ATE149483T1 - Kristalle von n-(trans-4- isopropylcyclohexylcarbonyl)-d-phenylalanin und verfahren zu ihrer herstellung - Google Patents
Kristalle von n-(trans-4- isopropylcyclohexylcarbonyl)-d-phenylalanin und verfahren zu ihrer herstellungInfo
- Publication number
- ATE149483T1 ATE149483T1 AT92306895T AT92306895T ATE149483T1 AT E149483 T1 ATE149483 T1 AT E149483T1 AT 92306895 T AT92306895 T AT 92306895T AT 92306895 T AT92306895 T AT 92306895T AT E149483 T1 ATE149483 T1 AT E149483T1
- Authority
- AT
- Austria
- Prior art keywords
- crystals
- solvent
- isopropylcyclohexylcarbonyl
- phenylalanine
- trans
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C231/00—Preparation of carboxylic acid amides
- C07C231/22—Separation; Purification; Stabilisation; Use of additives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/57—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of rings other than six-membered aromatic rings
- C07C233/63—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of rings other than six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Peptides Or Proteins (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP18969691 | 1991-07-30 | ||
JP19945391 | 1991-08-08 | ||
CA002114678A CA2114678C (en) | 1991-07-30 | 1994-02-01 | Crystals of n-(trans-4-isopropylcyclohexylcarbonyl)- d-phenylalanine and methods for preparing them |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE149483T1 true ATE149483T1 (de) | 1997-03-15 |
Family
ID=27169694
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT92306895T ATE149483T1 (de) | 1991-07-30 | 1992-07-29 | Kristalle von n-(trans-4- isopropylcyclohexylcarbonyl)-d-phenylalanin und verfahren zu ihrer herstellung |
Country Status (11)
Country | Link |
---|---|
US (1) | US5488150A (de) |
EP (1) | EP0526171B1 (de) |
JP (1) | JP2508949B2 (de) |
AT (1) | ATE149483T1 (de) |
BR (1) | BR1100807A (de) |
CA (1) | CA2114678C (de) |
DE (2) | DE10199058I2 (de) |
DK (1) | DK0526171T3 (de) |
ES (1) | ES2100291T3 (de) |
LU (2) | LU90843I2 (de) |
NL (1) | NL300063I2 (de) |
Families Citing this family (52)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2364145T3 (es) | 1996-11-15 | 2011-08-25 | Ajinomoto Co., Inc. | Composición de nateglinida en comprimidos. |
GB9713730D0 (en) | 1997-06-30 | 1997-09-03 | Ciba Geigy Ag | Organic compounds |
AR028299A1 (es) | 1999-09-17 | 2003-05-07 | Novartis Ag | Una composicion farmaceutica que comprende nateglinida, un proceso para su preparacion y el uso de dicha composicion para la preparacion de un medicamento para el tratamiento de desordenes metabolicos, especialmente diabetes, o de una enfermedad o condicion asociada con diabetes. |
US6878749B2 (en) | 1999-09-17 | 2005-04-12 | Novartis Ag | Method of treating metabolic disorders, especially diabetes, or a disease or condition associated with diabetes |
US6559188B1 (en) | 1999-09-17 | 2003-05-06 | Novartis Ag | Method of treating metabolic disorders especially diabetes, or a disease or condition associated with diabetes |
BRPI0107715B8 (pt) | 2000-01-21 | 2021-05-25 | Novartis Ag | produto farmacêutico compreendendo um inibidor de dipeptidilpeptidase-iv e metformina, bem como usos do dito produto farmacêutico e do inibidor de dipeptidilpeptidase-iv |
PE20020617A1 (es) | 2000-08-22 | 2002-08-05 | Novartis Ag | Composicion que comprende un antagonista del receptor at1 y un potenciador de la secrecion de insulina o un sensibilizante a la insulina |
RU2273629C2 (ru) * | 2000-10-18 | 2006-04-10 | Адзиномото Ко., Инк. | Способы получения кристаллов натеглинида |
MXPA03003483A (es) * | 2000-10-18 | 2003-07-14 | Ajinomoto Kk | Procedimiento para la preparacion de acilfenilalaninas. |
