GB1467528A - Piperazinium 1-p-chlorobenzoyl-2-methyl-5-methoxy-3-indolyl acetate - Google Patents

Piperazinium 1-p-chlorobenzoyl-2-methyl-5-methoxy-3-indolyl acetate

Info

Publication number
GB1467528A
GB1467528A GB682775A GB682775A GB1467528A GB 1467528 A GB1467528 A GB 1467528A GB 682775 A GB682775 A GB 682775A GB 682775 A GB682775 A GB 682775A GB 1467528 A GB1467528 A GB 1467528A
Authority
GB
United Kingdom
Prior art keywords
piperazinium
chlorobenzoyl
methoxy
methyl
indomethacin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB682775A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Laboratorios Roger SA
Original Assignee
Laboratorios Roger SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Laboratorios Roger SA filed Critical Laboratorios Roger SA
Publication of GB1467528A publication Critical patent/GB1467528A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/02—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements
    • C07D295/027—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements containing only one hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D209/26—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an acyl radical attached to the ring nitrogen atom
    • C07D209/28—1-(4-Chlorobenzoyl)-2-methyl-indolyl-3-acetic acid, substituted in position 5 by an oxygen or nitrogen atom; Esters thereof

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)

Abstract

1467528 Piperazine bis-indomethacin salt LABORATORIOS ROGER SA 18 Feb 1975 [2 March 1974] 6827/75 Heading C2C The invention comprises the title compound and a process for preparing it by stirring indomethacin with anhydrous piperazine in stoichiometric proportions, in presence of acetone, and cooling and filtering the mixture. Therapeutic compositions having antiinflammatory and analgesic activity comprise the above salt, and may be administered orally or rectally.
GB682775A 1974-03-02 1975-02-18 Piperazinium 1-p-chlorobenzoyl-2-methyl-5-methoxy-3-indolyl acetate Expired GB1467528A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES423834A ES423834A1 (en) 1974-03-02 1974-03-02 Piperazinium 1-p-chlorobenzoyl-2-methyl-5-methoxy-3-indolyl acetate

Publications (1)

Publication Number Publication Date
GB1467528A true GB1467528A (en) 1977-03-16

Family

ID=8466108

Family Applications (1)

Application Number Title Priority Date Filing Date
GB682775A Expired GB1467528A (en) 1974-03-02 1975-02-18 Piperazinium 1-p-chlorobenzoyl-2-methyl-5-methoxy-3-indolyl acetate

Country Status (4)

Country Link
BE (1) BE826038A (en)
ES (1) ES423834A1 (en)
FR (1) FR2262522B1 (en)
GB (1) GB1467528A (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4551475A (en) * 1981-02-24 1985-11-05 Ciba-Geigy Corporation Pharmaceutical preparations for topical application which contain salts of alkanecarboxylic acids
EP1893190A2 (en) * 2005-04-28 2008-03-05 Theraquest Biosciences, LLC Methods and compositions for treating pain

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS61152656A (en) * 1984-12-27 1986-07-11 Taiho Yakuhin Kogyo Kk Piperazine derivative

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4551475A (en) * 1981-02-24 1985-11-05 Ciba-Geigy Corporation Pharmaceutical preparations for topical application which contain salts of alkanecarboxylic acids
EP1893190A2 (en) * 2005-04-28 2008-03-05 Theraquest Biosciences, LLC Methods and compositions for treating pain
EP1893190A4 (en) * 2005-04-28 2010-07-28 Theraquest Biosciences Llc Methods and compositions for treating pain

Also Published As

Publication number Publication date
FR2262522B1 (en) 1980-02-08
ES423834A1 (en) 1976-06-01
BE826038A (en) 1975-06-16
FR2262522A1 (en) 1975-09-26

Similar Documents

Publication Publication Date Title
GB1418822A (en) Imidazo-and pyrimido-2,1-b-quinazolin-2-ones and a process for the preparation thereof
GB1459571A (en) Thiophene-2-sulphonamide derivatives and their use as therapeutic agents sheet orienting apparatus
ES439927A1 (en) 7-Methoxy-6-thiatetracyclines and their preparation
GB1456627A (en) Pyridobenzodiazepinones
SE7411243L (en)
GB1467528A (en) Piperazinium 1-p-chlorobenzoyl-2-methyl-5-methoxy-3-indolyl acetate
GB1362918A (en) Thioesters of guanidinoorganic acids and production thereof
ES413260A1 (en) Nn * 11 chikan 33 pirorijiniru * chiobenzuamidono seiho
ES417396A1 (en) A procedure for the production of a pharmaceutical composition. (Machine-translation by Google Translate, not legally binding)
GB1490290A (en) Preparation of penicillanic acid derivatives
GB1346279A (en) Hydantoin derivatives processes for their preparation and compositions incorporating them
ES437058A1 (en) Cyclopentane derivatives manufacture
ES409637A1 (en) 1,2,3,4,10,10a-hexahydropyrazino{8 1,2:a{9 indole-2-carboxamidines
ES435003A1 (en) Process for N-acylation of 7 amino cephem compounds
GB1464636A (en) /harmaceutical compositions containing 2-naphthyl-butyric acid derivatives
GB1219176A (en) Antihypertensive compositions and their preparation
GB1498083A (en) Pharmaceutical preparations
GB1492180A (en) Pharmaceutical composition for the treatment of hyperammoniemia
GB1468116A (en) Esters of 5-n-butyl-pyridine-2-carboxylic acid
ES438537A1 (en) 1-(2,4,6-Trihydroxyphenyl)-propanedione-(1,2)-compounds and therapeutic compositions
GB1468333A (en) Ketoglutaric acid derivatives
GB1284423A (en) Cyclohexa-1,4-diene-1-acetic acids
GB1470748A (en) 6-2-pyridyl-4h-s-triazolo-4,3-a-1,4-benzodiazepines
GB1283810A (en) Magnesium aspartate hydrohalides
GB1341329A (en) Indole derivatives process for producing them and compositions containing them

Legal Events

Date Code Title Description
PS Patent sealed
PCNP Patent ceased through non-payment of renewal fee