SI2531501T1 - Inhibitorji kinaze-1, ki regulirajo signal apoptoze - Google Patents
Inhibitorji kinaze-1, ki regulirajo signal apoptozeInfo
- Publication number
- SI2531501T1 SI2531501T1 SI201130115T SI201130115T SI2531501T1 SI 2531501 T1 SI2531501 T1 SI 2531501T1 SI 201130115 T SI201130115 T SI 201130115T SI 201130115 T SI201130115 T SI 201130115T SI 2531501 T1 SI2531501 T1 SI 2531501T1
- Authority
- SI
- Slovenia
- Prior art keywords
- inhibitors
- apoptosis signal
- regulating kinase
- kinase
- regulating
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
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- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
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Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US30086910P | 2010-02-03 | 2010-02-03 | |
EP11701347.4A EP2531501B1 (en) | 2010-02-03 | 2011-01-21 | Apoptosis signal-regulating kinase 1 inhibitors |
PCT/US2011/022137 WO2011097079A1 (en) | 2010-02-03 | 2011-01-21 | Apoptosis signal-regulating kinase 1 inhibitors |
Publications (1)
Publication Number | Publication Date |
---|---|
SI2531501T1 true SI2531501T1 (sl) | 2014-04-30 |
Family
ID=43645892
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SI201130115T SI2531501T1 (sl) | 2010-02-03 | 2011-01-21 | Inhibitorji kinaze-1, ki regulirajo signal apoptoze |
Country Status (14)
Country | Link |
---|---|
US (2) | US8802695B2 (sl) |
EP (1) | EP2531501B1 (sl) |
JP (1) | JP5711270B2 (sl) |
CN (1) | CN102834393B (sl) |
CA (1) | CA2787360C (sl) |
DK (1) | DK2531501T3 (sl) |
ES (1) | ES2445917T3 (sl) |
HR (1) | HRP20140114T1 (sl) |
PL (1) | PL2531501T3 (sl) |
PT (1) | PT2531501E (sl) |
RS (1) | RS53176B (sl) |
SI (1) | SI2531501T1 (sl) |
SM (1) | SMT201400012B (sl) |
WO (1) | WO2011097079A1 (sl) |
Families Citing this family (38)
Publication number | Priority date | Publication date | Assignee | Title |
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TWI598347B (zh) | 2009-07-13 | 2017-09-11 | 基利科學股份有限公司 | 調節細胞凋亡信號之激酶的抑制劑 |
CN102834393B (zh) * | 2010-02-03 | 2015-07-22 | 武田药品工业株式会社 | 细胞凋亡信号调节激酶1抑制剂 |
PT2588475E (pt) | 2010-07-02 | 2015-09-08 | Gilead Sciences Inc | Inibidores de cinase reguladora dos sinais da apoptose |
US9045485B2 (en) | 2010-12-16 | 2015-06-02 | Convergence Pharmaceuticals Limited | ASK 1 inhibiting pyrrolopyrimidine derivatives |
AU2012301617A1 (en) | 2011-09-02 | 2014-04-17 | Salk Institute For Biological Studies | CaMKII, IP3R, calcineurin, p38 and MK2/3 inhibitors to treat metabolic disturbances of obesity |
UY34573A (es) | 2012-01-27 | 2013-06-28 | Gilead Sciences Inc | Inhibidor de la quinasa que regula la señal de la apoptosis |
WO2013169704A2 (en) * | 2012-05-08 | 2013-11-14 | Merck Sharp & Dohme Corp. | TETRAHYDRONAPHTHYRIDINE AND RELATED BICYCLIC COMPOUNDS FOR INHIBITION OF RORgamma ACTIVITY AND THE TREATMENT OF DISEASE |
US11571431B2 (en) | 2013-12-04 | 2023-02-07 | Galmed Research And Development Ltd | Aramchol salts |
