FI935724A - (S) (+) - 2-ethoxy-4- / N- / 1- (2-PIPERIDINOFENYL) -3-methyl-1-BUTYL / AMINOKARBONYLMETYL / -BENSOESYRA - Google Patents

(S) (+) - 2-ethoxy-4- / N- / 1- (2-PIPERIDINOFENYL) -3-methyl-1-BUTYL / AMINOKARBONYLMETYL / -BENSOESYRA Download PDF

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Publication number
FI935724A
FI935724A FI935724A FI935724A FI935724A FI 935724 A FI935724 A FI 935724A FI 935724 A FI935724 A FI 935724A FI 935724 A FI935724 A FI 935724A FI 935724 A FI935724 A FI 935724A
Authority
FI
Finland
Prior art keywords
piperidinofenyl
bensoesyra
aminokarbonylmetyl
ethoxy
butyl
Prior art date
Application number
FI935724A
Other languages
Finnish (fi)
Other versions
FI106027B (en
FI935724A0 (en
Inventor
Wolfgang Grell
Andreas Greischel
Gabriele Zahn
Michael Mark
Hansjoerg Knorr
Eckhard Rupprecht
Ulrich Mueller
Original Assignee
Thomae Gmbh Dr K
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=36781542&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=FI935724(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from CA002111851A external-priority patent/CA2111851C/en
Application filed by Thomae Gmbh Dr K filed Critical Thomae Gmbh Dr K
Publication of FI935724A publication Critical patent/FI935724A/en
Publication of FI935724A0 publication Critical patent/FI935724A0/en
Application granted granted Critical
Publication of FI106027B publication Critical patent/FI106027B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C07D295/135—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
FI935724A 1991-06-21 1993-12-20 A process for the preparation of (S) (+) - 2-ethoxy-4- [N- [1- (2-piperidinophenyl) -3-methyl-1-butyl] aminocarbonylmethyl] -benzoic acid or its salt, and (S) -1- ( Preparation of N-acetyl-L-glutamine salt of 2-piperidinophenyl) -3-methyl-1-butylamine FI106027B (en)

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
EP9101147 1991-06-21
CA002111851A CA2111851C (en) 1991-06-21 1991-06-21 (s)(+)-2-ethoxy-4-[n-{1-(2-piperidino-phenyl)-3-methyl-1-butyl]aminocarbonylmethyl]benzoic acid
CA2111851 1991-06-21
SG1996002715A SG43036A1 (en) 1991-06-21 1991-06-21 (S) (+) -2-ethoxy-4-[N-[1-(2-piperidino-phenyl)-3-methyl- 1-buthyl]aminocarbony methyl] - benzoic a cid
PCT/EP1991/001147 WO1993000337A1 (en) 1991-06-21 1991-06-21 (s)(+)-2-ethoxy-4-[n-[1-(2-piperidinophenyl)-3-methyl-1-butyl]aminocarbonylmethyl]benzoic acid
SG9602715 1991-06-21
CN91104984 1991-07-22
CN91104984A CN1048722C (en) 1991-06-21 1991-07-22 (S)(+)-2-Ethoxy-4-[N-[1-(2-piperidino-phenyl)-3-methyl-1-butyl]-aminocarbonylmethyl]-benzoic acid, pharmaceutical compositions containing compound and processes for preparation thereof

Publications (3)

Publication Number Publication Date
FI935724A true FI935724A (en) 1993-12-20
FI935724A0 FI935724A0 (en) 1993-12-20
FI106027B FI106027B (en) 2000-11-15

Family

ID=36781542

Family Applications (1)

Application Number Title Priority Date Filing Date
FI935724A FI106027B (en) 1991-06-21 1993-12-20 A process for the preparation of (S) (+) - 2-ethoxy-4- [N- [1- (2-piperidinophenyl) -3-methyl-1-butyl] aminocarbonylmethyl] -benzoic acid or its salt, and (S) -1- ( Preparation of N-acetyl-L-glutamine salt of 2-piperidinophenyl) -3-methyl-1-butylamine

Country Status (8)

