DE10199058I2 - Kristalle von N-(trans-4-isopropylcyclohexylcarbonyl)-D-phenylalanin und Verfahren zu ihrer Herstellung - Google Patents

Kristalle von N-(trans-4-isopropylcyclohexylcarbonyl)-D-phenylalanin und Verfahren zu ihrer Herstellung

Info

Publication number
DE10199058I2
DE10199058I2 DE2001199058 DE10199058C DE10199058I2 DE 10199058 I2 DE10199058 I2 DE 10199058I2 DE 2001199058 DE2001199058 DE 2001199058 DE 10199058 C DE10199058 C DE 10199058C DE 10199058 I2 DE10199058 I2 DE 10199058I2
Authority
DE
Germany
Prior art keywords
crystals
solvent
isopropylcyclohexylcarbonyl
phenylalanine
trans
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
DE2001199058
Other languages
English (en)
Other versions
DE10199058I1 (de
Inventor
Michito Sumikawa
Yoshihito Koguchi
Takao Ohgane
Yasuo Irie
Satoji Takahashi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ALCM CO
Original Assignee
ALCM CO
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27169694&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE10199058(I2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by ALCM CO filed Critical ALCM CO
Publication of DE10199058I1 publication Critical patent/DE10199058I1/de
Application granted granted Critical
Publication of DE10199058I2 publication Critical patent/DE10199058I2/de
Active legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/22—Separation; Purification; Stabilisation; Use of additives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/57—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C07C233/63—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of rings other than six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DE2001199058 1991-07-30 1992-07-29 Kristalle von N-(trans-4-isopropylcyclohexylcarbonyl)-D-phenylalanin und Verfahren zu ihrer Herstellung Active DE10199058I2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP18969691 1991-07-30
JP19945391 1991-08-08
CA002114678A CA2114678C (en) 1991-07-30 1994-02-01 Crystals of n-(trans-4-isopropylcyclohexylcarbonyl)- d-phenylalanine and methods for preparing them

Publications (2)

Publication Number Publication Date
DE10199058I1 DE10199058I1 (de) 2002-01-24
DE10199058I2 true DE10199058I2 (de) 2006-04-27

Family

ID=27169694

Family Applications (2)

Application Number Title Priority Date Filing Date
DE2001199058 Active DE10199058I2 (de) 1991-07-30 1992-07-29 Kristalle von N-(trans-4-isopropylcyclohexylcarbonyl)-D-phenylalanin und Verfahren zu ihrer Herstellung
DE69217762T Expired - Lifetime DE69217762T2 (de) 1991-07-30 1992-07-29 Kristalle von N-(Trans-4-isopropylcyclohexylcarbonyl)-D-phenylalanin und Verfahren zu ihrer Herstellung

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE69217762T Expired - Lifetime DE69217762T2 (de) 1991-07-30 1992-07-29 Kristalle von N-(Trans-4-isopropylcyclohexylcarbonyl)-D-phenylalanin und Verfahren zu ihrer Herstellung

Country Status (11)

Country Link
US (1) US5488150A (de)
EP (1) EP0526171B1 (de)
JP (1) JP2508949B2 (de)
AT (1) ATE149483T1 (de)
BR (1) BR1100807A (de)
CA (1) CA2114678C (de)
DE (2) DE10199058I2 (de)
DK (1) DK0526171T3 (de)
ES (1) ES2100291T3 (de)
LU (2) LU90843I2 (de)
NL (1) NL300063I2 (de)

