ATE149483T1 - Kristalle von n-(trans-4- isopropylcyclohexylcarbonyl)-d-phenylalanin und verfahren zu ihrer herstellung - Google Patents

Kristalle von n-(trans-4- isopropylcyclohexylcarbonyl)-d-phenylalanin und verfahren zu ihrer herstellung

Info

Publication number
ATE149483T1
ATE149483T1 AT92306895T AT92306895T ATE149483T1 AT E149483 T1 ATE149483 T1 AT E149483T1 AT 92306895 T AT92306895 T AT 92306895T AT 92306895 T AT92306895 T AT 92306895T AT E149483 T1 ATE149483 T1 AT E149483T1
Authority
AT
Austria
Prior art keywords
crystals
solvent
isopropylcyclohexylcarbonyl
phenylalanine
trans
Prior art date
Application number
AT92306895T
Other languages
English (en)
Inventor
Michito Sumikawa
Yoshihito Koguchi
Takao Ohgane
Yasuo Irie
Satoji Takahashi
Original Assignee
Ajinomoto Kk
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27169694&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE149483(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Ajinomoto Kk filed Critical Ajinomoto Kk
Application granted granted Critical
Publication of ATE149483T1 publication Critical patent/ATE149483T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/22—Separation; Purification; Stabilisation; Use of additives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/57—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C07C233/63—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of rings other than six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
AT92306895T 1991-07-30 1992-07-29 Kristalle von n-(trans-4- isopropylcyclohexylcarbonyl)-d-phenylalanin und verfahren zu ihrer herstellung ATE149483T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP18969691 1991-07-30
JP19945391 1991-08-08
CA002114678A CA2114678C (en) 1991-07-30 1994-02-01 Crystals of n-(trans-4-isopropylcyclohexylcarbonyl)- d-phenylalanine and methods for preparing them

Publications (1)

Publication Number Publication Date
ATE149483T1 true ATE149483T1 (de) 1997-03-15

Family

ID=27169694

Family Applications (1)

Application Number Title Priority Date Filing Date
AT92306895T ATE149483T1 (de) 1991-07-30 1992-07-29 Kristalle von n-(trans-4- isopropylcyclohexylcarbonyl)-d-phenylalanin und verfahren zu ihrer herstellung

Country Status (11)

Country Link
US (1) US5488150A (de)
EP (1) EP0526171B1 (de)
JP (1) JP2508949B2 (de)
AT (1) ATE149483T1 (de)
BR (1) BR1100807A (de)
CA (1) CA2114678C (de)
DE (2) DE10199058I2 (de)
DK (1) DK0526171T3 (de)
ES (1) ES2100291T3 (de)
LU (2) LU90843I2 (de)
NL (1) NL300063I2 (de)

