SG43036A1 - (S) (+) -2-ethoxy-4-[N-[1-(2-piperidino-phenyl)-3-methyl- 1-buthyl]aminocarbony methyl] - benzoic a cid - Google Patents
(S) (+) -2-ethoxy-4-[N-[1-(2-piperidino-phenyl)-3-methyl- 1-buthyl]aminocarbony methyl] - benzoic a cidInfo
- Publication number
- SG43036A1 SG43036A1 SG1996002715A SG1996002715A SG43036A1 SG 43036 A1 SG43036 A1 SG 43036A1 SG 1996002715 A SG1996002715 A SG 1996002715A SG 1996002715 A SG1996002715 A SG 1996002715A SG 43036 A1 SG43036 A1 SG 43036A1
- Authority
- SG
- Singapore
- Prior art keywords
- methyl
- aminocarbony
- buthyl
- cid
- piperidino
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
- C07D295/135—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Diabetes (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Hydrogenated Pyridines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Priority Applications (14)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SG1996002715A SG43036A1 (en) | 1991-06-21 | 1991-06-21 | (S) (+) -2-ethoxy-4-[N-[1-(2-piperidino-phenyl)-3-methyl- 1-buthyl]aminocarbony methyl] - benzoic a cid |
SK1280-93A SK281246B6 (en) | 1991-06-21 | 1991-06-21 | (s)(+)-2-ethoxy-4-(n-(1-(2-piperidino-phenyl)-3-methyl-1- -butyl)amino-carbonylmethyl) benzoic acid, pharmaceutical compositions containing thereof, intermediates for its preparation, and process for its preparation |
JP3511056A JP2921982B2 (en) | 1991-06-21 | 1991-06-21 | (S) (+)-2-ethoxy-4- [N- [1- (2-piperidino-phenyl) -3-methyl-1-butyl] aminocarbonylmethyl] -benzoic acid, a pharmaceutical composition containing this compound And its preparation method |
EP91911959A EP0589874B1 (en) | 1991-06-21 | 1991-06-21 | Use of (s)(+)-2-ethoxy-4-[n-[1-(2-piperidinophenyl)-3-methyl-1-butyl]aminocarbonylmethyl]benzoic acid for the preparation of a longlasting antidiabetic medicament |
CA002111851A CA2111851C (en) | 1991-06-21 | 1991-06-21 | (s)(+)-2-ethoxy-4-[n-{1-(2-piperidino-phenyl)-3-methyl-1-butyl]aminocarbonylmethyl]benzoic acid |
AU80781/91A AU660930B2 (en) | 1991-06-21 | 1991-06-21 | (S)(+)-2-ethoxy-4-(N-(1-(2-piperidinophenyl)-3-methyl-1- butyl)aminocarbonylmethyl)benzoic acid |
PL91301997A PL170210B1 (en) | 1991-06-21 | 1991-06-21 | Method of obtaining a novel (s)(+)-2-ethoxy-4-(n-)1-(2-pieridynophenyl)-3-methyl-1-butyloamino carbonylomethyl)benzoic acid and its salts |
PCT/EP1991/001147 WO1993000337A1 (en) | 1991-06-21 | 1991-06-21 | (s)(+)-2-ethoxy-4-[n-[1-(2-piperidinophenyl)-3-methyl-1-butyl]aminocarbonylmethyl]benzoic acid |
CN91104984A CN1048722C (en) | 1991-06-21 | 1991-07-22 | (S)(+)-2-Ethoxy-4-[N-[1-(2-piperidino-phenyl)-3-methyl-1-butyl]-aminocarbonylmethyl]-benzoic acid, pharmaceutical compositions containing compound and processes for preparation thereof |
FI935724A FI106027B (en) | 1991-06-21 | 1993-12-20 | A process for the preparation of (S) (+) - 2-ethoxy-4- [N- [1- (2-piperidinophenyl) -3-methyl-1-butyl] aminocarbonylmethyl] -benzoic acid or its salt, and (S) -1- ( Preparation of N-acetyl-L-glutamine salt of 2-piperidinophenyl) -3-methyl-1-butylamine |
NO934726A NO303687B1 (en) | 1991-06-21 | 1993-12-20 | Analogous process for the preparation of the therapeutically active compound (S) (+) - 2-ethoxy-4- [N- [1- (2-piperidino-phenyl) -3-methyl-1-butyl] aminocarbonylmethyl] -benzoic acid |
