GB1459571A - Thiophene-2-sulphonamide derivatives and their use as therapeutic agents sheet orienting apparatus - Google Patents
Thiophene-2-sulphonamide derivatives and their use as therapeutic agents sheet orienting apparatusInfo
- Publication number
- GB1459571A GB1459571A GB3975374A GB3975374A GB1459571A GB 1459571 A GB1459571 A GB 1459571A GB 3975374 A GB3975374 A GB 3975374A GB 3975374 A GB3975374 A GB 3975374A GB 1459571 A GB1459571 A GB 1459571A
- Authority
- GB
- United Kingdom
- Prior art keywords
- thiophene
- therapeutic agents
- sulphonamide derivatives
- orienting apparatus
- compounds
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/30—Hetero atoms other than halogen
- C07D333/34—Sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/30—Hetero atoms other than halogen
- C07D333/36—Nitrogen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
1459571 Thiophene-2-sulphonamide derivatives PFIZER Ltd 10 Sept 1975 [12 Sept 1974] 39753/74 Heading C2C The invention comprises compounds of the Formula I where Ar represents a mono- or bi-cyclic aromatic group, optionally substituted; n is 0, 1 or 2 and R represents a hydrogen or halogen atom, or a C 1 to C 6 alkyl, C 1 to C 6 alkoxy, hydroxyl, nitro, amino or mono- or dialkylamino group; and the alkali metal or acid addition salts of such compounds. The compounds of Formula I are used as therapeutic agents.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB3975374A GB1459571A (en) | 1974-09-12 | 1974-09-12 | Thiophene-2-sulphonamide derivatives and their use as therapeutic agents sheet orienting apparatus |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB3975374A GB1459571A (en) | 1974-09-12 | 1974-09-12 | Thiophene-2-sulphonamide derivatives and their use as therapeutic agents sheet orienting apparatus |
Publications (1)
Publication Number | Publication Date |
---|---|
GB1459571A true GB1459571A (en) | 1976-12-22 |
Family
ID=10411298
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB3975374A Expired GB1459571A (en) | 1974-09-12 | 1974-09-12 | Thiophene-2-sulphonamide derivatives and their use as therapeutic agents sheet orienting apparatus |
Country Status (1)
Country | Link |
---|---|
GB (1) | GB1459571A (en) |
Cited By (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0042731A1 (en) * | 1980-06-21 | 1981-12-30 | Pfizer Limited | Larvicides, insecticides, acaricides and miticides, processes for preparing them and compositions containing them |
US4477466A (en) * | 1983-05-23 | 1984-10-16 | Merck & Co., Inc. | Acyloxy derivatives of [phenylsulfonyl(or sulfinyl)]thiophenesulfonamide for the topical treatment of elevated intraocular pressure |
EP0130109A2 (en) * | 1983-06-20 | 1985-01-02 | Merck & Co. Inc. | Derivatives of thiophenesulfonamide, their preparation and pharmaceutical composition for the topical treatment of elevated intraocular pressure |
US4542152A (en) * | 1983-05-23 | 1985-09-17 | Merck & Co., Inc. | 5-[Phenylsulfonyl(or sulfinyl)]thiophene-2-sulfonamides for the topical treatment of elevated intraocular pressure |
US4585787A (en) * | 1983-06-20 | 1986-04-29 | Merck & Co., Inc. | 5-[2(Or 3)-hydroxyphenylsulfonyl]thiophene-2-sulfonamides for the topical treatment of elevated intraocular pressure |
