IN2012DN02465A - - Google Patents

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Publication number
IN2012DN02465A
IN2012DN02465A IN2465DEN2012A IN2012DN02465A IN 2012DN02465 A IN2012DN02465 A IN 2012DN02465A IN 2465DEN2012 A IN2465DEN2012 A IN 2465DEN2012A IN 2012DN02465 A IN2012DN02465 A IN 2012DN02465A
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IN
India
Prior art keywords
present
provides
compounds
compound
pharmaceutically acceptable
Prior art date
Application number
Inventor
Iwakiyuki
Toshio Kawanami
Gary Michael Ksander
Muneto Mogi
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Novartis Ag
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Publication of IN2012DN02465A publication Critical patent/IN2012DN02465A/en

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/38—Nitrogen atoms
    • C07D231/40—Acylated on said nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D257/04—Five-membered rings
    • C07D257/06—Five-membered rings with nitrogen atoms directly attached to the ring carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
    • C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
    • C07D261/10—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D261/14—Nitrogen atoms

Abstract

The present invention provides a compound of Formula (I); or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R4, R6, A1, A2, X1, s and m are defined herein. The invention also relates to a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.
IN2465DEN2012 2009-11-20 2010-11-18 IN2012DN02465A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US26313709P 2009-11-20 2009-11-20
US35991410P 2010-06-30 2010-06-30
PCT/EP2010/067781 WO2011061271A1 (en) 2009-11-20 2010-11-18 Substituted carbamoylmethylamino acetic acid derivatives as novel nep inhibitors

Publications (1)

Publication Number Publication Date
IN2012DN02465A true IN2012DN02465A (en) 2015-08-21

Family

ID=43431937

Family Applications (1)

Application Number Title Priority Date Filing Date
IN2465DEN2012 IN2012DN02465A (en) 2009-11-20 2010-11-18

Country Status (37)

Country Link
US (4) US8222286B2 (en)
EP (2) EP2501683B1 (en)
JP (2) JP5543609B2 (en)
KR (1) KR101460421B1 (en)
CN (1) CN102666493B (en)
AR (1) AR079061A1 (en)
AU (1) AU2010320930B2 (en)
BR (1) BR112012011977A2 (en)
CA (1) CA2780150C (en)
CL (1) CL2012001298A1 (en)
CO (1) CO6540001A2 (en)
CR (1) CR20120237A (en)
DK (1) DK2501683T3 (en)
EA (1) EA021479B1 (en)
EC (1) ECSP12011978A (en)
ES (2) ES2481890T3 (en)
GT (1) GT201200153A (en)
HK (1) HK1170475A1 (en)
HN (1) HN2012001037A (en)
HR (1) HRP20140691T1 (en)
IL (1) IL219314A0 (en)
IN (1) IN2012DN02465A (en)
JO (1) JO2967B1 (en)
MA (1) MA33886B1 (en)
MX (1) MX2012005813A (en)
MY (1) MY158299A (en)
NZ (1) NZ599136A (en)
PE (1) PE20121311A1 (en)
PL (1) PL2501683T3 (en)
PT (1) PT2501683E (en)
RS (1) RS53422B (en)
SI (1) SI2501683T1 (en)
TN (1) TN2012000125A1 (en)
TW (1) TWI481598B (en)
UY (1) UY33044A (en)