NO1999017C NO1999017I1 (en) | 1991-06-21 | 1999-07-20 | Repaglinide |
GR990402743T GR3031654T3 (en) | 1991-06-21 | 1999-10-27 | Use of (s)(+)-2-ethoxy-4-[n-[1-(2-piperidinophenyl)-3-methyl-1-butyl]aminocarbonylmethyl]benzoic acid for the preparation of a longlasting antidiabetic medicament |
UY25923A UY25923A1 (en) | 1991-06-21 | 2000-01-17 | PHARMACEUTICAL COMPOSITION FOR THE TREATMENT OF DIABETES MELLITUS.- |
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CA002111851A CA2111851C (en) | 1991-06-21 | 1991-06-21 | (s)(+)-2-ethoxy-4-[n-{1-(2-piperidino-phenyl)-3-methyl-1-butyl]aminocarbonylmethyl]benzoic acid |
PCT/EP1991/001147 WO1993000337A1 (en) | 1991-06-21 | 1991-06-21 | (s)(+)-2-ethoxy-4-[n-[1-(2-piperidinophenyl)-3-methyl-1-butyl]aminocarbonylmethyl]benzoic acid |
SG1996002715A SG43036A1 (en) | 1991-06-21 | 1991-06-21 | (S) (+) -2-ethoxy-4-[N-[1-(2-piperidino-phenyl)-3-methyl- 1-buthyl]aminocarbony methyl] - benzoic a cid |
CN91104984A CN1048722C (en) | 1991-06-21 | 1991-07-22 | (S)(+)-2-Ethoxy-4-[N-[1-(2-piperidino-phenyl)-3-methyl-1-butyl]-aminocarbonylmethyl]-benzoic acid, pharmaceutical compositions containing compound and processes for preparation thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
SG43036A1 true SG43036A1 (en) | 1997-10-17 |
Family
ID=36781542
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG1996002715A SG43036A1 (en) | 1991-06-21 | 1991-06-21 | (S) (+) -2-ethoxy-4-[N-[1-(2-piperidino-phenyl)-3-methyl- 1-buthyl]aminocarbony methyl] - benzoic a cid |
Country Status (8)
Country | Link |
---|---|
EP (1) | EP0589874B1 (en) |
JP (1) | JP2921982B2 (en) |
CN (1) | CN1048722C (en) |
AU (1) | AU660930B2 (en) |
FI (1) | FI106027B (en) |
NO (2) | NO303687B1 (en) |
SG (1) | SG43036A1 (en) |
WO (1) | WO1993000337A1 (en) |
Families Citing this family (39)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2002500677A (en) * | 1997-06-13 | 2002-01-08 | ノボ ノルディスク アクティーゼルスカブ | Novel NIDDM therapy |
IN192862B (en) | 1999-11-16 | 2004-05-22 | Ranbaxy Lab Ltd | |
AR033390A1 (en) | 2000-08-22 | 2003-12-17 | Novartis Ag | A PHARMACEUTICAL COMPOSITION THAT INCLUDES AN ATTA RECEIVER ANTAGONIST AND A POTENTIATOR OF THE INSULIN SECRETION, THE USE OF SUCH COMPOSITION FOR THE MANUFACTURE OF A MEDICINAL PRODUCT AND A PARTS KIT |
EP2266590A3 (en) | 2002-02-22 | 2011-04-20 | Shire LLC | Active agent delivery sytems and methods for protecting and administering active agents |
US20040102477A1 (en) * | 2002-08-23 | 2004-05-27 | Dr. Reddy's Laboratories Limited | Polymorphic forms of (S)-Repaglinide and the processes for preparation thereof |
EP1636199A2 (en) * | 2003-05-14 | 2006-03-22 | Cilag AG | Method for the production of phenylacetic acid derivatives |
AU2003237595A1 (en) * | 2003-05-26 | 2004-12-13 | Biocon Limited | Process for the preparation of s(+)-2-ethoxy-4-(n-{1-(2-piperidinophelyl)-3-methyl-1- butyl} aminocarbonylmethyl)benzoic acid derivatives |
EP1664008A1 (en) * | 2003-08-28 | 2006-06-07 | Ranbaxy Laboratories Limited | Process for the preparation of amorphous form of repaglinide |
CN1305863C (en) * | 2004-12-27 | 2007-03-21 | 浙江大学 | Method for synthesizing (S)-isopropyl-(2-piperidine) phenyl-methylhistamine |
GT200600381A (en) | 2005-08-25 | 2007-03-28 | ORGANIC COMPOUNDS | |
FR2898894B1 (en) * | 2006-03-24 | 2008-06-06 | Genfit Sa | SUBSTITUTED N- (PHENETHYL) BENZAMIDE DERIVATIVE COMPOUNDS, PREPARATION AND USES |