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ES2364145T3 (es) 1996-11-15 2011-08-25 Ajinomoto Co., Inc. Composición de nateglinida en comprimidos.
GB9713730D0 (en) 1997-06-30 1997-09-03 Ciba Geigy Ag Organic compounds
AR028299A1 (es) 1999-09-17 2003-05-07 Novartis Ag Una composicion farmaceutica que comprende nateglinida, un proceso para su preparacion y el uso de dicha composicion para la preparacion de un medicamento para el tratamiento de desordenes metabolicos, especialmente diabetes, o de una enfermedad o condicion asociada con diabetes.
US6878749B2 (en) 1999-09-17 2005-04-12 Novartis Ag Method of treating metabolic disorders, especially diabetes, or a disease or condition associated with diabetes
US6559188B1 (en) 1999-09-17 2003-05-06 Novartis Ag Method of treating metabolic disorders especially diabetes, or a disease or condition associated with diabetes
BRPI0107715B8 (pt) 2000-01-21 2021-05-25 Novartis Ag produto farmacêutico compreendendo um inibidor de dipeptidilpeptidase-iv e metformina, bem como usos do dito produto farmacêutico e do inibidor de dipeptidilpeptidase-iv
PE20020617A1 (es) 2000-08-22 2002-08-05 Novartis Ag Composicion que comprende un antagonista del receptor at1 y un potenciador de la secrecion de insulina o un sensibilizante a la insulina
RU2273629C2 (ru) * 2000-10-18 2006-04-10 Адзиномото Ко., Инк. Способы получения кристаллов натеглинида
MXPA03003483A (es) * 2000-10-18 2003-07-14 Ajinomoto Kk Procedimiento para la preparacion de acilfenilalaninas.
MXPA03003686A (es) * 2000-10-24 2004-01-26 Ajinomoto Kk Preparaciones hidrofilas de farmaco que contienen nateglinida.
DK1334964T3 (da) * 2000-10-24 2007-09-24 Ajinomoto Kk Fremgangsmåde til fremstilling af nateglinidkrystaller med B form
ATE406885T1 (de) * 2000-10-24 2008-09-15 Ajinomoto Kk Nateglinid enthaltende präparate
AR035425A1 (es) * 2001-01-30 2004-05-26 Teijin Ltd Cristal de diclorhidrato del acido 3-(3-amidinofenil)-5-[({[1-(iminoetil)-4-piperidil]metil}amino)metil]benzoico y proceso para prepararlo
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BR0308316A (pt) * 2002-03-11 2004-12-28 Novartis Ag Sais de nateglinida
US7411089B2 (en) 2002-04-15 2008-08-12 Ajinomoto Co., Inc. Nateglinide crystals
JP4538842B2 (ja) * 2002-04-15 2010-09-08 味の素株式会社 新規ナテグリニド結晶
CN1304366C (zh) * 2002-04-15 2007-03-14 诺瓦提斯公司 N－(反式－4－异丙基环己基羰基)－d－苯丙氨酸的晶形
KR20040111490A (ko) * 2002-04-29 2004-12-31 바이오콘 리미티드 새로운 형태의 ｎ－（트랜스－4－이소프로필사이클로헥실카보닐）－ｄ－페닐알라닌
US6861553B2 (en) * 2002-07-03 2005-03-01 Teva Pharmaceuticals Industries Ltd. Process for preparing nateglinide and intermediates thereof
AU2003256454A1 (en) * 2002-07-03 2004-01-23 Teva Pharmaceutical Industries Ltd. Process for preparing nateglinide and intermediates thereof
US20050075400A1 (en) * 2002-07-18 2005-04-07 Ronit Yahalomi Polymorphic forms of nateglinide
US7148376B2 (en) * 2002-07-18 2006-12-12 Teva Pharmaceutical Industries Ltd. Polymorphic forms of nateglinide
US7534913B2 (en) * 2002-07-18 2009-05-19 Teva Pharmaceutica Industries Ltd. Crystalline form of nateglinide
US7420084B2 (en) * 2002-07-18 2008-09-02 Teva Pharmaceutical Industries Ltd. Polymorphic forms of nateglinide
US7358390B2 (en) * 2002-07-18 2008-04-15 Teva Pharmaceutical Industries Ltd. Polymorphic forms of nateglinide
US20040077725A1 (en) * 2002-08-28 2004-04-22 Dr. Reddy's Laboratories Limited Crystalline form of N-(trans-4-isopropylcyclohexane carbonyl)-D-phenylalanine and process for preparation thereof
EP1616886A4 (de) * 2003-02-18 2006-06-14 Konishi Co Ltd Kuratives harz, herstellungsverfahren und kurative harzzusammensetzung
