 1996-06-19
EP0526171B1 (de) 1997-03-05
DK0526171T3 (da) 1997-08-25
DE10199058I2 (de) 2006-04-27
ES2100291T3 (es) 1997-06-16
US5488150A (en) 1996-01-30
BR1100807A (pt) 1999-12-28
CA2114678C (en) 1999-04-27
CA2114678A1 (en) 1995-08-02
LU90846I2 (fr) 2002-02-04
DE10199058I1 (de) 2002-01-24
EP0526171A2 (de) 1993-02-03
DE69217762D1 (de) 1997-04-10
EP0526171A3 (en) 1993-05-05

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