US7763607B2 (en) * | 2006-04-27 | 2010-07-27 | Solvay Pharmaceuticals Gmbh | Pharmaceutical compositions comprising CBx cannabinoid receptor modulators and potassium channel modulators |
SI2724722T1 (en) * | 2006-10-20 | 2017-07-31 | Neurendo Pharma, Llc | Method of restoring the incretin effect |
US8101769B2 (en) * | 2007-02-15 | 2012-01-24 | Actavis Group Ptc Ehf | Process for preparing ethyl (S)-2-ethoxy-4-[N-[1-(2-piperidinophenyl)-3-methyl-1-butyl]aminocarbonyl methyl]benzoate and use thereof for the preparation of Repaglinide |
WO2009004485A2 (en) * | 2007-06-06 | 2009-01-08 | Actavis Group Ptc Ehf | Repaglinide substantially free of dimer impurity |
EP2019097A1 (en) * | 2007-07-25 | 2009-01-28 | Aurobindo Pharma Limited | Process for preparing (alphaS)-alpha-(2-methylpropyl)-2-(1-piperidinyl)benzenemethanamine |
DE102008046995B4 (en) * | 2008-09-12 | 2010-08-26 | Stada Arzneimittel Ag | 2-ethoxy-benzoic acid |
EP2177221A1 (en) | 2008-10-20 | 2010-04-21 | Krka Tovarna Zdravil, D.D., Novo Mesto | Process for the preparation of substantially optically pure Repaglinide and precursors thereof |
WO2010130796A1 (en) | 2009-05-15 | 2010-11-18 | Novartis Ag | Aryl pyridine as aldosterone synthase inhibitors |
MX2011012199A (en) | 2009-05-15 | 2011-12-08 | Novartis Ag | Benzoxazolone derivatives as aldosterone symthase inhibitors. |
EA201101672A1 (en) | 2009-05-28 | 2012-06-29 | Новартис Аг | SUBSTITUTED DERIVATIVES OF AMINOISAL ACID AS NEPRILISIN INHIBITORS |
BRPI1011657A2 (en) | 2009-05-28 | 2019-04-16 | Novartis Ag | substituted aminopropionic derivatives as neprilysin inhibitors |
JP5654608B2 (en) | 2009-11-17 | 2015-01-14 | ノバルティス アーゲー | Aryl-pyridine derivatives as aldosterone synthase inhibitors |
JO2967B1 (en) | 2009-11-20 | 2016-03-15 | نوفارتس ايه جي | Substituted carbamoylmethylamino acetic acid derivatives as novel NEP inhibitors |
ES2472446T3 (en) | 2009-11-30 | 2014-07-01 | Novartis Ag | Imidazole derivatives as aldosterone synthase inhibitors |
EP2364977A1 (en) | 2010-01-26 | 2011-09-14 | Reuter Chemische Apparatebau KG | Process for the enantiomeric enrichment of 3-methyl-1-(2-piperidinophenyl)-1-butylamine |
US8673974B2 (en) | 2010-11-16 | 2014-03-18 | Novartis Ag | Substituted amino bisphenyl pentanoic acid derivatives as NEP inhibitors |
US8877815B2 (en) | 2010-11-16 | 2014-11-04 | Novartis Ag | Substituted carbamoylcycloalkyl acetic acid derivatives as NEP |
CN102267959B (en) * | 2011-07-06 | 2013-05-01 | 海南锦瑞制药股份有限公司 | Repaglinide crystal, preparation method thereof, and solid oral preparation containing same |
CN103012319B (en) * | 2011-09-20 | 2015-06-10 | 浙江九洲药业股份有限公司 | Repaglinide intermediate synthesis process improvement |
CN102584743A (en) * | 2011-12-28 | 2012-07-18 | 中国药科大学 | Dimethylaminopyridine repaglinide eutectic |
UY35144A (en) | 2012-11-20 | 2014-06-30 | Novartis Ag | APELINE SYNTHETIC LINEAR MIMETICS FOR THE CARDIAC INSUFFICIENCY TREATMENT |
LT2956464T (en) | 2013-02-14 | 2018-07-10 | Novartis Ag | Substituted bisphenyl butanoic phosphonic acid derivatives as nep (neutral endopeptidase) inhibitors |
MX2016001020A (en) | 2013-07-25 | 2016-08-03 | Novartis Ag | Cyclic polypeptides for the treatment of heart failure. |
