MX2012013907A - Compuestos heteroarilo nitrogenados. - Google Patents
Compuestos heteroarilo nitrogenados.Info
- Publication number
- MX2012013907A MX2012013907A MX2012013907A MX2012013907A MX2012013907A MX 2012013907 A MX2012013907 A MX 2012013907A MX 2012013907 A MX2012013907 A MX 2012013907A MX 2012013907 A MX2012013907 A MX 2012013907A MX 2012013907 A MX2012013907 A MX 2012013907A
- Authority
- MX
- Mexico
- Prior art keywords
- containing heteroaryl
- heteroaryl compounds
- nitrogen containing
- compounds
- medicaments
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Psychiatry (AREA)
- Addiction (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Pain & Pain Management (AREA)
- Psychology (AREA)
- Obesity (AREA)
- Heart & Thoracic Surgery (AREA)
- Oncology (AREA)
- Endocrinology (AREA)
- Hospice & Palliative Care (AREA)
- Emergency Medicine (AREA)
- Rheumatology (AREA)
- Cardiology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
La invención se refiere a nuevos compuestos heteroarilo nitrogenados de fórmula (I) (Ver Formula) en la que A1, A2, R1, R2, R3, R4, R5 y R6 son tal como se define en la descripción y en las reivindicaciones, así como sales y ésteres fisiológicamente aceptables de los mismos. Los compuestos inhiben la PDE1OA y pueden utilizarse como medicamentos.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP10165427 | 2010-06-09 | ||
| PCT/EP2011/059234 WO2011154327A1 (en) | 2010-06-09 | 2011-06-06 | Nitrogen containing heteroaryl compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2012013907A true MX2012013907A (es) | 2012-12-17 |
Family
ID=44483879
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2012013907A MX2012013907A (es) | 2010-06-09 | 2011-06-06 | Compuestos heteroarilo nitrogenados. |
Country Status (24)
| Country | Link |
|---|---|
| US (1) | US8703768B2 (es) |
| EP (1) | EP2580207B1 (es) |
| JP (1) | JP5940523B2 (es) |
| KR (1) | KR101757959B1 (es) |
| CN (1) | CN102947292B (es) |
| AR (1) | AR081649A1 (es) |
| BR (1) | BR112012031343A2 (es) |
| CA (1) | CA2799022A1 (es) |
| CL (1) | CL2012003421A1 (es) |
| CO (1) | CO6620065A2 (es) |
| CR (1) | CR20120594A (es) |
| EA (1) | EA022075B1 (es) |
| EC (1) | ECSP12012330A (es) |
| HK (1) | HK1178900A1 (es) |
| IL (1) | IL223069A0 (es) |
| MA (1) | MA34340B1 (es) |
| MX (1) | MX2012013907A (es) |
| NZ (1) | NZ603230A (es) |
| PE (1) | PE20130279A1 (es) |
| SG (1) | SG185655A1 (es) |
| TW (1) | TW201202221A (es) |
| UA (1) | UA108105C2 (es) |
| WO (1) | WO2011154327A1 (es) |
| ZA (1) | ZA201209119B (es) |
Families Citing this family (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20110071004A (ko) * | 2008-10-14 | 2011-06-27 | 액테리온 파마슈티칼 리미티드 | 페네틸아미드 유도체 및 이의 헤테로시클릭 유사체 |
| KR101464060B1 (ko) | 2010-04-07 | 2014-11-20 | 에프. 호프만-라 로슈 아게 | 피라졸-4-일-헤테로사이클릴-카복사마이드 화합물 및 사용 방법 |
| EP2675791B1 (en) | 2011-02-18 | 2016-02-17 | Allergan, Inc. | Substituted 6,7-dialkoxy-3-isoquinolinol derivatives as inhibitors of phosphodiesterase 10 (pde10a) |
| EP2760857A1 (en) | 2011-09-27 | 2014-08-06 | F.Hoffmann-La Roche Ag | Pyrazol-4-yl-heterocyclyl-carboxamide compounds and methods of use |
| EP2712862A1 (en) * | 2012-09-28 | 2014-04-02 | Splicos | New anti-invasive compounds |
| WO2014058691A1 (en) * | 2012-10-08 | 2014-04-17 | Merck Sharp & Dohme Corp. | Inhibitors of irak4 activity |
| WO2014071044A1 (en) | 2012-11-01 | 2014-05-08 | Allergan, Inc. | Substituted 6,7-dialkoxy-3-isoquinoline derivatives as inhibitors of phosphodiesterase 10 (pde10a) |
| JP5642323B1 (ja) | 2013-02-27 | 2014-12-17 | 持田製薬株式会社 | 新規ピラゾール誘導体 |