WO (1) WO2011061271A1 (en)
ZA (1) ZA201202018B (en)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SG176010A1 (en) 2009-05-28 2011-12-29 Novartis Ag Substituted aminobutyric derivatives as neprilysin inhibitors
DK2435409T3 (en) * 2009-05-28 2014-10-27 Novartis Ag Substituted aminopropionic acid derivatives as neprilysin inhibitors
JO2967B1 (en) * 2009-11-20 2016-03-15 نوفارتس ايه جي Substituted carbamoylmethylamino acetic acid derivatives as novel NEP inhibitors
US8993631B2 (en) * 2010-11-16 2015-03-31 Novartis Ag Method of treating contrast-induced nephropathy
RS54348B1 (en) 2010-12-15 2016-02-29 Theravance Biopharma R&D Ip, Llc Neprilysin inhibitors
AR084290A1 (en) 2010-12-15 2013-05-08 Theravance Inc NEPRILISIN INHIBITORS, METHODS FOR THEIR PREPARATION AND INTERMEDIARIES USED THEREOF, PHARMACEUTICAL COMPOSITIONS THAT INCLUDE THEM AND THEIR USE IN THE MANUFACTURE OF MEDICINES TO TREAT DISEASES MEDIATED BY THE NEP INHIBITION
AU2012217615B2 (en) 2011-02-17 2016-09-29 Theravance Biopharma R&D Ip, Llc Substituted aminobutyric derivatives as neprilysin inhibitors
US8449890B2 (en) 2011-02-17 2013-05-28 Theravance, Inc. Neprilysin inhibitors
ES2699773T3 (en) 2011-05-31 2019-02-12 Theravance Biopharma R&D Ip Llc Neprilysin inhibitors
CA2835281A1 (en) 2011-05-31 2012-12-06 Theravance, Inc. Neprilysin inhibitors
EP2714662B1 (en) 2011-05-31 2017-10-11 Theravance Biopharma R&D IP, LLC Neprilysin inhibitors
TWI560172B (en) 2011-11-02 2016-12-01 Theravance Biopharma R&D Ip Llc Neprilysin inhibitors
ES2609810T3 (en) 2012-05-31 2017-04-24 Theravance Biopharma R&D Ip, Llc Nitric oxide donor neprilysin inhibitors
ES2710932T3 (en) 2012-06-08 2019-04-29 Theravance Biopharma R&D Ip Llc Neprilysin inhibitors
ES2700152T3 (en) 2012-06-08 2019-02-14 Theravance Biopharma R&D Ip Llc Neprilysin inhibitors
BR112015002821B1 (en) 2012-08-08 2022-10-18 Theravance Biopharma R&D Ip, Llc NEPRYLYSIN INHIBITOR COMPOUNDS AND PHARMACEUTICAL COMPOSITION
UY35144A (en) 2012-11-20 2014-06-30 Novartis Ag APELINE SYNTHETIC LINEAR MIMETICS FOR THE CARDIAC INSUFFICIENCY TREATMENT
BR112015019307A8 (en) 2013-02-14 2018-01-30 Novartis Ag bisphenyl substituted butanoic acid derivatives, their uses, and pharmaceutical composition
JP6295277B2 (en) * 2013-02-14 2018-03-14 ノバルティス アーゲー Substituted bisphenylbutanoic acid phosphonic acid derivatives as NEP (neutral endopeptidase) inhibitors
US8901169B2 (en) 2013-03-05 2014-12-02 Theravance Biopharma R&D Ip, Llc Neprilysin inhibitors
BR112016001376A2 (en) 2013-07-25 2017-10-24 Novartis Ag synthetic apelin polypeptide bioconjugates
SG11201600211XA (en) 2013-07-25 2016-02-26 Novartis Ag Cyclic polypeptides for the treatment of heart failure
SG11201606057PA (en) 2014-01-30 2016-08-30 Theravance Biopharma R&D Ip Llc 5-biphenyl-4-heteroarylcarbonylamino-pentanoic acid derivatives as neprilysin inhibitors
MX2016009760A (en) 2014-01-30 2016-11-08 Theravance Biopharma R&D Ip Llc Neprilysin inhibitors.
