CO6620065A2 - Compuestos heteroarilo nitrogenados - Google Patents
Compuestos heteroarilo nitrogenadosInfo
- Publication number
- CO6620065A2 CO6620065A2 CO12192367A CO12192367A CO6620065A2 CO 6620065 A2 CO6620065 A2 CO 6620065A2 CO 12192367 A CO12192367 A CO 12192367A CO 12192367 A CO12192367 A CO 12192367A CO 6620065 A2 CO6620065 A2 CO 6620065A2
- Authority
- CO
- Colombia
- Prior art keywords
- nitrogen compounds
- heteroaryl nitrogen
- heteroaryl
- compounds
- rson
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Psychiatry (AREA)
- Addiction (AREA)
- Diabetes (AREA)
- Psychology (AREA)
- Pain & Pain Management (AREA)
- Hematology (AREA)
- Cardiology (AREA)
- Endocrinology (AREA)
- Epidemiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Oncology (AREA)
- Hospice & Palliative Care (AREA)
- Rheumatology (AREA)
- Obesity (AREA)
- Emergency Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
La invención se refiere a nuevos compuestos heteroarilo nitrogenados de fórmula (I):en la que A,A, (a), R, R, R, R, Ry Rson tal como se define en la descripción y en las reivindicaciones, así como sales y esteres fisiológicamente aceptables de los mismos. Dichos compuestos inhiben la PDE10A y pueden utilizarse como medicamentos.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP10165427 | 2010-06-09 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CO6620065A2 true CO6620065A2 (es) | 2013-02-15 |
Family
ID=44483879
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CO12192367A CO6620065A2 (es) | 2010-06-09 | 2012-10-26 | Compuestos heteroarilo nitrogenados |
Country Status (24)
| Country | Link |
|---|---|
| US (1) | US8703768B2 (es) |
| EP (1) | EP2580207B1 (es) |
| JP (1) | JP5940523B2 (es) |
| KR (1) | KR101757959B1 (es) |
| CN (1) | CN102947292B (es) |
| AR (1) | AR081649A1 (es) |
| BR (1) | BR112012031343A2 (es) |
| CA (1) | CA2799022A1 (es) |
| CL (1) | CL2012003421A1 (es) |
| CO (1) | CO6620065A2 (es) |
| CR (1) | CR20120594A (es) |
| EA (1) | EA022075B1 (es) |
| EC (1) | ECSP12012330A (es) |
| HK (1) | HK1178900A1 (es) |
| IL (1) | IL223069A0 (es) |
| MA (1) | MA34340B1 (es) |
| MX (1) | MX2012013907A (es) |
| NZ (1) | NZ603230A (es) |
| PE (1) | PE20130279A1 (es) |
| SG (1) | SG185655A1 (es) |
| TW (1) | TW201202221A (es) |
| UA (1) | UA108105C2 (es) |
| WO (1) | WO2011154327A1 (es) |
| ZA (1) | ZA201209119B (es) |
Families Citing this family (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2012505263A (ja) * | 2008-10-14 | 2012-03-01 | アクテリオン ファーマシューティカルズ リミテッド | フェネチルアミド誘導体及びそれらのヘテロシクリル類似体 |
| EP2556066B1 (en) | 2010-04-07 | 2016-10-19 | F.Hoffmann-La Roche Ag | Pyrazol-4-yl-heterocyclyl-carboxamide compounds and methods of use |
| EP2675791B1 (en) | 2011-02-18 | 2016-02-17 | Allergan, Inc. | Substituted 6,7-dialkoxy-3-isoquinolinol derivatives as inhibitors of phosphodiesterase 10 (pde10a) |
| EP2760857A1 (en) | 2011-09-27 | 2014-08-06 | F.Hoffmann-La Roche Ag | Pyrazol-4-yl-heterocyclyl-carboxamide compounds and methods of use |
| EP2712862A1 (en) * | 2012-09-28 | 2014-04-02 | Splicos | New anti-invasive compounds |
| EP2903613B1 (en) * | 2012-10-08 | 2017-11-22 | Merck Sharp & Dohme Corp. | Pyrazole derivatives useful as inhibitors of irak4 activity |
| WO2014071044A1 (en) | 2012-11-01 | 2014-05-08 | Allergan, Inc. | Substituted 6,7-dialkoxy-3-isoquinoline derivatives as inhibitors of phosphodiesterase 10 (pde10a) |
| BR112015020302B1 (pt) | 2013-02-27 | 2023-04-18 | Mochida Pharmaceutical Co., Ltd | Derivado de pirazol, composição farmacêutica e composto intermediário |
| DK2991983T3 (en) * | 2013-04-29 | 2017-05-08 | Hoffmann La Roche | 2-PHENYL OR 2-HETARYLIMIDAZOLE [1,2-a] PYRIDINE DERIVATIVES |