Country Link
EP (1) EP0589874B1 (en)
JP (1) JP2921982B2 (en)
CN (1) CN1048722C (en)
AU (1) AU660930B2 (en)
FI (1) FI106027B (en)
NO (2) NO303687B1 (en)
SG (1) SG43036A1 (en)
WO (1) WO1993000337A1 (en)

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA985126B (en) 1997-06-13 1998-12-14 Novo Nordisk As Novel niddm regimen
IN192862B (en) * 1999-11-16 2004-05-22 Ranbaxy Lab Ltd
PE20020617A1 (en) 2000-08-22 2002-08-05 Novartis Ag COMPOSITION INCLUDING AN AT1 RECEPTOR ANTAGONIST AND AN INSULIN SECRETION POTENTIAL OR AN INSULIN SENSITIZER
JP4625637B2 (en) 2002-02-22 2011-02-02 シャイア エルエルシー Active substance delivery system and method for protecting and administering an active substance
AU2003260078A1 (en) * 2002-08-23 2004-03-11 Dr. Reddy's Laboratories Limited Crystalline and amorphous forms of (s) -repaglinide and the processes for preparation thereof
WO2004101540A2 (en) * 2003-05-14 2004-11-25 Cilag Ag Method for the production of phenylacetic acid derivatives
WO2004103983A1 (en) * 2003-05-26 2004-12-02 Biocon Limited Process for the preparation of s(+)-2-ethoxy-4-[n-{1-(2-piperidinophelyl)-3-methyl-1- butyl} aminocarbonylmethyl]benzoic acid derivatives
EP1664008A1 (en) * 2003-08-28 2006-06-07 Ranbaxy Laboratories Limited Process for the preparation of amorphous form of repaglinide
CN1305863C (en) * 2004-12-27 2007-03-21 浙江大学 Method for synthesizing (S)-isopropyl-(2-piperidine) phenyl-methylhistamine
GT200600381A (en) 2005-08-25 2007-03-28 ORGANIC COMPOUNDS
FR2898894B1 (en) * 2006-03-24 2008-06-06 Genfit Sa SUBSTITUTED N- (PHENETHYL) BENZAMIDE DERIVATIVE COMPOUNDS, PREPARATION AND USES
US7763607B2 (en) * 2006-04-27 2010-07-27 Solvay Pharmaceuticals Gmbh Pharmaceutical compositions comprising CBx cannabinoid receptor modulators and potassium channel modulators
BRPI0718420A2 (en) 2006-10-20 2013-11-12 Cpd Llc RESEARCH METHOD OF INCRETIN EFFECT
US8101769B2 (en) * 2007-02-15 2012-01-24 Actavis Group Ptc Ehf Process for preparing ethyl (S)-2-ethoxy-4-[N-[1-(2-piperidinophenyl)-3-methyl-1-butyl]aminocarbonyl methyl]benzoate and use thereof for the preparation of Repaglinide
US20100197732A1 (en) * 2007-06-06 2010-08-05 Actavis Group Ptc Ehf Repaglinide Substantially Free of Dimer Impurity
EP2019097A1 (en) 2007-07-25 2009-01-28 Aurobindo Pharma Limited Process for preparing (alphaS)-alpha-(2-methylpropyl)-2-(1-piperidinyl)benzenemethanamine
DE102008046995B4 (en) * 2008-09-12 2010-08-26 Stada Arzneimittel Ag 2-ethoxy-benzoic acid
EP2177221A1 (en) 2008-10-20 2010-04-21 Krka Tovarna Zdravil, D.D., Novo Mesto Process for the preparation of substantially optically pure Repaglinide and precursors thereof
CN102803217B (en) 2009-05-15 2015-06-17 诺华股份有限公司 Aryl pyridine as aldosterone synthase inhibitors
WO2010130773A2 (en) 2009-05-15 2010-11-18 Novartis Ag Benzoxazolone derivatives as aldosterone symthase inhibitors
ES2582395T3 (en) 2009-05-28 2016-09-12 Novartis Ag Substituted aminobutyric derivatives as neprilysin inhibitors