EA201791668A1 (en) 2015-01-23 2017-11-30 Новартис Аг SYNTHETIC CONJUGATES OF APELINE WITH FATTY ACID WITH IMPROVED HALF-PERIOD
CN107257785B (en) 2015-02-11 2020-07-07 施万生物制药研发Ip有限责任公司 (2S,4R) -5- (5 '-chloro-2' -fluorobiphenyl-4-yl) -4- (ethoxyoxalylamino) -2-hydroxymethyl-2-methylpentanoic acid as enkephalinase inhibitors
US9533962B2 (en) 2015-02-19 2017-01-03 Theravance Biopharma R&D Ip, Llc (2R,4R)-5-(5′-chloro-2′-fluorobiphenyl-4-yl)-2-hydroxy-4-[(5-methyloxazole-2-carbonyl)amino]pentanoic acid
KR20180114225A (en) 2016-03-08 2018-10-17 세라밴스 바이오파마 알앤디 아이피, 엘엘씨 (2S, 4R) -5- (5'-chloro-2'-fluoro- [1,1'-biphenyl] -4- yl) -2- (ethoxymethyl) -4- 5-carboxamido) -2-methylpentanoic acid < / RTI >
UY38072A (en) 2018-02-07 2019-10-01 Novartis Ag COMPOSITIONS DERIVED FROM BUTANOIC ESTER SUBSTITUTED WITH BISPHENYL AS INHIBITORS OF NEP, COMPOSITIONS AND COMBINATIONS OF THE SAME
EP3887388A1 (en) 2018-11-27 2021-10-06 Novartis AG Cyclic peptides as proprotein convertase subtilisin/kexin type 9 (pcsk9) inhibitors for the treatment of metabolic disorders
CN113166101A (en) 2018-11-27 2021-07-23 诺华股份有限公司 Cyclic pentameric compounds as proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors for the treatment of metabolic disorders
UY38485A (en) 2018-11-27 2020-06-30 Novartis Ag CYCLIC TETRAMER COMPOUNDS AS PROPROTEIN CONVERTASE SUBTILISIN / KEXIN TYPE 9 (PCSK9) INHIBITORS, METHOD OF TREATMENT, USE AND PREPARATION
EP3986853A1 (en) 2019-06-19 2022-04-27 NMD Pharma A/S Compounds for the treatment of neuromuscular disorders
WO2023084449A1 (en) 2021-11-12 2023-05-19 Novartis Ag Diaminocyclopentylpyridine derivatives for the treatment of a disease or disorder

Family Cites Families (133)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2954076C2 (en) * 1978-11-25 1988-02-25 Nippon Kayaku K.K., Tokio/Tokyo, Jp
DE2951135A1 (en) 1979-12-19 1981-06-25 Hoechst Ag, 6230 Frankfurt SULFONYL UREAS, METHOD FOR THE PRODUCTION THEREOF, PHARMACEUTICAL PREPARATIONS BASED ON THESE COMPOUNDS AND THEIR USE
EP0038046B1 (en) 1980-04-11 1984-02-29 The Wellcome Foundation Limited Pharmaceutical amides, and preparation, formulations and use thereof
PT72878B (en) 1980-04-24 1983-03-29 Merck & Co Inc Process for preparing mannich-base hydroxamic acid pro-drugs for the improved delivery of non-steroidal anti-inflammatory agents
US4610816A (en) * 1980-12-18 1986-09-09 Schering Corporation Substituted dipeptides as inhibitors of enkephalinases
IE53315B1 (en) * 1980-12-18 1988-10-12 Schering Corp Substituted dipeptides,processes for their preparation and pharmaceutical compositions containing them and their use in the inhibition of enkephalinase
US4721726A (en) * 1980-12-18 1988-01-26 Schering Corporation Substituted dipeptides as inhibitors of enkephalinases
JPS5865260A (en) 1981-10-13 1983-04-18 Microbial Chem Res Found 3-amino-2-hydroxy-4-phenylbutyric acid derivative and pharmaceutical composition
FR2518088B1 (en) * 1981-12-16 1987-11-27 Roques Bernard NOVEL AMINO ACID DERIVATIVES AND THEIR THERAPEUTIC APPLICATION
NZ201001A (en) * 1982-06-17 1986-02-21 Schering Corp Substituted dipeptide derivatives and method of preparation