| GB201316600D0 (en) * | 2013-09-18 | 2013-10-30 | Redx Pharma Ltd | Agricultural chemicals |
| US20160264536A1 (en) * | 2013-10-23 | 2016-09-15 | Takeda Pharmaceutical Company Limited | Heterocyclic compound |
| US9200016B2 (en) | 2013-12-05 | 2015-12-01 | Allergan, Inc. | Substituted 6, 7-dialkoxy-3-isoquinoline derivatives as inhibitors of phosphodiesterase 10 (PDE 10A) |
| EA038960B1 (ru) * | 2015-01-30 | 2021-11-15 | Басф Се | Гербицидные фенилпиримидины |
| MX2017009624A (es) * | 2015-02-06 | 2017-11-20 | Merck Patent Gmbh | Macrociclos de piridazinona como inhibidores de cinasas asociadas al receptor de interleucina 1(irak) y sus usos. |
| CN104610189A (zh) * | 2015-02-10 | 2015-05-13 | 佛山市赛维斯医药科技有限公司 | 一类含环丙基脒结构sglt2/sglt1双靶点抑制剂及用途 |
| CN104974075A (zh) * | 2015-08-07 | 2015-10-14 | 新秀化学（烟台）有限公司 | 一种n, n-二(2,2,6,6-四甲基-4-哌啶基) -1,3-苯二甲酰胺的制备方法 |
| EP4302834A3 (en) * | 2016-07-12 | 2024-07-17 | Revolution Medicines, Inc. | 2,5-disubstituted 3-methyl pyrazines and 2,5,6-trisubstituted 3-methyl pyrazines as allosteric shp2 inhibitors |
| CN109476647A (zh) | 2016-07-26 | 2019-03-15 | 巴斯夫欧洲公司 | 除草的嘧啶化合物 |
| EP3490381A1 (en) | 2016-07-27 | 2019-06-05 | Basf Se | Herbicidal pyrimidine compounds |
| WO2018019767A1 (en) | 2016-07-27 | 2018-02-01 | Basf Se | Herbicidal pyridine compounds |
| CN109561684A (zh) | 2016-07-28 | 2019-04-02 | 巴斯夫欧洲公司 | 除草的嘧啶化合物 |
| MX2019008696A (es) | 2017-01-23 | 2019-09-13 | Revolution Medicines Inc | Compuestos de piridina como inhibidores de shp2 alostericos. |
| TWI820013B (zh) | 2017-01-23 | 2023-11-01 | 美商銳新醫藥公司 | 作為別構ｓｈｐ２抑制劑之雙環化合物 |
| MX2020003579A (es) | 2017-10-12 | 2020-07-22 | Revolution Medicines Inc | Compuestos de piridina, pirazina, y triazina como inhibidores de shp2 alostericos. |
| MX2020006273A (es) | 2017-12-15 | 2020-09-14 | Revolution Medicines Inc | Compuestos policiclicos como inhibidores alostericos de shp2. |
| WO2019121352A1 (en) | 2017-12-20 | 2019-06-27 | Basf Se | Herbicidal pyrimidine compounds |
| WO2019121374A1 (en) | 2017-12-20 | 2019-06-27 | Basf Se | Herbicidal pyrimidine compounds |
| WO2019123195A1 (en) | 2017-12-20 | 2019-06-27 | Pi Industries Ltd. | Pyrazolopyridine-diamides, their use as insecticide and processes for preparing the same. |
| CN112955443A (zh) | 2018-09-19 | 2021-06-11 | 拜耳公司 | 具有除草活性的取代的苯基嘧啶酰肼 |
| BR122023020853A2 (pt) * | 2018-11-02 | 2024-01-16 | Merck Sharp & Dohme Llc | Compostos 2-amino-n-heteroaril-nicotinamidas, composição farmacêutica que os compreende e usos dos mesmos |
| JP7288074B2 (ja) | 2019-10-31 | 2023-06-06 | 富士フイルム株式会社 | ピラジン誘導体またはその塩およびその利用 |
| EP4190402A4 (en) | 2020-07-30 | 2023-10-25 | FUJIFILM Corporation | HETEROCYCLIC COMPOUND CONTAINING NITROGEN OR SALT THEREOF, APPLICATION THEREOF, AND INTERMEDIATE THEREOF |
| AU2021377248A1 (en) | 2020-11-13 | 2023-06-22 | Inipharm, Inc. | Dichlorophenol hsd17b13 inhibitors and uses thereof |
| EP4319872A1 (en) * | 2021-04-05 | 2024-02-14 | Inipharm, Inc. | Thiazole/isothiazole hsd17b13 inhibitors and uses thereof |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9910079D0 (en) | 1999-05-01 | 1999-06-30 | Smithkline Beecham Plc | Novel compounds |
| EP1193261A1 (en) | 2000-10-02 | 2002-04-03 | Warner-Lambert Company | New thiadiazoles and their use as phosphodiesterase-7 inhibitors |
| WO2005012485A2 (en) | 2003-07-31 | 2005-02-10 | Bayer Pharmaceuticals Corporation | Methods for treating diabetes and related disorders using pde10a inhibitors |
| US7163937B2 (en) | 2003-08-21 | 2007-01-16 | Bristol-Myers Squibb Company | Cyclic derivatives as modulators of chemokine receptor activity |