EP0182691A1 (en) * | 1984-11-02 | 1986-05-28 | Merck & Co. Inc. | Substituted thiophene-2-sulfonamides and their preparation |
US4668697A (en) * | 1983-10-31 | 1987-05-26 | Merck & Co., Inc. | Elevated intraocular pressure lowering benzo-[b]-thiophene-2-sulfonamide derivatives, compositions, and method of use therefor |
EP0228237A1 (en) * | 1985-12-24 | 1987-07-08 | Merck & Co. Inc. | Substituted thiophene-2-sulfonamide antiglaucoma agents |
US4721794A (en) * | 1984-11-02 | 1988-01-26 | Merck & Co., Inc. | Substituted thiophene-2-sulfonamide antiglaucoma agents |
US4788192A (en) * | 1983-06-20 | 1988-11-29 | Merck & Co., Inc. | 2-Sulfamoylbenzo(b)thiophene derivatives pharmaceutical compositions and use |
EP0295049A2 (en) * | 1987-06-08 | 1988-12-14 | Merck & Co. Inc. | Thiophene sulfonamide antiglaucoma agents |
US4929637A (en) * | 1985-12-24 | 1990-05-29 | Merck & Co., Inc. | Substituted thiophene-2-sulfonamide antiglaucoma agents |
EP0479480A2 (en) * | 1990-10-01 | 1992-04-08 | Merck & Co. Inc. | Substituted thieno(2,3-B)(1,4)thiazine-6-sulfonamides as antiglaucoma agents |
US8680139B2 (en) | 2009-04-01 | 2014-03-25 | Progenra | Anti-neoplastic compounds, compositions and methods |
US11364300B2 (en) | 2018-05-01 | 2022-06-21 | Revolution Medicines, Inc. | C40-, C28-, and C-32-linked rapamycin analogs as mTOR inhibitors |
US11596633B2 (en) | 2017-09-07 | 2023-03-07 | Revolution Medicines, Inc. | SHP2 inhibitor compositions and methods for treating cancer |
US11661401B2 (en) | 2016-07-12 | 2023-05-30 | Revolution Medicines, Inc. | 2,5-disubstituted 3-methyl pyrazines and 2,5,6-trisubstituted 3-methyl pyrazines as allosteric SHP2 inhibitors |
US11673896B2 (en) | 2017-01-23 | 2023-06-13 | Revolution Medicines, Inc. | Pyridine compounds as allosteric SHP2 inhibitors |
US11673901B2 (en) | 2017-12-15 | 2023-06-13 | Revolution Medicines, Inc. | Polycyclic compounds as allosteric SHP2 inhibitors |
US11685749B2 (en) | 2018-05-01 | 2023-06-27 | Revolution Medicines, Inc. | C26-linked rapamycin analogs as mTOR inhibitors |
US11702411B2 (en) | 2017-10-12 | 2023-07-18 | Revolution Medicines, Inc. | Pyridine, pyrazine, and triazine compounds as allosteric SHP2 inhibitors |
US11739093B2 (en) | 2017-01-23 | 2023-08-29 | Revolution Medicines, Inc. | Substituted pyrazolopyrazines, imidazopyrazines and [1,2,4]triazolopyrazines as allosteric SHP2 inhibitors |
-
1974
- 1974-09-12 GB GB3975374A patent/GB1459571A/en not_active Expired
Cited By (26)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0042731A1 (en) * | 1980-06-21 | 1981-12-30 | Pfizer Limited | Larvicides, insecticides, acaricides and miticides, processes for preparing them and compositions containing them |
US4477466A (en) * | 1983-05-23 | 1984-10-16 | Merck & Co., Inc. | Acyloxy derivatives of [phenylsulfonyl(or sulfinyl)]thiophenesulfonamide for the topical treatment of elevated intraocular pressure |
US4542152A (en) * | 1983-05-23 | 1985-09-17 | Merck & Co., Inc. | 5-[Phenylsulfonyl(or sulfinyl)]thiophene-2-sulfonamides for the topical treatment of elevated intraocular pressure |
EP0130109A2 (en) * | 1983-06-20 | 1985-01-02 | Merck & Co. Inc. | Derivatives of thiophenesulfonamide, their preparation and pharmaceutical composition for the topical treatment of elevated intraocular pressure |