DE3376649D1 (en) 1982-06-17 1988-06-23 Schering Corp Substituted dipeptides, methods for their production, pharmaceutical compositions containing them, method for making such pharmaceutical compositions
US4617307A (en) 1984-06-20 1986-10-14 Ciba-Geigy Corporation Substituted imidazo[1,5-A]pyridine derivatives as aromatase inhibitors
US4889861A (en) 1982-12-21 1989-12-26 Ciba-Geigy Corp. Substituted imidazo[1,5-a]pyridine derivatives and other substituted bicyclic derivatives and their use as aromatase inhibitors
PH22224A (en) 1983-01-28 1988-07-01 Schering Corp Phosphorus containing amide compounds and pharmaceutical compositions containing them
US4559332A (en) 1983-04-13 1985-12-17 Ciba Geigy Corporation 20-Spiroxanes and analogues having an open ring E, processes for their manufacture, and pharmaceutical preparations thereof
DE3467754D1 (en) 1983-10-03 1988-01-07 Squibb & Sons Inc ENKEPHALINASE INHIBITORS
DE3347565A1 (en) 1983-12-30 1985-07-11 Thomae Gmbh Dr K NEW PHENYL ACETIC DERIVATIVES, MEDICINAL PRODUCTS CONTAINING THESE COMPOUNDS AND METHOD FOR THE PRODUCTION THEREOF
JPS60248659A (en) * 1984-05-25 1985-12-09 Microbial Chem Res Found 3(n-(mercaptoacyl))amino-4-arylbutyric acid derivative and analgesic containing said derivative as active component
JPS6354321A (en) 1985-03-27 1988-03-08 Ajinomoto Co Inc Blood sugar lowering agent
FR2597865B1 (en) 1986-04-29 1990-11-09 Roussel Uclaf NOVEL DERIVATIVES OF A BENZYL ALKYL CARBOXYLIC ACID SUBSTITUTED BY A RADICAL 4-PYRIDINYL AMINOCARBONYL, THEIR PREPARATION PROCESS, THE NEW INTERMEDIATES OBTAINED, THEIR APPLICATION AS MEDICAMENTS AND THE PHARMACEUTICAL COMPOSITIONS
US5118666A (en) 1986-05-05 1992-06-02 The General Hospital Corporation Insulinotropic hormone
US5120712A (en) 1986-05-05 1992-06-09 The General Hospital Corporation Insulinotropic hormone
FR2605004B1 (en) 1986-09-25 1989-01-13 Centre Nat Rech Scient NOVEL AMINO ACID DERIVATIVES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITION CONTAINING THEM
CA1337400C (en) 1987-06-08 1995-10-24 Norma G. Delaney Inhibitors of neutral endopeptidase
AU4211989A (en) * 1988-08-18 1990-03-23 California Biotechnology, Inc. Atrial natriuretic peptide clearance inhibitors
FR2651229B1 (en) 1989-08-24 1991-12-13 Inst Nat Sante Rech Med NOVEL AMINO ACID DERIVATIVES, THEIR PREPARATION PROCESS AND THEIR THERAPEUTIC APPLICATION.
FR2652087B1 (en) * 1989-09-15 1993-10-15 Bioprojet Ste Civile AMINO ACID DERIVATIVES, THEIR PREPARATION PROCESS AND THEIR THERAPEUTIC APPLICATIONS.
US5407960A (en) 1989-12-22 1995-04-18 Schering Corporation Mercaptocycloacyl aminoacid endopeptidase inhibitors
ATE164852T1 (en) 1990-01-24 1998-04-15 Douglas I Buckley GLP-1 ANALOGUE USABLE IN DIABETES TREATMENT
US5223516A (en) * 1990-03-22 1993-06-29 E. R. Squibb & Sons, Inc. 3,3,3-trifluoro-2-mercaptomethyl-N-tetrazolyl substituted propanamides and method of using same
US5200426A (en) * 1990-08-14 1993-04-06 Board Of Regents, The University Of Texas Inhibitors of neutral endopeptidase/CALLA as chemotherapeutic agents
JPH04149166A (en) 1990-10-12 1992-05-22 Nippon Kayaku Co Ltd Novel keto acid amide derivative
CA2058797A1 (en) 1991-02-01 1992-08-02 Michael John Broadhurst Amino acid derivatives
