EA201490599A1 - Соединения триазолопиридина в качестве ингибиторов фосфодиэстеразы pde10a - Google Patents

Соединения триазолопиридина в качестве ингибиторов фосфодиэстеразы pde10a

Info

Publication number
EA201490599A1
EA201490599A1 EA201490599A EA201490599A EA201490599A1 EA 201490599 A1 EA201490599 A1 EA 201490599A1 EA 201490599 A EA201490599 A EA 201490599A EA 201490599 A EA201490599 A EA 201490599A EA 201490599 A1 EA201490599 A1 EA 201490599A1
Authority
EA
Eurasian Patent Office
Prior art keywords
pde10a
compounds
triazolopiridine
phosphodystterase
inhibitors
Prior art date
Application number
EA201490599A
Other languages
English (en)
Inventor
Александр Флор
Катрин Грёбке Цбинден
Маттиас Кёрнер
Original Assignee
Ф.Хоффманн-Ля Рош Аг
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=46851999&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EA201490599(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Ф.Хоффманн-Ля Рош Аг filed Critical Ф.Хоффманн-Ля Рош Аг
Publication of EA201490599A1 publication Critical patent/EA201490599A1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Abstract

Настоящее изобретение касается триазолопиридинов формулы (I)где R, Rи Rтаковы, как определено в описании и формуле изобретения, а также их физиологически приемлемых солей. Эти соединения ингибируют PDE10A и могут применяться в качестве лекарственных средств.
EA201490599A 2011-09-19 2012-09-17 Соединения триазолопиридина в качестве ингибиторов фосфодиэстеразы pde10a EA201490599A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP11181752 2011-09-19
PCT/EP2012/068203 WO2013041472A1 (en) 2011-09-19 2012-09-17 Triazolopyridine compounds as pde10a inhibitors

Publications (1)

Publication Number Publication Date
EA201490599A1 true EA201490599A1 (ru) 2014-07-30

Family

ID=46851999

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201490599A EA201490599A1 (ru) 2011-09-19 2012-09-17 Соединения триазолопиридина в качестве ингибиторов фосфодиэстеразы pde10a

Country Status (18)

Country Link
US (2) US8946427B2 (ru)
EP (1) EP2758396B1 (ru)
JP (1) JP2014526533A (ru)
KR (1) KR101584925B1 (ru)
CN (1) CN103827114B (ru)
AU (1) AU2012311713A1 (ru)
BR (1) BR112014006248A2 (ru)
CA (1) CA2846758C (ru)
CL (1) CL2014000641A1 (ru)
CO (1) CO6900144A2 (ru)
EA (1) EA201490599A1 (ru)
ES (1) ES2626801T3 (ru)
IL (1) IL231403A0 (ru)
MX (1) MX2014003025A (ru)
PE (1) PE20141553A1 (ru)
SG (1) SG11201400759RA (ru)
UA (1) UA108711C2 (ru)
WO (1) WO2013041472A1 (ru)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013043520A1 (en) 2011-09-22 2013-03-28 Merck Sharp & Dohme Corp. Triazolopyridyl compounds as aldosterone synthase inhibitors
EP2757882B1 (en) 2011-09-22 2020-11-04 Merck Sharp & Dohme Corp. Imidazopyridyl compounds as aldosterone synthase inhibitors
EP2991984B1 (en) 2013-04-30 2017-03-08 F. Hoffmann-La Roche AG Palladium-catalyzed coupling of pyrazole amides
TWI652014B (zh) 2013-09-13 2019-03-01 美商艾佛艾姆希公司 雜環取代之雙環唑殺蟲劑
KR20170032328A (ko) 2014-07-30 2017-03-22 모찌다 세이야쿠 가부시끼가이샤 피라졸 유도체의 제조 방법
WO2016017719A1 (ja) * 2014-07-30 2016-02-04 持田製薬株式会社 ピラゾール誘導体の製造方法
CN112679467A (zh) 2015-03-11 2021-04-20 Fmc公司 杂环取代的二环唑杀有害生物剂
WO2016144678A1 (en) 2015-03-12 2016-09-15 E I Du Pont De Nemours And Company Heterocycle-substituted bicyclic azole pesticides
EP3359545B1 (en) 2015-10-08 2024-03-20 FMC Corporation Heterocycle-substituted bicyclic azole pesticides
CN111108106B (zh) * 2017-08-22 2023-02-03 拜耳公司 作为害虫防治剂的杂环衍生物
US20220242869A1 (en) 2019-05-27 2022-08-04 Nihon Nohyaku Co., Ltd. Condensed heterocyclic compound having a bridgehead nitrogen atom or salt thereof, agricultural or horticultural insecticide comprising the compound, and method for using the insecticide
AR119140A1 (es) 2019-06-13 2021-11-24 Pi Industries Ltd Compuestos heterocíclicos fusionados y su uso como agentes de control de plagas
CN110396157B (zh) * 2019-08-07 2021-07-30 广州市建筑科学研究院有限公司 缓释型聚羧酸纳米减水剂及其制备方法和应用