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EP1741447B1 (de) 2000-01-21 2013-09-18 Novartis AG Zusammensetzungen bestehend aus Dipeptidylpeptidase-IV Inhibitoren und Antidiabetica
AR033390A1 (es) 2000-08-22 2003-12-17 Novartis Ag Una composicion farmaceutica que comprende un antagonista del receptor at1 y un potenciador de la secrecion de insulina, el uso de dicha composicion para la fabricacion de un medicamento y un kit de partes
CN1232502C (zh) * 2000-10-18 2005-12-21 味之素株式会社 那格列胺结晶的制备方法
KR100783306B1 (ko) * 2000-10-18 2007-12-10 아지노모토 가부시키가이샤 아실페닐알라닌의 제조방법
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MXPA03003685A (es) * 2000-10-24 2004-01-26 Ajinomoto Kk Preparaciones que contienen nateglinida.
DE60130014T2 (de) * 2000-10-24 2008-05-08 Ajinomoto Co., Inc. Verfahren zur herstellung der b-form von nateglinid-kristallen
AR035425A1 (es) * 2001-01-30 2004-05-26 Teijin Ltd Cristal de diclorhidrato del acido 3-(3-amidinofenil)-5-[({[1-(iminoetil)-4-piperidil]metil}amino)metil]benzoico y proceso para prepararlo
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US20050234129A1 (en) * 2002-03-11 2005-10-20 Sutton Paul A Salts of nateglinide
US7411089B2 (en) 2002-04-15 2008-08-12 Ajinomoto Co., Inc. Nateglinide crystals
WO2003087039A1 (fr) * 2002-04-15 2003-10-23 Ajinomoto Co., Inc. Nouveau cristal de nateglinide
AU2003242520A1 (en) * 2002-04-15 2003-10-27 Novartis Ag Crystal forms of n-(trans-4-isopropylcyclohexylcarbonyl)-d-phenylalanine
EP1499586A4 (de) * 2002-04-29 2006-01-18 Biocon Ltd Neue form von n-(trans-4-isopropylcyclohexylcarbonyl)-d-phenylalanin
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US6861553B2 (en) * 2002-07-03 2005-03-01 Teva Pharmaceuticals Industries Ltd. Process for preparing nateglinide and intermediates thereof
US7534913B2 (en) * 2002-07-18 2009-05-19 Teva Pharmaceutica Industries Ltd. Crystalline form of nateglinide
US7420084B2 (en) * 2002-07-18 2008-09-02 Teva Pharmaceutical Industries Ltd. Polymorphic forms of nateglinide
US7148376B2 (en) * 2002-07-18 2006-12-12 Teva Pharmaceutical Industries Ltd. Polymorphic forms of nateglinide
US20050075400A1 (en) * 2002-07-18 2005-04-07 Ronit Yahalomi Polymorphic forms of nateglinide
US7358390B2 (en) * 2002-07-18 2008-04-15 Teva Pharmaceutical Industries Ltd. Polymorphic forms of nateglinide
US20040077725A1 (en) * 2002-08-28 2004-04-22 Dr. Reddy's Laboratories Limited Crystalline form of N-(trans-4-isopropylcyclohexane carbonyl)-D-phenylalanine and process for preparation thereof
US7449519B2 (en) * 2003-02-18 2008-11-11 Konishi Co., Ltd. Curing resin, method for producing same and curing resin composition
HU227073B1 (hu) * 2003-07-10 2010-06-28 Richter Gedeon Nyrt Eljárás királisan tiszta N-(transz-4-izopropil-ciklohexilkarbonil)-D-fenil-alanin (nateglinid) és kristálymódosulatainak elõállítására, valamint a G-kristálymódosulata
CA2563793A1 (en) * 2004-05-07 2005-11-24 Teva Pharmaceutical Industries Ltd. Polymorphic forms of nateglinide
US7425648B2 (en) 2005-01-03 2008-09-16 A.M.S.A. Anonima Materie Sintetiche E. Affini S.P.A. Process for the preparation of nateglinide, preferably in B-form
GT200600381A (es) 2005-08-25 2007-03-28 Compuestos organicos
