CR20130318A - Nuevos compuestos de benzodioxol-piperazina - Google Patents

Nuevos compuestos de benzodioxol-piperazina

Info

Publication number
CR20130318A
CR20130318A CR20130318A CR20130318A CR20130318A CR 20130318 A CR20130318 A CR 20130318A CR 20130318 A CR20130318 A CR 20130318A CR 20130318 A CR20130318 A CR 20130318A CR 20130318 A CR20130318 A CR 20130318A
Authority
CR
Costa Rica
Prior art keywords
compounds
new
piperazina
benzodioxol
formula
Prior art date
Application number
CR20130318A
Other languages
English (en)
Inventor
Sarmiento Rosa Maria Rodriguez
Juergen Wichmann
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of CR20130318A publication Critical patent/CR20130318A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
    • C07D317/62—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to atoms of the carbocyclic ring
    • C07D317/66—Nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Addiction (AREA)
  • Pain & Pain Management (AREA)
  • Anesthesiology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

LA PRESENTE INVENCIÓN SE REFIERE A NUEVOS MODULADORES DUALES DE LOS RECEPTORES DE LA 5-HT2A Y DE LA D3, DE LA FÓRMULA (I), EN LA QUE n, Y, R1, R3 Y R4 TIENEN LOS SIGNIFICADOS AQUÍ DEFINIDOS, ASÍ COMO LAS SALES Y ÉSTERES FARMACÉUTICAMENTE ACEPTABLES DE LOS MISMOS. LA PRESENTE INVENCIÓN SE REFIERE ADEMÁS DE A LA OBTENCIÓN DE LOS COMPUESTOS DE LA FÓRMULA (I), A COMPOSICIONES FARMACÉUTICAS QUE LOS CONTIENEN Y A SU UTILIZACIÓN COMO MEDICAMENTOS.-
CR20130318A 2011-02-17 2013-06-25 Nuevos compuestos de benzodioxol-piperazina CR20130318A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP11154780 2011-02-17
PCT/EP2012/052440 WO2012110470A1 (en) 2011-02-17 2012-02-14 Novel benzodioxole piperazine compounds

Publications (1)

Publication Number Publication Date
CR20130318A true CR20130318A (es) 2013-09-03

Family

ID=45722618

Family Applications (1)

Application Number Title Priority Date Filing Date
CR20130318A CR20130318A (es) 2011-02-17 2013-06-25 Nuevos compuestos de benzodioxol-piperazina

Country Status (19)

Country Link
US (1) US8722683B2 (es)
EP (1) EP2675798B1 (es)
JP (1) JP2014505715A (es)
KR (1) KR20140006953A (es)
CN (1) CN103380122B (es)
AR (1) AR085236A1 (es)
AU (1) AU2012217150A1 (es)
BR (1) BR112013020656A2 (es)
CA (1) CA2823988A1 (es)
CO (1) CO6761304A2 (es)
CR (1) CR20130318A (es)
EA (1) EA201391124A1 (es)
EC (1) ECSP13012838A (es)
ES (1) ES2546430T3 (es)
HK (1) HK1189880A1 (es)
MA (1) MA34946B1 (es)
MX (1) MX2013008531A (es)
SG (1) SG192819A1 (es)
WO (1) WO2012110470A1 (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106518841B (zh) * 2015-09-15 2019-03-05 浙江京新药业股份有限公司 环己烷衍生物或其立体异构体或盐及其制备与应用
EP3495363B1 (en) 2016-07-28 2023-08-23 Shionogi & Co., Ltd Nitrogen-containing condensed ring compounds having dopamine d3 receptor antagonistic effect
US11447484B2 (en) 2018-01-26 2022-09-20 Shionogi & Co., Ltd. Cyclic compound having dopamine D3 receptor antagonistic effect
TW201938537A (zh) 2018-01-26 2019-10-01 日商鹽野義製藥股份有限公司 具有多巴胺ｄ３受體拮抗作用的稠環化合物
CN111770754B (zh) * 2019-01-30 2023-09-19 江苏豪森药业集团有限公司 一种多环类衍生物调节剂、其制备方法和应用
CN110372557B (zh) * 2019-08-06 2021-05-18 上海勋和医药科技有限公司 环己烷胺类d3/d2受体部分激动剂

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3347381B2 (ja) * 1993-01-27 2002-11-20 協和醗酵工業株式会社 ペットフード
WO1996039133A1 (en) 1995-06-06 1996-12-12 Neurobiological Technologies, Inc. Novel n-substituted-2-amino-3',4'-methylene-dioxypropiophenones
EP1683790A1 (en) * 2005-01-24 2006-07-26 Institut National De La Sante Et De La Recherche Medicale (Inserm) 3,4-dihydro-2-naphthamide derivatives as selective dopamine D3 ligands
HUP0500170A3 (en) * 2005-02-03 2007-11-28 Richter Gedeon Nyrt Piperazine derivatives, process for producing them and pharmaceutical compositions containing them
ES2399447T3 (es) 2006-02-17 2013-04-01 F. Hoffmann-La Roche Ag Derivados benzoil-piperidina como moduladores de 5HT2/D3
CN101535258B (zh) * 2006-10-31 2012-12-05 弗·哈夫曼-拉罗切有限公司 5ht2a和d3受体的醚衍生物双重调节剂
RU2480466C2 (ru) * 2007-07-26 2013-04-27 Ф.Хоффманн-Ля Рош Аг Двойные модуляторы 5-ht2a и d3-рецепторов
US7875610B2 (en) * 2007-12-03 2011-01-25 Richter Gedeon Nyrt. Pyrimidinyl-piperazines useful as D3/D2 receptor ligands
MX2011002628A (es) * 2008-09-22 2011-04-05 Hoffmann La Roche Moduladores de los receptores d3 y 5-ht2a de piperazina.
EP2334644A1 (en) * 2008-09-23 2011-06-22 F. Hoffmann-La Roche AG Pyridinylpiperazin derivatives useful as modulators of dopamine d3 receptors
US8586579B2 (en) * 2010-06-21 2013-11-19 Hoffmann-La Roche Inc. Anellated pyridine compounds
US8598357B2 (en) * 2011-03-03 2013-12-03 Hoffmann-La Roche Inc. Benzodioxole piperidine compounds

Also Published As

Publication number Publication date
CA2823988A1 (en) 2012-08-23
ES2546430T3 (es) 2015-09-23
MA34946B1 (fr) 2014-03-01
AR085236A1 (es) 2013-09-18
US20130040948A1 (en) 2013-02-14
ECSP13012838A (es) 2013-09-30
HK1189880A1 (en) 2014-06-20
EP2675798B1 (en) 2015-07-01
JP2014505715A (ja) 2014-03-06
EA201391124A1 (ru) 2014-02-28
KR20140006953A (ko) 2014-01-16
BR112013020656A2 (pt) 2016-10-18
US8722683B2 (en) 2014-05-13
EP2675798A1 (en) 2013-12-25
CO6761304A2 (es) 2013-09-30
AU2012217150A1 (en) 2013-05-02
SG192819A1 (en) 2013-09-30
CN103380122A (zh) 2013-10-30
MX2013008531A (es) 2013-08-12
CN103380122B (zh) 2015-04-29
WO2012110470A1 (en) 2012-08-23

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