US4585787A (en) * | 1983-06-20 | 1986-04-29 | Merck & Co., Inc. | 5-[2(Or 3)-hydroxyphenylsulfonyl]thiophene-2-sulfonamides for the topical treatment of elevated intraocular pressure |
EP0130109A3 (en) * | 1983-06-20 | 1986-11-26 | Merck & Co. Inc. | Derivatives of thiophenesulfonamide, their preparation and pharmaceutical composition for the topical treatment of elevated intraocular pressure |
US4788192A (en) * | 1983-06-20 | 1988-11-29 | Merck & Co., Inc. | 2-Sulfamoylbenzo(b)thiophene derivatives pharmaceutical compositions and use |
US4668697A (en) * | 1983-10-31 | 1987-05-26 | Merck & Co., Inc. | Elevated intraocular pressure lowering benzo-[b]-thiophene-2-sulfonamide derivatives, compositions, and method of use therefor |
EP0182691A1 (en) * | 1984-11-02 | 1986-05-28 | Merck & Co. Inc. | Substituted thiophene-2-sulfonamides and their preparation |
US4721794A (en) * | 1984-11-02 | 1988-01-26 | Merck & Co., Inc. | Substituted thiophene-2-sulfonamide antiglaucoma agents |
EP0228237A1 (en) * | 1985-12-24 | 1987-07-08 | Merck & Co. Inc. | Substituted thiophene-2-sulfonamide antiglaucoma agents |
US4929637A (en) * | 1985-12-24 | 1990-05-29 | Merck & Co., Inc. | Substituted thiophene-2-sulfonamide antiglaucoma agents |
EP0295049A3 (en) * | 1987-06-08 | 1989-03-08 | Merck & Co. Inc. | Thiophene sulfonamide antiglaucoma agents |
EP0295049A2 (en) * | 1987-06-08 | 1988-12-14 | Merck & Co. Inc. | Thiophene sulfonamide antiglaucoma agents |
US4847289A (en) * | 1987-06-08 | 1989-07-11 | Merck & Co., Inc. | Thiophene sulfonamide antiglaucoma agents |
EP0479480A2 (en) * | 1990-10-01 | 1992-04-08 | Merck & Co. Inc. | Substituted thieno(2,3-B)(1,4)thiazine-6-sulfonamides as antiglaucoma agents |
EP0479480A3 (en) * | 1990-10-01 | 1992-04-22 | Merck & Co. Inc. | Substituted thieno(2,3-b)(1,4)thiazine-6-sulfonamides as antiglaucoma agents |
US8680139B2 (en) | 2009-04-01 | 2014-03-25 | Progenra | Anti-neoplastic compounds, compositions and methods |
US11661401B2 (en) | 2016-07-12 | 2023-05-30 | Revolution Medicines, Inc. | 2,5-disubstituted 3-methyl pyrazines and 2,5,6-trisubstituted 3-methyl pyrazines as allosteric SHP2 inhibitors |
US11673896B2 (en) | 2017-01-23 | 2023-06-13 | Revolution Medicines, Inc. | Pyridine compounds as allosteric SHP2 inhibitors |
US11739093B2 (en) | 2017-01-23 | 2023-08-29 | Revolution Medicines, Inc. | Substituted pyrazolopyrazines, imidazopyrazines and [1,2,4]triazolopyrazines as allosteric SHP2 inhibitors |
US11596633B2 (en) | 2017-09-07 | 2023-03-07 | Revolution Medicines, Inc. | SHP2 inhibitor compositions and methods for treating cancer |
US11702411B2 (en) | 2017-10-12 | 2023-07-18 | Revolution Medicines, Inc. | Pyridine, pyrazine, and triazine compounds as allosteric SHP2 inhibitors |
US11673901B2 (en) | 2017-12-15 | 2023-06-13 | Revolution Medicines, Inc. | Polycyclic compounds as allosteric SHP2 inhibitors |
US11685749B2 (en) | 2018-05-01 | 2023-06-27 | Revolution Medicines, Inc. | C26-linked rapamycin analogs as mTOR inhibitors |
US11364300B2 (en) | 2018-05-01 | 2022-06-21 | Revolution Medicines, Inc. | C40-, C28-, and C-32-linked rapamycin analogs as mTOR inhibitors |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PS | Patent sealed | ||
PCNP | Patent ceased through non-payment of renewal fee |