| US20070149547A1 (en) | 2004-02-12 | 2007-06-28 | Celine Bonnefous | Bipyridyl amides as modulators of metabotropic glutamate receptor-5 |
| AU2006222289A1 (en) * | 2005-03-04 | 2006-09-14 | F. Hoffmann-La Roche Ag | Pyridine-2-carboxamide derivatives as mG1uR5 antagonists |
| US20060199828A1 (en) | 2005-03-04 | 2006-09-07 | Georg Jaeschke | Pyrazine-2-carboxyamide derivatives |
| AR057987A1 (es) | 2005-11-24 | 2008-01-09 | Astrazeneca Ab | Compuestos agonistas de cb1 (receptor cannabinoide) |
| US8822497B2 (en) | 2007-03-01 | 2014-09-02 | Novartis Ag | PIM kinase inhibitors and methods of their use |
| US20090105124A1 (en) | 2007-08-23 | 2009-04-23 | Kalypsys, Inc. | Heterocyclic modulators of tgr5 |
| US8470820B2 (en) | 2010-01-22 | 2013-06-25 | Hoffman-La Roche Inc. | Nitrogen-containing heteroaryl derivatives |
-
2011
- 2011-06-02 US US13/151,301 patent/US8703768B2/en active Active
- 2011-06-06 CA CA2799022A patent/CA2799022A1/en not_active Abandoned
- 2011-06-06 JP JP2013513638A patent/JP5940523B2/ja not_active Expired - Fee Related
- 2011-06-06 WO PCT/EP2011/059234 patent/WO2011154327A1/en active Application Filing
- 2011-06-06 MA MA35502A patent/MA34340B1/fr unknown
- 2011-06-06 MX MX2012013907A patent/MX2012013907A/es active IP Right Grant
- 2011-06-06 KR KR1020137000568A patent/KR101757959B1/ko active IP Right Grant
- 2011-06-06 EA EA201291282A patent/EA022075B1/ru not_active IP Right Cessation
- 2011-06-06 UA UAA201214955A patent/UA108105C2/ru unknown
- 2011-06-06 NZ NZ603230A patent/NZ603230A/xx not_active IP Right Cessation
- 2011-06-06 SG SG2012085015A patent/SG185655A1/en unknown
- 2011-06-06 BR BR112012031343A patent/BR112012031343A2/pt not_active Application Discontinuation
- 2011-06-06 CN CN201180027950.8A patent/CN102947292B/zh not_active Expired - Fee Related
- 2011-06-06 PE PE2012002298A patent/PE20130279A1/es not_active Application Discontinuation
- 2011-06-06 EP EP11723077.1A patent/EP2580207B1/en not_active Not-in-force
- 2011-06-07 AR ARP110101963A patent/AR081649A1/es unknown
- 2011-06-08 TW TW100120008A patent/TW201202221A/zh unknown
-
2012
- 2012-10-26 CO CO12192367A patent/CO6620065A2/es active IP Right Grant
- 2012-11-15 IL IL223069A patent/IL223069A0/en unknown
- 2012-11-26 CR CR20120594A patent/CR20120594A/es unknown
- 2012-12-03 ZA ZA2012/09119A patent/ZA201209119B/en unknown
- 2012-12-05 CL CL2012003421A patent/CL2012003421A1/es unknown
- 2012-12-07 EC ECSP12012330 patent/ECSP12012330A/es unknown
-
2013
- 2013-05-17 HK HK13105859.4A patent/HK1178900A1/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| CA2799022A1 (en) | 2011-12-15 |
| PE20130279A1 (es) | 2013-03-08 |
| HK1178900A1 (en) | 2013-09-19 |
| ZA201209119B (en) | 2015-05-27 |
| IL223069A0 (en) | 2013-02-03 |
| NZ603230A (en) | 2013-09-27 |
| ECSP12012330A (es) | 2012-12-28 |
| EP2580207A1 (en) | 2013-04-17 |
| KR20130112858A (ko) | 2013-10-14 |
| CN102947292B (zh) | 2015-08-19 |
| JP5940523B2 (ja) | 2016-06-29 |
| TW201202221A (en) | 2012-01-16 |
| EA201291282A1 (ru) | 2013-06-28 |
| US20110306589A1 (en) | 2011-12-15 |
| EP2580207B1 (en) | 2017-09-27 |
| MX2012013907A (es) | 2012-12-17 |
| CN102947292A (zh) | 2013-02-27 |
| MA34340B1 (fr) | 2013-06-01 |
| CL2012003421A1 (es) | 2013-07-26 |
| BR112012031343A2 (pt) | 2016-11-01 |
| WO2011154327A1 (en) | 2011-12-15 |
| UA108105C2 (ru) | 2015-03-25 |
| CR20120594A (es) | 2013-01-03 |
| EA022075B1 (ru) | 2015-10-30 |
| AR081649A1 (es) | 2012-10-10 |
| KR101757959B1 (ko) | 2017-07-14 |
| SG185655A1 (en) | 2012-12-28 |
| US8703768B2 (en) | 2014-04-22 |
| JP2013528193A (ja) | 2013-07-08 |
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