AU654331B2 (en) 1991-03-30 1994-11-03 Kissei Pharmaceutical Co. Ltd. Succinic acid compounds
US5294632A (en) * 1991-05-01 1994-03-15 Ciba-Geigy Corporation Phosphono/biaryl substituted dipetide derivatives
RU2086544C1 (en) 1991-06-13 1997-08-10 Хоффманн-Ля Рош АГ Benzenesulfonamide derivatives of pyrimidine or their salts, pharmaceutical composition for treatment of diseases associated with endothelin activity
WO1993000337A1 (en) 1991-06-21 1993-01-07 Dr. Karl Thomae Gmbh (s)(+)-2-ethoxy-4-[n-[1-(2-piperidinophenyl)-3-methyl-1-butyl]aminocarbonylmethyl]benzoic acid
GB9114006D0 (en) 1991-06-28 1991-08-14 Fujisawa Pharmaceutical Co New propionamide derivatives,processes for the preparation thereof and pharmaceutical composition comprising the same
DE10199058I2 (en) 1991-07-30 2006-04-27 Alcm Co Crystals of N- (trans-4-isopropylcyclohexylcarbonyl) -D-phenylalanine and process for their preparation
EP0533130A1 (en) 1991-09-19 1993-03-24 Hoechst Aktiengesellschaft 2-Hydroxymethylpyridines, the corresponding pyridine-N-oxides and derivatives thereof, process for their preparation and their use
CA2078759C (en) 1991-09-27 2003-09-16 Alan M. Warshawsky Novel carboxyalkyl derivatives useful as inhibitors of enkephalinase and ace
US5273990A (en) * 1992-09-03 1993-12-28 Ciba-Geigy Corporation Phosphono substituted tetrazole derivatives
US5250522A (en) * 1992-10-09 1993-10-05 Ciba-Geigy Corporation Phosphono/biaryl substituted amino acid derivatives
WO1993011782A1 (en) 1991-12-19 1993-06-24 Southwest Foundation For Biomedical Research Cetp inhibitor polypeptide, antibodies against the synthetic polypeptide and prophylactic and therapeutic anti-atherosclerosis treatments
US5217996A (en) * 1992-01-22 1993-06-08 Ciba-Geigy Corporation Biaryl substituted 4-amino-butyric acid amides
JPH06234630A (en) 1992-12-17 1994-08-23 Tanabe Seiyaku Co Ltd Neutral metalloendopeptidase inhibitor
AU6267894A (en) 1993-03-02 1994-09-26 G.D. Searle & Co. N-acyl beta amino acid derivatives useful as platelet aggregation inhibitors
JP3576193B2 (en) 1993-12-03 2004-10-13 第一製薬株式会社 Biphenylmethyl-substituted valerylamide derivatives
IL111785A0 (en) 1993-12-03 1995-01-24 Ferring Bv Dp-iv inhibitors and pharmaceutical compositions containing them
US5705483A (en) 1993-12-09 1998-01-06 Eli Lilly And Company Glucagon-like insulinotropic peptides, compositions and methods
US5517996A (en) * 1994-04-21 1996-05-21 Hitachi Medical Corporation Ultrasonic diagnostic apparatus
IT1270261B (en) 1994-06-21 1997-04-29 Zambon Spa PEPTIDAL DERIVATIVES WITH INHIBITIVE ACTIVITY OF METALLOPEPTIDASES
US5512549A (en) 1994-10-18 1996-04-30 Eli Lilly And Company Glucagon-like insulinotropic peptide analogs, compositions, and methods of use
CN1055681C (en) * 1994-11-04 2000-08-23 参天制药株式会社 Novel 1,3-dialkylurea derivativa having hydroxyl group
WO1996018606A1 (en) * 1994-12-14 1996-06-20 Santen Pharmaceutical Co., Ltd. Novel 1,3-dialkylurea derivatives
TW313568B (en) 1994-12-20 1997-08-21 Hoffmann La Roche
US5550119A (en) * 1995-03-02 1996-08-27 Ciba-Geigy Corporation Phosphono substituted tetrazole derivatives as ECE inhibitors