| SG11201508912YA (en) * | 2013-04-29 | 2015-11-27 | Hoffmann La Roche | 2-PHENYL OR 2-HETARYL IMIDAZOL[1,2-a]PYRIDINE DERIVATIVES |
| GB201316600D0 (en) * | 2013-09-18 | 2013-10-30 | Redx Pharma Ltd | Agricultural chemicals |
| US20160264536A1 (en) * | 2013-10-23 | 2016-09-15 | Takeda Pharmaceutical Company Limited | Heterocyclic compound |
| US9200016B2 (en) | 2013-12-05 | 2015-12-01 | Allergan, Inc. | Substituted 6, 7-dialkoxy-3-isoquinoline derivatives as inhibitors of phosphodiesterase 10 (PDE 10A) |
| MX2017009843A (es) * | 2015-01-30 | 2017-11-02 | Basf Se | Fenilpirimidinas herbicidas. |
| US9624246B2 (en) * | 2015-02-06 | 2017-04-18 | Merck Patent Gmbh | Pyridazinone macrocycles as IRAK inhibitors and uses thereof |
| CN104610189A (zh) * | 2015-02-10 | 2015-05-13 | 佛山市赛维斯医药科技有限公司 | 一类含环丙基脒结构sglt2/sglt1双靶点抑制剂及用途 |
| CN104974075A (zh) * | 2015-08-07 | 2015-10-14 | 新秀化学（烟台）有限公司 | 一种n, n-二(2,2,6,6-四甲基-4-哌啶基) -1,3-苯二甲酰胺的制备方法 |
| JP6916279B2 (ja) * | 2016-07-12 | 2021-08-11 | レヴォリューション・メディスンズ，インコーポレイテッド | アロステリックｓｈｐ２阻害剤としての２，５−二置換３−メチルピラジンおよび２，５，６−三置換３−メチルピラジン |
| AU2017302983A1 (en) | 2016-07-26 | 2019-01-03 | Basf Se | Herbicidal pyrimidine compounds |
| WO2018019765A1 (en) | 2016-07-27 | 2018-02-01 | Basf Se | Herbicidal pyrimidine compounds |
| WO2018019767A1 (en) | 2016-07-27 | 2018-02-01 | Basf Se | Herbicidal pyridine compounds |
| CA3030217A1 (en) | 2016-07-28 | 2018-02-01 | Basf Se | Herbicidal pyrimidine compounds |
| EP4230623A3 (en) | 2017-01-23 | 2023-10-11 | Revolution Medicines, Inc. | Pyridine compounds as allosteric shp2 inhibitors |
| WO2018136265A1 (en) | 2017-01-23 | 2018-07-26 | Revolution Medicines, Inc. | Bicyclic compounds as allosteric shp2 inhibitors |
| CA3078565A1 (en) | 2017-10-12 | 2019-04-18 | Revolution Medicines, Inc. | Pyridine, pyrazine, and triazine compounds as allosteric shp2 inhibitors |
| EP3724189B1 (en) | 2017-12-15 | 2023-10-04 | Revolution Medicines, Inc. | Polycyclic compounds as allosteric shp2 inhibitors |
| WO2019121352A1 (en) | 2017-12-20 | 2019-06-27 | Basf Se | Herbicidal pyrimidine compounds |
| WO2019123195A1 (en) * | 2017-12-20 | 2019-06-27 | Pi Industries Ltd. | Pyrazolopyridine-diamides, their use as insecticide and processes for preparing the same. |
| WO2019121374A1 (en) | 2017-12-20 | 2019-06-27 | Basf Se | Herbicidal pyrimidine compounds |
| WO2020058062A1 (de) | 2018-09-19 | 2020-03-26 | Bayer Aktiengesellschaft | Herbizid wirksame substituierte phenylpyrimidinhydrazide |
| EA202191177A1 (ru) * | 2018-11-02 | 2021-07-28 | Мерк Шарп И Доум Корп. | 2-амино-n-гетероарилникотинамиды в качестве ингибиторов nav1.8 |
| WO2021085582A1 (ja) | 2019-10-31 | 2021-05-06 | 富士フイルム株式会社 | ピラジン誘導体またはその塩およびその利用 |
| WO2022025174A1 (ja) | 2020-07-30 | 2022-02-03 | 富士フイルム株式会社 | 含窒素複素環化合物またはその塩、その利用、およびその中間体 |
| WO2022103960A1 (en) | 2020-11-13 | 2022-05-19 | Inipharm, Inc. | Dichlorophenol hsd17b13 inhibitors and uses thereof |
| WO2022216627A1 (en) * | 2021-04-05 | 2022-10-13 | Inipharm, Inc. | Thiazole/isothiazole hsd17b13 inhibitors and uses thereof |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9910079D0 (en) | 1999-05-01 | 1999-06-30 | Smithkline Beecham Plc | Novel compounds |
| EP1193261A1 (en) | 2000-10-02 | 2002-04-03 | Warner-Lambert Company | New thiadiazoles and their use as phosphodiesterase-7 inhibitors |
| US20070032404A1 (en) | 2003-07-31 | 2007-02-08 | Bayer Pharmaceuticals Corporation | Methods for treating diabetes and related disorders using pde10a inhibitors |
| US7163937B2 (en) | 2003-08-21 | 2007-01-16 | Bristol-Myers Squibb Company | Cyclic derivatives as modulators of chemokine receptor activity |
