MX2020003579A - Compuestos de piridina, pirazina, y triazina como inhibidores de shp2 alostericos. - Google Patents
Compuestos de piridina, pirazina, y triazina como inhibidores de shp2 alostericos.Info
- Publication number
- MX2020003579A MX2020003579A MX2020003579A MX2020003579A MX2020003579A MX 2020003579 A MX2020003579 A MX 2020003579A MX 2020003579 A MX2020003579 A MX 2020003579A MX 2020003579 A MX2020003579 A MX 2020003579A MX 2020003579 A MX2020003579 A MX 2020003579A
- Authority
- MX
- Mexico
- Prior art keywords
- pyrazine
- pyridine
- triazine compounds
- shp2 inhibitors
- allosteric shp2
- Prior art date
Links
- KYQCOXFCLRTKLS-UHFFFAOYSA-N Pyrazine Chemical compound C1=CN=CC=N1 KYQCOXFCLRTKLS-UHFFFAOYSA-N 0.000 title 2
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 title 2
- PCNDJXKNXGMECE-UHFFFAOYSA-N Phenazine Natural products C1=CC=CC2=NC3=CC=CC=C3N=C21 PCNDJXKNXGMECE-UHFFFAOYSA-N 0.000 title 1
- 230000003281 allosteric effect Effects 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 title 1
- 150000003918 triazines Chemical class 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4965—Non-condensed pyrazines
- A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
- C07D491/107—Spiro-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
La presente descripción está dirigida a los inhibidores de SHP2 y a su uso en el tratamiento de enfermedades. También se describen composiciones farmacéuticas que los comprenden.
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762571760P | 2017-10-12 | 2017-10-12 | |
| US201862615353P | 2018-01-09 | 2018-01-09 | |
| US201862678889P | 2018-05-31 | 2018-05-31 | |
| PCT/US2018/055502 WO2019075265A1 (en) | 2017-10-12 | 2018-10-11 | PYRIDINE, PYRAZINE AND TRIAZINE COMPOUNDS AS ALLOSTERIC INHIBITORS OF SHP2 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2020003579A true MX2020003579A (es) | 2020-07-22 |
Family
ID=64049755
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2020003579A MX2020003579A (es) | 2017-10-12 | 2018-10-11 | Compuestos de piridina, pirazina, y triazina como inhibidores de shp2 alostericos. |
Country Status (16)
| Country | Link |
|---|---|
| US (2) | US11702411B2 (es) |
| EP (1) | EP3694848A1 (es) |
| JP (1) | JP2020536881A (es) |
| KR (1) | KR20200070295A (es) |
| CN (1) | CN111212834B (es) |
| AU (1) | AU2018347516A1 (es) |
| BR (1) | BR112020007058A2 (es) |
| CA (1) | CA3078565A1 (es) |
| CO (1) | CO2020003714A2 (es) |
| IL (1) | IL273756A (es) |
| MX (1) | MX2020003579A (es) |
| PH (1) | PH12020550216A1 (es) |
| RU (1) | RU2020115095A (es) |
| SG (1) | SG11202002941WA (es) |
| TW (1) | TW201930292A (es) |
| WO (1) | WO2019075265A1 (es) |
Families Citing this family (87)
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| JO3517B1 (ar) | 2014-01-17 | 2020-07-05 | Novartis Ag | ان-ازاسبيرو الكان حلقي كبديل مركبات اريل-ان مغايرة وتركيبات لتثبيط نشاط shp2 |
| AU2017274199B2 (en) | 2016-05-31 | 2021-09-23 | Board Of Regents, The University Of Texas System | Heterocyclic inhibitors of PTPN11 |
| EA202092442A3 (ru) | 2016-06-07 | 2021-08-31 | Джакобио Фармасьютикалс Ко., Лтд. | Новые гетероциклические производные, применимые в качестве ингибиторов shp2 |
| CN109415360B (zh) | 2016-06-14 | 2021-11-02 | 诺华股份有限公司 | 用于抑制shp2活性的化合物和组合物 |
| KR102598895B1 (ko) | 2016-07-12 | 2023-11-07 | 레볼루션 메디슨즈, 인크. | 다른자리 입체성 shp2 억제제로서의 2,5-이치환 3-메틸 피라진 및 2,5,6-3치환 3-메틸 피라진 |
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2020
- 2020-03-27 CO CONC2020/0003714A patent/CO2020003714A2/es unknown
- 2020-03-31 PH PH12020550216A patent/PH12020550216A1/en unknown
- 2020-04-01 IL IL273756A patent/IL273756A/en unknown
- 2020-04-10 US US16/845,539 patent/US11702411B2/en active Active
-
2023
- 2023-04-05 US US18/131,226 patent/US20240067636A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| WO2019075265A1 (en) | 2019-04-18 |
| EP3694848A1 (en) | 2020-08-19 |
| PH12020550216A1 (en) | 2021-02-15 |
| CA3078565A1 (en) | 2019-04-18 |
| IL273756A (en) | 2020-05-31 |
| CN111212834B (zh) | 2024-01-19 |
| RU2020115095A (ru) | 2021-11-12 |
| US20240067636A1 (en) | 2024-02-29 |
| US20200339552A1 (en) | 2020-10-29 |
| KR20200070295A (ko) | 2020-06-17 |
| US11702411B2 (en) | 2023-07-18 |
| CO2020003714A2 (es) | 2020-04-24 |
| AU2018347516A1 (en) | 2020-05-07 |
| BR112020007058A2 (pt) | 2020-10-06 |
| CN111212834A (zh) | 2020-05-29 |
| RU2020115095A3 (es) | 2022-01-31 |
| TW201930292A (zh) | 2019-08-01 |
| JP2020536881A (ja) | 2020-12-17 |
| SG11202002941WA (en) | 2020-04-29 |
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