WO2007033266A2 (en) 2005-09-14 2007-03-22 Takeda Pharmaceutical Company Limited Dipeptidyl peptidase inhibitors for treating diabetis
WO2007119580A1 (ja) * 2006-03-31 2007-10-25 Ajinomoto Co., Inc. カルボン酸クロリド化合物の製造方法
KR101125932B1 (ko) * 2006-12-06 2012-03-22 아이디유엔 파마슈티칼즈, 인코포레이티드 (3ｓ)-3-［ｎ-(ｎ'-(2-ｔｅｒｔ-부틸페닐)옥사밀)알라니닐］아미노-5-(2',3',5',6'-테트라플루오로페녹시)-4-옥소펜탄산의 결정 형태
WO2010130796A1 (en) 2009-05-15 2010-11-18 Novartis Ag Aryl pyridine as aldosterone synthase inhibitors
EA201101672A1 (ru) 2009-05-28 2012-06-29 Новартис Аг Замещенные производные аминомасляной кислоты в качестве ингибиторов неприлизина
BRPI1011657A2 (pt) 2009-05-28 2019-04-16 Novartis Ag derivados aminopropiônicos substituídos como inibidores de neprilisina
WO2011041293A1 (en) 2009-09-30 2011-04-07 Takeda Pharmaceutical Company Limited Pyrazolo [1, 5-a] pyrimidine derivatives as apoptosis signal-regulating kinase 1 inhibitors
JP5654608B2 (ja) 2009-11-17 2015-01-14 ノバルティス アーゲー アルドステロンシンターゼ阻害剤としてのアリール−ピリジン誘導体
JO2967B1 (en) 2009-11-20 2016-03-15 نوفارتس ايه جي Acetic acid derivatives of carbamoyl methyl amino are substituted as new NEP inhibitors
ES2472446T3 (es) 2009-11-30 2014-07-01 Novartis Ag Derivados de imidazol como inhibidores de aldosterona sintasa
SI2531501T1 (sl) 2010-02-03 2014-04-30 Takeda Pharmaceutical Company Limited Inhibitorji kinaze-1, ki regulirajo signal apoptoze
US8673974B2 (en) 2010-11-16 2014-03-18 Novartis Ag Substituted amino bisphenyl pentanoic acid derivatives as NEP inhibitors
US8877815B2 (en) 2010-11-16 2014-11-04 Novartis Ag Substituted carbamoylcycloalkyl acetic acid derivatives as NEP
UY35144A (es) 2012-11-20 2014-06-30 Novartis Ag Miméticos lineales sintéticos de apelina para el tratamiento de insuficiencia cardiaca
LT2956464T (lt) 2013-02-14 2018-07-10 Novartis Ag Pakeisti bisfenilbutanoinės fosfonrūgšties dariniai, kaip nep (neutralios endopeptidazės) inhibitoriai
US9340582B2 (en) 2013-07-25 2016-05-17 Novartis Ag Bioconjugates of synthetic apelin polypeptides
MX2016001020A (es) 2013-07-25 2016-08-03 Novartis Ag Polipeptidos ciclicos para el tratamiento de insuficiencia cardiaca.
AU2016209968B2 (en) 2015-01-23 2018-11-29 Novartis Ag Synthetic apelin fatty acid conjugates with improved half-life
UY38072A (es) 2018-02-07 2019-10-01 Novartis Ag Compuestos derivados de éster butanoico sustituido con bisfenilo como inhibidores de nep, composiciones y combinaciones de los mismos
CN109369443A (zh) * 2018-11-05 2019-02-22 扬子江药业集团江苏海慈生物药业有限公司 一种新的那格列奈h晶型的制备方法

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JPS6354321A (ja) * 1985-03-27 1988-03-08 Ajinomoto Co Inc 血糖降下剤

Also Published As

Publication number Publication date
DE10199058I1 (de) 2002-01-24
JPH05208943A (ja) 1993-08-20
LU90843I2 (fr) 2002-02-04
NL300063I1 (nl) 2001-12-01
CA2114678C (en) 1999-04-27
LU90846I2 (fr) 2002-02-04
DE69217762D1 (de) 1997-04-10
BR1100807A (pt) 1999-12-28
NL300063I2 (nl) 2002-02-01
EP0526171A3 (en) 1993-05-05
DE69217762T2 (de) 1997-10-09
ATE149483T1 (de) 1997-03-15
ES2100291T3 (es) 1997-06-16
EP0526171A2 (de) 1993-02-03
US5488150A (en) 1996-01-30
CA2114678A1 (en) 1995-08-02
JP2508949B2 (ja) 1996-06-19
DK0526171T3 (da) 1997-08-25
EP0526171B1 (de) 1997-03-05

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