MXPA03003686A (es) * | 2000-10-24 | 2004-01-26 | Ajinomoto Kk | Preparaciones hidrofilas de farmaco que contienen nateglinida. |
DK1334964T3 (da) * | 2000-10-24 | 2007-09-24 | Ajinomoto Kk | Fremgangsmåde til fremstilling af nateglinidkrystaller med B form |
ATE406885T1 (de) * | 2000-10-24 | 2008-09-15 | Ajinomoto Kk | Nateglinid enthaltende präparate |
AR035425A1 (es) * | 2001-01-30 | 2004-05-26 | Teijin Ltd | Cristal de diclorhidrato del acido 3-(3-amidinofenil)-5-[({[1-(iminoetil)-4-piperidil]metil}amino)metil]benzoico y proceso para prepararlo |
WO2003022251A1 (en) * | 2001-09-12 | 2003-03-20 | Alembic Limited | Novel stable crystal form of n-trans-4-isopropylcyclohexyl carbonyl)-d-phenylalanine and process of preparation |
BR0308316A (pt) * | 2002-03-11 | 2004-12-28 | Novartis Ag | Sais de nateglinida |
US7411089B2 (en) | 2002-04-15 | 2008-08-12 | Ajinomoto Co., Inc. | Nateglinide crystals |
JP4538842B2 (ja) * | 2002-04-15 | 2010-09-08 | 味の素株式会社 | 新規ナテグリニド結晶 |
CN1304366C (zh) * | 2002-04-15 | 2007-03-14 | 诺瓦提斯公司 | N-(反式-4-异丙基环己基羰基)-d-苯丙氨酸的晶形 |
KR20040111490A (ko) * | 2002-04-29 | 2004-12-31 | 바이오콘 리미티드 | 새로운 형태의 n-(트랜스-4-이소프로필사이클로헥실카보닐)-d-페닐알라닌 |
US6861553B2 (en) * | 2002-07-03 | 2005-03-01 | Teva Pharmaceuticals Industries Ltd. | Process for preparing nateglinide and intermediates thereof |
AU2003256454A1 (en) * | 2002-07-03 | 2004-01-23 | Teva Pharmaceutical Industries Ltd. | Process for preparing nateglinide and intermediates thereof |
US20050075400A1 (en) * | 2002-07-18 | 2005-04-07 | Ronit Yahalomi | Polymorphic forms of nateglinide |
US7148376B2 (en) * | 2002-07-18 | 2006-12-12 | Teva Pharmaceutical Industries Ltd. | Polymorphic forms of nateglinide |
US7534913B2 (en) * | 2002-07-18 | 2009-05-19 | Teva Pharmaceutica Industries Ltd. | Crystalline form of nateglinide |
US7420084B2 (en) * | 2002-07-18 | 2008-09-02 | Teva Pharmaceutical Industries Ltd. | Polymorphic forms of nateglinide |
US7358390B2 (en) * | 2002-07-18 | 2008-04-15 | Teva Pharmaceutical Industries Ltd. | Polymorphic forms of nateglinide |
US20040077725A1 (en) * | 2002-08-28 | 2004-04-22 | Dr. Reddy's Laboratories Limited | Crystalline form of N-(trans-4-isopropylcyclohexane carbonyl)-D-phenylalanine and process for preparation thereof |
EP1616886A4 (de) * | 2003-02-18 | 2006-06-14 | Konishi Co Ltd | Kuratives harz, herstellungsverfahren und kurative harzzusammensetzung |
HU227073B1 (hu) * | 2003-07-10 | 2010-06-28 | Richter Gedeon Nyrt | Eljárás királisan tiszta N-(transz-4-izopropil-ciklohexilkarbonil)-D-fenil-alanin (nateglinid) és kristálymódosulatainak elõállítására, valamint a G-kristálymódosulata |
US20060004102A1 (en) * | 2004-05-07 | 2006-01-05 | Shlomit Wizel | Polymorphic forms of nateglinide |
US7425648B2 (en) | 2005-01-03 | 2008-09-16 | A.M.S.A. Anonima Materie Sintetiche E. Affini S.P.A. | Process for the preparation of nateglinide, preferably in B-form |
GT200600381A (es) | 2005-08-25 | 2007-03-28 | Compuestos organicos | |
KR101352588B1 (ko) | 2005-09-14 | 2014-01-17 | 다케다 야쿠힌 고교 가부시키가이샤 | 당뇨병 치료용 디펩티딜 펩티다아제 억제제 |
KR101399916B1 (ko) * | 2006-03-31 | 2014-05-28 | 아지노모토 가부시키가이샤 | 카복실산 클로라이드 화합물의 제조방법 |
CN103923169B (zh) * | 2006-12-06 | 2017-05-24 | 科内图斯医药公司 | (3s)‑3‑[n‑(n’‑(2‑叔丁基苯基)草氨酰基)丙氨酰基]氨基‑5‑(2’,3’,5’,6’‑四氟苯氧基)‑4‑氧代戊酸的结晶形式 |
MY184008A (en) | 2009-05-15 | 2021-03-17 | Novartis Ag | Aryl pyridine as aldosterone synthase inhibitors |
MX2011012627A (es) | 2009-05-28 | 2011-12-14 | Novartis Ag | Derivados aminobutiricos sustituidos como inhibidores de nepralisina. |
ME01923B (me) | 2009-05-28 | 2015-05-20 | Novartis Ag | Supstituisani derivati aminopropionske kiseline kao inhibitori neprilizina |
