CO6741154A2 - Compuestos de triazolopiridina - Google Patents

Compuestos de triazolopiridina

Info

Publication number
CO6741154A2
CO6741154A2 CO13105814A CO13105814A CO6741154A2 CO 6741154 A2 CO6741154 A2 CO 6741154A2 CO 13105814 A CO13105814 A CO 13105814A CO 13105814 A CO13105814 A CO 13105814A CO 6741154 A2 CO6741154 A2 CO 6741154A2
Authority
CO
Colombia
Prior art keywords
triazolopyridine compounds
compounds
triazolopyridine
pde1oa
medicines
Prior art date
Application number
CO13105814A
Other languages
English (en)
Inventor
Alexander Flohr
Luca Gobbi
Zbinden Katrin Groebke
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of CO6741154A2 publication Critical patent/CO6741154A2/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Abstract

La invención se refiere a compuestos de triazolopiridina de la fórmula (I)en la que R1, R2, R3 y R4 tienen los significados definidos en la descripción y en las reivindicaciones, así como a las sales fisiológicamente aceptables de los mismos. Estos compuestos inhiben la PDE1OA y pueden utilizarse como medicamentos.
CO13105814A 2010-12-07 2013-04-25 Compuestos de triazolopiridina CO6741154A2 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP10194014 2010-12-07

Publications (1)

Publication Number Publication Date
CO6741154A2 true CO6741154A2 (es) 2013-08-30

Family

ID=45099086

Family Applications (1)

Application Number Title Priority Date Filing Date
CO13105814A CO6741154A2 (es) 2010-12-07 2013-04-25 Compuestos de triazolopiridina

Country Status (30)

Country Link
US (1) US8349824B2 (es)
EP (1) EP2649070B1 (es)
JP (1) JP5932828B2 (es)
KR (1) KR20130128426A (es)
CN (1) CN103237803B (es)
AR (1) AR084152A1 (es)
AU (1) AU2011340685A1 (es)
BR (1) BR112013013912A2 (es)
CA (1) CA2816829C (es)
CL (1) CL2013001591A1 (es)
CO (1) CO6741154A2 (es)
CR (1) CR20130239A (es)
CY (1) CY1115863T1 (es)
DK (1) DK2649070T3 (es)
EA (1) EA022607B1 (es)
EC (1) ECSP13012667A (es)
ES (1) ES2520647T3 (es)
HR (1) HRP20141200T1 (es)
IL (1) IL225969A0 (es)
MA (1) MA35086B1 (es)
MX (1) MX2013006054A (es)
PE (1) PE20140226A1 (es)
PL (1) PL2649070T3 (es)
PT (1) PT2649070E (es)
RS (1) RS53677B1 (es)
SG (1) SG190305A1 (es)
SI (1) SI2649070T1 (es)
UA (1) UA109037C2 (es)
WO (1) WO2012076430A1 (es)
ZA (1) ZA201303811B (es)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013043518A1 (en) 2011-09-22 2013-03-28 Merck Sharp & Dohme Corp. Imidazopyridyl compounds as aldosterone synthase inhibitors
EP2757883B1 (en) * 2011-09-22 2021-01-13 Merck Sharp & Dohme Corp. Triazolopyridyl compounds as aldosterone synthase inhibitors
BR112014016427A8 (pt) * 2012-02-09 2017-07-04 Hoffmann La Roche processo para a preparação de derivados de 2-fenil-[1,2,4]triazolo[1,5-a]piridina
CN104955825A (zh) * 2013-01-31 2015-09-30 霍夫曼-拉罗奇有限公司 放射性标记的化合物
PT2963037T (pt) * 2013-02-27 2019-04-23 Mochida Pharm Co Ltd Novo derivado de pirazole
CA2909477A1 (en) 2013-04-30 2014-11-06 F. Hoffmann-La Roche Ag Pd-catalyzed coupling of pyrazole amides
CN105229005B (zh) * 2013-05-31 2018-01-02 日产化学工业株式会社 杂环酰胺化合物
WO2015006689A1 (en) 2013-07-12 2015-01-15 University Of South Alabama Treatment and diagnosis of cancer and precancerous conditions using pde10a inhibitors and methods to measure pde10a expression
US9902723B2 (en) 2014-07-30 2018-02-27 Mochida Pharmaceutical Co., Ltd. Pyrazole derivative manufacturing method
WO2016017711A1 (ja) 2014-07-30 2016-02-04 持田製薬株式会社 ピラゾール誘導体の製造方法
WO2020021024A1 (en) * 2018-07-26 2020-01-30 Phenex Pharmaceuticals Ag Substituted bicyclic compounds as modulators of the aryl hydrocarbon receptor (ahr)
JP2023528896A (ja) 2020-06-05 2023-07-06 ノエマ ファーマ アクツィエンゲゼルシャフト トゥレット症候群の治療のためのホスホジエステラーゼ１０阻害剤の使用
KR20230171918A (ko) 2021-01-28 2023-12-21 노에마 파르마 아게 소아-발병 유창성 장애의 치료 방법

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2534432A1 (en) 2003-07-31 2005-02-10 Bayer Pharmaceuticals Corporation Methods for treating diabetes and related disorders using pde10a inhibitors
TWI501965B (zh) 2008-06-20 2015-10-01 Lundbeck & Co As H 作為ｐｄｅ１０ａ酵素抑制劑之新穎苯基咪唑衍生物

Also Published As

Publication number Publication date
ECSP13012667A (es) 2013-08-30
IL225969A0 (en) 2013-06-27
PL2649070T3 (pl) 2015-03-31
WO2012076430A1 (en) 2012-06-14
RS53677B1 (en) 2015-04-30
CN103237803B (zh) 2016-04-13
DK2649070T3 (da) 2014-10-13
CY1115863T1 (el) 2017-01-25
HRP20141200T1 (hr) 2015-02-13
SI2649070T1 (sl) 2014-12-31
SG190305A1 (en) 2013-06-28
AU2011340685A1 (en) 2013-05-23
KR20130128426A (ko) 2013-11-26
PE20140226A1 (es) 2014-03-08
US8349824B2 (en) 2013-01-08
ES2520647T3 (es) 2014-11-11
MA35086B1 (fr) 2014-05-02
MX2013006054A (es) 2013-06-18
CA2816829C (en) 2018-12-04
UA109037C2 (uk) 2015-07-10
AR084152A1 (es) 2013-04-24
CN103237803A (zh) 2013-08-07
CL2013001591A1 (es) 2013-12-27
CR20130239A (es) 2013-06-27
JP2013544859A (ja) 2013-12-19
JP5932828B2 (ja) 2016-06-08
EP2649070B1 (en) 2014-09-17
CA2816829A1 (en) 2012-06-14
ZA201303811B (en) 2014-04-30
PT2649070E (pt) 2014-11-21
EA022607B1 (ru) 2016-01-29
EA201390799A1 (ru) 2013-12-30
EP2649070A1 (en) 2013-10-16
US20120142665A1 (en) 2012-06-07
BR112013013912A2 (pt) 2016-09-13

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