ME01923B (en) 2009-05-28 2015-05-20 Novartis Ag Substituted aminopropionic derivatives as neprilysin inhibitors
EP2993169B1 (en) 2009-11-17 2017-12-20 Novartis AG Aryl-pyridine derivatives as aldosterone synthase inhibitors
JO2967B1 (en) 2009-11-20 2016-03-15 نوفارتس ايه جي Substituted carbamoylmethylamino acetic acid derivatives as novel NEP inhibitors
JP5575913B2 (en) 2009-11-30 2014-08-20 ノバルティス アーゲー Imidazole derivatives as aldosterone synthase inhibitors
EP2364977A1 (en) 2010-01-26 2011-09-14 Reuter Chemische Apparatebau KG Process for the enantiomeric enrichment of 3-methyl-1-(2-piperidinophenyl)-1-butylamine
US8673974B2 (en) 2010-11-16 2014-03-18 Novartis Ag Substituted amino bisphenyl pentanoic acid derivatives as NEP inhibitors
US8877815B2 (en) 2010-11-16 2014-11-04 Novartis Ag Substituted carbamoylcycloalkyl acetic acid derivatives as NEP
CN102267959B (en) * 2011-07-06 2013-05-01 海南锦瑞制药股份有限公司 Repaglinide crystal, preparation method thereof, and solid oral preparation containing same
CN103012319B (en) * 2011-09-20 2015-06-10 浙江九洲药业股份有限公司 Repaglinide intermediate synthesis process improvement
CN102584743A (en) * 2011-12-28 2012-07-18 中国药科大学 Dimethylaminopyridine repaglinide eutectic
UY35144A (en) 2012-11-20 2014-06-30 Novartis Ag APELINE SYNTHETIC LINEAR MIMETICS FOR THE CARDIAC INSUFFICIENCY TREATMENT
EP2956464B1 (en) 2013-02-14 2018-03-28 Novartis AG Substituted bisphenyl butanoic phosphonic acid derivatives as nep (neutral endopeptidase) inhibitors
SG11201600208RA (en) 2013-07-25 2016-02-26 Novartis Ag Bioconjugates of synthetic apelin polypeptides
EA201690278A1 (en) 2013-07-25 2016-06-30 Новартис Аг CYCLIC POLYPEPTIDES FOR TREATMENT OF HEART FAILURE
ES2787223T3 (en) 2014-11-07 2020-10-15 Univ Minnesota Salts and compositions useful for treating diseases
KR20170103970A (en) 2015-01-23 2017-09-13 노파르티스 아게 Synthetic Apelin Fatty Acid Conjugate with Improved Half-life
WO2018034627A1 (en) 2016-08-18 2018-02-22 İlko Ilaç Sanayi Ve Ticaret Anonim Şirketi Pharmaceutical composition of antidiabetic tablet
UY38072A (en) 2018-02-07 2019-10-01 Novartis Ag COMPOSITIONS DERIVED FROM BUTANOIC ESTER SUBSTITUTED WITH BISPHENYL AS INHIBITORS OF NEP, COMPOSITIONS AND COMBINATIONS OF THE SAME

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3347565A1 (en) * 1983-12-30 1985-07-11 Thomae Gmbh Dr K NEW PHENYL ACETIC DERIVATIVES, MEDICINAL PRODUCTS CONTAINING THESE COMPOUNDS AND METHOD FOR THE PRODUCTION THEREOF

Also Published As

Publication number Publication date
JP2921982B2 (en) 1999-07-19
WO1993000337A1 (en) 1993-01-07
CN1068820A (en) 1993-02-10
EP0589874A1 (en) 1994-04-06
JPH06508816A (en) 1994-10-06
NO1999017I1 (en) 1999-07-20
CN1048722C (en) 2000-01-26
FI106027B (en) 2000-11-15
NO934726D0 (en) 1993-12-20
SG43036A1 (en) 1997-10-17
FI935724A0 (en) 1993-12-20
EP0589874B1 (en) 1999-09-08
AU660930B2 (en) 1995-07-13
NO303687B1 (en) 1998-08-17
NO934726L (en) 1993-12-20
AU8078191A (en) 1993-01-25

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