US5703092A (en) * 1995-04-18 1997-12-30 The Dupont Merck Pharmaceutical Company Hydroxamic acid compounds as metalloprotease and TNF inhibitors
US5710171A (en) * 1995-05-24 1998-01-20 Merck & Co., Inc. Bisphenyl inhibitors of farnesyl-protein transferase
DE122010000020I1 (en) 1996-04-25 2010-07-08 Prosidion Ltd Method for lowering the blood glucose level in mammals
IL118657A0 (en) 1996-06-14 1996-10-16 Arad Dorit Inhibitors for picornavirus proteases
JP2002514179A (en) 1996-09-04 2002-05-14 ワーナー―ランバート・コンパニー Biphenylbutyric acid and its derivatives as inhibitors of matrix metalloproteinases
FR2755135B1 (en) 1996-10-25 2002-12-27 Inst Nat Sante Rech Med NOVEL (ALPHA-AMINOPHOSPHINO) PEPTIDES DERIVATIVES, PROCESS FOR THEIR PREPARATION AND COMPOSITIONS CONTAINING THEM
TW492957B (en) 1996-11-07 2002-07-01 Novartis Ag N-substituted 2-cyanopyrrolidnes
CA2291762A1 (en) 1997-05-29 1998-12-03 Merck & Co., Inc. Biarylalkanoic acids as cell adhesion inhibitors
WO1999026923A1 (en) 1997-11-20 1999-06-03 Merck & Co., Inc. Para-aminomethylaryl carboxamide derivatives
AU1463499A (en) 1997-11-21 1999-06-15 Merck & Co., Inc. Substituted pyrrole derivatives as cell adhesion inhibitors
ES2221227T3 (en) 1997-11-24 2004-12-16 MERCK & CO., INC. SUBSTITUTED DERIVATIVES OF BETA-ALANINA AS INHIBITORS OF CELLULAR ADHESION.
MY153569A (en) 1998-01-20 2015-02-27 Mitsubishi Tanabe Pharma Corp Inhibitors of ?4 mediated cell adhesion
US6169103B1 (en) * 1998-03-03 2001-01-02 Warner-Lambert Fluorine-substituted biphenyl butyric acids and their derivatives as inhibitors of matrix metalloproteinases
GT199900147A (en) 1998-09-17 1999-09-06 1, 2, 3, 4- TETRAHIDROQUINOLINAS 2-SUBSTITUTED 4-AMINO SUBSTITUTED.
US6197786B1 (en) 1998-09-17 2001-03-06 Pfizer Inc 4-Carboxyamino-2-substituted-1,2,3,4-tetrahydroquinolines
CO5150173A1 (en) 1998-12-10 2002-04-29 Novartis Ag COMPOUNDS N- (REPLACED GLYCLE) -2-DIPEPTIDYL-IV PEPTIDASE INHIBITING CYANOPIRROLIDINS (DPP-IV) WHICH ARE EFFECTIVE IN THE TREATMENT OF CONDITIONS MEDIATED BY DPP-IV INHIBITION
JP4070357B2 (en) 1999-06-03 2008-04-02 花王株式会社 Skin preparation
GB2354440A (en) 1999-07-20 2001-03-28 Merck & Co Inc Aryl amides as cell adhesion inhibitors
US6677341B2 (en) 1999-09-23 2004-01-13 Pharmacia Corporation (R)-Chiral halogenated substituted heteroaryl benzyl aminoalcohol compounds useful for inhibiting cholesteryl ester transfer protein activity
US6509330B2 (en) * 2000-02-17 2003-01-21 Bristol-Myers Squibb Company Hydroxamic acid containing compounds useful as ACE inhibitors and/or NEP inhibotors
CN1422152A (en) 2000-04-12 2003-06-04 诺瓦提斯公司 Combination of organic compound
WO2002026696A1 (en) 2000-09-29 2002-04-04 Prolifix Limited Carbamic acid compounds comprising an amide linkage as hdac inhibitors
IL162661A0 (en) 2002-01-17 2005-11-20 Novartis Ag Pharmaceutical compositions comprising valsartan and nep inhibitors
JP4233353B2 (en) 2002-02-27 2009-03-04 田辺三菱製薬株式会社 Pharmaceutical composition
US20040063761A1 (en) * 2002-08-06 2004-04-01 Kuduk Scott D. 2-(biarylalkyl)amino-3-(fluoroalkanoylamino)pyridine derivatives
BR0313293A (en) 2002-08-07 2005-06-14 Novartis Ag Organic compounds
CN100447142C (en) 2002-11-18 2008-12-31 诺瓦提斯公司 Imidazo[1, 5a]pyridine derivatives and methods for treating aldosterone mediated diseases