HU227073B1 (hu) * 2003-07-10 2010-06-28 Richter Gedeon Nyrt Eljárás királisan tiszta N-(transz-4-izopropil-ciklohexilkarbonil)-D-fenil-alanin (nateglinid) és kristálymódosulatainak elõállítására, valamint a G-kristálymódosulata
US20060004102A1 (en) * 2004-05-07 2006-01-05 Shlomit Wizel Polymorphic forms of nateglinide
US7425648B2 (en) 2005-01-03 2008-09-16 A.M.S.A. Anonima Materie Sintetiche E. Affini S.P.A. Process for the preparation of nateglinide, preferably in B-form
GT200600381A (es) 2005-08-25 2007-03-28 Compuestos organicos
KR101352588B1 (ko) 2005-09-14 2014-01-17 다케다 야쿠힌 고교 가부시키가이샤 당뇨병 치료용 디펩티딜 펩티다아제 억제제
KR101399916B1 (ko) * 2006-03-31 2014-05-28 아지노모토 가부시키가이샤 카복실산 클로라이드 화합물의 제조방법
CN103923169B (zh) * 2006-12-06 2017-05-24 科内图斯医药公司 (3s)‑3‑[n‑(n’‑(2‑叔丁基苯基)草氨酰基)丙氨酰基]氨基‑5‑(2’,3’,5’,6’‑四氟苯氧基)‑4‑氧代戊酸的结晶形式
MY184008A (en) 2009-05-15 2021-03-17 Novartis Ag Aryl pyridine as aldosterone synthase inhibitors
MX2011012627A (es) 2009-05-28 2011-12-14 Novartis Ag Derivados aminobutiricos sustituidos como inhibidores de nepralisina.
ME01923B (me) 2009-05-28 2015-05-20 Novartis Ag Supstituisani derivati aminopropionske kiseline kao inhibitori neprilizina
WO2011041293A1 (en) 2009-09-30 2011-04-07 Takeda Pharmaceutical Company Limited Pyrazolo [1, 5-a] pyrimidine derivatives as apoptosis signal-regulating kinase 1 inhibitors
WO2011061168A1 (en) 2009-11-17 2011-05-26 Novartis Ag Aryl-pyridine derivatives as aldosterone synthase inhibitors
JO2967B1 (en) 2009-11-20 2016-03-15 نوفارتس ايه جي Acetic acid derivatives of carbamoyl methyl amino are substituted as new NEP inhibitors
JP5575913B2 (ja) 2009-11-30 2014-08-20 ノバルティス アーゲー アルドステロン合成酵素阻害剤としてのイミダゾール誘導体
DK2531501T3 (en) 2010-02-03 2014-02-24 Takeda Pharmaceutical APOPTOSESIGNALREGULERENDE KINASE 1 inhibitors
US8877815B2 (en) 2010-11-16 2014-11-04 Novartis Ag Substituted carbamoylcycloalkyl acetic acid derivatives as NEP
US8673974B2 (en) 2010-11-16 2014-03-18 Novartis Ag Substituted amino bisphenyl pentanoic acid derivatives as NEP inhibitors
UY35144A (es) 2012-11-20 2014-06-30 Novartis Ag Miméticos lineales sintéticos de apelina para el tratamiento de insuficiencia cardiaca
TR201808541T4 (tr) 2013-02-14 2018-07-23 Novartis Ag Nep (nötr endopeptidaz) inhibitörleri olarak ikame edilmiş bisfenil butanoik fosfonik asit türevleri.
CN105612172A (zh) 2013-07-25 2016-05-25 诺华股份有限公司 用于治疗心力衰竭的环状多肽
CN105705167A (zh) 2013-07-25 2016-06-22 诺华股份有限公司 合成的apelin多肽的生物缀合物
SG11201704758XA (en) 2015-01-23 2017-08-30 Novartis Ag Synthetic apelin fatty acid conjugates with improved half-life
UY38072A (es) 2018-02-07 2019-10-01 Novartis Ag Compuestos derivados de éster butanoico sustituido con bisfenilo como inhibidores de nep, composiciones y combinaciones de los mismos
CN109369443A (zh) * 2018-11-05 2019-02-22 扬子江药业集团江苏海慈生物药业有限公司 一种新的那格列奈h晶型的制备方法

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US196222A (en) * 1877-10-16 Improvement in belt-tighteners
JPS6354321A (ja) * 1985-03-27 1988-03-08 Ajinomoto Co Inc 血糖降下剤

Also Published As

Publication number Publication date
DK0526171T3 (da) 1997-08-25
DE69217762D1 (de) 1997-04-10
EP0526171A2 (de) 1993-02-03
BR1100807A (pt) 1999-12-28
EP0526171B1 (de) 1997-03-05
JP2508949B2 (ja) 1996-06-19
DE10199058I1 (de) 2002-01-24
DE10199058I2 (de) 2006-04-27
JPH05208943A (ja) 1993-08-20
LU90843I2 (fr) 2002-02-04
NL300063I1 (nl) 2001-12-01
EP0526171A3 (en) 1993-05-05
DE69217762T2 (de) 1997-10-09
US5488150A (en) 1996-01-30
LU90846I2 (fr) 2002-02-04
ES2100291T3 (es) 1997-06-16
CA2114678C (en) 1999-04-27
NL300063I2 (nl) 2002-02-01
CA2114678A1 (en) 1995-08-02

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