UY36265A - “derivados de pirrolo[2,3-d]pirimidina”. - Google Patents

“derivados de pirrolo[2,3-d]pirimidina”.

Info

Publication number
UY36265A
UY36265A UY0001036265A UY36265A UY36265A UY 36265 A UY36265 A UY 36265A UY 0001036265 A UY0001036265 A UY 0001036265A UY 36265 A UY36265 A UY 36265A UY 36265 A UY36265 A UY 36265A
Authority
UY
Uruguay
Prior art keywords
pyrimidine
derivatives
pirrolo
pirrolo derivatives
jak
Prior art date
Application number
UY0001036265A
Other languages
English (en)
Inventor
Mihir D Parikh
Karen J Coffman
James M Duerr
Matthew R Reese
Samad Tarek
Sciabola Simone
Jamison B Tuttle
Michael L Vazquez
Patrick Robert Verhoest
Kaila Neelu
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of UY36265A publication Critical patent/UY36265A/es

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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5386—1,4-Oxazines, e.g. morpholine spiro-condensed or forming part of bridged ring systems
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    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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    • C07D491/04—Ortho-condensed systems
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  • Health & Medical Sciences (AREA)
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  • Pharmacology & Pharmacy (AREA)
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  • Diabetes (AREA)
  • Pain & Pain Management (AREA)
  • Dermatology (AREA)
  • Pulmonology (AREA)
  • Hematology (AREA)
  • Psychiatry (AREA)
  • Endocrinology (AREA)
  • Rheumatology (AREA)
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  • Oncology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Psychology (AREA)
  • Communicable Diseases (AREA)
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Abstract

En la presente, se describen derivados de pirrolo{2,3-d}pirimidina, su uso como inhibidores de la quinasa Janus (JAK), las composiciones farmacéuticas que los contienen y sus usos terapéuticos.
UY0001036265A 2014-08-12 2015-08-10 “derivados de pirrolo[2,3-d]pirimidina”. UY36265A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201462036276P 2014-08-12 2014-08-12
US201562189347P 2015-07-07 2015-07-07

Publications (1)

Publication Number Publication Date
UY36265A true UY36265A (es) 2016-04-01

Family

ID=54148574

Family Applications (1)

Application Number Title Priority Date Filing Date
UY0001036265A UY36265A (es) 2014-08-12 2015-08-10 “derivados de pirrolo[2,3-d]pirimidina”.

Country Status (8)

Country Link
US (1) US10966980B2 (es)
EP (1) EP3180344B1 (es)
JP (1) JP6585158B2 (es)
CA (1) CA2899888A1 (es)
ES (1) ES2750655T3 (es)
TW (1) TW201619159A (es)
UY (1) UY36265A (es)
WO (1) WO2016024185A1 (es)

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US10111882B2 (en) 2016-09-14 2018-10-30 Gilead Sciences, Inc. SYK inhibitors
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WO2018195471A1 (en) 2017-04-21 2018-10-25 Gilead Sciences, Inc. Syk inhibitors in combination with hypomethylating agents
US20220040197A1 (en) * 2017-12-21 2022-02-10 Gliapharm Sa Compositions and methods of treatment for neurological disorders comprising a dementia
US11365188B2 (en) 2018-03-21 2022-06-21 Xibin Liao JAK inhibitors
US10815240B2 (en) 2018-07-06 2020-10-27 Pfizer Inc. Manufacturing process and intermediates for a pyrrolo[2,3-d]pyrimidine compound and use thereof
US10744136B2 (en) 2018-11-05 2020-08-18 Avista Pharma Solutions, Inc. Sulfonamide derivatives as JAK inhibitors
MX2021011606A (es) 2019-04-02 2021-12-10 Aligos Therapeutics Inc Compuestos dirigidos a prmt5.
WO2020232470A1 (en) 2019-05-13 2020-11-19 Boragen, Inc. Chemical compounds
CN110483338A (zh) * 2019-08-14 2019-11-22 苏州汉德创宏生化科技有限公司 一种大环类抑制剂中间体环庚烷基磺酰氯的合成方法
EP4157845A1 (en) * 2020-05-28 2023-04-05 Pfizer Inc. Pyrrolo[2,3-d]pyrimidine derivatives
CN112697912B (zh) * 2020-12-14 2021-09-21 上海博悦生物科技有限公司 一种检测枸橼酸托法替布中间体及其相关杂质的方法
MX2023009352A (es) 2021-02-10 2023-08-16 Iolyx Therapeutics Inc Metodos para la administracion oftalmica de roflumilast.
WO2024173234A1 (en) * 2023-02-13 2024-08-22 Arase Therapeutics Inc. Inhibitors of parg

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