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6355653B1 (en) * 1999-09-06 2002-03-12 Hoffmann-La Roche Inc. Amino-triazolopyridine derivatives
WO2005012485A2 (en) 2003-07-31 2005-02-10 Bayer Pharmaceuticals Corporation Methods for treating diabetes and related disorders using pde10a inhibitors
NL2000397C2 (nl) * 2006-01-05 2007-10-30 Pfizer Prod Inc Bicyclische heteroarylverbindingen als PDE10 inhibitoren.
JPWO2010035745A1 (ja) * 2008-09-25 2012-02-23 杏林製薬株式会社 ヘテロ環ビアリール誘導体及びそれらを有効成分とするｐｄｅ阻害剤
WO2010059836A1 (en) * 2008-11-20 2010-05-27 Decode Genetics Ehf Substituted aza-bridged bicyclics for cardiovascular and cns disease
EP2417135A1 (en) * 2009-04-07 2012-02-15 Schering Corporation Substituted triazolopyridines and analogs thereof
SI2480546T1 (sl) * 2009-09-24 2015-03-31 F. Hoffmann-La Roche Ag Derivati imidazopiridina ali imidazopirimidina kot inhibitorji fosfodiesteraze 10a
EP3550853A1 (en) 2009-11-24 2019-10-09 Nokia Technologies Oy An apparatus
TWI485151B (zh) * 2009-12-17 2015-05-21 Lundbeck & Co As H 作為ｐｄｅ１０ａ酵素抑制劑之雜芳香族苯基咪唑衍生物
TWI487705B (zh) * 2009-12-17 2015-06-11 Lundbeck & Co As H 作為ｐｄｅ１０ａ酵素抑制劑之雜芳香族芳基三唑衍生物
TW201200516A (en) * 2009-12-17 2012-01-01 Lundbeck & Co As H Phenylimidazole derivatives comprising an ethynylene linker as PDE10A enzyme inhibitors

Also Published As

Publication number Publication date
US20150099735A1 (en) 2015-04-09
CA2846758A1 (en) 2013-03-28
AU2012311713A1 (en) 2014-03-13
WO2013041472A1 (en) 2013-03-28
NZ621597A (en) 2015-04-24
JP2014526533A (ja) 2014-10-06
CL2014000641A1 (es) 2014-11-14
KR101584925B1 (ko) 2016-01-12
KR20140075716A (ko) 2014-06-19
PE20141553A1 (es) 2014-10-30
US9227970B2 (en) 2016-01-05
US8946427B2 (en) 2015-02-03
MX2014003025A (es) 2014-05-28
EP2758396A1 (en) 2014-07-30
EP2758396B1 (en) 2017-03-29
CN103827114B (zh) 2016-08-24
SG11201400759RA (en) 2014-07-30
IL231403A0 (en) 2014-04-30
BR112014006248A2 (pt) 2017-04-11
US20140303141A1 (en) 2014-10-09
UA108711C2 (ru) 2015-05-25
CO6900144A2 (es) 2014-03-20
CA2846758C (en) 2017-09-12
ES2626801T3 (es) 2017-07-26
CN103827114A (zh) 2014-05-28

Similar Documents

Publication Publication Date Title
EA201490599A1 (ru) Соединения триазолопиридина в качестве ингибиторов фосфодиэстеразы pde10a
EA201291282A1 (ru) Азотсодержащие гетероарильные соединения
EA201390799A1 (ru) Триазолопиридины
EA201590224A1 (ru) Имидазотриазинкарбонитрилы, используемые в качестве ингибиторов киназы
EA201391285A1 (ru) Производные тетрагидрохинолина, полезные в качестве ингибиторов бромодомена
EA201491672A1 (ru) Гетероциклильные соединения как ингибиторы mek
EA201391274A1 (ru) Аминохинолины в качестве ингибиторов киназ
MA34069B1 (fr) Dérivés de n-(imidazopyrimidin-7-yl)hétéroarylamide et leur utilisation comme inhibiteurs de pde10a)
EA201591166A1 (ru) Ингибиторы аутотаксина
EA201590748A1 (ru) Противовирусные соединения против rsv
EA201490471A1 (ru) Пиридазиноновые соединения и их применение в качестве ингибиторов daao
EA201400412A1 (ru) ЗАМЕЩЕННЫЕ БЕНЗИЛИНДАЗОЛЫ ДЛЯ ПРИМЕНЕНИЯ В КАЧЕСТВЕ ИНГИБИТОРОВ Bub1 КИНАЗЫ ДЛЯ ЛЕЧЕНИЯ ГИПЕРПРОЛИФЕРАТИВНЫХ ЗАБОЛЕВАНИЙ
UA114087C2 (xx) Похідні піридину
EA202190619A1 (ru) Противовирусные соединения
EA201490596A1 (ru) Новые производные дигидрохинолин-2-она
EA201290980A1 (ru) Производные 1-амино-2-циклопропилэтилбороновой кислоты
EA201591195A1 (ru) Новые хинолоновые производные
UA111770C2 (uk) Інгібітори бромдомену
EA201492214A1 (ru) Ингибиторы вируса гепатита с
EA201600366A1 (ru) Производные бензимидазол-пролина
EA201201680A1 (ru) Морфолинопиримидины и их применение в терапии
EA201390766A1 (ru) БЕНЗОКСАЗЕПИНЫ КАК ИНГИБИТОРЫ PI3K/mTOR И СПОСОБЫ ИХ ИСПОЛЬЗОВАНИЯ И ПОЛУЧЕНИЯ
EA201290880A1 (ru) Новые соединения - ингибиторы фермента
EA201490567A1 (ru) Новые бициклические производные дигидрохинолин-2-она
EA201500426A1 (ru) Производные пирролотриазинона в качестве ингибиторов pi3k