US20040142379A1 (en) 2003-01-16 2004-07-22 Carlsberg Research Laboratory Affinity fishing for ligands and proteins receptors
CA2514733A1 (en) 2003-02-28 2004-09-16 Transform Pharmaceuticals, Inc. Pharmaceutical co-crystal compositions of drugs such as carbamazepine, celecoxib, olanzapine, itraconazole, topiramate, modafinil, 5-fluorouracil, hydrochlorothiazide, acetaminophen, aspirin, flurbiprofen, phenytoin and ibuprofen
AU2004236247B2 (en) 2003-04-30 2008-11-06 The Institutes For Pharmaceutical Discovery, Llc Substituted amino carboxylic acids as inhibitors of protein tyrosine phosphatase-1 B
JP2007500707A (en) 2003-07-29 2007-01-18 リブ−エックス ファーマシューティカルズ，インコーポレイテッド Biarylheterocyclic amines, amides and sulfur-containing compounds and methods for making and using the compounds
WO2005014532A1 (en) 2003-08-08 2005-02-17 Transtech Pharma, Inc. Aryl and heteroaryl compounds, compositions and methods of use
DE602005008416D1 (en) 2004-03-26 2008-09-04 Lilly Co Eli COMPOUNDS FOR THE TREATMENT OF DYSLIPIDEMY
UA90269C2 (en) 2004-04-02 2010-04-26 Мицубиси Танабе Фарма Корпорейшн Tetrahydroquinoline derivatives and a process for preparing the same
TW200611898A (en) 2004-05-28 2006-04-16 Speedel Experimenta Ag Organic compounds
EP1765777A2 (en) 2004-05-28 2007-03-28 Speedel Experimenta AG Bicyclic, nitrogen-containing heterocycles as aromatase inhibitors
US20080076794A1 (en) 2004-05-28 2008-03-27 Peter Herold Heterocyclic Compounds And Their Use As Aldosterone Synthase Inhibitors
WO2006005726A2 (en) 2004-07-09 2006-01-19 Speedel Experimenta Ag Heterocyclic compounds
WO2006020358A2 (en) 2004-07-27 2006-02-23 Smithkline Beecham Corporation Novel biphenyl compounds and their use
WO2006015885A1 (en) 2004-08-13 2006-02-16 University College Dublin, National University Of Ireland, Dublin Amino acid dehydrogenase-derived biocatalysts
WO2006055725A2 (en) 2004-11-18 2006-05-26 The Institutes For Pharmaceutical Discovery, Llc Substituted amino acids as protein tyrosine phosphatase inhibitors
WO2006069096A1 (en) 2004-12-20 2006-06-29 Pharmacyclics, Inc. Silanol derivatives as inhibitors of histone deacetylase
MY146830A (en) * 2005-02-11 2012-09-28 Novartis Ag Combination of organic compounds
TW200716636A (en) 2005-05-31 2007-05-01 Speedel Experimenta Ag Heterocyclic spiro-compounds
TW200716105A (en) 2005-05-31 2007-05-01 Speedel Experimenta Ag Imidazole compounds
TW200716634A (en) 2005-05-31 2007-05-01 Speedel Experimenta Ag Heterocyclic spiro-compounds
GT200600381A (en) 2005-08-25 2007-03-28 ORGANIC COMPOUNDS
WO2007045663A2 (en) 2005-10-19 2007-04-26 Novartis Ag Combination of an ati receptor antagonist and a np inhibitor fro treating ia hypertension and heartfailure
JP2009514961A (en) 2005-11-08 2009-04-09 ノバルティス アクチエンゲゼルシャフト Combination of angiotensin II receptor blocker, calcium channel blocker and other active agents
AR057882A1 (en) * 2005-11-09 2007-12-26 Novartis Ag DOUBLE ACTION COMPOUNDS OF ANGIOTENSIN RECEPTOR BLOCKERS AND NEUTRAL ENDOPEPTIDASE INHIBITORS
AR056888A1 (en) 2005-12-09 2007-10-31 Speedel Experimenta Ag HIDEROCICLIL IMIDAZOL DERIVATIVES