| WO2005079802A1 (en) | 2004-02-12 | 2005-09-01 | Merck & Co., Inc. | Bipyridyl amides as modulators of metabotropic glutamate receptor-5 |
| KR100929942B1 (ko) * | 2005-03-04 | 2009-12-04 | 에프. 호프만-라 로슈 아게 | Ｍｇｌｕｒ５ 길항제로서 피리딘-2-카복사미드 유도체 |
| US20060199828A1 (en) | 2005-03-04 | 2006-09-07 | Georg Jaeschke | Pyrazine-2-carboxyamide derivatives |
| AR057987A1 (es) | 2005-11-24 | 2008-01-09 | Astrazeneca Ab | Compuestos agonistas de cb1 (receptor cannabinoide) |
| MX2009009304A (es) | 2007-03-01 | 2009-11-18 | Novartis Ag | Inhibidores de cinasa pim y metodos para su uso. |
| US20090105124A1 (en) | 2007-08-23 | 2009-04-23 | Kalypsys, Inc. | Heterocyclic modulators of tgr5 |
| US8470820B2 (en) | 2010-01-22 | 2013-06-25 | Hoffman-La Roche Inc. | Nitrogen-containing heteroaryl derivatives |
-
2011
- 2011-06-02 US US13/151,301 patent/US8703768B2/en active Active
- 2011-06-06 MX MX2012013907A patent/MX2012013907A/es active IP Right Grant
- 2011-06-06 BR BR112012031343A patent/BR112012031343A2/pt not_active Application Discontinuation
- 2011-06-06 WO PCT/EP2011/059234 patent/WO2011154327A1/en active Application Filing
- 2011-06-06 CN CN201180027950.8A patent/CN102947292B/zh not_active Expired - Fee Related
- 2011-06-06 CA CA2799022A patent/CA2799022A1/en not_active Abandoned
- 2011-06-06 JP JP2013513638A patent/JP5940523B2/ja not_active Expired - Fee Related
- 2011-06-06 EA EA201291282A patent/EA022075B1/ru not_active IP Right Cessation
- 2011-06-06 MA MA35502A patent/MA34340B1/fr unknown
- 2011-06-06 EP EP11723077.1A patent/EP2580207B1/en not_active Not-in-force
- 2011-06-06 PE PE2012002298A patent/PE20130279A1/es not_active Application Discontinuation
- 2011-06-06 SG SG2012085015A patent/SG185655A1/en unknown
- 2011-06-06 KR KR1020137000568A patent/KR101757959B1/ko active IP Right Grant
- 2011-06-06 UA UAA201214955A patent/UA108105C2/ru unknown
- 2011-06-06 NZ NZ603230A patent/NZ603230A/xx not_active IP Right Cessation
- 2011-06-07 AR ARP110101963A patent/AR081649A1/es unknown
- 2011-06-08 TW TW100120008A patent/TW201202221A/zh unknown
-
2012
- 2012-10-26 CO CO12192367A patent/CO6620065A2/es active IP Right Grant
- 2012-11-15 IL IL223069A patent/IL223069A0/en unknown
- 2012-11-26 CR CR20120594A patent/CR20120594A/es unknown
- 2012-12-03 ZA ZA2012/09119A patent/ZA201209119B/en unknown
- 2012-12-05 CL CL2012003421A patent/CL2012003421A1/es unknown
- 2012-12-07 EC ECSP12012330 patent/ECSP12012330A/es unknown
-
2013
- 2013-05-17 HK HK13105859.4A patent/HK1178900A1/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| EA022075B1 (ru) | 2015-10-30 |
| EP2580207A1 (en) | 2013-04-17 |
| CN102947292B (zh) | 2015-08-19 |
| EP2580207B1 (en) | 2017-09-27 |
| BR112012031343A2 (pt) | 2016-11-01 |
| CR20120594A (es) | 2013-01-03 |
| JP5940523B2 (ja) | 2016-06-29 |
| SG185655A1 (en) | 2012-12-28 |
| UA108105C2 (ru) | 2015-03-25 |
| CL2012003421A1 (es) | 2013-07-26 |
| CN102947292A (zh) | 2013-02-27 |
| IL223069A0 (en) | 2013-02-03 |
| NZ603230A (en) | 2013-09-27 |
| HK1178900A1 (en) | 2013-09-19 |
| JP2013528193A (ja) | 2013-07-08 |
| KR20130112858A (ko) | 2013-10-14 |
| AR081649A1 (es) | 2012-10-10 |
| US8703768B2 (en) | 2014-04-22 |
| ECSP12012330A (es) | 2012-12-28 |
| CO6620065A2 (es) | 2013-02-15 |
| CA2799022A1 (en) | 2011-12-15 |
| KR101757959B1 (ko) | 2017-07-14 |
| MA34340B1 (fr) | 2013-06-01 |
| EA201291282A1 (ru) | 2013-06-28 |
| WO2011154327A1 (en) | 2011-12-15 |
| PE20130279A1 (es) | 2013-03-08 |
| TW201202221A (en) | 2012-01-16 |
| US20110306589A1 (en) | 2011-12-15 |
| ZA201209119B (en) | 2015-05-27 |
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