WO2011041293A1 (en) | 2009-09-30 | 2011-04-07 | Takeda Pharmaceutical Company Limited | Pyrazolo [1, 5-a] pyrimidine derivatives as apoptosis signal-regulating kinase 1 inhibitors |
WO2011061168A1 (en) | 2009-11-17 | 2011-05-26 | Novartis Ag | Aryl-pyridine derivatives as aldosterone synthase inhibitors |
JO2967B1 (en) | 2009-11-20 | 2016-03-15 | نوفارتس ايه جي | Acetic acid derivatives of carbamoyl methyl amino are substituted as new NEP inhibitors |
JP5575913B2 (ja) | 2009-11-30 | 2014-08-20 | ノバルティス アーゲー | アルドステロン合成酵素阻害剤としてのイミダゾール誘導体 |
DK2531501T3 (en) | 2010-02-03 | 2014-02-24 | Takeda Pharmaceutical | APOPTOSESIGNALREGULERENDE KINASE 1 inhibitors |
US8877815B2 (en) | 2010-11-16 | 2014-11-04 | Novartis Ag | Substituted carbamoylcycloalkyl acetic acid derivatives as NEP |
US8673974B2 (en) | 2010-11-16 | 2014-03-18 | Novartis Ag | Substituted amino bisphenyl pentanoic acid derivatives as NEP inhibitors |
UY35144A (es) | 2012-11-20 | 2014-06-30 | Novartis Ag | Miméticos lineales sintéticos de apelina para el tratamiento de insuficiencia cardiaca |
TR201808541T4 (tr) | 2013-02-14 | 2018-07-23 | Novartis Ag | Nep (nötr endopeptidaz) inhibitörleri olarak ikame edilmiş bisfenil butanoik fosfonik asit türevleri. |
CN105612172A (zh) | 2013-07-25 | 2016-05-25 | 诺华股份有限公司 | 用于治疗心力衰竭的环状多肽 |
CN105705167A (zh) | 2013-07-25 | 2016-06-22 | 诺华股份有限公司 | 合成的apelin多肽的生物缀合物 |
SG11201704758XA (en) | 2015-01-23 | 2017-08-30 | Novartis Ag | Synthetic apelin fatty acid conjugates with improved half-life |
UY38072A (es) | 2018-02-07 | 2019-10-01 | Novartis Ag | Compuestos derivados de éster butanoico sustituido con bisfenilo como inhibidores de nep, composiciones y combinaciones de los mismos |
CN109369443A (zh) * | 2018-11-05 | 2019-02-22 | 扬子江药业集团江苏海慈生物药业有限公司 | 一种新的那格列奈h晶型的制备方法 |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US196222A (en) * | 1877-10-16 | Improvement in belt-tighteners | ||
JPS6354321A (ja) * | 1985-03-27 | 1988-03-08 | Ajinomoto Co Inc | 血糖降下剤 |
-
1992
- 1992-07-29 JP JP4202686A patent/JP2508949B2/ja not_active Expired - Lifetime
- 1992-07-29 EP EP92306895A patent/EP0526171B1/de not_active Expired - Lifetime
- 1992-07-29 DE DE2001199058 patent/DE10199058I2/de active Active
- 1992-07-29 AT AT92306895T patent/ATE149483T1/de active
- 1992-07-29 DK DK92306895.1T patent/DK0526171T3/da active
- 1992-07-29 DE DE69217762T patent/DE69217762T2/de not_active Expired - Lifetime
- 1992-07-29 ES ES92306895T patent/ES2100291T3/es not_active Expired - Lifetime
-
1993
- 1993-12-14 US US08/166,144 patent/US5488150A/en not_active Expired - Lifetime
-
1994
- 1994-02-01 CA CA002114678A patent/CA2114678C/en not_active Expired - Lifetime
-
1997
- 1997-05-12 BR BR1100807-5A patent/BR1100807A/pt active IP Right Grant
-
2001
- 2001-09-28 NL NL300063C patent/NL300063I2/nl unknown
- 2001-09-28 LU LU90843C patent/LU90843I2/fr unknown
- 2001-10-03 LU LU90846C patent/LU90846I2/fr unknown
Also Published As
Publication number | Publication date |
---|---|
DK0526171T3 (da) | 1997-08-25 |
DE69217762D1 (de) | 1997-04-10 |
EP0526171A2 (de) | 1993-02-03 |
BR1100807A (pt) | 1999-12-28 |
EP0526171B1 (de) | 1997-03-05 |
JP2508949B2 (ja) | 1996-06-19 |
DE10199058I1 (de) | 2002-01-24 |
DE10199058I2 (de) | 2006-04-27 |
JPH05208943A (ja) | 1993-08-20 |
LU90843I2 (fr) | 2002-02-04 |
NL300063I1 (nl) | 2001-12-01 |
EP0526171A3 (en) | 1993-05-05 |
DE69217762T2 (de) | 1997-10-09 |
US5488150A (en) | 1996-01-30 |
LU90846I2 (fr) | 2002-02-04 |
ES2100291T3 (es) | 1997-06-16 |
CA2114678C (en) | 1999-04-27 |
NL300063I2 (nl) | 2002-02-01 |
CA2114678A1 (en) | 1995-08-02 |
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