EP2009080A4 (en) 2006-04-04 2010-05-26 Taiyo Nippon Sanso Corp Method for separation of methane, methane separator, and methane utilization system
TW200808812A (en) 2006-04-12 2008-02-16 Speedel Experimenta Ag Imidazo compounds
TW200808813A (en) 2006-04-12 2008-02-16 Speedel Experimenta Ag Imidazo compounds
EP2018166A2 (en) 2006-05-15 2009-01-28 Irm Llc Terephthalamate compounds and compositions, and their use as hiv integrase inhibitors
EP1886695A1 (en) 2006-06-27 2008-02-13 Speedel Experimenta AG Pharmaceutical combination of an aldosterone synthase inhibitor and a glucocorticoid receptor antagonist or a cortisol synthesis inhibitor or a corticotropin releasing factor antagonist
KR20090055595A (en) 2006-08-25 2009-06-02 노파르티스 아게 Fused imidazole derivatives for the treatment of disorders mediated by aldosterone synthase and/or 11-beta-hydroxylase and/or aromatase
EP1903027A1 (en) 2006-09-13 2008-03-26 Novartis AG Process for preparing biaryl substituted 4-amino-butyric acid or derivatives thereof and their use in the production of NEP inhibitors
MX2009006630A (en) 2006-12-18 2009-06-30 Novartis Ag 4-imidazolyl-1,2,3,4-tetrahydroquinoline derivatives and their use as aldosterone/11-beta-hydroxylase inhibitors.
KR20090091817A (en) 2006-12-18 2009-08-28 노파르티스 아게 Imidazoles as aldosterone synthase inhibitors
RU2009127642A (en) 2006-12-18 2011-01-27 Новартис АГ (CH) 1-SUBSTITUTED IMIDAZOLE DERIVATIVES AND THEIR APPLICATION AS ALDOSTEROSYNTHASE INHIBITORS
MY151993A (en) 2007-01-12 2014-07-31 Novartis Ag Process for preparing 5-biphenyl-4-amino-2-methyl pentanoic acid
TW200838501A (en) * 2007-02-02 2008-10-01 Theravance Inc Dual-acting antihypertensive agents
PL2134720T3 (en) 2007-03-29 2011-04-29 Novartis Ag Heterocyclic spiro-compounds
TWI448284B (en) * 2007-04-24 2014-08-11 Theravance Inc Dual-acting antihypertensive agents
WO2008138561A1 (en) 2007-05-10 2008-11-20 R & D Biopharmaceuticals Gmbh Tubulysine derivatives
TWI406850B (en) 2007-06-05 2013-09-01 Theravance Inc Dual-acting benzoimidazole antihypertensive agents
SI3067043T1 (en) 2007-11-06 2023-04-28 Novartis Ag Pharmaceutical compositions based on superstructures of angiotensin receptor antagonist/blocker (arb) and neutral endopeptidase (nep) inhibitor
WO2009076288A1 (en) 2007-12-11 2009-06-18 Theravance, Inc. Dual-acting benzoimidazole derivative and their use as antihypertensive agents
EP2070928A1 (en) 2007-12-12 2009-06-17 NERVIANO MEDICAL SCIENCES S.r.l. 7-azaindol-3-ylacrylamides active as kinase inhibitors
PE20091364A1 (en) 2008-01-17 2009-10-13 Novartis Ag PROCESS FOR THE PREPARATION OF NEP INHIBITORS
WO2010011821A2 (en) 2008-07-24 2010-01-28 Theravance, Inc. Dual-acting antihypertensive agents
DK2435409T3 (en) * 2009-05-28 2014-10-27 Novartis Ag Substituted aminopropionic acid derivatives as neprilysin inhibitors
SG176010A1 (en) * 2009-05-28 2011-12-29 Novartis Ag Substituted aminobutyric derivatives as neprilysin inhibitors
KR101821090B1 (en) 2009-09-23 2018-01-22 제지앙 지우조우 파마슈티칼 컴퍼니 리미티드 Process for manufacture of n-acylbiphenyl alanine
JO2967B1 (en) * 2009-11-20 2016-03-15 نوفارتس ايه جي Substituted carbamoylmethylamino acetic acid derivatives as novel NEP inhibitors

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