CO2020003714A2 - Compuestos de piridina, pirazina, y triazina como inhibidores de shp2 alostéricos - Google Patents

Compuestos de piridina, pirazina, y triazina como inhibidores de shp2 alostéricos

Info

Publication number
CO2020003714A2
CO2020003714A2 CONC2020/0003714A CO2020003714A CO2020003714A2 CO 2020003714 A2 CO2020003714 A2 CO 2020003714A2 CO 2020003714 A CO2020003714 A CO 2020003714A CO 2020003714 A2 CO2020003714 A2 CO 2020003714A2
Authority
CO
Colombia
Prior art keywords
pyrazine
pyridine
triazine compounds
shp2 inhibitors
allosteric shp2
Prior art date
Application number
CONC2020/0003714A
Other languages
English (en)
Inventor
Walter Won
Elena S Koltun
Kevin Mellem
Naing Aay
Andreas Buckl
Jie Jack Li
Adrian Liam Gill
Christos Tzitzilonis
Ashutosh Jogalekar
James Joseph Cregg
Original Assignee
Revolution Medicines Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Revolution Medicines Inc filed Critical Revolution Medicines Inc
Publication of CO2020003714A2 publication Critical patent/CO2020003714A2/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
    • A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • C07D491/107—Spiro-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring

Abstract

La presente descripción está dirigida a los inhibidores de SHP2 y a su uso en el tratamiento de enfermedades. También se describen composiciones farmacéuticas que los comprenden.
CONC2020/0003714A 2017-10-12 2020-03-27 Compuestos de piridina, pirazina, y triazina como inhibidores de shp2 alostéricos CO2020003714A2 (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201762571760P 2017-10-12 2017-10-12
US201862615353P 2018-01-09 2018-01-09
US201862678889P 2018-05-31 2018-05-31
PCT/US2018/055502 WO2019075265A1 (en) 2017-10-12 2018-10-11 PYRIDINE, PYRAZINE AND TRIAZINE COMPOUNDS AS ALLOSTERIC INHIBITORS OF SHP2

Publications (1)

Publication Number Publication Date
CO2020003714A2 true CO2020003714A2 (es) 2020-04-24

Family

ID=64049755

Family Applications (1)

Application Number Title Priority Date Filing Date
CONC2020/0003714A CO2020003714A2 (es) 2017-10-12 2020-03-27 Compuestos de piridina, pirazina, y triazina como inhibidores de shp2 alostéricos

Country Status (16)

Country Link
US (2) US11702411B2 (es)
EP (1) EP3694848A1 (es)
JP (1) JP2020536881A (es)
KR (1) KR20200070295A (es)
CN (1) CN111212834B (es)
AU (1) AU2018347516A1 (es)
BR (1) BR112020007058A2 (es)
CA (1) CA3078565A1 (es)
CO (1) CO2020003714A2 (es)
IL (1) IL273756A (es)
MX (1) MX2020003579A (es)
PH (1) PH12020550216A1 (es)
RU (1) RU2020115095A (es)
SG (1) SG11202002941WA (es)
TW (1) TW201930292A (es)
WO (1) WO2019075265A1 (es)

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