CA2930232C (en) * | 2013-12-04 | 2020-09-15 | Galmed Research & Development Ltd. | Aramchol salts |
TW201618781A (zh) | 2014-08-13 | 2016-06-01 | 吉李德科學股份有限公司 | 治療肺高血壓之方法 |
BR112017005693A2 (pt) | 2014-09-24 | 2017-12-12 | Gilead Sciences Inc | método para tratar e/ou prevenir uma doença hepática, e, composição farmacêutica. |
CN107108519B (zh) | 2014-12-23 | 2020-11-03 | 吉利德科学公司 | 制备ask1抑制剂的方法 |
MA41252A (fr) | 2014-12-23 | 2017-10-31 | Gilead Sciences Inc | Formes solides d'un inhibiteur d'ask 1 |
US10849911B2 (en) | 2015-06-10 | 2020-12-01 | Galmed Research And Development Ltd. | Low dose compositions of Aramachol salts |
US20190084928A1 (en) * | 2016-04-01 | 2019-03-21 | National University Corporation Chiba University | Method for producing nitrogen-containing aromatic amide, method for producing pyrrole-imidazole polyamide, and compound |
EP3241830A1 (de) | 2016-05-04 | 2017-11-08 | Bayer CropScience Aktiengesellschaft | Kondensierte bicyclische heterocyclen-derivate als schädlingsbekämpfungsmittel |
MA45918A (fr) | 2016-08-15 | 2019-06-19 | Bayer Ag | Dérivés hétérocycliques bicycliques condensés utilisés comme pesticides |
TWI752155B (zh) | 2017-02-01 | 2022-01-11 | 德商菲尼克斯製藥股份有限公司 | 芳香烴受體(AhR)調節劑化合物 |
TWI674260B (zh) | 2017-02-01 | 2019-10-11 | 德商菲尼克斯製藥股份有限公司 | 芳基烴受體(AhR)調節劑化合物 |
JOP20190221A1 (ar) * | 2017-04-05 | 2019-09-23 | Seal Rock Therapeutics Inc | مركبات مثبطات كيناز منظم لإشارات الاستماتة 1 (ask1) واستخداماتها |
EP3621615B1 (en) | 2017-05-12 | 2023-11-15 | Enanta Pharmaceuticals, Inc. | Apoptosis signal-regulating kinase 1 inhibitors and methods of use thereof |
US10450301B2 (en) | 2017-05-25 | 2019-10-22 | Enanta Pharmaceuticals, Inc. | Apoptosis signal-regulating kinase 1 inhibitors and methods of use thereof |
WO2018218044A2 (en) * | 2017-05-25 | 2018-11-29 | Enanta Pharmaceuticals Inc | Apoptosis signal-regulating kinase 1 inhibitors and methods of use thereof |
US10253018B2 (en) | 2017-05-25 | 2019-04-09 | Enanta Pharmaceuticals, Inc. | Apoptosis signal-regulating kinase 1 inhibitors and methods of use thereof |
CN110770233B (zh) * | 2017-06-19 | 2022-07-26 | 广东东阳光药业有限公司 | 稠合双环类化合物及其在药物中的应用 |
WO2019046186A1 (en) | 2017-08-28 | 2019-03-07 | Enanta Pharmaceuticals, Inc. | INHIBITORS OF KINASE 1 REGULATING THE APOPTOTIC SIGNAL CONTAINING TETRAZOLES AND METHODS OF USE THEREOF |
US11434249B1 (en) | 2018-01-02 | 2022-09-06 | Seal Rock Therapeutics, Inc. | ASK1 inhibitor compounds and uses thereof |
WO2019213239A1 (en) | 2018-05-02 | 2019-11-07 | Enanta Pharmaceuticals Inc. | Apoptosis signal-regulating kinase 1 inhibitors and methods of use thereof |
CA3097982A1 (en) | 2018-05-02 | 2019-11-07 | Enanta Pharmaceuticals, Inc. | Tetrazole containing apoptosis signal-regulating kinase 1 inhibitors and methods of use thereof |
WO2020010140A1 (en) * | 2018-07-03 | 2020-01-09 | Novartis Inflammasome Research, Inc. | Nlrp modulators |