US9340582B2 (en) | 2013-07-25 | 2016-05-17 | Novartis Ag | Bioconjugates of synthetic apelin polypeptides |
EP3215154B1 (en) | 2014-11-07 | 2020-01-29 | Regents of the University of Minnesota | Salts and compositions useful for treating disease |
AU2016209968B2 (en) | 2015-01-23 | 2018-11-29 | Novartis Ag | Synthetic apelin fatty acid conjugates with improved half-life |
WO2018034627A1 (en) | 2016-08-18 | 2018-02-22 | İlko Ilaç Sanayi Ve Ticaret Anonim Şirketi | Pharmaceutical composition of antidiabetic tablet |
UY38072A (en) | 2018-02-07 | 2019-10-01 | Novartis Ag | COMPOSITIONS DERIVED FROM BUTANOIC ESTER SUBSTITUTED WITH BISPHENYL AS INHIBITORS OF NEP, COMPOSITIONS AND COMBINATIONS OF THE SAME |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3347565A1 (en) * | 1983-12-30 | 1985-07-11 | Thomae Gmbh Dr K | NEW PHENYL ACETIC DERIVATIVES, MEDICINAL PRODUCTS CONTAINING THESE COMPOUNDS AND METHOD FOR THE PRODUCTION THEREOF |
-
1991
- 1991-06-21 AU AU80781/91A patent/AU660930B2/en not_active Expired
- 1991-06-21 JP JP3511056A patent/JP2921982B2/en not_active Expired - Lifetime
- 1991-06-21 SG SG1996002715A patent/SG43036A1/en unknown
- 1991-06-21 WO PCT/EP1991/001147 patent/WO1993000337A1/en active IP Right Grant
- 1991-06-21 EP EP91911959A patent/EP0589874B1/en not_active Expired - Lifetime
- 1991-07-22 CN CN91104984A patent/CN1048722C/en not_active Expired - Lifetime
-
1993
- 1993-12-20 NO NO934726A patent/NO303687B1/en not_active IP Right Cessation
- 1993-12-20 FI FI935724A patent/FI106027B/en not_active IP Right Cessation
-
1999
- 1999-07-20 NO NO1999017C patent/NO1999017I1/en unknown
Also Published As
Publication number | Publication date |
---|---|
NO303687B1 (en) | 1998-08-17 |
FI935724A (en) | 1993-12-20 |
NO1999017I1 (en) | 1999-07-20 |
NO934726D0 (en) | 1993-12-20 |
AU660930B2 (en) | 1995-07-13 |
EP0589874A1 (en) | 1994-04-06 |
WO1993000337A1 (en) | 1993-01-07 |
JP2921982B2 (en) | 1999-07-19 |
JPH06508816A (en) | 1994-10-06 |
NO934726L (en) | 1993-12-20 |
FI935724A0 (en) | 1993-12-20 |
CN1048722C (en) | 2000-01-26 |
AU8078191A (en) | 1993-01-25 |
EP0589874B1 (en) | 1999-09-08 |
FI106027B (en) | 2000-11-15 |
CN1068820A (en) | 1993-02-10 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
SG43036A1 (en) | (S) (+) -2-ethoxy-4-[N-[1-(2-piperidino-phenyl)-3-methyl- 1-buthyl]aminocarbony methyl] - benzoic a cid | |
GB2268590B (en) | A tape measure device | |
GB2216729B (en) | A compact transformer | |
AU116452S (en) | A telephone | |
HRP921023A2 (en) | New phenylpyrazolic fungicides | |
GB2273527B (en) | A hinge | |
GB9124743D0 (en) | Squeeze pack | |
GB2252401B (en) | A heater-humidifier-dehumidifier unit | |
GB2260958B (en) | A wrapping device | |
NO953116D0 (en) | A bale wrapping apparatus | |
ZA91136B (en) | A horseshoe | |
AU118299S (en) | A personal computer unit | |
GB9200432D0 (en) | An improvement for a pre-knotted necktie | |
AU118302S (en) | A personal computer | |
GB9208574D0 (en) | A baler | |
GB9125041D0 (en) | A hinge | |
GB9510353D0 (en) | Moulding compositons containing a polymide | |
GB2258628B (en) | A bale accumulator | |
GB2263209B (en) | A telephone | |
AU116023S (en) | A scarf | |
AU113994S (en) | A scarf | |
AU112117S (en) | A scarf | |
AU113925S (en) | A tie | |
PL53757Y1 (en) | Sound signalling device for a kettle | |
AU116441S (en) | A Telephone |