MA53225A (fr) * | 2018-08-14 | 2021-06-23 | Biogen Ma Inc | Agents inhibiteurs d'ask1 |
US10968199B2 (en) | 2018-08-22 | 2021-04-06 | Enanta Pharmaceuticals, Inc. | Cycloalkyl-containing apoptosis signal-regulating kinase 1 inhibitors and methods of use thereof |
WO2020106707A1 (en) | 2018-11-19 | 2020-05-28 | Enanta Pharmaceuticals, Inc. | Apoptosis signal-regulating kinase 1 inhibitors and methods of use thereof |
US11466033B2 (en) | 2019-03-25 | 2022-10-11 | Enanta Pharmaceuticals, Inc. | Substituted pyridines as apoptosis signal-regulating kinase 1 inhibitors |
WO2020229982A1 (en) * | 2019-05-10 | 2020-11-19 | Takeda Pharmaceutical Company Limited | Antibody drug conjugates |
CN111808079A (zh) * | 2020-08-05 | 2020-10-23 | 中国药科大学 | 吲哚类ask1小分子抑制剂及其制备方法和应用 |
WO2024054749A2 (en) * | 2022-09-08 | 2024-03-14 | Bridge Medicines | Inhibitors of enl/af9 yeats and flt3 |
CN115368352B (zh) * | 2022-10-25 | 2023-08-15 | 南京盛德瑞尔医药科技有限公司 | 一种葡萄糖激酶激动剂及其制备方法和应用 |
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-
2011
- 2011-01-21 CN CN201180016037.8A patent/CN102834393B/zh not_active Expired - Fee Related
- 2011-01-21 CA CA2787360A patent/CA2787360C/en not_active Expired - Fee Related
- 2011-01-21 ES ES11701347.4T patent/ES2445917T3/es active Active
- 2011-01-21 RS RS20140066A patent/RS53176B/en unknown
- 2011-01-21 DK DK11701347.4T patent/DK2531501T3/en active
- 2011-01-21 EP EP11701347.4A patent/EP2531501B1/en active Active
- 2011-01-21 PT PT117013474T patent/PT2531501E/pt unknown
- 2011-01-21 WO PCT/US2011/022137 patent/WO2011097079A1/en active Application Filing
- 2011-01-21 US US13/577,182 patent/US8802695B2/en not_active Expired - Fee Related
- 2011-01-21 JP JP2012551994A patent/JP5711270B2/ja not_active Expired - Fee Related
- 2011-01-21 PL PL11701347T patent/PL2531501T3/pl unknown
- 2011-01-21 SI SI201130115T patent/SI2531501T1/sl unknown
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2014
- 2014-01-27 SM SM201400012T patent/SMT201400012B/xx unknown
- 2014-02-06 HR HRP20140114AT patent/HRP20140114T1/hr unknown
- 2014-07-21 US US14/336,871 patent/US9403819B2/en not_active Expired - Fee Related
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US20140329850A1 (en) | 2014-11-06 |
HRP20140114T1 (hr) | 2014-03-14 |
EP2531501A1 (en) | 2012-12-12 |
US8802695B2 (en) | 2014-08-12 |
US20120316194A1 (en) | 2012-12-13 |
JP5711270B2 (ja) | 2015-04-30 |
SMT201400012B (it) | 2014-03-07 |
CA2787360A1 (en) | 2011-08-11 |
JP2013518881A (ja) | 2013-05-23 |
DK2531501T3 (en) | 2014-02-24 |
CN102834393B (zh) | 2015-07-22 |
PT2531501E (pt) | 2014-02-17 |
CA2787360C (en) | 2019-03-05 |
EP2531501B1 (en) | 2013-11-20 |
US9403819B2 (en) | 2016-08-02 |
WO2011097079A1 (en) | 2011-08-11 |
ES2445917T3 (es) | 2014-03-06 |
RS53176B (en) | 2014-06-30 |
PL2531501T3 (pl) | 2014-05-30 |
CN102834393A (zh) | 2012-12-19 |
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